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  1. Article ; Online: Migraine Management in Women: Exploring the Impact of Combined Hormonal Contraceptives on Menstrual Migraine.

    Nagarakanti, Sindhu / Vegunta, Suneela / David, Paru S

    Journal of women's health (2002)

    2024  

    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2023.1026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Moving toward health equity: the influence of race and ethnicity on choice and quality of life of menopause treatment in midlife women.

    David, Paru S / Kling, Juliana M

    Menopause (New York, N.Y.)

    2022  Volume 29, Issue 12, Page(s) 1353–1354

    MeSH term(s) Female ; Humans ; Quality of Life ; Ethnicity ; Health Equity ; Menopause ; Health Status
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1205262-0
    ISSN 1530-0374 ; 1072-3714
    ISSN (online) 1530-0374
    ISSN 1072-3714
    DOI 10.1097/GME.0000000000002116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spotlight on the Noncontraceptive Benefits of Contraceptives.

    David, Paru S / Kling, Juliana M

    Journal of women's health (2002)

    2020  Volume 29, Issue 7, Page(s) 887–888

    MeSH term(s) Contraceptives, Oral ; Female ; Humans ; Parturition ; Pregnancy
    Chemical Substances Contraceptives, Oral
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2020.8404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Menopausal Hormone Therapy in Older Women: Examining the Current Balance of Evidence.

    David, Paru S / Sobel, Talia / Sahni, Sabrina / Mehta, Jaya / Kling, Juliana M

    Drugs & aging

    2023  Volume 40, Issue 8, Page(s) 675–683

    Abstract: Menopause occurs in all women. During the menopause transition, 80% of women experience vasomotor symptoms that can last an average of 7-10 years or longer, sometimes into the seventh and eighth decades of life. Understanding how to manage vasomotor ... ...

    Abstract Menopause occurs in all women. During the menopause transition, 80% of women experience vasomotor symptoms that can last an average of 7-10 years or longer, sometimes into the seventh and eighth decades of life. Understanding how to manage vasomotor symptoms (VMS) in older menopausal women is important since these symptoms can negatively impact quality of life. This review provides a practical guide on how to approach VMS treatment either with menopausal hormone therapy or non-hormone options. When initiating, as well as continuing hormone therapy, the factors clinicians should consider as they weigh risks and benefits include assessing a woman's risks related to cardiovascular disease, breast cancer, and osteoporosis. Utilizing a shared decision-making approach in regard to menopausal symptom management should aim to support women and help them maintain health and quality of life.
    MeSH term(s) Female ; Humans ; Aged ; Estrogen Replacement Therapy/adverse effects ; Quality of Life ; Menopause ; Hormone Replacement Therapy ; Osteoporosis
    Language English
    Publishing date 2023-06-21
    Publishing country New Zealand
    Document type Review ; Journal Article
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-023-01043-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Clinical Review on Paroxetine and Emerging Therapies for the Treatment of Vasomotor Symptoms.

    David, Paru S / Smith, Taryn L / Nordhues, Hannah C / Kling, Juliana M

    International journal of women's health

    2022  Volume 14, Page(s) 353–361

    Abstract: Most women experience vasomotor symptoms (VMS) during their menopausal transition. Menopausal hormone therapy (HT) is the most effective treatment for VMS, but some women choose not to use HT or have contraindications to using HT. Non-hormonal treatment ... ...

    Abstract Most women experience vasomotor symptoms (VMS) during their menopausal transition. Menopausal hormone therapy (HT) is the most effective treatment for VMS, but some women choose not to use HT or have contraindications to using HT. Non-hormonal treatment options should be offered to these symptomatic menopausal women. Multiple large randomized controlled trials have demonstrated statistically significant reductions in hot flash severity and/or frequency with the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). To date, paroxetine mesylate remains the only non-hormonal treatment that has been approved by the United States Food and Drug Administration (FDA) for the management of moderate to severe postmenopausal vasomotor symptoms. Lower doses are needed to reduce VMS than those used to treat anxiety or depression, which is beneficial since side effects are typically dose dependent. The recommended dosage is 7.5 mg once daily at bedtime. Dose dependent side effects include nausea, fatigue, and dizziness. Knowing potential medication interactions is critical such as with medications that can lead to serotonin syndrome, concomitant use with monoamine oxidase inhibitors and being aware of p450 drug metabolism is essential for patients taking drugs that utilize the CYP2D6 enzyme for metabolism including tamoxifen. This review discusses in detail the available data supporting the use of paroxetine for the treatment of VMS, including side effects and considerations regarding prescribing. A discussion of other emerging treatments is included as well, including estetrol, oxybutynin and neurokinin 3 (NK3) receptor antagonists.
    Language English
    Publishing date 2022-03-10
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508161-5
    ISSN 1179-1411
    ISSN 1179-1411
    DOI 10.2147/IJWH.S282396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Human Trafficking Education

    Devika M Das / Jennifer MV Talbott / Jordan S Dutcher / Matthew Buras / Elisabeth Lim / Suneela Vegunta / Paru David / Juliana M Kling

    Journal of Medical Education and Curricular Development, Vol

    A Pilot Study of Integration into Medical School Curriculum

    2023  Volume 10

    Abstract: OBJECTIVES Few medical schools incorporate formal education on human trafficking (HT) and sex trafficking (ST) into their curriculum. Our objective was to develop, implement, and evaluate education on HT and ST in the first-year medical student ... ...

    Abstract OBJECTIVES Few medical schools incorporate formal education on human trafficking (HT) and sex trafficking (ST) into their curriculum. Our objective was to develop, implement, and evaluate education on HT and ST in the first-year medical student curriculum. METHODS The curriculum included a standardized patient (SP) experience and lecture. As part of their mandatory sexual health course, students interviewed an SP who presented with red flags for ST and then participated in a discussion led by a physician-facilitator in an observed small group setting. A multiple-choice survey to assess knowledge about HT and ST was developed and administered to students before and after the SP interview. RESULTS Of the 50 first-year medical students, 29 (58%) participated in the survey. Compared with the students’ baseline scores (according to the percentage of correct responses), scores after the educational intervention showed a significant increase in percentage correct on questions related to trafficking definition and scope (elder care, P = .01; landscaping, P = .03); victim identification ( P < .001); referral to services ( P < .001); legal issues ( P = .01); and security ( P < .001). On the basis of the feedback, a 2-hour lecture, which was adapted from the American Medical Women's Association–Physicians Against the Trafficking of Humans “Learn to Identify and Fight Trafficking” training, was presented the next year to all first-year medical students as part of their longitudinal clinical skills course and before the SP case. Curriculum objectives included learning trafficking definitions, victim/survivor identification, intersections with health care, the local impact of HT, and available resources. CONCLUSION This curriculum fulfills course objectives and could be replicated at other institutions. Further evaluation of this pilot curriculum is necessary to evaluate its effectiveness.
    Keywords Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
    Subject code 370
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Associations between childhood adversity and age at natural menopause.

    Kling, Juliana M / Saadedine, Mariam / Faubion, Stephanie S / Shufelt, Chrisandra L / Mara, Kristin C / Enders, Felicity T / David, Paru S / Kapoor, Ekta

    Menopause (New York, N.Y.)

    2023  Volume 30, Issue 11, Page(s) 1085–1089

    Abstract: Objective: Adverse childhood experiences (ACEs) are reported in more than half of the women in the United States and have been shown to negatively impact the menopause experience. The objective of this study was to evaluate the association between ACEs ... ...

    Abstract Objective: Adverse childhood experiences (ACEs) are reported in more than half of the women in the United States and have been shown to negatively impact the menopause experience. The objective of this study was to evaluate the association between ACEs and age at natural menopause.
    Methods: This is a cross-sectional study conducted among participants of the Data Registry on the Experiences of Aging, Menopause, and Sexuality (DREAMS). The registry included women who were seen for consultations in the women's health clinic at Mayo Clinic, Rochester, between May 2015 and December 2016. Only postmenopausal women were included in this analysis. Childhood adversity was assessed with the validated ACE questionnaire. Age at natural menopause was self-reported. The association between ACEs and age at menopause was evaluated using a multivariable linear regression model adjusting for multiple confounders.
    Results: A total of 350 women were evaluated. The mean age was 59.2 years, and a majority were White (92.9%), married/partnered (82%), and educated (91.2% with at least some college education). Women with a history of at least four ACEs were estimated to reach natural menopause 1.3 years sooner than women with no ACE in multivariable analysis, but the results were not statistically significant (95% confidence interval, -3.2 to 0.6; P = 0.18).
    Conclusions: Although stressful life experiences such as ACEs may negatively influence health for midlife women, this study did not find an association with the age at natural menopause.
    MeSH term(s) Female ; Humans ; Middle Aged ; Cross-Sectional Studies ; Adverse Childhood Experiences ; Menopause ; Aging ; Women's Health
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1205262-0
    ISSN 1530-0374 ; 1072-3714
    ISSN (online) 1530-0374
    ISSN 1072-3714
    DOI 10.1097/GME.0000000000002249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Human Trafficking Education: A Pilot Study of Integration into Medical School Curriculum.

    Das, Devika M / Talbott, Jennifer Mv / Dutcher, Jordan S / Buras, Matthew / Lim, Elisabeth / Vegunta, Suneela / David, Paru / Kling, Juliana M

    Journal of medical education and curricular development

    2023  Volume 10, Page(s) 23821205231164088

    Abstract: Objectives: Few medical schools incorporate formal education on human trafficking (HT) and sex trafficking (ST) into their curriculum. Our objective was to develop, implement, and evaluate education on HT and ST in the first-year medical student ... ...

    Abstract Objectives: Few medical schools incorporate formal education on human trafficking (HT) and sex trafficking (ST) into their curriculum. Our objective was to develop, implement, and evaluate education on HT and ST in the first-year medical student curriculum.
    Methods: The curriculum included a standardized patient (SP) experience and lecture. As part of their mandatory sexual health course, students interviewed an SP who presented with red flags for ST and then participated in a discussion led by a physician-facilitator in an observed small group setting. A multiple-choice survey to assess knowledge about HT and ST was developed and administered to students before and after the SP interview.
    Results: Of the 50 first-year medical students, 29 (58%) participated in the survey. Compared with the students' baseline scores (according to the percentage of correct responses), scores after the educational intervention showed a significant increase in percentage correct on questions related to trafficking definition and scope (elder care,
    Conclusion: This curriculum fulfills course objectives and could be replicated at other institutions. Further evaluation of this pilot curriculum is necessary to evaluate its effectiveness.
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2798123-X
    ISSN 2382-1205
    ISSN 2382-1205
    DOI 10.1177/23821205231164088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Contraception in perimenopause: when to discontinue.

    Long, Margaret E / David, Paru S / Casey, Petra M

    Journal of women's health (2002)

    2015  Volume 24, Issue 5, Page(s) 409–410

    MeSH term(s) Contraception ; Contraceptive Agents, Female/adverse effects ; Estrogen Replacement Therapy/methods ; Female ; Humans ; Intrauterine Devices ; Menstruation Disturbances/drug therapy ; Middle Aged ; Perimenopause
    Chemical Substances Contraceptive Agents, Female
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2015.5243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: You can't fool mother nature: new directions in oral contraception.

    Mayer, Anita P / Files, Julia A / David, Paru S

    Journal of women's health (2002)

    2012  Volume 21, Issue 3, Page(s) 366–367

    MeSH term(s) Contraceptives, Oral ; Female ; Humans
    Chemical Substances Contraceptives, Oral
    Language English
    Publishing date 2012-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2012.3511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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