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  1. Article: Overcoming the challenges of a misdiagnosed rare lung disease - Idiopathic pleuroparenchymal fibroelastosis.

    Garg, Shivam / Upadhya, Pratap / Kumar, Arul / Stephen, Norton / Subramanian, Bala

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2023  

    Abstract: Pleuroparenchymal fibroelastosis (PPFE) is a rare condition characterized by pleural and subpleural lung fibroelastosis with an upper lobe predominance. We present the third case of idiopathic pleuroparenchymal fibroelastosis (IPPFE) from India, as well ... ...

    Abstract Pleuroparenchymal fibroelastosis (PPFE) is a rare condition characterized by pleural and subpleural lung fibroelastosis with an upper lobe predominance. We present the third case of idiopathic pleuroparenchymal fibroelastosis (IPPFE) from India, as well as the second antemortem diagnosis. A 27-year-old man presented with a one-year history of mMRC class II dry cough and shortness of breath. He described a fifteen-kilogram weight loss. After a clinico-radiological diagnosis, he was given anti-tubercular treatment and referred because he showed no improvement. A high-resolution computed tomography of the chest revealed bilateral upper lobe bullae, parenchymal and subpleural fibrosis, and irregular pleural thickening. PPFE was found in surgical lung and pleural biopsies. He was given systemic glucocorticoids but did not respond clinically or radiologically. Pirfenidone and a lung transplant were out of reach for him. He died nine months after being diagnosed with his condition. Finally, IPPFE is an extremely rare entity, with only three cases reported from our subcontinent. As a result, it is easily underdiagnosed or misdiagnosed; clinician awareness of this condition is critical for better diagnosis and management.
    Language English
    Publishing date 2023-08-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2023.2632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: When attacked by a new enemy, do not forget the old ones. A tale of 2 diseases: tuberculosis and COVID-19.

    Chawla, Gopal / Upadhya, Pratap / Vadala, Rohit / Ananthraju, Arpitha

    Advances in respiratory medicine

    2021  Volume 88, Issue 6, Page(s) 633–635

    Abstract: e two diseases together. ...

    Abstract e two diseases together.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/diagnosis
    Language English
    Publishing date 2021-01-13
    Publishing country Poland
    Document type Letter
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.5603/ARM.a2020.0170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nil Intervention is at Times the Best Intervention: Benign emptying of pneumonectomy space.

    Upadhya, Pratap / Bai, Muniza / Gunasekaran, Veeraraghavan / Dwivedi, Dharm P / Shahana, M P

    Sultan Qaboos University medical journal

    2023  Volume 23, Issue 4, Page(s) 539–542

    Abstract: A sudden drop of air-fluid level in the pneumonectomy space in the absence of a bronchopleural fistula and pleural infection is termed benign emptying of the pneumonectomy space (BEPS). We report a 28-year-old female patient who presented to a tertiary ... ...

    Abstract A sudden drop of air-fluid level in the pneumonectomy space in the absence of a bronchopleural fistula and pleural infection is termed benign emptying of the pneumonectomy space (BEPS). We report a 28-year-old female patient who presented to a tertiary care referral centre, in Pondicherry, India in 2020 with multiple episodes of vomiting. Subsequent to a left-sided pneumonectomy due to tuberculosis, she was diagnosed with BEPS. Generally, patients with BEPS are clinically stable, afebrile with no fluid expectoration and have a normal white blood cell count. Bronchoscopy reveals an intact bronchial stump and pleural fluid cultures are often sterile. In terms of management, close monitoring and early detection of a bronchopleural fistula are the key points. BEPS should be a differential diagnosis in case of a drop in the air-fluid level of the post-pneumonectomy space. Awareness of this entity is crucial as it helps prevent unnecessary and morbid surgical interventions.
    MeSH term(s) Female ; Humans ; Adult ; Pneumonectomy ; Bronchial Fistula/diagnosis ; Bronchial Fistula/surgery ; Pleural Diseases/diagnosis ; Pleural Diseases/surgery ; Bronchoscopy ; India
    Language English
    Publishing date 2023-11-30
    Publishing country Oman
    Document type Case Reports
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.12.2022.071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Rare Case of Lung Hypoplasia, Cardiac Anomalies and Ovarian Tumour in a Patient with Mayer-Rokitansky-Küster-Hauser Syndrome.

    Upadhya, Pratap / Arpitha, A / Sivaselvi, C / Papa, Dasari / Vignesh, K

    Sultan Qaboos University medical journal

    2022  Volume 23, Issue 4, Page(s) 556–559

    Abstract: Hypoplasia of the lung is an uncommon congenital abnormality of the respiratory system in contrast to pulmonary agenesis. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the congenital absence of the upper two-thirds of the vagina and uterus with ... ...

    Abstract Hypoplasia of the lung is an uncommon congenital abnormality of the respiratory system in contrast to pulmonary agenesis. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the congenital absence of the upper two-thirds of the vagina and uterus with normal secondary sexual characteristics, ovary and normal karyotype. We report a 31-year-old female patient who presented in 2022 with cough with expectoration, left-side chest pain and breathlessness for 4 years to tertiary hospital, Puducherry, India. She was evaluated for amenorrhoea and diagnosed as MRKH syndrome and the patient underwent right-side oophorectomy for right ovarian torsion with a tumour. Computed tomography pulmonary angiogram and fiberoptic endoscopy were suggestive of left lung hypoplasia and the patient was advised symptomatic treatment for lung hypoplasia and planned for vaginoplasty for which she refused.
    MeSH term(s) Female ; Humans ; Adult ; Abnormalities, Multiple/diagnosis ; Heart Defects, Congenital ; Ovarian Neoplasms ; Lung/diagnostic imaging
    Language English
    Publishing date 2022-09-11
    Publishing country Oman
    Document type Case Reports
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.1.2023.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cocaine-Induced Steroid Resistant Organising Pneumonia in a Young Male: The Lows of Getting High.

    Nadaf, Zeenathalam / Upadhya, Pratap / A, Jeevanandham / K, Sai Anudeep / Mohanty Mohapatra, Madhusmita

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46923

    Abstract: Organizing pneumonia (OP) is a diffuse parenchymal lung disease occurring due to injury to the alveoli leading to typical histopathological features. Infections, connective tissue disorders, and medications are common aetiologies of OP. Cocaine-induced ... ...

    Abstract Organizing pneumonia (OP) is a diffuse parenchymal lung disease occurring due to injury to the alveoli leading to typical histopathological features. Infections, connective tissue disorders, and medications are common aetiologies of OP. Cocaine-induced OP is uncommon. The patient had a fever and sore throat for two days corresponding to crack inhalation, followed by breathlessness that rapidly progressed to acute hypoxemic respiratory failure within one week. Radiology showed bilateral consolidation and ground glass opacities but did not respond to empiric treatment with antibiotics. After a multidisciplinary discussion, he was provisionally diagnosed as OP and treated with an intravenous methylprednisolone pulse dosage followed by oral prednisolone. OP was confirmed by surgical lung biopsy with the detection of Masson bodies. In view of progressive respiratory failure, steroid-resistant OP was diagnosed, and rituximab was administered as a second-line agent, but unfortunately, succumbed to respiratory failure. OP should be considered a differential in patients with consolidation who are non-responsive to initial conventional treatment. Multidisciplinary discussion and early lung biopsy to initiate immunosuppressants in the inflammatory stage of OP are emphasized for a possible better response.
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: An unexpected and unusual cause of pulmonary hypertension in a patient with hypersensitivity pneumonitis: a partial anomalous pulmonary venous connection causing pulmonary artery hypertension.

    Upadhya, Pratap / Garg, Shivam / A, Jeevanandham / Ponraj, Nesamani Daniel / Wayez, Ahmed

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2023  Volume 94, Issue 1

    Abstract: Partial anomalous pulmonary venous connection (PAPVC) occurs when any pulmonary vein, but not all, drains directly into the right atrium or its venous tributaries. PAPVC can very rarely present as an individual cause of pulmonary artery hypertension. ... ...

    Abstract Partial anomalous pulmonary venous connection (PAPVC) occurs when any pulmonary vein, but not all, drains directly into the right atrium or its venous tributaries. PAPVC can very rarely present as an individual cause of pulmonary artery hypertension. Here we are presenting the case of a 41-year-old farmer with a history of exertional dyspnea for the past 3 years, which increased over 6 months. Chest high-resolution computed tomography was suggestive of non-fibrotic hypersensitivity pneumonitis. Hence, the patient was started on systemic steroids, with which the patient's oxygen saturation improved. On 2D echocardiography, the right ventricle systolic pressure was 48 + right atrial pressure. Right heart catheterization showed a mean pulmonary artery pressure of 73 mmHg and pulmonary vascular resistance of 8.7. On further evaluation, a computed tomography pulmonary angiogram was done, which surprisingly revealed the left superior pulmonary vein draining into the left brachiocephalic vein.
    MeSH term(s) Humans ; Adult ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Pulmonary Artery ; Pulmonary Veins/diagnostic imaging ; Heart Atria ; Alveolitis, Extrinsic Allergic/diagnosis ; Alveolitis, Extrinsic Allergic/diagnostic imaging
    Language English
    Publishing date 2023-03-03
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2023.2497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An unexpected and unusual cause of pulmonary hypertension in a patient with hypersensitivity pneumonitis

    Pratap Upadhya / Shivam Garg / Jeevanandham A. / Nesamani Daniel Ponraj / Ahmed Wayez

    Monaldi Archives for Chest Disease (2023)

    partial anomalous pulmonary venous connection causing pulmonary artery hypertension

    2023  

    Abstract: Partial anomalous pulmonary venous connection (PAPVC) occurs when any pulmonary vein, but not all, drains directly into the right atrium or its venous tributaries. PAPVC can very rarely present as an individual cause of pulmonary artery hypertension. ... ...

    Abstract Partial anomalous pulmonary venous connection (PAPVC) occurs when any pulmonary vein, but not all, drains directly into the right atrium or its venous tributaries. PAPVC can very rarely present as an individual cause of pulmonary artery hypertension. Here we are presenting a case of a 41-year-old farmer with a history of exertional dyspnoea for the past three years, which increased over 6 months. Chest high-resolution computed tomography (HRCT) was suggestive of non-fibrotic hypersensitivity pneumonitis. Hence the patient was started on systemic steroids, with which the patient’s oxygen saturation improved. On 2D-ECHO, the right ventricle systolic pressure was 48+RAP. Right heart catheterization showed mean pulmonary artery pressure of 73 mmHG, PVR 8.7. On further evaluation, CTPA was done, which surprisingly revealed the left superior pulmonary vein draining into the left brachiocephalic vein.
    Keywords Partial anomalous pulmonary venous connection ; non-fibrotic hypersensitivity pneumonitis ; pulmonary hypertension ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Carcinoid Tumor of the Lung

    Ravindrachari Mulukoju / Ganga Ravindra Adimulam / Sneha Leo / Pratap Upadhya / Pampa Chakravarthy Toi

    Jurnal Respirasi, Vol 9, Iss 3, Pp 220-

    Hospital-Based Descriptive Study

    2023  Volume 228

    Abstract: Introduction: Bronchial carcinoids are slow-growing tumors that are usually asymptomatic until the later stages and mimic most benign conditions clinically. This study presented pulmonary carcinoids (PCs) in terms of diagnosis and management in a ... ...

    Abstract Introduction: Bronchial carcinoids are slow-growing tumors that are usually asymptomatic until the later stages and mimic most benign conditions clinically. This study presented pulmonary carcinoids (PCs) in terms of diagnosis and management in a tertiary care center. Case: The mean age of presentation was 42.5 years old. Right lung involvement was more common, and the frequency was higher in men. In all patients, second to fourth generations of airways were the site of involvement. The most common symptom was a dry cough. Bronchoscopic biopsy complemented by immune histochemistry was the main diagnostic modality. The majority of patients (60%) had a typical PC. Stage I or III of the disease was the most common presentation. Nine lobectomies and two pneumonectomies were performed on 11 of 15 patients. These patients are performing well to date. Four patients were given only chemotherapy, of which one has survived. The longest follow-up period was 26 months. Conclusion: A high degree of clinical suspicion and familiarity with carcinoids is essential for early identification and a positive clinical outcome, especially in typical carcinoids (TC), as there are no obvious risk factors and various clinico-radiological presentations. In this study of 15 cases, most of the PCs were right-sided and more common in males. The use of a biopsy, either by a guided bronchoscopy or by computed tomography (CT), was confirmatory, and surgical removal was the treatment of choice. Medical therapy may be considered for select patients with carcinoid syndrome or terminal disease.
    Keywords bronchoscopy ; cancer ; carcinoid tumor ; lung neoplasms ; neuroendocrine tumors ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Universitas Airlangga
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Endocrine paraneoplastic syndromes in lung cancer: a respiratory physician's perspective.

    Upadhya, Pratap / Ananthraju, Arpitha / Vadala, Rohit / Mohanty Mohapatra, Madhusmita

    Advances in respiratory medicine

    2021  Volume 89, Issue 4, Page(s) 403–412

    Abstract: Lung malignancy is known to be one of the leading causes of cancer-related mortality. Endocrine paraneoplastic syndromes in lung cancer are common. These are due to secretion of various substances and not because of direct tumour invasion or me-tastasis. ...

    Abstract Lung malignancy is known to be one of the leading causes of cancer-related mortality. Endocrine paraneoplastic syndromes in lung cancer are common. These are due to secretion of various substances and not because of direct tumour invasion or me-tastasis. These syndromes have also been associated with lung cancer prognosis. This review describes the many endocrine paraneoplastic syndromes seen in lung cancer and narrates their incidence, biology, clinical features, diagnosis, and management.
    MeSH term(s) Carcinoma, Small Cell/complications ; Carcinoma, Small Cell/diagnosis ; Disease Progression ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Paraneoplastic Endocrine Syndromes/complications ; Paraneoplastic Endocrine Syndromes/diagnosis
    Language English
    Publishing date 2021-08-18
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.5603/ARM.a2021.0075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Hospital treatment of severe acute exacerbation of chronic obstructive pulmonary disease in COVID-19 situation: back to basics.

    Upadhya, Pratap / Vadala, Rohit / A, Arpitha

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2020  Volume 90, Issue 4

    Abstract: Patients of chronic obstructive pulmonary disease (COPD) during COVID-19 pandemic have higher morbidity. Treatment of these patients require aerosolization procedures like nebulization and noninvasive modalities for ventilation like non-invasive ... ...

    Abstract Patients of chronic obstructive pulmonary disease (COPD) during COVID-19 pandemic have higher morbidity. Treatment of these patients require aerosolization procedures like nebulization and noninvasive modalities for ventilation like non-invasive ventilation (NIV) and high flow nasal cannula (HFNC). Role of these procedures in corona virus transmission when treating a case of acute exacerbation of chronic obstructive pulmonary disease should be further studied.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cannula ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Progression ; Hospitalization ; Humans ; Infection Control/organization & administration ; Noninvasive Ventilation ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2020.1424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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