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Article ; Online: High-Resolution Photoelectron Spectroscopy of the Ground and First Excited Electronic States of MgXe

Kreis, C / Schmitz, J R / Merkt, F

The journal of physical chemistry. A

2024 Volume 128, Issue 16, Page(s) 3149–3157

Abstract: We report on the characterization of the ... ...

Abstract	We report on the characterization of the X
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.4c00940
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Improving Pediatric Procedural Skills for EMS Clinicians: A Longitudinal Simulation-Based Curriculum with Novel, Remote, First-Person-View Video-Based Outcome Measurement.

Lee, Sang Hoon / Riney, Lauren C / Merkt, Brant / McDonough, Shawn D / Baker, Jordan / Boyd, Stephanie / Zhang, Yin / Geis, Gary L

Prehospital emergency care

2024 Volume 28, Issue 2, Page(s) 352–362

Abstract: Objective: Emergency medical services (EMS) clinicians are expected to provide expert care to all patients, but face obstacles in maintaining skillsets required in the care of critically ill or injured children. The objectives of this study were to ... ...

Abstract	Objective: Emergency medical services (EMS) clinicians are expected to provide expert care to all patients, but face obstacles in maintaining skillsets required in the care of critically ill or injured children. The objectives of this study were to describe and assess the effectiveness of a pediatric-focused, simulation-based, procedural training program for EMS clinicians, delivered on-site by a pediatric simulation education team. We also describe a novel, remote, asynchronous performance outcome measurement system using first-person-view video review. Methods: This was a prospective study of simulation-based training and procedural outcomes. The study population involved EMS clinicians at three fire-based EMS agencies stratified as urban, suburban, and rural sites. The primary outcome was performance of intraosseous catheterization (IO), bag-valve-mask ventilation (BVM), and supraglottic device placement (SGD), measured across three time points. Secondary outcomes were identification of differences across EMS agencies and participant survey responses. Results: We obtained video data from 122 clinicians, totaling 561 videos, with survey response rates of 89.0-91.3%. Pre-intervention scores were high: least-square means (95% confident-intervals) 9.5 (8.9, 10.2) for IO; 9.6 (9.3, 9.9) for BVM; and 11.6 (10.9, 12.2) for SGD. There was significant improvement post-intervention: 11.5 (10.7, 12.3) for IO; 11.0 (10.7, 11.4) for BVM; and 13.6 (12.8, 14.4) for SGD. Improvement was maintained at follow-up after a median of 9.5 months: 10.5 (9.8, 11.2) for IO; 10.2 (9.9, 10.6) for BVM; and 12.4 (11.7, 13.1) for SGD. There were no statistical differences between sites. Of survey respondents, half had not cared for a critically ill or injured child in at least a year, the vast majority had not had hands-on pediatric training in over 6 months, and the majority felt that training should occur at least every 6 months. Conclusions: Our pediatric-focused, simulation-based procedural training program was associated with improvement and maintenance of high-baseline procedural performance for EMS clinicians over the study period. Findings were consistent across sites. Remote assessment was feasible. Participant surveys emphasized a desire for more pediatric-focused training and highlighted the low frequency of clinical exposure to procedures potentially needed in the care of critically ill or injured pediatric patients.
MeSH term(s)	Humans ; Child ; Emergency Medical Services ; Prospective Studies ; Critical Illness ; Respiration, Artificial ; Curriculum
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1461751-1
ISSN	1545-0066 ; 1090-3127
ISSN (online)	1545-0066
ISSN	1090-3127
DOI	10.1080/10903127.2023.2263555
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Book ; Thesis: Psychological compensation in attention deficit hyperactivity disorder - Application of a theoretical framework

Merkt, Anne

2013

Abstract: ... on the application of a new theoretical framework (Bäckman & Dixon). - (1) Ehm, J.-H, Merkt, J., Gawrilow, C ... Merkt, J., & Gawrilow, C. (2014, submitted). Health, dietary habits, and achievement motivation ... in college students with self-reported ADHD diagnosis. Journal of Attention Disorders. (3) Merkt, J ...

Title translation	Psychologische Kompensation bei Aufmerksamkeitsstörung mit Hyperaktivität - Anwendung eines theoretischen Rahmenkonzepts
Abstract	The cumulative dissertation contains three contributions investigating the awareness of deficits and psychological compensation in attention deficit disorder with hyperactivity (ADHD) based on the application of a new theoretical framework (Bäckman & Dixon). - (1) Ehm, J.-H, Merkt, J., Gawrilow, C., & Hasselhorn, M. (2014, im Druck). Selbstkonzept und Schulleistungen von Grundschülern mit ADHS-Symptomen. Zeitschrift für Entwicklungspsychologie und Pädagogische Psychologie. DOI: 10.1026/0049-8637/a000102. (2) Merkt, J., & Gawrilow, C. (2014, submitted). Health, dietary habits, and achievement motivation in college students with self-reported ADHD diagnosis. Journal of Attention Disorders. (3) Merkt, J., Singmann, H., Bodenburg, S., Goossens-Merkt, H., Kappes, A., Wendt, M., & Gawrilow, C. (2013). Flanker performance in female college students with ADHD - A diffusion model analysis. Attention Deficit and Hyperactivity Disorders, 5 (4), 321-341. DOI: 10.1007/s12402-013-0110-1.
Keywords	Achievement Motivation ; Attention Deficit Disorder with Hyperactivity ; Aufmerksamkeitsstörung mit Hyperaktivität ; Bewältigungsverhalten ; Coping Behavior ; Leistungsmotivation ; Selbsteinschätzung ; Selbstkonzept ; Selbstwahrnehmung ; Self-Concept ; Self-Evaluation ; Self-Perception
Language	English
Size	76 pp.
Publisher	Universität, Fachbereich Psychologie und Sportwissenschaften
Publishing place	Frankfurt a. M.
Document type	Book ; Thesis
Note	Elektronische Publikation im Internet. Kumulative Dissertation
Database	PSYNDEX

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Article ; Online: Mini-batch optimization enables training of ODE models on large-scale datasets.

Stapor, Paul / Schmiester, Leonard / Wierling, Christoph / Merkt, Simon / Pathirana, Dilan / Lange, Bodo M H / Weindl, Daniel / Hasenauer, Jan

Nature communications

2022 Volume 13, Issue 1, Page(s) 34

Abstract: Quantitative dynamic models are widely used to study cellular signal processing. A critical step in modelling is the estimation of unknown model parameters from experimental data. As model sizes and datasets are steadily growing, established parameter ... ...

Abstract	Quantitative dynamic models are widely used to study cellular signal processing. A critical step in modelling is the estimation of unknown model parameters from experimental data. As model sizes and datasets are steadily growing, established parameter optimization approaches for mechanistic models become computationally extremely challenging. Mini-batch optimization methods, as employed in deep learning, have better scaling properties. In this work, we adapt, apply, and benchmark mini-batch optimization for ordinary differential equation (ODE) models, thereby establishing a direct link between dynamic modelling and machine learning. On our main application example, a large-scale model of cancer signaling, we benchmark mini-batch optimization against established methods, achieving better optimization results and reducing computation by more than an order of magnitude. We expect that our work will serve as a first step towards mini-batch optimization tailored to ODE models and enable modelling of even larger and more complex systems than what is currently possible.
MeSH term(s)	Algorithms ; Benchmarking ; Cell Line, Tumor ; Computational Biology/methods ; Gene Knockout Techniques ; Humans ; Machine Learning ; Models, Biological ; Neoplasms ; Signal Transduction ; Software
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-27374-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Actual and perceived knowledge about COVID-19

Granderath, Julia S. / Sondermann, Christina / Martin, Andreas / Merkt, Martin

Frontiers in Psychology

The role of information behavior in media

2021

Abstract: The COVID-19 pandemic poses a health threat that has dominated media coverage. However, not much is known about individual media use to acquire knowledge about COVID-19. To address this open research question, this study investigated how the perceived ... ...

Title translation	Tatsächliches und wahrgenommenes Wissen über COVID-19: Die Rolle des Informationsverhaltens in Bezug auf Medien
Abstract	The COVID-19 pandemic poses a health threat that has dominated media coverage. However, not much is known about individual media use to acquire knowledge about COVID-19. To address this open research question, this study investigated how the perceived threat is linked to media use and how media use is associated with perceived and actual knowledge about COVID-19. In a German online survey conducted between April 16 and April 27, 2020, N = 952 participants provided information on their perceived threat and media use to inform themselves about COVID-19. In this process, they indicated how well they were informed about COVID-19 (perceived knowledge) and subsequently completed a COVID-19 knowledge test (actual knowledge). Results indicated that individuals who felt more threatened by COVID-19 used media more often to inform themselves (b = 0.20, p < 0.001) but focused on fewer different media channels (b = 0.01, p < 0.001). Further, frequent media use was associated with higher perceived knowledge (b = 0.47, p < 0.001), but not with higher actual knowledge about COVID-19 (b = -0.01, p = 0.938), reflecting an illusion of knowledge. Additionally, using fewer media channels was linked to higher perceived (b = 2.21, p < 0.001) and actual knowledge (b = 2.08, p = 0.008). Finally, explorative analyses on the use of different media channels revealed that an illusion of knowledge emerged for using social media, public television, and newspapers. Potential explanations for the findings and implications for future research are discussed.
Keywords	COVID-19 ; Gesundheitswissen ; Health Knowledge ; Information Seeking ; Informationssuche ; Knowledge Level ; Mass Media ; Massenmedien ; Risikowahrnehmung ; Risk Perception ; Wissensstand
Language	English
Document type	Article
DOI	10.3389/fpsyg.2021.778886
Database	PSYNDEX

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Book ; Online: Agile Maneuvers in Legged Robots

Mastalli, Carlos / Merkt, Wolfgang / Xin, Guiyang / Shim, Jaehyun / Mistry, Michael / Havoutis, Ioannis / Vijayakumar, Sethu

a Predictive Control Approach

2022

Abstract: Planning and execution of agile locomotion maneuvers have been a longstanding challenge in legged robotics. It requires to derive motion plans and local feedback policies in real-time to handle the nonholonomy of the kinetic momenta. To achieve so, we ... ...

Abstract	Planning and execution of agile locomotion maneuvers have been a longstanding challenge in legged robotics. It requires to derive motion plans and local feedback policies in real-time to handle the nonholonomy of the kinetic momenta. To achieve so, we propose a hybrid predictive controller that considers the robot's actuation limits and full-body dynamics. It combines the feedback policies with tactile information to locally predict future actions. It converges within a few milliseconds thanks to a feasibility-driven approach. Our predictive controller enables ANYmal robots to generate agile maneuvers in realistic scenarios. A crucial element is to track the local feedback policies as, in contrast to whole-body control, they achieve the desired angular momentum. To the best of our knowledge, our predictive controller is the first to handle actuation limits, generate agile locomotion maneuvers, and execute optimal feedback policies for low level torque control without the use of a separate whole-body controller. Comment: 20 pages, 16 figures
Keywords	Computer Science - Robotics ; Computer Science - Artificial Intelligence ; Electrical Engineering and Systems Science - Systems and Control
Subject code	629
Publishing date	2022-03-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Health, Dietary Habits, and Achievement Motivation in College Students With Self-Reported ADHD Diagnosis.

Merkt, Julia / Gawrilow, Caterina

Journal of attention disorders

2014 Volume 20, Issue 9, Page(s) 727–740

Abstract: Objective: The present study aimed to investigate aspects of health and motivation in a subpopulation of college students with ADHD.: Method: Seventy-seven college students with self-reported ADHD (49 women; M age = 25.82, SD = 4.62) and 120 college ... ...

Abstract	Objective: The present study aimed to investigate aspects of health and motivation in a subpopulation of college students with ADHD. Method: Seventy-seven college students with self-reported ADHD (49 women; M age = 25.82, SD = 4.62) and 120 college students without ADHD (65 women; M age = 25.17, SD = 5.41) participated in an online survey assessing their health, dietary habits, and achievement motivation. Results: College students with ADHD showed impairment in psychological functioning, impairment in their mental health, and reported more ambition and less self-control. Furthermore, we found gender differences: Women with ADHD reported worse psychological functioning, and the gender differences in obsessive-compulsive behavior and compensatory effort were mediated by the timing of diagnosis. Conclusion: College students, especially women, with ADHD struggle with health-related issues. Some of these gender differences might be due to under diagnosis of girls in childhood. Differences in achievement motivation might indicate compensatory mechanisms.
MeSH term(s)	Achievement ; Adult ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Feeding Behavior ; Female ; Health Status ; Humans ; Male ; Motivation ; Self Report ; Self-Control ; Sex Factors ; Students/psychology ; Students/statistics & numerical data ; Surveys and Questionnaires ; Universities
Language	English
Publishing date	2014-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/1087054714523127
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Article ; Online: Blood CD3-(CD56 or 16)+ natural killer cell distributions are heterogeneous in healthy adults and suppressed by azathioprine in patients with ANCA-associated vasculitides.

Merkt, Wolfgang / Salzer, Ulrich / Thiel, Jens / Jandova, Ilona / Bergner, Raoul / Venhoff, Ana C / Venhoff, Nils

BMC immunology

2021 Volume 22, Issue 1, Page(s) 26

Abstract: Background: Cytotoxic Natural Killer (NK) cells are increasingly recognized as a powerful tool to induce targeted cell death in cancer and autoimmune diseases. Still, basic blood NK cell parameters are poorly defined. The aims of this study were 1) to ... ...

Abstract	Background: Cytotoxic Natural Killer (NK) cells are increasingly recognized as a powerful tool to induce targeted cell death in cancer and autoimmune diseases. Still, basic blood NK cell parameters are poorly defined. The aims of this study were 1) to establish reference values of NK cell counts and percentages in healthy adults; 2) to describe these parameters in the prototype autoimmune disease group ANCA-associated vasculitis (AAV); and 3) to investigate whether NK cell counts and percentages may be used as activity biomarkers in the care of AAV patients, as suggested by a preceding study. Methods: CD3-(CD56 or 16)+ NK cell counts and percentages were determined in 120 healthy adults. Lymphocyte subset and clinical data from two German vasculitis centers were analyzed retrospectively (in total 407 measurements, including 201/49/157 measurements from 64/16/39 patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), respectively). Results: CD3-(CD56 or 16)+ NK cell counts and percentages in healthy adults were highly variable, not Gaussian distributed and independent of age and sex. NK cell percentages ranged from 1.9 to 37.9% of lymphocytes, and were significantly more dispersed in AAV (0.3 to 57.6%), while the median percentage was not different between AAV and healthy donors. In contrast, median NK cell counts were significantly lower in AAV compared to healthy donors. Sub-group analyses revealed that NK cell counts were low independent of AAV entity and disease activity. Azathioprine therapy was associated with significantly lower NK cell counts and percentages compared to non-azathioprine therapies. In 13.6% of azathioprine-treated patients, percentages were </= 1% which may be interpreted as temporary NK cell deficiency. NK cell counts and percentages could not separate active from inactive AAV.<br />Conclusions: NK cell counts and percentages in blood are heterogeneous and can presently not be recommended as biomarker in clinical care of AAV patients. Azathioprine treatment was associated with significantly low NK cells. These findings may be relevant for the development of drugs that aim at exploiting NK cell cytotoxicity and may help to identify patients at risk to develop malignant or infectious co-morbidities.
MeSH term(s)	Adult ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Azathioprine/therapeutic use ; Blood Cells/immunology ; CD3 Complex/metabolism ; CD56 Antigen/metabolism ; Cytotoxicity, Immunologic ; Female ; Healthy Volunteers ; Humans ; Immunosuppression Therapy ; Immunosuppressive Agents/therapeutic use ; Killer Cells, Natural/immunology ; Lymphocyte Subsets/immunology ; Male ; Receptors, IgG/metabolism ; Retrospective Studies
Chemical Substances	CD3 Complex ; CD56 Antigen ; Immunosuppressive Agents ; Receptors, IgG ; Azathioprine (MRK240IY2L)
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041500-X
ISSN	1471-2172 ; 1471-2172
ISSN (online)	1471-2172
ISSN	1471-2172
DOI	10.1186/s12865-021-00416-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sequential Cu-Catalyzed Four- and Five-Component Syntheses of Luminescent 3-Triazolylquinoxalines.

Merkt, Franziska K / Pieper, Konstantin / Klopotowski, Maximilian / Janiak, Christoph / Müller, Thomas J J

Chemistry (Weinheim an der Bergstrasse, Germany)

2019 Volume 25, Issue 40, Page(s) 9447–9455

Abstract: 3-Triazolylquinoxalines can be readily synthesized by applying two complementary synthetic protocols starting from heterocyclic π nucleophiles or (hetero)aryl glyoxylic acids in a consecutive four- or five-component reaction. Conceptually, the sequential ...

Abstract	3-Triazolylquinoxalines can be readily synthesized by applying two complementary synthetic protocols starting from heterocyclic π nucleophiles or (hetero)aryl glyoxylic acids in a consecutive four- or five-component reaction. Conceptually, the sequential use of a single cuprous salt for alkynylation and Cu-catalyzed alkyne-azide cycloaddition (CuAAC) in a one-pot fashion sets the stage for activation-alkynylation-cyclocondensation-CuAAC or glyoxylation-alkynylation-cyclocondensation-CuAAC sequences in good yields. The diversity-oriented generation of differently substituted 3-triazolylquinoxalines is an excellent entry to tunable emission solvatorchromic fluorophores with triazole ligation. The electronic structure, corroborated by DFT and TD-DFT calculations, rationalizes the charge transfer character of relevant absorptions and large Stokes shifts as well as the electronic innocence of the triazole substituents.
Language	English
Publishing date	2019-04-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201900277
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Article: Health, dietary habits, and achievement motivation in college students with self-reported ADHD diagnosis

Merkt, Julia / Gawrilow, Caterina

Journal of Attention Disorders

2016 Volume 20, Issue 9, Page(s) 727–740

Abstract: Objective: The present study aimed to investigate aspects of health and motivation in a subpopulation of college students with ADHD. Method: Seventy-seven college students with self-reported ADHD (49 women; M age = 25.82, SD = 4.62) and 120 college ... ...

Title translation	Gesundheit, Ernährungsgewohnheiten und Leistungsmotivation bei Studierenden mit selbstberichteter ADHS
Abstract	Objective: The present study aimed to investigate aspects of health and motivation in a subpopulation of college students with ADHD. Method: Seventy-seven college students with self-reported ADHD (49 women; M age = 25.82, SD = 4.62) and 120 college students without ADHD (65 women; M age = 25.17, SD = 5.41) participated in an online survey assessing their health, dietary habits, and achievement motivation. Results: College students with ADHD showed impairment in psychological functioning, impairment in their mental health, and reported more ambition and less self-control. Furthermore, gender differences were found: Women with ADHD reported worse psychological functioning, and the gender differences in obsessive-compulsive behavior and compensatory effort were mediated by the timing of diagnosis. Conclusion: College students, especially women, with ADHD struggle with health-related issues. Some of these gender differences might be due to under diagnosis of girls in childhood. Differences in achievement motivation might indicate compensatory mechanisms.
Keywords	Achievement Motivation ; Attention Deficit Disorder with Hyperactivity ; Aufmerksamkeitsstörung mit Hyperaktivität ; College Students ; Diets ; Ernährungsweisen ; Geschlechtsunterschiede beim Menschen ; Gesunde Ernährungsweise ; Gesundheit ; Gewohnheiten ; Habits ; Health ; Healthy Eating ; Human Sex Differences ; Leistungsmotivation ; Studierende (Bachelorstudium)
Language	English
Document type	Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/1087054714523127
Database	PSYNDEX

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