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  1. Article ; Online: The authors reply.

    Anderson, Michaela R / Madahar, Purnema / Baldwin, Matthew R

    Critical care medicine

    2024  Volume 52, Issue 4, Page(s) e206–e207

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006197
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    Zs.A 1261: Show issues Location:
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  2. Article ; Online: Metabolic Syndrome and Acute Respiratory Distress Syndrome Outcomes: A Most Ingenious Paradox or a Devil in the Details?

    Anderson, Michaela R / Shashaty, Michael G S

    Critical care medicine

    2024  Volume 52, Issue 3, Page(s) 502–505

    MeSH term(s) Humans ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Respiratory Distress Syndrome/complications ; Respiratory Distress Syndrome/epidemiology
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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  3. Article ; Online: Rationing scarce healthcare capacity: A study of the ventilator allocation guidelines during the COVID-19 pandemic.

    Anderson, David R / Aydinliyim, Tolga / Bjarnadóttir, Margrét V / Çil, Eren B / Anderson, Michaela R

    Production and operations management

    2023  

    Abstract: In the United States, even though national guidelines for allocating scarce healthcare resources are lacking, 26 states have specific ventilator allocation guidelines to be invoked in case of a shortage. While several states developed their guidelines in ...

    Abstract In the United States, even though national guidelines for allocating scarce healthcare resources are lacking, 26 states have specific ventilator allocation guidelines to be invoked in case of a shortage. While several states developed their guidelines in response to the recent COVID-19 pandemic, New York State developed these guidelines in 2015 as "pandemic influenza is a foreseeable threat, one that we cannot ignore." The primary objective of this study is to assess the existing procedures and priority rules in place for allocating/rationing scarce ventilator capacity and propose alternative (and improved) priority schemes. We first build machine learning models using inpatient records of COVID-19 patients admitted to New York-Presbyterian/Columbia University Irving Medical Center and an affiliated community health center to predict survival probabilities as well as ventilator length-of-use. Then, we use the resulting point estimators and their uncertainties as inputs for a multiclass priority queueing model with abandonments to assess three priority schemes: (i) SOFA-P (Sequential Organ Failure Assessment based prioritization), which most closely mimics the existing practice by prioritizing patients with sufficiently low SOFA scores; (ii) ISP (incremental survival probability), which assigns priority based on patient-level survival predictions; and (iii) ISP-LU (incremental survival probability per length-of-use), which takes into account survival predictions and resource use duration. Our findings highlight that our proposed priority scheme, ISP-LU, achieves a demonstrable improvement over the other two alternatives. Specifically, the expected number of survivals increases
    Language English
    Publishing date 2023-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151364-8
    ISSN 1937-5956 ; 1059-1478
    ISSN (online) 1937-5956
    ISSN 1059-1478
    DOI 10.1111/poms.13934
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  4. Article ; Online: Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection.

    Anderson, Michaela R / Ferrante, Anthony W / Baldwin, Matthew R

    Annals of internal medicine

    2021  Volume 174, Issue 6, Page(s) 886

    MeSH term(s) Body Mass Index ; COVID-19 ; Humans ; Intubation, Intratracheal/adverse effects ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0015
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  5. Article ; Online: Hospital Length of Stay for Patients with Severe COVID-19: Implications for Remdesivir's Value.

    Anderson, Michaela R / Bach, Peter B / Baldwin, Matthew R

    PharmacoEconomics - open

    2020  Volume 5, Issue 1, Page(s) 129–131

    Language English
    Publishing date 2020-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2874287-4
    ISSN 2509-4254 ; 2509-4262
    ISSN (online) 2509-4254
    ISSN 2509-4262
    DOI 10.1007/s41669-020-00243-6
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  6. Article ; Online: Current Beliefs and Practices Regarding the Management of Obesity in Patients with Progressive Interstitial Lung Disease.

    Anderson, Michaela R / Aronson, Kerri I / Diamond, Joshua M / Christie, Jason D / Singer, Jonathan P

    Annals of the American Thoracic Society

    2022  

    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202201-019RL
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5828: Show issues Location:
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  7. Article ; Online: Impact of Obesity in Critical Illness.

    Anderson, Michaela R / Shashaty, Michael G S

    Chest

    2021  Volume 160, Issue 6, Page(s) 2135–2145

    Abstract: The prevalence of obesity is rising worldwide. Adipose tissue exerts anatomic and physiological effects with significant implications for critical illness. Changes in respiratory mechanics cause expiratory flow limitation, atelectasis, and V̇/Q̇ mismatch ...

    Abstract The prevalence of obesity is rising worldwide. Adipose tissue exerts anatomic and physiological effects with significant implications for critical illness. Changes in respiratory mechanics cause expiratory flow limitation, atelectasis, and V̇/Q̇ mismatch with resultant hypoxemia. Altered work of breathing and obesity hypoventilation syndrome may cause hypercapnia. Challenging mask ventilation and peri-intubation hypoxemia may complicate intubation. Patients with obesity are at increased risk of ARDS and should receive lung-protective ventilation based on predicted body weight. Increased positive end expiratory pressure (PEEP), coupled with appropriate patient positioning, may overcome the alveolar decruitment and intrinsic PEEP caused by elevated baseline pleural pressure; however, evidence is insufficient regarding the impact of high PEEP strategies on outcomes. Venovenous extracorporeal membrane oxygenation may be safely performed in patients with obesity. Fluid management should account for increased prevalence of chronic heart and kidney disease, expanded blood volume, and elevated acute kidney injury risk. Medication pharmacodynamics and pharmacokinetics may be altered by hydrophobic drug distribution to adipose depots and comorbid liver or kidney disease. Obesity is associated with increased risk of VTE and infection; appropriate dosing of prophylactic anticoagulation and early removal of indwelling catheters may decrease these risks. Obesity is associated with improved critical illness survival in some studies. It is unclear whether this reflects a protective effect or limitations inherent to observational research. Obesity is associated with increased risk of intubation and death in SARS-CoV-2 infection. Ongoing molecular studies of adipose tissue may deepen our understanding of how obesity impacts critical illness pathophysiology.
    MeSH term(s) COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Critical Illness ; Humans ; Obesity/complications ; Obesity/physiopathology ; Respiration, Artificial
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.08.001
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  8. Article ; Online: Provider beliefs and practices regarding the management of obesity in lung transplant recipients.

    Diamond, Joshua M / Benvenuto, Luke / Claridge, Tamara / Witek, Stephanie / Christie, Jason D / Singer, Jonathan P / Anderson, Michaela R

    JHLT open

    2023  Volume 3

    Abstract: Obesity at the time of lung transplant is associated with decreased survival. How providers manage obesity after lung transplantation is unknown. We performed an international survey of lung transplant providers to assess beliefs and practices regarding ... ...

    Abstract Obesity at the time of lung transplant is associated with decreased survival. How providers manage obesity after lung transplantation is unknown. We performed an international survey of lung transplant providers to assess beliefs and practices regarding post-transplant obesity management. Eighty-one providers initiated the survey and 73 (90%) completed the full survey. Respondents were primarily North American-based pulmonary physicians. Nearly all providers believe treating obesity improves quality of life (99%) and survival (95%) after lung transplantation, but that only 41% of patients attempting weight loss are successful. While respondents nearly always recommend diet (96%), exercise (92%), and dietician consultation (89%), they less frequently recommend prescription weight loss medications (29%) or bariatric surgery (11%). Lung transplant providers are motivated to treat obesity in transplant recipients. However, there is a gap between general obesity treatment guidelines and lung transplant practice. Additional training, education, and trials in this population could address this gap.
    Language English
    Publishing date 2023-11-24
    Publishing country United States
    Document type Journal Article
    ISSN 2950-1334
    ISSN (online) 2950-1334
    DOI 10.1016/j.jhlto.2023.100028
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  9. Article: The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.

    Koons, Brittany / Anderson, Michaela R / Smith, Patrick J / Greenland, John R / Singer, Jonathan P

    Current transplantation reports

    2022  Volume 9, Issue 3, Page(s) 149–159

    Abstract: Purpose: Older adults (age ≥ 65 years) are the fastest growing age group undergoing lung transplantation. Further, international consensus document for the selection of lung transplant candidates no longer suggest a fixed upper age limit. Although ... ...

    Abstract Purpose: Older adults (age ≥ 65 years) are the fastest growing age group undergoing lung transplantation. Further, international consensus document for the selection of lung transplant candidates no longer suggest a fixed upper age limit. Although carefully selected older adults can derive great benefit, understanding which older adults will do well after transplant with improved survival and health-related qualiy of life is key to informed decision-making. Herein, we review the epidemiology of aging in lung transplantation and its impact on outcomes, highlight selected physiological measures that may be informative when evaluating and managing older lung transplant patients, and identify directions for future research.
    Recent findings: In general, listing and transplanting older, sicker patients has contributed to worse clinical outcomes and greater healthcare use. Emerging evidence suggest that measures of physiological age, such as frailty, body composition, and neurocognitive and psychosocial function, may better identify risk for poor transplant outcomes than chronlogical age.
    Summary: The evidence base to inform transplant decision-making and improvements in care for older adults is small but growing. Multipronged efforts at the intersection of aging and lung transplantation are needed to improve the clinical and patient centered outcomes for this large and growing cohort of patients. Future research should focus on identifying novel and ideally modifiable risk factors for poor outcomes specific to older adults, better approaches to measuring physiological aging (e.g., frailty, body composition, neurocognitive and psychosocial function), and the underlying mechanisms of physiological aging. Finally, interventions that can improve clinical and patient centered outcomes for older adults are needed.
    Language English
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2196-3029
    ISSN 2196-3029
    DOI 10.1007/s40472-022-00365-2
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  10. Article ; Online: Accuracy and Reproducibility of Automated Measurement of Body Composition: A Lung Transplant Body Composition Cohort Study.

    Anderson, Michaela R / Diamond, Joshua / Shashaty, Michael / Singer, Jonathan P / Tong, Yubing / Udupa, Jayaram / Torigian, Drew A / Palmer, Scott / Lederer, David J / Christie, Jason D / Al-Naamani, Nadine

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 9, Page(s) 1363–1366

    MeSH term(s) Humans ; Cohort Studies ; Reproducibility of Results ; Body Composition ; Lung Transplantation
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202301-061RL
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