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  1. Book ; Thesis: Der Kliniker Paul Moritz Merbach (1819 - 1899) - zwischen antiker Tradition und "physiologischer" Heilkunde

    Eckardt, Cornelia

    2013  

    Author's details von Cornelia Eckardt
    Language German
    Size 152 Bl. : Ill., Kt., 31 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2013
    Note Zsfassung in engl. Sprache
    HBZ-ID HT018174579
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Impact of the COVID-19 pandemic on an emergency department-based opt-out HIV screening program in a South Florida hospital: An interrupted time series analysis, July 2018-March 2021.

    Niu, Jianli / Sareli, Candice / Eckardt, Paula A

    American journal of infection control

    2022  Volume 50, Issue 9, Page(s) 994–998

    Abstract: Background: The COVID-19 pandemic has posed a tremendous burden on healthcare services. We evaluated its impact on an emergency department (ED)-based opt-out Human immunodeficiency virus (HIV) testing in a public healthcare system.: Methods: The ... ...

    Abstract Background: The COVID-19 pandemic has posed a tremendous burden on healthcare services. We evaluated its impact on an emergency department (ED)-based opt-out Human immunodeficiency virus (HIV) testing in a public healthcare system.
    Methods: The programmatic data of ED-based HIV testing from July 2018 to March 2021 at the Memorial Regional Hospital, Hollywood, Florida was analyzed by interrupted time series analysis to evaluate the immediate and gradual effects of the COVID-19 pandemic on the number of monthly HIV tests, with an interruption point at March 2020.
    Results: The average number of monthly HIV tests were significantly lower during the pandemic than the pre-pandemic (791 ± 187 vs 1745 ± 266, P < .001). There was a slight decline trend in the number of monthly HIV tests before the pandemic (estimate -10.29, P = .541). HIV testing dramatically decreased during the initial 7 months of the pandemic, compared to the pre-pandemic period, with the largest decline in the number of HIV tests on March 2020 (estimate -678.48, P = .007). HIV testing slightly increased every month (estimate 4.84, P = .891) during the pandemic period, and the number of HIV tests per month rebounded to the pre-pandemic levels by October 2020.
    Conclusions: ED-based HIV testing significantly decreased during the initial 7 months of the pandemic in south Florida. Multiple strategies are necessary to maintain HIV testing during this pandemic era.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; Emergency Service, Hospital ; Florida/epidemiology ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Testing ; Hospitals ; Humans ; Interrupted Time Series Analysis ; Mass Screening ; Pandemics
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2022.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Optimierte Katheterablation von Vorhofflimmern

    Schade, Anja / Schulze, Paul Christian / Deisenhofer, Isabel Valentine / Eckardt, Lars

    Evaluation von Single-Shot-Verfahren und substratbasierten Technologien

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Dr. med. Anja Schade
    Language German ; English
    Size 133 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Friedrich-Schiller-Universität Jena, 2023
    Note Zeitschriftenaufsätze in englischer Sprache ; Kumulative Dissertation, enthält Zeitschriftenaufsätze ; Tag der Lehrbefähigung: 12.12.2023
    HBZ-ID HT030704301
    Database Catalogue ZB MED Medicine, Health

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  4. Article: Cytomegalovirus reactivation in critically-ill Coronavirus Disease 2019 patients: A case series of 11 patients.

    Kim, Myeongji / Jacob, Jeffy / Mayer, Daniel / Eckardt, Paula Andrea

    IDCases

    2022  Volume 27, Page(s) e01402

    Abstract: The mortality associated with Coronavirus Disease 2019 is greatly influenced by known risk factors such as elderly age, cardiovascular disease, hypertension, diabetes, and immunosuppression. As cytomegalovirus reactivation in critically ill patients has ... ...

    Abstract The mortality associated with Coronavirus Disease 2019 is greatly influenced by known risk factors such as elderly age, cardiovascular disease, hypertension, diabetes, and immunosuppression. As cytomegalovirus reactivation in critically ill patients has been linked with higher morbidity and mortality in intensive care settings, it has been suggested that cytomegalovirus reactivation might lead to worse clinical outcomes of patients with Coronavirus Disease 2019. Here we describe the clinical course of 11 patients with Coronavirus Disease 2019 and concomitant cytomegalovirus viremia. We conclude that further research is necessary to formulate guidelines on diagnosis and treatment of cytomegalovirus reactivation in Coronavirus Disease 2019 patients.
    Language English
    Publishing date 2022-01-11
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characteristics, Vaccination Status and Outcomes Among Healthy Younger Adults in a Large Public Healthcare System in the South Florida Region.

    Samuels, Shenae / Niu, Jianli / Sareli, Candice / Sareli, Aharon / Eckardt, Paula

    Journal of community health

    2022  Volume 47, Issue 2, Page(s) 371–377

    Abstract: Nationally, the 18-49 years old age group are less likely to be vaccinated compared to those 50 years and older. Data describing the risk of COVID-19 severe illness that requires hospitalization among younger healthy adults is limited. In an effort to ... ...

    Abstract Nationally, the 18-49 years old age group are less likely to be vaccinated compared to those 50 years and older. Data describing the risk of COVID-19 severe illness that requires hospitalization among younger healthy adults is limited. In an effort to underscore the importance of vaccination and provide data that may influence COVID-19 risk perception, COVID-19 data of a sample of hospitalized non-elderly age group who clinically may not be considered as high risk for severe COVID-19 illness are presented. Specifically, this retrospective chart review (spanning the period of March 2020 to September 2021) provides a descriptive analysis examining the characteristics, vaccination status and outcomes of adults who were hospitalized at Memorial Healthcare System with laboratory-confirmed COVID-19. The study's data focuses on non-pregnant adults, aged 18-49 years old, without underlying conditions and with no reported history of smoking. As a sub-analysis, data on young and otherwise healthy pregnant females who were hospitalized with COVID-19, as well as data stratified by the pre-Delta and Delta variant dominant period are also presented. There was a total of 482 young and otherwise healthy non-pregnant adults who were hospitalized with COVID-19. Overall, more than 13% of our study population had severe COVID-19 disease. Further, a higher proportion of unvaccinated patients had severe COVID-19 compared to those who received at least one dose of the vaccine. All ventilator or ECMO placements, 30-day readmissions and deaths occurred among unvaccinated patients.
    MeSH term(s) Adolescent ; Adult ; COVID-19/epidemiology ; Delivery of Health Care ; Female ; Florida/epidemiology ; Humans ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious ; Retrospective Studies ; SARS-CoV-2 ; Vaccination ; Young Adult
    Language English
    Publishing date 2022-01-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 426631-6
    ISSN 1573-3610 ; 0094-5145
    ISSN (online) 1573-3610
    ISSN 0094-5145
    DOI 10.1007/s10900-022-01062-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Epidemiology and Predictors of Outcomes Among Confirmed COVID-19 Cases in a Large Community Healthcare System in South Florida.

    Samuels, Shenae / Niu, Jianli / Sareli, Candice / Eckardt, Paula

    Journal of community health

    2021  Volume 46, Issue 4, Page(s) 822–831

    Abstract: The novel coronavirus disease 2019 (COVID-19) continues to be a major public health concern. The aim of this study was to describe the presenting characteristics, epidemiology and predictors of outcomes among confirmed COVID-19 cases seen at a large ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) continues to be a major public health concern. The aim of this study was to describe the presenting characteristics, epidemiology and predictors of outcomes among confirmed COVID-19 cases seen at a large community healthcare system which serves the epicenter and diverse region of Florida. We conducted a retrospective analysis of individuals with lab-confirmed SARS-CoV-2 infection who were seen, from March 2, 2020 to May 31, 2020, at Memorial Healthcare System in South Florida. Data was extracted from a COVID-19 registry of patients with lab-confirmed SARS-CoV-2 infection. Univariate and backward stepwise multivariate logistic regression models were used to determine predictors of key study outcomes. There were a total of 1692 confirmed COVID-19 patients included in this study. Increasing age was found to be a significant predictor of hospitalization, 30-day readmission and death. Having a temperature of 38 °C or more and increasing comorbidity score were also associated with an increased risk of hospitalization. Significant predictors of ICU admission included having a saturated oxygen level less than 90%, hypertension, dementia, rheumatologic disease, having a respiratory rate greater than 24 breaths per minute. Being of Hispanic ethnicity and immunosuppressant utilization greatly increased the risk of 30-day readmission. Having an oxygen saturation less than 90% and an underlying neurological disorder were associated with an increased likelihood of death. Results show that a patient's demographic, underlying condition and vitals at triage may increase or reduce their risk of hospitalization, ICU admission, 30-day readmission or death.
    MeSH term(s) Adolescent ; Adult ; Aftercare ; Aged ; Aged, 80 and over ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; COVID-19/ethnology ; COVID-19/mortality ; COVID-19/therapy ; Child ; Child, Preschool ; Delivery of Health Care ; Female ; Florida/epidemiology ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Mortality/ethnology ; Outcome Assessment, Health Care ; Patient Discharge ; Patient Readmission ; Retrospective Studies ; SARS-CoV-2 ; Young Adult
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2021-01-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 426631-6
    ISSN 1573-3610 ; 0094-5145
    ISSN (online) 1573-3610
    ISSN 0094-5145
    DOI 10.1007/s10900-020-00957-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Emergency Room "Opt-Out" HIV Testing Pre- and During COVID-19 Pandemic in a Large Community Health System.

    Eckardt, Paula / Niu, Jianli / Montalvo, Sheila

    Journal of the International Association of Providers of AIDS Care

    2021  Volume 20, Page(s) 23259582211041260

    Abstract: Background: South Florida has the highest HIV rates across the country. Emergency Rooms (ERs) are optimal clinical sites for the identification of people living with HIV. We aimed to evaluate the feasibility and yield of opt-out HIV testing among ER ... ...

    Abstract Background: South Florida has the highest HIV rates across the country. Emergency Rooms (ERs) are optimal clinical sites for the identification of people living with HIV. We aimed to evaluate the feasibility and yield of opt-out HIV testing among ER patients in a large community healthcare system in South Florida, and determine the impact of the COVID-19 pandemic on HIV testing.
    Methods: This was a retrospective study conducted in the Memorial Healthcare System, Hollywood, Florida. HIV test was offered on an "opt-out" basis to patients aged 16 years or older presenting to the ER of the Memorial Regional Hospital between July 2018 and August 2020. Number of ER visits, HIV testing offered, acceptance of HIV testing, tested positive for HIV infection and linkage to care were reviewed and analyzed.
    Results: A total of 105,264 (53.7%) patients of 196,110 ER visits were eligible for HIV testing and 39,261 (37.3%) completed HIV testing. Of those tested, 206 (0.5%) patients tested positive, with 54 (26.2%) new infected patients and 152 (73.8%) known infected patients who had not disclosed their status. 45 (60%) of 75 patients with known HIV infections who were not engaged in HIV care were successfully relinked into care after testing, and engagement in care increased from 50.7% pre-testing to 80.3% post-testing (p = 0.001). 45 (83.3%) of 54 newly diagnosed patients were successfully linked into care. During the COVID-19 pandemic, there was a significant reduction in both the ER visits and HIV tests as compared with the pre-pandemic period (p = 0.007 and p < 0.001, respectively).
    Conclusion: An "Opt-out" HIV testing program was successfully implemented in a community hospital ERs. The use of this strategy successfully identified patients with undiagnosed HIV infection and improved their engagement in HIV care. Given the impact of COVID-19 pandemic on the testing program, new strategies should develop to reduce service disruption and maintain the progress of "Opt-out" HIV testing.
    MeSH term(s) COVID-19 ; Community Health Planning ; Emergency Service, Hospital ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Testing ; Humans ; Mass Screening ; Pandemics ; Patient Acceptance of Health Care ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2709037-1
    ISSN 2325-9582 ; 2325-9574
    ISSN (online) 2325-9582
    ISSN 2325-9574
    DOI 10.1177/23259582211041260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bictegravir/emtricitabine/tenofovir alafenamide in a virologically suppressed adult with HIV and end-stage renal disease on chronic peritoneal dialysis: A case report.

    Partosh, Dor / Sherman, Elizabeth M / Eckardt, Paula A / Unger, Nathan / Montalvo, Sheila

    International journal of STD & AIDS

    2022  Volume 34, Issue 2, Page(s) 139–141

    Abstract: Despite increasing rates of renal replacement therapy, data supporting the safe and effective use of HIV treatment guidelines preferred regimens in people on hemodialysis or peritoneal dialysis is limited. Bictegravir/emtricitabine/tenofovir alafenamide ( ...

    Abstract Despite increasing rates of renal replacement therapy, data supporting the safe and effective use of HIV treatment guidelines preferred regimens in people on hemodialysis or peritoneal dialysis is limited. Bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) is a guideline recommended initial regimen for most people with HIV with FDA-approval for use in virologically suppressed people receiving chronic hemodialysis; however, the safety and efficacy of BIC/FTC/TAF remains unknown when used in patients on chronic ambulatory peritoneal dialysis (CAPD). We report the first case of BIC/FTC/TAF use in CAPD.
    MeSH term(s) Adult ; Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Emtricitabine/therapeutic use ; Adenine/therapeutic use ; Drug Combinations ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Peritoneal Dialysis
    Chemical Substances tenofovir alafenamide (EL9943AG5J) ; bictegravir (8GB79LOJ07) ; Anti-HIV Agents ; Emtricitabine (G70B4ETF4S) ; Adenine (JAC85A2161) ; Drug Combinations
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624221140949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: HIV Neuropathy-Associated Foot Drop, a Presenting Sign of HIV Infection, Resolving After Initiation of Antiretroviral Therapy: A Clinical Vignette.

    Mohan, Abhinav / Tarras, Seth / Eckardt, Paula A

    American journal of physical medicine & rehabilitation

    2020  Volume 100, Issue 7, Page(s) e94–e97

    Abstract: Abstract: Peripheral neuropathy is one of the most frequent complaints in patients with HIV. Many complex syndromes exist, with the etiology being secondary to the disease process itself, antiretroviral medication, or immune reconstitution. However, ... ...

    Abstract Abstract: Peripheral neuropathy is one of the most frequent complaints in patients with HIV. Many complex syndromes exist, with the etiology being secondary to the disease process itself, antiretroviral medication, or immune reconstitution. However, isolated mononeuropathy is rare. In this case, we present a previously healthy man who complained of several months of worsening right foot drop that did not improve with physical therapy or lifestyle interventions. He had begun to use an solid ankle-foot orthotic on this right lower limb to minimize tripping and prevent falls. He had no other neuromuscular involvement or constitutional complaints. Nerve conduction study of the right lower limb showed decreased peak amplitude, prolonged distal latency, and decreased conduction velocity of the deep peroneal nerve. Electromyography revealed abnormal insertional activity and absent motor unit action potentials in both the right tibialis anterior and right extensor digitorum brevis muscles. Magnetic resonance imaging of the right lower limb was suggestive of acute/subacute denervation of the right tibialis anterior muscle. An extensive laboratory workup revealed active HIV infection with a significant viral load. Once the diagnosis was made, the patient was started on antiretroviral treatment. Six months later, his foot drop had entirely resolved, in association with significant improvements in viral load and CD4 count. He has since been ambulating without assistive devices and his HIV/AIDS disease process remains well controlled. This clinical vignette is the first, to our knowledge, to illustrate that an acute focal mononeuropathy causing foot drop and gait dysfunction in an otherwise healthy-appearing individual can be a heralding sign of HIV/AIDS. Furthermore, it also suggests that this functional deficit can be reversed with timely initiation of antiretroviral treatment. Early recognition, diagnosis, and treatment in this patient have not only led to an uncomplicated AIDS disease course but also restored his ability to ambulate with complete independence and improved his quality of life.
    Language English
    Publishing date 2020-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000001629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of Inappropriate Antibiotic Orders During Implementation of a Multidisciplinary Antimicrobial Stewardship Program Within the Primary Care Setting.

    Singh-Franco, Devada / Hosein Mohammed, Sheerida / Eckardt, Paula A / Goldman, Jennifer / Wolowich, William R

    Journal of patient safety

    2022  Volume 18, Issue 5, Page(s) e889–e894

    Abstract: Objective: The aim of the study was to describe implementation of an outpatient antibiotic stewardship program at primary care practices in South Florida and the proportion of appropriate and inappropriate orders and reasons for inappropriateness during ...

    Abstract Objective: The aim of the study was to describe implementation of an outpatient antibiotic stewardship program at primary care practices in South Florida and the proportion of appropriate and inappropriate orders and reasons for inappropriateness during the intervention.
    Methods: An antibiotic stewardship committee at a large hospital system implemented aspects of The Core Elements of Outpatient Antibiotic Stewardship at outpatient facilities in 2018. Interventions included an education/awareness campaign directed at prescribers (audit and feedback, routine education at prescribers' meetings, availability of updated guidelines in a shared drive and antibiogram via intranet) and patients (posters, tear-off sheets on symptom relief for viral illness). Orders were evaluated using clinical documentation, current antibiogram, and Infectious Diseases Society of America guidelines. An appropriate order was defined as a correct antibiotic and dose/frequency and duration of therapy. An inappropriate antibiotic order was defined as not meeting 1 or more of the abovementioned conditions. Descriptive statistics assessed the data.
    Results: In this retrospective review of 2934 oral antibiotic orders from January 1 to December 31, 2018, 2565 (87.4%) were necessary while 369 (12.6%) were unnecessary. Of 2565 necessary orders, 1448 (56.5%) were appropriate while 1117 (43.5%) were inappropriate. Of 1117 inappropriate orders, 24.9% had all 3 conditions; 41.5% of inappropriate orders were solely due to wrong duration of therapy.
    Conclusions: Although our institution demonstrated commitment to optimizing antibiotic prescribing by providing resources to clinicians and patients about evidence-based antibiotic prescribing, inappropriate antibiotic prescribing was persistent. The interventions used must continue to evolve and include point-of-care access to guidelines and clinical decision support tools.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Humans ; Inappropriate Prescribing/prevention & control ; Outpatients ; Practice Patterns, Physicians' ; Primary Health Care
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2394324-5
    ISSN 1549-8425 ; 1549-8417
    ISSN (online) 1549-8425
    ISSN 1549-8417
    DOI 10.1097/PTS.0000000000000968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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