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Book ; Thesis: Vergleich von vier Testmethoden zur Bestimmung des prostataspezifischen Antigens (PSA)

Pfitzenmaier, Jesco

1995

Author's details	vorgelegt von Jesco Pfitzenmaier
Language	German
Size	119 S. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 1997
HBZ-ID	HT007565780
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Article ; Online: Editorial comment.

Pfitzenmaier, Jesco

The Journal of urology

2010 Volume 183, Issue 3, Page(s) 1009

MeSH term(s)	Disease Progression ; Humans ; Male ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Survival Rate
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2010-03
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2009.11.082
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Article ; Online: Editorial comment.

Pfitzenmaier, Jesco

The Journal of urology

2009 Volume 182, Issue 4, Page(s) 1363

MeSH term(s)	Humans ; Male ; Neoplasm Recurrence, Local/pathology ; Predictive Value of Tests ; Prostatectomy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Reproducibility of Results
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2009.06.133
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Analysis of Several Pathways for Efficient Killing of Prostate Cancer Stem Cells: A Central Role of NF-κB RELA.

Witte, Kaya E / Pfitzenmaier, Jesco / Storm, Jonathan / Lütkemeyer, Melanie / Wimmer, Clara / Schulten, Wiebke / Czaniera, Nele / Geisler, Marvin / Förster, Christine / Wilkens, Ludwig / Knabbe, Cornelius / Mertzlufft, Fritz / Kaltschmidt, Barbara / Am Esch, Jan Schulte / Kaltschmidt, Christian

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: Prostate cancer is a common cause of death worldwide. Here, we isolated cancer stem cells (CSCs) from four adenocarcinomas of the prostate (Gleason scores from 3 + 3 up to 4 + 5). CSCs were characterized by the expression of the stem cell ... ...

Abstract	Prostate cancer is a common cause of death worldwide. Here, we isolated cancer stem cells (CSCs) from four adenocarcinomas of the prostate (Gleason scores from 3 + 3 up to 4 + 5). CSCs were characterized by the expression of the stem cell markers
Language	English
Publishing date	2021-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22168901
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Article: Is the Standard Artificial Urinary Sphincter AMS 800 Still a Treatment Option for the Irradiated Male Patient Presenting with a Devastated Bladder Outlet?

Journal of clinical medicine

2023 Volume 12, Issue 12

Abstract: Background: Circular urethral compression with an artificial sphincter allows control of voiding, even in patients with severe stress urinary incontinence, but it heightens the risk of urethral atrophy and erosion. This study of one of the largest ... ...

Abstract	Background: Circular urethral compression with an artificial sphincter allows control of voiding, even in patients with severe stress urinary incontinence, but it heightens the risk of urethral atrophy and erosion. This study of one of the largest populations of patients treated with radiotherapy investigates the additive effect of the post-radiogenic stricture of the membranous urethra/bladder neck on AMS 800 artificial urinary sphincter outcomes. Methods: In a retrospective multicenter cohort study, we analyzed patients fitted with an AMS 800, comparing those who had received radiotherapy with patients presenting a devastated bladder outlet (stricture of the membranous urethra/bladder neck). We determined the correlation between these groups of patients using both univariate and stepwise adjusted multivariate regression. The revision-free interval was estimated by a Kaplan-Meier plot and compared by applying the log-rank test. A Results: Of the 123 irradiated patients we identified, 62 (50.4%) had undergone at least one prior desobstruction for bladder-neck/urethra stenosis. After a mean follow-up of 21 months, the latter tended to achieve social continence less frequently (25.7% vs. 35%; Conclusions: A devastated bladder outlet is associated with a lower proportion of men with social continence and a significantly higher need for revision compared with irradiated patients without a history of urethral stenosis. Alternative surgical procedures should be discussed beforehand, especially in cases of recurrent urethral stenosis.
Language	English
Publishing date	2023-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12124002
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Article ; Online: Is the Standard Artificial Urinary Sphincter AMS 800 Still a Treatment Option for the Irradiated Male Patient Presenting with a Devastated Bladder Outlet?

Journal of Clinical Medicine, Vol 12, Iss 4002, p

2023 Volume 4002

Abstract	Background: Circular urethral compression with an artificial sphincter allows control of voiding, even in patients with severe stress urinary incontinence, but it heightens the risk of urethral atrophy and erosion. This study of one of the largest populations of patients treated with radiotherapy investigates the additive effect of the post-radiogenic stricture of the membranous urethra/bladder neck on AMS 800 artificial urinary sphincter outcomes. Methods: In a retrospective multicenter cohort study, we analyzed patients fitted with an AMS 800, comparing those who had received radiotherapy with patients presenting a devastated bladder outlet (stricture of the membranous urethra/bladder neck). We determined the correlation between these groups of patients using both univariate and stepwise adjusted multivariate regression. The revision-free interval was estimated by a Kaplan–Meier plot and compared by applying the log-rank test. A p value below 0.05 was considered statistically significant. Results: Of the 123 irradiated patients we identified, 62 (50.4%) had undergone at least one prior desobstruction for bladder-neck/urethra stenosis. After a mean follow-up of 21 months, the latter tended to achieve social continence less frequently (25.7% vs. 35%; p = 0.08). Revision was required significantly more often for this group (43.1% vs. 26.3%; p = 0.05) due to urethral erosion in 18 of 25 cases. A stenosis recurred in five cases; desobstruction was performed in two cases, leading to erosion in both. Multivariate analysis revealed a significantly higher risk of revision when recurrent stenosis necessitated at least two prior desobstructions (HR 2.8; p = 0.003). Conclusions: A devastated bladder outlet is associated with a lower proportion of men with social continence and a significantly higher need for revision compared with irradiated patients without a history of urethral stenosis. Alternative surgical procedures should be discussed beforehand, especially in cases of recurrent urethral stenosis.
Keywords	devastated bladder outlet ; AMS 800 ; artificial urinary sphincter ; male stress incontinence ; prostate radiotherapy ; bladder neck stenosis ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hormonal therapy in the elderly prostate cancer patient.

Pfitzenmaier, Jesco / Altwein, Jens E

Deutsches Arzteblatt international

2009 Volume 106, Issue 14, Page(s) 242–247

Abstract: Background: Prostatic cancer (PCa) is the most common cancer in men in Germany. The goal of this review is to define the indication for hormonal treatment in patients over age 70.: Methods: A selective search of the literature up to 2008 for the ... ...

Abstract	Background: Prostatic cancer (PCa) is the most common cancer in men in Germany. The goal of this review is to define the indication for hormonal treatment in patients over age 70. Methods: A selective search of the literature up to 2008 for the terms "prostate cancer", "androgen suppression and deprivation", "hormone therapy", "LHRH analogs", "antiandrogens", "active surveillance", and "watchful waiting" was performed in the Medline and Cochrane databases. The guidelines of the American Society of Clinical Oncology (ASCO, 2007) and the European Society of Urology (EAU, 2008) were also taken into account. Results: Hormonal therapy is not indicated for patients with organ-confined, well-differentiated or moderately differentiated tumors who are otherwise in good health. It is beneficial in the treatment of locally advanced cancer with an unfavorable Gleason score. For patients with organ-confined cancers who are in poor general condition, hormonal therapy is deferred until symptoms arise. The guidelines recommend hormonal therapy in case of PSA elevations greater than 1.5 ng/mL after attempted curative treatment. Symptomatic metastases require immediate hormonal therapy. Intermittent androgen deprivation is an attractive alternative. Conclusions: In patients over age 70, an attempt at curative treatment is only reasonable if the life expectancy exceeds 10 years. Hormonal therapy is the treatment of choice for patients with undifferentiated, locally advanced prostate cancer, recurrences as defined by PSA elevation, and symptomatic metastases.
MeSH term(s)	Androgen Antagonists/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use ; Dose-Response Relationship, Drug ; Gonadotropin-Releasing Hormone/therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/mortality ; Survival Analysis ; Survival Rate ; Treatment Outcome
Chemical Substances	Androgen Antagonists ; Antineoplastic Agents, Hormonal ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2009-04-03
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.2009.0242
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Article: Nanopore Sequencing Reveals Global Transcriptome Signatures of Mitochondrial and Ribosomal Gene Expressions in Various Human Cancer Stem-like Cell Populations.

Witte, Kaya E / Hertel, Oliver / Windmöller, Beatrice A / Helweg, Laureen P / Höving, Anna L / Knabbe, Cornelius / Busche, Tobias / Greiner, Johannes F W / Kalinowski, Jörn / Noll, Thomas / Mertzlufft, Fritz / Beshay, Morris / Pfitzenmaier, Jesco / Kaltschmidt, Barbara / Kaltschmidt, Christian / Banz-Jansen, Constanze / Simon, Matthias

Cancers

2021 Volume 13, Issue 5

Abstract: Cancer stem cells (CSCs) are crucial mediators of tumor growth, metastasis, therapy resistance, and recurrence in a broad variety of human cancers. Although their biology is increasingly investigated within the distinct types of cancer, direct ... ...

Abstract	Cancer stem cells (CSCs) are crucial mediators of tumor growth, metastasis, therapy resistance, and recurrence in a broad variety of human cancers. Although their biology is increasingly investigated within the distinct types of cancer, direct comparisons of CSCs from different tumor types allowing comprehensive mechanistic insights are rarely assessed. In the present study, we isolated CSCs from endometrioid carcinomas, glioblastoma multiforme as well as adenocarcinomas of lung and prostate and assessed their global transcriptomes using full-length cDNA nanopore sequencing. Despite the expression of common CSC markers, principal component analysis showed a distinct separation of the CSC populations into three clusters independent of the specific type of tumor. However, GO-term and KEGG pathway enrichment analysis revealed upregulated genes related to ribosomal biosynthesis, the mitochondrion, oxidative phosphorylation, and glycolytic pathways, as well as the proteasome, suggesting a great extent of metabolic flexibility in CSCs. Interestingly, the GO term "NF-kB binding" was likewise found to be elevated in all investigated CSC populations. In summary, we here provide evidence for high global transcriptional similarities between CSCs from various tumors, which particularly share upregulated gene expression associated with mitochondrial and ribosomal activity. Our findings may build the basis for identifying novel therapeutic strategies targeting CSCs.
Language	English
Publishing date	2021-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13051136
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Article ; Online: Adherence to the EAU Guideline Recommendations for Local Tumor Treatment in Penile Cancer: Results of the European PROspective Penile Cancer Study Group Survey (E-PROPS).

Pallauf, Maximilian / Hempel, Marie C / Hupe, Marie C / May, Matthias / Haccius, Marlene / Weckermann, Dorothea / Lebentrau, Steffen / Hoschke, Bernd / Necknig, Ulrike / Pfitzenmaier, Jesco / Manka, Lukas / Nuhn, Philipp / Törzsök, Peter / Lusuardi, Lukas / Merseburger, Axel S

Advances in therapy

2020 Volume 37, Issue 12, Page(s) 4969–4980

Abstract: Introduction: Penile cancer (PeCa) is an orphan disease in European countries. The current guidelines are predominantly based on retrospective studies with a low level of evidence. In our study, we aimed to identify predictors for guideline-conform ... ...

Abstract	Introduction: Penile cancer (PeCa) is an orphan disease in European countries. The current guidelines are predominantly based on retrospective studies with a low level of evidence. In our study, we aimed to identify predictors for guideline-conform treatment and hypothesize that reference centers for PeCa and physicians' experience promote guideline compliance and therefore correct local tumor therapy. Methods: This study is part of the European PROspective Penile Cancer Study (E-PROPS), an international collaboration group evaluating therapeutic management for PeCa in Central Europe. For this module, a 14-item-survey was developed and sent to 681 urologists in 45 European centers. Three questions focused on therapeutic decisions for PeCa in clinical stage Tis, Ta-T1a, and T1b. Four questions addressed potential personal confounders. Survey results were analyzed by bootstrap-adjusted stepwise multivariate linear regression analysis to identify predictors for EAU guideline-conform local treatment of PeCa. Results: For local therapy of cTis 80.4% recommended guideline-conform treatment, for cTa-cT1a 87.3% and for cT1b 59.1%. In total, 42.4% chose a correct approach in all tumor stages. The number of PeCa patients treated at the hospital, a higher level of training of the physicians, resource-based answering and the option of penile-sparing surgery offered at the hospital matched with giving guideline-conform recommendations and thus accurate local tumor treatment. Conclusion: Patients with PeCa are best treated by experienced physicians, in centers with a high number of cases, which also offer a wide range of local tumor therapy. This could be offered in reference centers.
MeSH term(s)	Europe ; Guideline Adherence/statistics & numerical data ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Organ Sparing Treatments ; Penile Neoplasms/pathology ; Penile Neoplasms/surgery ; Penile Neoplasms/therapy ; Practice Guidelines as Topic/standards ; Practice Patterns, Physicians'/standards ; Prospective Studies ; Retrospective Studies ; Surveys and Questionnaires
Language	English
Publishing date	2020-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-020-01514-8
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Article ; Online: Analysis of Several Pathways for Efficient Killing of Prostate Cancer Stem Cells

Kaya E. Witte / Jesco Pfitzenmaier / Jonathan Storm / Melanie Lütkemeyer / Clara Wimmer / Wiebke Schulten / Nele Czaniera / Marvin Geisler / Christine Förster / Ludwig Wilkens / Cornelius Knabbe / Fritz Mertzlufft / Barbara Kaltschmidt / Jan Schulte am Esch / Christian Kaltschmidt

International Journal of Molecular Sciences, Vol 22, Iss 8901, p

A Central Role of NF-κB RELA

2021 Volume 8901

Abstract	Prostate cancer is a common cause of death worldwide. Here, we isolated cancer stem cells (CSCs) from four adenocarcinomas of the prostate (Gleason scores from 3 + 3 up to 4 + 5). CSCs were characterized by the expression of the stem cell markers TWIST , the epithelial cell adhesion molecule ( EPCAM ), the transcription factors SNAI1 ( SNAIL ) and SNAI2 ( SLUG ) and cancer markers such as CD44 and prominin-1 (CD133). All investigated CSC populations contained a fraction highly positive for aldehyde dehydrogenase (ALDH) function and displayed robust expressions of programmed cell death 1 (PD-1) ligands. Furthermore, we investigated immunotherapeutic approaches but had no success even with the clinically used PD-1 inhibitor pembrolizumab. In addition, we studied another death-inducing pathway via interferon gamma signaling and detected high-level upregulations of human leukocyte antigen A (HLA-A) and beta 2-microglobulin (B2M) with only moderate killing efficacy. To examine further killing mechanisms in prostate cancer stem cells (PCSCs), we analyzed NF-κB signaling. Surprisingly, two patient-specific populations of PCSCs were found: one with canonical NF-κB signaling and another one with blunted NF-κB activation, which can be efficiently killed by tumor necrosis factor (TNF). Thus, culturing of PCSCs and analysis of respective NF-κB induction potency after surgery might be a powerful tool for optimizing patient-specific treatment options, such as the use of TNF-inducing chemotherapeutics and/or NF-κB inhibitors.
Keywords	prostate cancer ; cancer stem cells ; nuclear factor “kappa-light-chain-enhancer” of activated B-cells ; tumor necrosis factor ; interferon gamma ; immune checkpoint therapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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