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Article ; Online: Temporal disposition of pelvic girdle, vagina and vulva in relation to urovagina in cycling and pregnant-postpartum cows.

Sood, Pankaj / Vatasyan, Subrahmanyam / Chaudhary, Jitendra Kumar

Reproduction in domestic animals = Zuchthygiene

2024 Volume 59, Issue 3, Page(s) e14552

Abstract: Urovagina (UV) is less studied in cows. The vaginal contents, constrictor vestibule muscle activity, circulating progesterone, pelvic girdle, vagina and vulva angles were compared on Days 0 and 14 within and between UV (UV group; n = 36) and normal (N ... ...

Abstract	Urovagina (UV) is less studied in cows. The vaginal contents, constrictor vestibule muscle activity, circulating progesterone, pelvic girdle, vagina and vulva angles were compared on Days 0 and 14 within and between UV (UV group; n = 36) and normal (N group; n = 36) cows. The oestrous duration was compared among the groups. Parameters for various UV severities were also compared. Another set of pregnant-postpartum cows (P-PP group; n = 31) underwent monthly evaluations for UV and the angles from the third month of pregnancy until the second month postpartum. The effect of age, parity and body condition score on UV severities on Day 0, and parity on angles in the P-PP group was evaluated. Different variables were correlated in different groups. The UV group was repeat breeder, exhibited prolonged oestrus and reduced progesterone on Day 14. The latter increased with UV severity on Day 0. On Day 14, severe form of UV was more prevalent. The UV severity increased with parity. In the UV group, a cranioventral pelvic girdle on Day 0 became more cranioventral on Day 14 and was correlated with the vagina moving from a caudodorsal position on Day 0 to a cranioventral position on Day 14. In the P-PP group, the pelvic girdle and vagina remained caudodorsal and UV was undetectable throughout the study. Vagina and vulva displayed a parity-by-month interaction in the P-PP group. To summarize, the UV characteristics were influenced by the oestrous cycle stage, pelvic girdle angles, and parity.
MeSH term(s)	Pregnancy ; Female ; Cattle ; Animals ; Progesterone ; Postpartum Period/physiology ; Vagina ; Estrus/physiology ; Vulva ; Parity
Chemical Substances	Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2024-01-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1015187-4
ISSN	1439-0531 ; 0936-6768
ISSN (online)	1439-0531
ISSN	0936-6768
DOI	10.1111/rda.14552
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Article ; Online: Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2.

Chaudhary, Jitendra Kumar / Ahamad, Naseem / Rath, Pramod C

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 97

Abstract: Background: Interferon regulatory factors (IRF-1 and IRF-2) are transcription factors widely implicated in various cellular processes, including regulation of inflammatory responses to pathogens, cell proliferation, oncogenesis, differentiation, ... ...

Abstract	Background: Interferon regulatory factors (IRF-1 and IRF-2) are transcription factors widely implicated in various cellular processes, including regulation of inflammatory responses to pathogens, cell proliferation, oncogenesis, differentiation, autophagy, and apoptosis. Methods: We have studied the expression of IRF-1, IRF-2 mRNAs by RT-PCR, cellular localization of the proteins by immunofluorescence, and expression of mRNAs of genes regulated by IRF-1, IRF-2 by RT-PCR in mouse bone marrow cells (BMCs) and mesenchymal stem cells (MSCs). Results: Higher level of IRF-1 mRNA was observed in BMCs and MSCs compared to that of IRF-2. Similarly, differential expression of IRF-1 and IRF-2 proteins was observed in BMCs and MSCs. IRF-1 was predominantly localized in the cytoplasm, whereas IRF-2 was localized in the nuclei of BMCs. MSCs showed nucleo-cytoplasmic distribution of IRF-1 and nuclear localization of IRF-2. Constitutive expression of IRF-1 and IRF-2 target genes: monocyte chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), and caspase-1 was observed in both BMCs and MSCs. MSCs showed constitutive expression of the pluripotency-associated factors, Oct3/4 and Sox-2. Lipopolysaccharide (LPS)-treatment of MSCs induced prominent cellular localization of IRF-1 and IRF-2. Conclusions: Our results suggest that IRF-1 and IRF-2 exhibit differential expression of their mRNAs and subcellular localization of the proteins in BMCs and MSCs. These cells also show differential levels of constitutive expression of IRF-1 and IRF-2 target genes. This may regulate immune-responsive properties of BMCs and MSCs through IRF-1, IRF-2-dependent gene expression and protein-protein interaction. Regulating IRF-1 and IRF-2 may be helpful for immunomodulatory functions of MSCs for cell therapy and regenerative medicine.
MeSH term(s)	Animals ; Mice ; Bone Marrow ; Bone Marrow Cells ; Cytoplasm ; Interferon Regulatory Factors/genetics ; Mesenchymal Stem Cells
Chemical Substances	Interferon Regulatory Factors ; Irf1 protein, mouse ; Irf2 protein, mouse
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-09025-9
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Article ; Online: CRISPR-Based Therapies: Revolutionizing Drug Development and Precision Medicine.

Chanchal, Dilip Kumar / Chaudhary, Jitendra Singh / Kumar, Pushpendra / Agnihotri, Neha / Porwal, Prateek

Current gene therapy

2024 Volume 24, Issue 3, Page(s) 193–207

Abstract: With the discovery of CRISPR-Cas9, drug development and precision medicine have undergone a major change. This review article looks at the new ways that CRISPR-based therapies are being used and how they are changing the way medicine is done. CRISPR ... ...

Abstract	With the discovery of CRISPR-Cas9, drug development and precision medicine have undergone a major change. This review article looks at the new ways that CRISPR-based therapies are being used and how they are changing the way medicine is done. CRISPR technology's ability to precisely and flexibly edit genes has opened up new ways to find, validate, and develop drug targets. Also, it has made way for personalized gene therapies, precise gene editing, and advanced screening techniques, all of which hold great promise for treating a wide range of diseases. In this article, we look at the latest research and clinical trials that show how CRISPR could be used to treat genetic diseases, cancer, infectious diseases, and other hard-to-treat conditions. However, ethical issues and problems with regulations are also discussed in relation to CRISPR-based therapies, which shows how important it is to use them safely and responsibly. As CRISPR continues to change how drugs are made and used, this review shines a light on the amazing things that have been done and what the future might hold in this rapidly changing field.
MeSH term(s)	Humans ; Precision Medicine/methods ; CRISPR-Cas Systems ; Gene Editing/methods ; Genetic Therapy/methods ; Drug Development ; Neoplasms/therapy ; Neoplasms/genetics ; Neoplasms/drug therapy ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics
Language	English
Publishing date	2024-01-17
Publishing country	United Arab Emirates
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2146187-9
ISSN	1875-5631 ; 1566-5232
ISSN (online)	1875-5631
ISSN	1566-5232
DOI	10.2174/0115665232275754231204072320
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Article: Numerical simulation of burn injuries with temperature-dependent thermal conductivity and metabolism under different surface heat sources.

Ansari, Faishal / Chaudhary, Rajneesh Kumar / Singh, Jitendra

Journal of thermal biology

2023 Volume 116, Page(s) 103656

Abstract: In the present paper, the phenomena of heat transport inside human forearm tissue are studied through a one-dimensional nonlinear bioheat transfer model under the influence of various boundary and interface conditions. In this study, we considered ... ...

Abstract	In the present paper, the phenomena of heat transport inside human forearm tissue are studied through a one-dimensional nonlinear bioheat transfer model under the influence of various boundary and interface conditions. In this study, we considered temperature-dependent thermal conductivity and metabolic heat to predict temperature distribution inside the forearm tissue. We have studied the temperature distribution inside inner tissue and bone because it has been found that burn injuries are mostly affected by layer thickness. The temperature distribution inside human forearm tissue is analyzed using the finite difference and bvp4c numerical techniques. To examine the accuracy of present numerical code, we compare the obtained numerical result with the exact analytical result in a specific case and find an excellent agreement with the exact results. We also validated our present numerical code with a hybrid scheme based on Runge-Kutta (4,5) and finite difference technique and found it in good compliance. From the obtained results, we observed that the homogeneous heat flux has a greater impact on the temperature at the outer surface of the skin, but the sinusoidal heat flux has a greater impact on the temperature of the subcutaneous layer and inner tissue. It is found that there is no burn injury in the first type of heat source (T
MeSH term(s)	Humans ; Hot Temperature ; Temperature ; Hyperthermia, Induced ; Thermal Conductivity ; Models, Biological ; Computer Simulation ; Burns
Language	English
Publishing date	2023-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2023.103656
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Article: Workstation peril: Paradoxical inability to ventilate in manual/spontaneous mode with mechanical ventilation modes unaffected.

Shah, Shagun B / Dubey, Jitendra Kumar / Chaudhary, Vineet / Chawla, Rajiv

Indian journal of anaesthesia

2022 Volume 66, Issue 8, Page(s) 612–614

Language	English
Publishing date	2022-08-22
Publishing country	India
Document type	Journal Article
ZDB-ID	412570-8
ISSN	0019-5049
ISSN	0019-5049
DOI	10.4103/ija.ija_243_22
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Article ; Online: Polymeric optical fiber biosensor with PAMAM dendrimer-based surface modification and PlGF detection for pre-eclampsia diagnosis.

Chaudhary, Ratan Kumar / Madaboosi, Narayanan / Satija, Jitendra / Nandagopal, Balaji / Srinivasan, Ramprasad / Sai, V V R

Biosensors & bioelectronics

2024 Volume 257, Page(s) 116312

Abstract: Pre-eclampsia (PE) is a life-threatening complication that occurs during pregnancy, affecting a large number of pregnant women and newborns worldwide. Rapid, on-site and affordable screening of PE at an early stage is necessary to ensure timely treatment ...

Abstract	Pre-eclampsia (PE) is a life-threatening complication that occurs during pregnancy, affecting a large number of pregnant women and newborns worldwide. Rapid, on-site and affordable screening of PE at an early stage is necessary to ensure timely treatment and minimize both maternal and neonatal morbidity and mortality rates. Placental growth factor (PlGF) is an angiogenic blood biomarker used for PE diagnosis. Herein, we report the plasmonic fiber optic absorbance biosensor (P-FAB) strategy for detecting PlGF at femtomolar concentration using polymethyl methacrylate (PMMA) based U-bent polymeric optical fiber (POF) sensor probes. A novel poly(amidoamine) (PAMAM) dendrimer based PMMA surface modification is established to obtain a greater immobilization of the bioreceptors compared to a linear molecule like hexamethylenediamine (HMDA). Plasmonic sandwich immunoassay was realized by immobilizing the mouse anti-PlGF (3H1) on the U-bent POF sensor probe surface and gold nanoparticles (AuNP) labels conjugated with mouse anti-PlGF (6H9). The POF sensor probes could measure PlGF within 30 min using the P-FAB strategy. The limit-of-detection (LoD) was found to be 0.19 pg/mL and 0.57 pg/mL in phosphate-buffered saline and 10× diluted serum, respectively. The clinical sample testing, with eleven positive and eleven negative preeclamptic pregnancy samples, successfully confirmed the accuracy, reliability, specificity, and sensitivity of the P-FAB based POF sensor platform, thereby paving the way for cost-effective technology for PlGF detection and its potential for pre-eclampsia diagnosis.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2024.116312
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Article: Hybridization of ANFIS and fuzzy logic for groundwater quality assessment

Shwetank / Suhas / Chaudhary, Jitendra Kumar

Groundwater for sustainable development. 2022 Aug., v. 18

2022

Abstract: In this paper, to analyse the groundwater quality, the hybridization of Takagi-Sugeno fuzzy model, and Adaptive Neuro-Fuzzy Inference System (ANFIS) has been used. Initially, the Takagi-Sugeno fuzzy inference system has been used to find the groundwater ... ...

Abstract	In this paper, to analyse the groundwater quality, the hybridization of Takagi-Sugeno fuzzy model, and Adaptive Neuro-Fuzzy Inference System (ANFIS) has been used. Initially, the Takagi-Sugeno fuzzy inference system has been used to find the groundwater quality. The Takagi-Sugeno system results, along with primary data, have been applied in four ANFIS models to identify the best ANFIS model using training, testing, and validation processes. Four ANFIS models have been designed; ANFIS-1, ANFIS-2, ANFIS-3, and ANFIS-4. Five water quality parameters, Calcium (Ca), Fluoride (F−), Magnesium (Mg), Sulphate (SO42−), and Nitrate (NO3−), in 454 groundwater samples have been used to analyse groundwater quality. The results of Takagi-Sugeno fuzzy inference system indicates that all samples are useful for drinking purpose. As per the results obtained from all four models, the best model is ANFIS-2, as it has the minimum error. This paper's primary objective is to prepare a hybrid model that can be used to make a decision on drinking groundwater quality.
Keywords	calcium ; decision making ; fluorides ; fuzzy logic ; groundwater ; hybridization ; magnesium ; nitrates ; sulfates ; sustainable development ; water quality
Language	English
Dates of publication	2022-08
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2352-801X
DOI	10.1016/j.gsd.2022.100777
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Article ; Online: Recent Advances in Additive Manufacturing, Applications and Challenges for Dentistry: A Review.

Chaudhary, Swati / Avinashi, Sarvesh Kumar / Rao, Jitendra / Gautam, Chandkiram

ACS biomaterials science & engineering

2023 Volume 9, Issue 7, Page(s) 3987–4019

Abstract: Technological advancement in the field of dentistry has to be proven in new avenues for professionals as well as laboratory programmers. An advanced type of technology is emerging based on digitalization, as a computerized three-dimensional (3-D) model, ... ...

Abstract	Technological advancement in the field of dentistry has to be proven in new avenues for professionals as well as laboratory programmers. An advanced type of technology is emerging based on digitalization, as a computerized three-dimensional (3-D) model, additive manufacturing also called 3-D printing, allows formation of block pieces by adding material layer-by-layer. The additive manufacturing (AM) approach has offered extreme progress in the broad choice of distinct zones, permitting the production of fragments of all possible varieties of substances such as metal, polymer, ceramic, and composites. The significant goal of current the article is to recapitulate the recent scenarios including the imminent perspective of AM techniques and challenges in dentistry. Moreover, this article reviews the recent developments of 3-D printing advancements along with the advantages and disadvantages. Herein, various AM technologies comprising vat photopolymerization (VPP), material jetting, material extrusion, selective laser sintering (SLS), selective laser melting (SLM), and direct metal laser sintering (DMLS) technologies based powder bed fusion technologies/direct energy deposition/sheet lamination centered on binder jetting technologies were discussed in detail. This paper attempts to provide a balanced view by emphasizing the economic, scientific, and technical challenges and presenting an overview of methods to discuss the similarities based on the authors' continuing research and development.
MeSH term(s)	Printing, Three-Dimensional ; Ceramics ; Polymers ; Dentistry
Chemical Substances	Polymers
Language	English
Publishing date	2023-06-11
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.2c01561
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Article: Numerical estimation of temperature response with step heating of a multi-layer skin under the generalized boundary condition.

Chaudhary, Rajneesh Kumar / Chaurasiya, Vikas / Singh, Jitendra

Journal of thermal biology

2022 Volume 108, Page(s) 103278

Abstract: In this article, we discussed a one-dimensional bioheat transfer mathematical model that describes the process of temperature distribution in tissue for the multi-layer skin under the step heating generalized boundary condition. The finite difference ... ...

Abstract	In this article, we discussed a one-dimensional bioheat transfer mathematical model that describes the process of temperature distribution in tissue for the multi-layer skin under the step heating generalized boundary condition. The finite difference scheme is used to estimate the temperature profile along with time and distance. We discussed the stability of the numerical scheme and also validated the accuracy of the numerical code by comparing the present results with the previous reference results. To remove heat from the skin is considered by the surface temperature, heat flux, and ambient temperature to be zero with the help of the unit step like function. Then, we observed that the skin temperature in the second kind boundary condition was slowly decreasing over time as compared to the first and third kind boundary conditions. The temperature or heat flux at the skin surface is assumed to be high then there is negligible effect of the blood perfusion rate on the temperature response over a short time period and the effect of blood perfusion rate is visible when the time duration is long. Effect of blood perfusion rate, heating and after removal of heating, water diffusion, and generalized boundary condition for the analysis of the behavior of temperature response in multi-layer skin are discussed in detail and the results obtained are presented graphically.
MeSH term(s)	Heating ; Hot Temperature ; Models, Biological ; Skin ; Skin Temperature ; Temperature
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2022.103278
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Article: Numerical estimation of temperature response with step heating of a multi-layer skin under the generalized boundary condition

Chaudhary, Rajneesh Kumar / Chaurasiya, Vikas / Singh, Jitendra

Journal of thermal biology. 2022 Aug., v. 108

2022

Abstract	In this article, we discussed a one-dimensional bioheat transfer mathematical model that describes the process of temperature distribution in tissue for the multi-layer skin under the step heating generalized boundary condition. The finite difference scheme is used to estimate the temperature profile along with time and distance. We discussed the stability of the numerical scheme and also validated the accuracy of the numerical code by comparing the present results with the previous reference results. To remove heat from the skin is considered by the surface temperature, heat flux, and ambient temperature to be zero with the help of the unit step like function. Then, we observed that the skin temperature in the second kind boundary condition was slowly decreasing over time as compared to the first and third kind boundary conditions. The temperature or heat flux at the skin surface is assumed to be high then there is negligible effect of the blood perfusion rate on the temperature response over a short time period and the effect of blood perfusion rate is visible when the time duration is long. Effect of blood perfusion rate, heating and after removal of heating, water diffusion, and generalized boundary condition for the analysis of the behavior of temperature response in multi-layer skin are discussed in detail and the results obtained are presented graphically.
Keywords	ambient temperature ; blood ; heat transfer ; mathematical models ; skin temperature ; surface temperature ; temperature profiles
Language	English
Dates of publication	2022-08
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2022.103278
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