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Article ; Online: Update on management of keloid and hypertrophic scars: A systemic review.

Elsaie, Mohamed L

2021 Volume 20, Issue 9, Page(s) 2729–2738

Abstract: Numerous therapeutic strategies have been described for prevention and reduction of hypertrophic scars and keloids, but none of the treatments is effective in all patients. No universal consensus in treatment regimen has been established, and there is ... ...

Abstract	Numerous therapeutic strategies have been described for prevention and reduction of hypertrophic scars and keloids, but none of the treatments is effective in all patients. No universal consensus in treatment regimen has been established, and there is limited evidence-based literature to guide the correct management. The process of scar development is complex and requires deeper understanding of the molecular mechanisms that cause their development and recurrences. Despite many available modes of targeting keloid and hypertrophic scars, yet they remain an ongoing challenge to patients and clinicians. To date, no one therapy has been universally accepted as the gold standard for the treatment of all excessive scars nor has the capability of complete scar resolution The search of literature included peer-reviewed articles including clinical trials and scientific reviews. Literature was identified from electronic databases (MEDLINE/PubMed) through May 2021 and references of respective articles and only the articles published in English language were included.
MeSH term(s)	Humans ; Cicatrix, Hypertrophic/pathology ; Cicatrix, Hypertrophic/therapy ; Keloid/pathology ; Keloid/therapy ; Recurrence
Language	English
Publishing date	2021-07-03
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14310
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Article ; Online: Successful treatment of long-standing alopecia totalis with intralesional methotrexate.

Elsaie, Mohamed L / Hasan, Mohamed S

Journal of cosmetic dermatology

2021 Volume 21, Issue 2, Page(s) 855–856

MeSH term(s)	Alopecia/drug therapy ; Alopecia Areata ; Humans ; Methotrexate
Chemical Substances	Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2021-04-24
Publishing country	England
Document type	Letter
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14117
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Article: The Immunogenetics of Acne.

Elsaie, Mohamed L / Aly, Dalia G

Advances in experimental medicine and biology

2022 Volume 1367, Page(s) 137–154

Abstract: Acne vulgaris results from a complex interaction between environment and genetic factors. While colonization of the pilosebaceous unit with Propionibacterium was previously considered to be the main cause of acne, the contribution of host-related factors ...

Abstract	Acne vulgaris results from a complex interaction between environment and genetic factors. While colonization of the pilosebaceous unit with Propionibacterium was previously considered to be the main cause of acne, the contribution of host-related factors that allow the growth of the bacteria and its immune response against bacterial components are now considered to be more important. Many of these host characteristics have a genetic base that is either involved in the regulation of the immune responses or the steroid hormones metabolisms. This chapter aims to explore the functions of these genes and their role in the pathogenesis of acne.
MeSH term(s)	Acne Vulgaris/genetics ; Acne Vulgaris/microbiology ; Humans ; Immunogenetics ; Propionibacterium acnes/physiology ; Skin/pathology
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-92616-8_6
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Article ; Online: Dermoscopy-assisted prevalence of hair loss after COVID-19 vaccination among an Egyptian population: a cross-sectional study.

Ammar, Amr M / Ibrahim, Ibrahim S / Mohamed, Abbas N / Elsaie, Mohamed L

Irish journal of medical science

2023 Volume 193, Issue 2, Page(s) 755–760

Abstract: Abstact: BACKGROUND: Coronavirus disease (COVID-19) currently named SARS-CoV-2 is a contagious disease caused by a coronavirus; incompatible data are present on the possible relationship among COVID-19 vaccines and hair loss.: Aims: The objective of ... ...

Abstract	Abstact: BACKGROUND: Coronavirus disease (COVID-19) currently named SARS-CoV-2 is a contagious disease caused by a coronavirus; incompatible data are present on the possible relationship among COVID-19 vaccines and hair loss. Aims: The objective of the current study was to assess dermoscopically the prevalence of hair loss among an Egyptian population following COVID-19 vaccination. Methods: A total of 2000 participants were enrolled in this cross-sectional study. Adult males and females who received one of recognized COVID-19 vaccine were included, irrespective of the status of previous COVID-19 infection. Those who were aged less than 18 years or above 60 years were excluded. Furthermore, subjects self-reporting hair loss were assessed by dermoscopy. Results: Among the studied cases, n = 478 (23.9%) complained of hair loss following vaccination. The majority of cases noticed their hair loss during the first 2 months post-vaccination (n = 215 after the first month and n = 158 after the 2nd month respectively). Conclusion: We reported prevalence of post-vaccination hair fall that was confirmed by trichoscopy and which affected approximately one quarter of participants who received COVID-19 vaccines. Other factors, such as stress and infection, cannot be excluded and remain to be further investigated by larger multicenter studies.
MeSH term(s)	Adult ; Male ; Female ; Humans ; COVID-19 Vaccines/adverse effects ; Cross-Sectional Studies ; Dermoscopy ; Egypt/epidemiology ; Prevalence ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Alopecia/epidemiology ; Alopecia/etiology ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-08-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-023-03493-5
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Article ; Online: Comparative study between intralesional injection of MMR, BCG, and candida albicans antigen in treatment of multiple recalcitrant warts.

Eldahshan, Ramadan Mohamed / Ashry, Walaa Mohamed Omar / Elsaie, Mohamed L

Journal of cosmetic dermatology

2022 Volume 21, Issue 3, Page(s) 1120–1126

Abstract: Background: Cutaneous warts represent a challenging condition to treat.: Objective: To evaluate the safety and efficacy of intralesional injection of MMR (mumps, measles, and rubella) antigen, BCG (bacillus Calmette-Guerin) vaccine, and candida ... ...

Abstract	Background: Cutaneous warts represent a challenging condition to treat. Objective: To evaluate the safety and efficacy of intralesional injection of MMR (mumps, measles, and rubella) antigen, BCG (bacillus Calmette-Guerin) vaccine, and candida antigen for the treatment of multiple warts. Methods: A total of ninety (90) clinically confirmed adult patients complaining of recalcitrant extragenital warts of various sizes and durations were recruited in this randomized clinical trial. They were divided into three groups (A, B, and C). Each group consisted of (30) patients. Group (A) subjects received intralesional MMR injections. Group (B) subjects received intralesional BCG injection and Group (C) received intralesional candida antigen injection. Results: Full clearance of warts was observed in (73.33%, 70%, and 43.33%) in groups A, B, and C, respectively. Infrequent side effects including pain, erythema, and minimal induration were reported in all groups but did not necessitate termination of treatment. Conclusion: All the three modalities used demonstrated a simple, safe modality with low adverse events, and with no recurrence. To achieve an optimal response with an ideal immunotherapeutic agent and ideal dose, further comparative studies are warranted and on different populations and larger sample sizes.
MeSH term(s)	Adult ; BCG Vaccine/therapeutic use ; Candida albicans ; Humans ; Injections, Intralesional ; Measles-Mumps-Rubella Vaccine/therapeutic use ; Treatment Outcome ; Warts/drug therapy
Chemical Substances	BCG Vaccine ; Measles-Mumps-Rubella Vaccine
Language	English
Publishing date	2022-01-08
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14737
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Article ; Online: Intralesional injection of tuberculin purified protein derivative (PPD) versus measles, mumps, and rubella (MMR) vaccine in treatment of molluscum contagiosum: a comparative study.

Zaky, Mohamed S / Atallah, Rabie B / Mohyeldeen, Aya M Saad / Elsaie, Mohamed L

Scientific reports

2024 Volume 14, Issue 1, Page(s) 288

Abstract: Molluscum contagiosum (MC) is a skin and mucous membrane infection caused by the molluscum virus (MCV). To evaluate safety and efficacy of intralesional injection of tuberculin purified protein derivative (PPD) antigen injection versus MMR (mumps, ... ...

Abstract	Molluscum contagiosum (MC) is a skin and mucous membrane infection caused by the molluscum virus (MCV). To evaluate safety and efficacy of intralesional injection of tuberculin purified protein derivative (PPD) antigen injection versus MMR (mumps, measles, rubella) antigen for the treatment of molluscum contagiosum (MC). A total of thirty clinically confirmed patients of molluscum were recruited for this trial. Patients who were divided into three groups (A, B and C). Each group consisted of (30) patients. Group (A) subjects received intralesional MMR injections, group (B) subjects received intralesional PPD injection and group (C) received intralesional saline injection. The results of the present study revealed complete clearance of the injected lesions in 12 patients (80%), partial response in 3 patients (20%) of group (A). In group (B), complete clearance of the treated warts was observed in 11 patients (73.3%) and partial response in 4 (26.7%) of patients. In group (C), the majority of patients 8 (53.3%) demonstrated no response while 7 (46.7%) patients showed only partial clearance. We established a good safety and efficacy profile for tuberculin PPD and MMR antigens in treatment of molluscum contagiosum.
MeSH term(s)	Humans ; Injections, Intralesional ; Measles-Mumps-Rubella Vaccine/therapeutic use ; Molluscum Contagiosum/drug therapy ; Treatment Outcome ; Tuberculin
Chemical Substances	Measles-Mumps-Rubella Vaccine ; Tuberculin
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Clinical Trial ; Comparative Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49182-2
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Article ; Online: Interest in aesthetics during COVID-19 pandemic: A Google trends analysis.

Elsaie, Mohamed L / Youssef, Eman A

Journal of cosmetic dermatology

2021 Volume 20, Issue 6, Page(s) 1571–1572

MeSH term(s)	COVID-19 ; Esthetics ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-03-31
Publishing country	England
Document type	Letter
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14101
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Article ; Online: Topical timolol maleate 0.5% after fractional carbon dioxide laser versus fractional carbon dioxide laser alone in treatment of acne scars: split face comparative study.

Hawwas, Aya Reda Mohamed / Mohamed, Hassan Abou Khodair / Sayedahmed, Osama Magdy Elshahat / Elsaie, Mohamed L

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9402

Abstract: Acne is a common inflammatory condition that mostly involves the face, chest and back. A number of different modalities had been employed for treating scars of which laser remains to be a pivotal choice. We aimed to compare the efficacy of topical ... ...

Abstract	Acne is a common inflammatory condition that mostly involves the face, chest and back. A number of different modalities had been employed for treating scars of which laser remains to be a pivotal choice. We aimed to compare the efficacy of topical timolol maleate 0.5% after fractional CO2 (AFCO2) laser versus fractional CO2 Laser alone for treatment of atrophic acne scars. A split-face comparative clinical experiment on 30 cases of atrophic post-acne scars that were treated on one side with ablative fractional CO2 laser followed by timolol application while with only ablative fractional CO2 laser on the other side. Following treatment, both sides demonstrated significant improvement with the laser + timolol treated side showing better improvement; yet not significantly higher than the laser only treated side. In conclusion, both topical timolol maleate 0.5% after fractional CO2 laser and fractional CO2 laser may achieve comparable significant improvement. The good safety profile, easy accessibility, low cost, and non-invasive nature merits the use of timolol in acne scars pending verification by larger sample reproduced and controlled trials.
MeSH term(s)	Humans ; Acne Vulgaris/complications ; Acne Vulgaris/therapy ; Atrophy ; Carbon Dioxide ; Cicatrix/etiology ; Cicatrix/therapy ; Cicatrix/pathology ; Lasers, Gas/therapeutic use ; Timolol/therapeutic use ; Treatment Outcome
Chemical Substances	Carbon Dioxide (142M471B3J) ; Timolol (817W3C6175)
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36398-5
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Article ; Online: Comparative study of the efficacy and safety of topical minoxidil 2% versus topical bimatoprost 0.01% versus topical bimatoprost 0.03% in treatment of eyebrow hypotrichosis: a randomized controlled trial.

Zaky, Mohamed S / Hashem, Osama A / Mahfouz, Sara M / Elsaie, Mohamed L

Archives of dermatological research

2023 Volume 315, Issue 9, Page(s) 2635–2641

Abstract: Eyebrows are an important feature of facial identity and communications in human beings as well as an important eye defense shield from dust and foreign bodies. To compare the efficacy and safety between 0.01%, 0.03% bimatoprost and minoxidil 2% in gel ... ...

Abstract	Eyebrows are an important feature of facial identity and communications in human beings as well as an important eye defense shield from dust and foreign bodies. To compare the efficacy and safety between 0.01%, 0.03% bimatoprost and minoxidil 2% in gel formulations for eyebrow enhancement. Sixty eligible subjects were female or male, aged 18 years or older with eyebrow hypotrichosis, defined as either a Grade 1 or 2 on the Global Eyebrow Assessment (GEBA) scale. Patients were randomized into 3 groups using block randomization. Group a (20 patients) applied topical 0.03% bimatoprost gel once daily onto both eyebrows, group b (20 patients) applied topical 0.01% bimatoprost gel once daily onto both eyebrows while group c (20 patients) applied topical minoxidil 2% gel once daily onto both eyebrows. A significant improvement in GEBA score was reported in all the three groups after treatment (P ≤ 0.001); however, there was no statistically significant difference between the three groups (P1 = 0.091; P2 = 0.102; P3 = 0.663). Bimatoprost is equally efficacious as minoxidil in enhancement of eyebrows with a more favorable response produced by the 0.03% concentration.
MeSH term(s)	Humans ; Male ; Female ; Bimatoprost/adverse effects ; Minoxidil/adverse effects ; Eyebrows ; Hypotrichosis/drug therapy ; Administration, Topical ; Treatment Outcome ; Double-Blind Method
Chemical Substances	Bimatoprost (QXS94885MZ) ; Minoxidil (5965120SH1)
Language	English
Publishing date	2023-07-30
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-023-02679-2
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Article ; Online: Comparison between the efficacy of terbinafine and itraconazole orally vs. the combination of the two drugs in treating recalcitrant dermatophytosis.

Hassaan, Zinab Rabia Abo Almaati / Mohamed, Hassan Abou Khodair / Eldahshan, Ramadan Mohamed / Elsaie, Mohamed L

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19037

Abstract: Fungal infections are a challenging to treat cutaneous condition. Approximately 20-25% of humans are affected by superficial fungal infections that invade and multiply within keratinized tissues. To compare the efficacy of either terbinafine or ... ...

Abstract	Fungal infections are a challenging to treat cutaneous condition. Approximately 20-25% of humans are affected by superficial fungal infections that invade and multiply within keratinized tissues. To compare the efficacy of either terbinafine or itraconazole orally versus the combination of the two drugs in the treatment of recalcitrant dermatophytosis. The current study included 45 patients with recalcitrant dermatophytosis who were distributed into 3 groups (each of 15 patients); Group A received terbinafine 250 mg twice a day for 4 weeks. Group B received itraconazole 200 mg twice a day for 4 weeks. Group C received terbinafine 250 mg once daily and itraconazole 200 mg once daily for 4 weeks. The patients were followed up for 12 weeks after initiation of treatment by clinical and microbiological assessment to determine the cure rate. At the end of twelve weeks, 12 (80%) patients in group A; 13 (86.7%) patients in group B and 15 (100%) patients in group C were completely cured. Despite of cure rates being higher in the combined group C; yet results were not statistically significant (p = 0.207). Clinical cure rates were non significantly higher in itraconazole + terbinafine combined group (p = 0.207). Combination of terbinafine and itraconazole had a higher clinical and mycological cure rate when compared to the use of either drug alone as monotherapy. Further randomized, multicenter, large cohort studies are warranted to validate the use of combination antifungal treatments.
MeSH term(s)	Humans ; Antifungal Agents/therapeutic use ; Dermatomycoses/drug therapy ; Itraconazole/therapeutic use ; Terbinafine/therapeutic use ; Tinea/drug therapy ; Treatment Outcome
Chemical Substances	Antifungal Agents ; Itraconazole (304NUG5GF4) ; Terbinafine (G7RIW8S0XP)
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46361-z
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