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  1. Article ; Online: Author response: Reducing birth defects in women with epilepsy: Research leading to results.

    Pennell, Page B

    Neurology

    2020  Volume 95, Issue 4, Page(s) 191

    MeSH term(s) Anticonvulsants ; Epilepsy ; Female ; Humans
    Chemical Substances Anticonvulsants
    Keywords covid19
    Language English
    Publishing date 2020-07-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Benefits and Risks of Periconceptional Folic Acid Supplementation.

    Voinescu, P Emanuela / Pennell, Page B / Meador, Kimford

    JAMA neurology

    2023  Volume 80, Issue 4, Page(s) 420–421

    MeSH term(s) Humans ; Folic Acid/adverse effects ; Dietary Supplements ; Risk Assessment
    Chemical Substances Folic Acid (935E97BOY8)
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.0095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unravelling the heterogeneity of epilepsy for optimal individualised treatment: advances in 2019.

    Pennell, Page B

    The Lancet. Neurology

    2019  Volume 19, Issue 1, Page(s) 8–10

    MeSH term(s) Epilepsy/etiology ; Epilepsy/therapy ; Humans ; Neurology/trends ; Precision Medicine
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(19)30430-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Neurology illnesses and pregnancy

    Pennell, Page B.

    (Neurologic clinics ; 22,4)

    2004  

    Author's details guest ed. Page B. Pennell
    Series title Neurologic clinics ; 22,4
    Collection
    Language English
    Size X S., S. 727 - 926 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014201610
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Prescribing antiepileptic drugs to women of reproductive age.

    Pennell, Page B

    The Lancet. Neurology

    2018  Volume 17, Issue 6, Page(s) 485–486

    Language English
    Publishing date 2018-04-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(18)30154-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Changes in Seizure Frequency and Antiepileptic Therapy during Pregnancy. Reply.

    Pennell, Page B / Meador, Kimford J

    The New England journal of medicine

    2021  Volume 384, Issue 10, Page(s) 977–978

    MeSH term(s) Anticonvulsants/adverse effects ; Epilepsy/drug therapy ; Female ; Humans ; Pregnancy ; Seizures/chemically induced ; Seizures/drug therapy
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2101226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antiepileptic Drugs in Pregnancy-Quick Decisions With Long-term Consequences.

    Pennell, Page B

    JAMA neurology

    2018  Volume 75, Issue 6, Page(s) 652–654

    MeSH term(s) Anticonvulsants ; Child ; Epilepsy ; Female ; Humans ; Language ; Mathematics ; Pregnancy ; Pregnancy Complications ; Valproic Acid
    Chemical Substances Anticonvulsants ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2018-02-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2017.5060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author response: Reducing birth defects in women with epilepsy: Research leading to results.

    Pennell, Page B / Meador, Kimford J

    Neurology

    2020  Volume 95, Issue 4, Page(s) 189–190

    MeSH term(s) Anticonvulsants ; Epilepsy ; Female ; Humans
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2020-07-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lamotrigine and exogenous estrogen among females with epilepsy: A retrospective analysis of administrative claims data.

    Kirkpatrick, Laura / Terman, Samuel W / Harrison, Elizabeth / Pennell, Page B

    Epilepsy & behavior : E&B

    2023  Volume 149, Page(s) 109514

    Abstract: Objective: Exogenous estrogen reduces lamotrigine serum concentrations. Little is known about whether providers adjust lamotrigine doses for addition of exogenous estrogen among people with epilepsy, despite expert recommendations. We determined the ... ...

    Abstract Objective: Exogenous estrogen reduces lamotrigine serum concentrations. Little is known about whether providers adjust lamotrigine doses for addition of exogenous estrogen among people with epilepsy, despite expert recommendations. We determined the incidence of dose increases in lamotrigine following incident prescription of estrogen among females with epilepsy (FWE) in claims data.
    Methods: We used Optum's de-identified Clinformatics® Data Mart Database to create a cohort of U.S. FWE prescribed lamotrigine at a stable dose, with a subsequent prescription for estrogen from 2011 to 2021. We calculated cumulative incidence functions of dose increases in lamotrigine following prescription of exogenous estrogen. We performed a Cox proportional hazards model for multiple candidate predictors of a lamotrigine dose increase.
    Results: The cohort included 643 FWE, with median age of 31 (interquartile ratio [IQR] 20-42). The cumulative incidence of any lamotrigine increase was 28% (95% confidence interval [CI] 25%-32%). The median number of days after the first estrogen fill until the first lamotrigine adjustment was 118 (IQR 48-188). In unadjusted Cox models, older age, use of estrogen in hormone replacement therapy as opposed to contraception, and annual household income of $50,000-$99,999 (compared with <$50,000) were significant negative predictors of a dose adjustment in lamotrigine with hazard ratios (HRs) of 0.82 (95% CI 0.72-0.92), 0.63 (95% CI 0.42-0.95), and 0.62 (95% CI 0.40-0.95). In the adjusted Cox model, age and income remained significant predictors with HRs of 0.79 (95% CI 0.66-0.94) and 0.59 (95% CI 0.36-0.95).
    Conclusion: Dose increase of lamotrigine following addition of exogenous estrogen is rare among U.S. FWE, with potential disparities based on age and income level. More guidance may be needed for providers on this topic.
    MeSH term(s) Female ; Humans ; Lamotrigine/therapeutic use ; Retrospective Studies ; Anticonvulsants/therapeutic use ; Epilepsy/drug therapy ; Epilepsy/epidemiology ; Estrogens/therapeutic use
    Chemical Substances Lamotrigine (U3H27498KS) ; Anticonvulsants ; Estrogens
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2023.109514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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