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  1. Article ; Online: Endocrine regulation of fetal metabolism towards term.

    Fowden, Abigail L / Forhead, Alison J

    Domestic animal endocrinology

    2021  Volume 78, Page(s) 106657

    Abstract: Hormones have an important role in regulating fetal metabolism in relation to the prevailing nutritional conditions both in late gestation and during the prepartum period as the fetus prepares for birth. In particular, the pancreatic, thyroid and adrenal ...

    Abstract Hormones have an important role in regulating fetal metabolism in relation to the prevailing nutritional conditions both in late gestation and during the prepartum period as the fetus prepares for birth. In particular, the pancreatic, thyroid and adrenal hormones all affect fetal uptake and utilization of nutrients for oxidative metabolism, tissue accretion and fuel storage. These hormones also influence the fetal metabolic preparations for the nutritional transition from intra- to extra-uterine life. This review discusses the role of insulin, glucagon, thyroxine, tri-iodothyronine, cortisol and the catecholamines in these processes during normal intrauterine conditions and in response to maternal undernutrition with particular emphasis on the sheep fetus. It also considers the metabolic interactions between these hormones and their role in the maturation of key tissues, such as the liver, skeletal muscle and adipose tissue, in readiness for their new metabolic functions after birth. Endocrine regulation of fetal metabolism is shown to be multifactorial and dynamic with a central role in optimizing metabolic fitness for survival both in utero and at birth.
    MeSH term(s) Animals ; Endocrine System/physiology ; Female ; Fetus ; Hydrocortisone/metabolism ; Maternal-Fetal Exchange ; Pregnancy ; Sheep ; Thyroxine
    Chemical Substances Thyroxine (Q51BO43MG4) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 594468-5
    ISSN 1879-0054 ; 0739-7240
    ISSN (online) 1879-0054
    ISSN 0739-7240
    DOI 10.1016/j.domaniend.2021.106657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4204: Show issues Location:
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  2. Article ; Online: Stress during pregnancy and its life-long consequences for the infant.

    Fowden, Abigail L

    The Journal of physiology

    2017  Volume 595, Issue 15, Page(s) 5055–5056

    MeSH term(s) Female ; Fetal Development ; Humans ; Infant ; Insulin ; Phenotype ; Placenta ; Pregnancy ; Resource Allocation
    Chemical Substances Insulin
    Language English
    Publishing date 2017-07-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP274444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Endocrine regulation of fetal metabolism towards term

    Fowden, Abigail L. / Forhead, Alison J.

    Domestic animal endocrinology. 2022 Jan., v. 78

    2022  

    Abstract: Hormones have an important role in regulating fetal metabolism in relation to the prevailing nutritional conditions both in late gestation and during the prepartum period as the fetus prepares for birth. In particular, the pancreatic, thyroid and adrenal ...

    Abstract Hormones have an important role in regulating fetal metabolism in relation to the prevailing nutritional conditions both in late gestation and during the prepartum period as the fetus prepares for birth. In particular, the pancreatic, thyroid and adrenal hormones all affect fetal uptake and utilization of nutrients for oxidative metabolism, tissue accretion and fuel storage. These hormones also influence the fetal metabolic preparations for the nutritional transition from intra- to extra-uterine life. This review discusses the role of insulin, glucagon, thyroxine, tri-iodothyronine, cortisol and the catecholamines in these processes during normal intrauterine conditions and in response to maternal undernutrition with particular emphasis on the sheep fetus. It also considers the metabolic interactions between these hormones and their role in the maturation of key tissues, such as the liver, skeletal muscle and adipose tissue, in readiness for their new metabolic functions after birth. Endocrine regulation of fetal metabolism is shown to be multifactorial and dynamic with a central role in optimizing metabolic fitness for survival both in utero and at birth.
    Keywords adipose tissue ; aerobiosis ; catecholamines ; cortisol ; fetus ; glucagon ; insulin ; liver ; malnutrition ; pregnancy ; prepartum period ; sheep ; skeletal muscle ; triiodothyronine
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 594468-5
    ISSN 1879-0054 ; 0739-7240
    ISSN (online) 1879-0054
    ISSN 0739-7240
    DOI 10.1016/j.domaniend.2021.106657
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 4204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations.

    Zaugg, Jonas / Lopez-Tello, Jorge / Musial, Barbara / Vaughan, Owen R / Fowden, Abigail L / Albrecht, Christiane / Sferruzzi-Perri, Amanda N

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 151

    Abstract: Obesity and gestational diabetes (GDM) impact fetal growth during pregnancy. Iron is an essential micronutrient needed for energy-intense feto-placental development, but if mis-handled can lead to oxidative stress and ferroptosis (iron-dependent cell ... ...

    Abstract Obesity and gestational diabetes (GDM) impact fetal growth during pregnancy. Iron is an essential micronutrient needed for energy-intense feto-placental development, but if mis-handled can lead to oxidative stress and ferroptosis (iron-dependent cell death). In a mouse model showing maternal obesity and glucose intolerance, we investigated the association of materno-fetal iron handling and placental ferroptosis, oxidative damage and stress signalling activation with fetal growth. Female mice were fed a standard chow or high fat, high sugar (HFHS) diet during pregnancy and outcomes were measured at day (d)16 or d19 of pregnancy. In HFHS-fed mice, maternal hepcidin was reduced and iron status maintained (tissue iron levels) at both d16 and d19. However, fetal weight, placental iron transfer capacity, iron deposition, TFR1 expression and ERK2-mediated signalling were reduced and oxidative damage-related lipofuscin accumulation in the placenta was increased in HFHS-fed mice. At d19, whilst TFR1 remained decreased, fetal weight was normal and placental weight, iron content and iron transporter genes (Dmt1, Zip14, and Fpn1) were reduced in HFHS-fed mice. Furthermore, there was stress kinase activation (increased phosphorylated p38MAPK, total ERK and JNK) in the placenta from HFHS-fed mice at d19. In summary, a maternal HFHS diet during pregnancy impacts fetal growth trajectory in association with changes in placental iron handling, ferroptosis and stress signalling. Downregulation of placental iron transporters in HFHS mice may protect the fetus from excessive oxidative iron. These findings suggest a role for alterations in placental iron homeostasis in determining perinatal outcomes of pregnancies associated with GDM and/or maternal obesity.
    MeSH term(s) Humans ; Pregnancy ; Female ; Animals ; Mice ; Iron ; Ferroptosis ; Fetal Weight ; Obesity, Maternal ; Placenta ; Fetus ; Diet, High-Fat/adverse effects
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05192-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 195: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Sex-Specific Effects of a Maternal Obesogenic Diet High in Fat and Sugar on Offspring Adiposity, Growth, and Behavior.

    Mort, Emily J / Heritage, Sophie / Jones, Susan / Fowden, Abigail L / Camm, Emily J

    Nutrients

    2023  Volume 15, Issue 21

    Abstract: With rising rates of human obesity, this study aimed to determine the relationship between maternal diet-induced obesity, offspring morphometrics, and behavior in mice. Pregnant and lactating female mice fed a diet high in fat and sugar (HFHS) commonly ... ...

    Abstract With rising rates of human obesity, this study aimed to determine the relationship between maternal diet-induced obesity, offspring morphometrics, and behavior in mice. Pregnant and lactating female mice fed a diet high in fat and sugar (HFHS) commonly consumed by human populations showed decreased food, calorie, and protein intake but increased adiposity at the expense of lean mass. The pre-weaning body weight of the HFHS offspring was reduced for the first postnatal week but not thereafter, with HFHS female offspring having higher body weights by weaning due to continuing higher fractional growth rates. Post-weaning, there were minor differences in offspring food and protein intake. Maternal diet, however, affected fractional growth rate and total body fat content of male but not female HFHS offspring. The maternal diet did not affect the offspring's locomotor activity or social behavior in either sex. Both the male and female HFHS offspring displayed reduced anxiety-related behaviors, with sex differences in particular aspects of the elevated plus maze task. In the novel object recognition task, performance was impaired in the male but not female HFHS offspring. Collectively, the findings demonstrate that maternal obesity alters the growth, adiposity, and behavior of male and female offspring, with sex-specific differences.
    MeSH term(s) Humans ; Female ; Male ; Pregnancy ; Mice ; Animals ; Adiposity ; Sugars/metabolism ; Lactation ; Diet, High-Fat/adverse effects ; Obesity/etiology ; Obesity/metabolism ; Adipose Tissue/metabolism ; Maternal Nutritional Physiological Phenomena
    Chemical Substances Sugars
    Language English
    Publishing date 2023-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15214594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Age and an obesogenic diet affect mouse behaviour in a sex-dependent manner.

    Mort, Emily J / Fordington, Surina / Heritage, Sophie / Fowden, Abigail L / Jones, Susan / Camm, Emily J

    The European journal of neuroscience

    2023  Volume 58, Issue 2, Page(s) 2451–2468

    Abstract: Obesity is rising globally and is associated with neurodevelopmental and psychiatric disorders among children, adolescents and young adults. Whether obesity is the cause or the consequence of these disorders remains unclear. To examine the behavioural ... ...

    Abstract Obesity is rising globally and is associated with neurodevelopmental and psychiatric disorders among children, adolescents and young adults. Whether obesity is the cause or the consequence of these disorders remains unclear. To examine the behavioural effects of obesity systematically, locomotion, anxiety and social behaviour were assessed in male and female C57Bl/6J mice using the open field, elevated plus maze and social preference task. First, the effects of age and sex were examined in control mice, before investigating post-weaning consumption of a high fat-high sugar diet commonly consumed in human populations with high rates of obesity. In the open field and elevated plus maze, locomotor activity and anxiety-related behaviours reduced with aging in both sexes, but with different sex-specific profiles. The high fat-high sugar diet reduced food and calorie intake and increased body mass and fat deposition in both sexes. In the open field, both male and female mice on the obesogenic diet showed reduced locomotion; whereas, in the elevated plus maze, only females fed with the obesogenic diet displayed reduced anxiety-related behaviours. Both male and female mice on the obesogenic diet had a significantly higher social preference index than the control group. In conclusion, the findings demonstrate that the behavioural effects of age and diet-induced obesity all depend on the sex of the mouse. This emphasises the importance of considering the age of the animal and including both sexes when assessing behavioural phenotypes arising from dietary manipulations.
    MeSH term(s) Humans ; Child ; Mice ; Male ; Animals ; Female ; Adolescent ; Behavior, Animal ; Obesity/etiology ; Obesity/psychology ; Diet, High-Fat/adverse effects ; Diet, High-Fat/psychology ; Mice, Inbred C57BL ; Sugars/pharmacology
    Chemical Substances Sugars
    Language English
    Publishing date 2023-06-28
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2548: Show issues Location:
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  7. Article ; Online: Metabolic Consequences of Glucocorticoid Exposure before Birth.

    Fowden, Abigail L / Vaughan, Owen R / Murray, Andrew J / Forhead, Alison J

    Nutrients

    2022  Volume 14, Issue 11

    Abstract: Glucocorticoids have an important role in development of the metabolic phenotype in utero. They act as environmental and maturational signals in adapting feto-placental metabolism to maximize the chances of survival both before and at birth. They ... ...

    Abstract Glucocorticoids have an important role in development of the metabolic phenotype in utero. They act as environmental and maturational signals in adapting feto-placental metabolism to maximize the chances of survival both before and at birth. They influence placental nutrient handling and fetal metabolic processes to support fetal growth, fuel storage and energy production with respect to nutrient availability. More specifically, they regulate the transport, utilization and production of a range of nutrients by the feto-placental tissues that enables greater metabolic flexibility in utero while minimizing any further drain on maternal resources during periods of stress. Near term, the natural rise in fetal glucocorticoid concentrations also stimulates key metabolic adaptations that prepare tissues for the new energy demanding functions after birth. Glucocorticoids, therefore, have a central role in the metabolic communication between the mother, placenta and fetus that optimizes offspring metabolic phenotype for survival to reproductive age. This review discusses the effects of maternal and fetal glucocorticoids on the supply and utilization of nutrients by the feto-placental tissues with particular emphasis on studies using quantitative methods to assess metabolism in rodents and sheep in vivo during late pregnancy. It considers the routes of glucocorticoid overexposure in utero, including experimental administration of synthetic glucocorticoids, and the mechanisms by which these hormones control feto-placental metabolism at the molecular, cellular and systems levels. It also briefly examines the consequences of intrauterine glucocorticoid overexposure for postnatal metabolic health and the generational inheritance of metabolic phenotype.
    MeSH term(s) Animals ; Female ; Fetal Development ; Fetus/metabolism ; Glucocorticoids/metabolism ; Parturition ; Placenta/metabolism ; Pregnancy ; Sheep
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14112304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Comparative fetal and neonatal physiology

    Silver, Marian / Fowden, Abigail L.

    reviews in memory of Marian Silver

    (Equine veterinary journal : Supplement ; 24)

    1997  

    Author's details ed.: Abigail L. Fowden
    Series title Equine veterinary journal : Supplement ; 24
    Equine veterinary journal
    Equine veterinary journal ; Supplement
    Collection Equine veterinary journal
    Equine veterinary journal ; Supplement
    Language English
    Size VIII, 117 S. : Ill., graph. Darst.
    Publishing place Newmarket, Suffolk
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT011102129
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 3105 -Suppl.24- not available for loan Zeitschriften-Lesesaal

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  9. Book: Foetal maturation

    Fowden, Abigail L.

    comparative aspects of normal and disturbed development

    (Equine veterinary journal : Supplement ; 14)

    1993  

    Author's details ed.: A. L. Fowden
    Series title Equine veterinary journal : Supplement ; 14
    Equine veterinary journal
    Equine veterinary journal ; Supplement
    Collection Equine veterinary journal
    Equine veterinary journal ; Supplement
    Keywords Fetal Development ; Horses
    Language English
    Size 52 S. : Ill., graph. Darst.
    Publisher R & W
    Publishing place Newmarket, Suffolk
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007233150
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3105 -Suppl.14- verfügbar in Königswinter Königswinter

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  10. Article: Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy.

    Lopez-Tello, Jorge / Salazar-Petres, Esteban / Webb, Liam / Fowden, Abigail L / Sferruzzi-Perri, Amanda N

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 928210

    Abstract: Pregnancy requires adaptations in maternal metabolism to support fetal growth. The phosphoinositol-3-kinase (PI3K) signalling pathway controls multiple biological processes and defects in this pathway are linked to metabolic disorders including insulin ... ...

    Abstract Pregnancy requires adaptations in maternal metabolism to support fetal growth. The phosphoinositol-3-kinase (PI3K) signalling pathway controls multiple biological processes and defects in this pathway are linked to metabolic disorders including insulin resistance and glucose intolerance in non-pregnant animals. However, relatively little is known about the contribution of PI3K signalling to the maternal metabolic adaptations during pregnancy. Using mice with partial inactivation of the PI3K isoform, p110α (due to a heterozygous dominant negative mutation;
    Language English
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.928210
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