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  1. Article: SARS-CoV-2 et le transport de sodium: une stratégie diabolique.

    Rossier, Bernard C

    Revue medicale suisse

    2020  Volume 16, Issue 701, Page(s) 1450–1455

    Abstract: The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available. Can we explain why so many people remain asymptomatic but nevertheless highly contagious explaining the speed with which the pandemic has ... ...

    Title translation SARS-CoV-2 and sodium transport: a diabolical strategy.
    Abstract The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available. Can we explain why so many people remain asymptomatic but nevertheless highly contagious explaining the speed with which the pandemic has spread around the world? Can we explain why the acute respiratory distress syndrome (ARDS) appears late but can so quickly have a fatal outcome? In the lung, mucociliary clearance (CMC) and alveolar clearance (CA) depend on the transport of sodium through the plasma membrane of epithelial cells. This transport is mediated by a highly selective sodium channel (Epithelial Sodium Channel = ENaC) which could be a key element in the pulmonary pathophysiology of SARS-CoV-2 infection.
    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Humans ; Ion Transport ; Models, Biological ; Pandemics ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sodium/metabolism
    Chemical Substances Sodium (9NEZ333N27)
    Keywords covid19
    Language French
    Publishing date 2020-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5998: Show issues Location:
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  2. Article: [SARS-CoV-2 and sodium transport: a diabolical strategy]

    Rossier, Bernard C.

    Revue medicale suisse

    Abstract: The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available Can we explain why so many people remain asymptomatic but nevertheless highly contagious explaining the speed with which the pandemic has ... ...

    Abstract The Covid 19 pandemic remains a serious public health problem until effective drugs and/or vaccines are available Can we explain why so many people remain asymptomatic but nevertheless highly contagious explaining the speed with which the pandemic has spread around the world? Can we explain why the acute respiratory distress syndrome (ARDS) appears late but can so quickly have a fatal outcome? In the lung, mucociliary clearance (CMC) and alveolar clearance (CA) depend on the transport of sodium through the plasma membrane of epithelial cells This transport is mediated by a highly selective sodium channel (Epithelial Sodium Channel = ENaC) which could be a key element in the pulmonary pathophysiology of SARS-CoV-2 infection
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #728007
    Database COVID19

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  3. Article ; Online: A Pathophysiological Model for COVID-19: Critical Importance of Transepithelial Sodium Transport upon Airway Infection.

    Gentzsch, Martina / Rossier, Bernard C

    Function (Oxford, England)

    2020  Volume 1, Issue 2, Page(s) zqaa024

    Abstract: The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding of disease ... ...

    Abstract The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding of disease mechanisms, that is, the physiology and pathophysiology underlying the function of the organ targeted by the virus. Since the beginning of the pandemic, tireless efforts around the globe have led to numerous publications on the virus, its receptor, its entry into the cell, its cytopathic effects, and how it triggers innate and native immunity but the role of apical sodium transport mediated by the epithelial sodium channel (ENaC) during the early phases of the infection in the airways has received little attention. We propose a pathophysiological model that defines the possible role of ENaC in this process.
    MeSH term(s) Humans ; COVID-19 ; Sodium/metabolism ; Biological Transport ; Ion Transport ; Epithelial Sodium Channels/metabolism
    Chemical Substances Sodium (9NEZ333N27) ; Epithelial Sodium Channels
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqaa024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Osmoregulation during Long-Term Fasting in Lungfish and Elephant Seal: Old and New Lessons for the Nephrologist.

    Rossier, Bernard C

    Nephron

    2016  Volume 134, Issue 1, Page(s) 5–9

    Abstract: Vertebrates control the osmolality of their extra- and intra-cellular compartments despite large variations in salt and water intake. Aldosterone-dependent sodium reabsorption and vasopressin-dependent water transport in the distal nephron and collecting ...

    Abstract Vertebrates control the osmolality of their extra- and intra-cellular compartments despite large variations in salt and water intake. Aldosterone-dependent sodium reabsorption and vasopressin-dependent water transport in the distal nephron and collecting duct play a critical role in the final control of sodium and water balance. Long-term fasting (no eating, no drinking) represents an osmotic challenge for survival. Evolution has found very different solutions to meet this challenge. To illustrate this point, I will discuss osmoregulation of a mammal (elephant seal pup) and of a fish (lungfish) that are able to survive long-term fasting for months or even years. Homer W. Smith taught us how informative comparative anatomy and physiology of the kidney could help physiologists and nephrologists to better understand how the kidney works. In recent years, comparative genomics, transcriptomics and proteomics across the tree of life have led to the emergence of a new discipline, evolutionary medicine. In the near future, physiologists and nephrologists will benefit from this new field of investigation, thanks to its potential for the identification of novel drug targets and therapies.
    MeSH term(s) Animals ; Arginine Vasopressin/physiology ; Biological Evolution ; Fasting ; Fishes/physiology ; Osmoregulation ; Renin-Angiotensin System ; Seals, Earless/physiology
    Chemical Substances Arginine Vasopressin (113-79-1)
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000444307
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 169: Show issues Location:
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  5. Article ; Online: Epithelial sodium channel (ENaC) and the control of blood pressure.

    Rossier, Bernard C

    Current opinion in pharmacology

    2014  Volume 15, Page(s) 33–46

    Abstract: The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. ... ...

    Abstract The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in the maintenance of sodium balance, blood volume and blood pressure. In this review, we discuss recent advances in our understanding of ENaC function and regulation relevant to the control of sodium balance and blood pressure. The identification of novel drug targets should help in the development of the next generation of diuretics and of new therapies for the treatment of hypertension.
    MeSH term(s) Animals ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Epithelial Sodium Channels/physiology ; Humans ; Molecular Targeted Therapy
    Chemical Substances Antihypertensive Agents ; Epithelial Sodium Channels
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2013.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5608: Show issues Location:
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  6. Article: A pathophysiological model for COVID-19: Critical importance of transepithelial sodium transport upon airway infection

    Gentzsch, Martina / Rossier, Bernard C.

    Function

    Abstract: The COVID-19 pandemic remains a serious public health problem, and will continue to be until effective drugs and/or vaccines are available The rational development of drugs critically depends on our understanding of disease mechanisms, i e, the ... ...

    Abstract The COVID-19 pandemic remains a serious public health problem, and will continue to be until effective drugs and/or vaccines are available The rational development of drugs critically depends on our understanding of disease mechanisms, i e, the physiology and pathophysiology underlying the function of the organ targeted by the virus Since the beginning of the pandemic, tireless efforts around the globe have led to numerous publications on the virus, its receptor, its entry into the cell, its cytopathic effects and how it triggers innate and native immunity but the role of apical sodium transport mediated by the epithelial sodium channel (ENaC) during the early phases of the infection in the airways has received little attention We propose a pathophysiological model that defines the possible role of ENaC in this process
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #817406
    Database COVID19

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  7. Article ; Online: A Pathophysiological Model for COVID-19

    Gentzsch, Martina / Rossier, Bernard C

    Function

    Critical Importance of Transepithelial Sodium Transport upon Airway Infection

    2020  Volume 1, Issue 2

    Abstract: Abstract The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding of ... ...

    Abstract Abstract The Coronavirus Disease 2019 (COVID-19) pandemic remains a serious public health problem and will continue to be until effective drugs and/or vaccines are available. The rational development of drugs critically depends on our understanding of disease mechanisms, that is, the physiology and pathophysiology underlying the function of the organ targeted by the virus. Since the beginning of the pandemic, tireless efforts around the globe have led to numerous publications on the virus, its receptor, its entry into the cell, its cytopathic effects, and how it triggers innate and native immunity but the role of apical sodium transport mediated by the epithelial sodium channel (ENaC) during the early phases of the infection in the airways has received little attention. We propose a pathophysiological model that defines the possible role of ENaC in this process.
    Keywords covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ISSN 2633-8823
    DOI 10.1093/function/zqaa024
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article: Osmoregulation during Long-Term Fasting in Lungfish and Elephant Seal: Old and New Lessons for the Nephrologist

    Rossier, Bernard C.

    Nephron

    2016  Volume 134, Issue 1, Page(s) 5–9

    Abstract: Vertebrates control the osmolality of their extra- and intra-cellular compartments despite large variations in salt and water intake. Aldosterone-dependent sodium reabsorption and vasopressin-dependent water transport in the distal nephron and collecting ...

    Institution Department of Pharmacology and Toxicology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
    Abstract Vertebrates control the osmolality of their extra- and intra-cellular compartments despite large variations in salt and water intake. Aldosterone-dependent sodium reabsorption and vasopressin-dependent water transport in the distal nephron and collecting duct play a critical role in the final control of sodium and water balance. Long-term fasting (no eating, no drinking) represents an osmotic challenge for survival. Evolution has found very different solutions to meet this challenge. To illustrate this point, I will discuss osmoregulation of a mammal (elephant seal pup) and of a fish (lungfish) that are able to survive long-term fasting for months or even years. Homer W. Smith taught us how informative comparative anatomy and physiology of the kidney could help physiologists and nephrologists to better understand how the kidney works. In recent years, comparative genomics, transcriptomics and proteomics across the tree of life have led to the emergence of a new discipline, evolutionary medicine. In the near future, physiologists and nephrologists will benefit from this new field of investigation, thanks to its potential for the identification of novel drug targets and therapies.
    Keywords Arginine vasopressin ; Aldosterone ; Kidney function ; Osmoregulation ; Renin angiotensin system ; Salt balance ; Water balance
    Language English
    Publishing date 2016-02-23
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Clinical Practice: Mini-Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000444307
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 169: Show issues Location:
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  9. Article ; Online: Hypertension finds a new rhythm.

    Rossier, Bernard C

    Nature medicine

    2010  Volume 16, Issue 1, Page(s) 27–28

    MeSH term(s) Aldosterone/biosynthesis ; Aldosterone/physiology ; Animals ; Circadian Rhythm/physiology ; Cryptochromes/genetics ; Cryptochromes/physiology ; Hypertension/enzymology ; Hypertension/etiology ; Hypertension/genetics ; Mice ; Progesterone Reductase/genetics ; Progesterone Reductase/physiology ; Steroid Isomerases/genetics ; Steroid Isomerases/physiology
    Chemical Substances Cry1 protein, mouse ; Cry2 protein, mouse ; Cryptochromes ; Aldosterone (4964P6T9RB) ; Progesterone Reductase (EC 1.1.1.145) ; Steroid Isomerases (EC 5.3.3.-) ; steroid delta-isomerase (EC 5.3.3.1)
    Language English
    Publishing date 2010-01-07
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm0110-27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Place de l'enseignement à distance dans l'éducation et la formation du chercheur.

    Rossier, Bernard C / Kraehenbuhl, Jean-Pierre / Rossier, Michelle

    Medecine sciences : M/S

    2014  Volume 30, Issue 6-7, Page(s) 603–604

    Title translation Role of distance learning in the education and the training of the investigator.
    MeSH term(s) Biomedical Research/education ; Biomedical Research/standards ; Computer-Assisted Instruction/methods ; Computer-Assisted Instruction/standards ; Education, Continuing/methods ; Education, Distance ; Humans ; Individuality ; Research Personnel/education ; User-Computer Interface
    Language French
    Publishing date 2014-06
    Publishing country France
    Document type Editorial
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20143006001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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