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  1. Article ; Online: Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies.

    Drechsler, Yvonne / Dong, Charli / Clark, David E / Kaur, Gagandeep

    Veterinary medicine (Auckland, N.Z.)

    2024  Volume 15, Page(s) 15–29

    Abstract: Atopic dermatitis (AD) is a common inflammatory and pruritic allergic skin disease in humans and dogs worldwide. The pathogenesis of AD is multifactorial, immunologically complex, and may involve genetic factors, epidermal barrier dysfunction, microbiome ...

    Abstract Atopic dermatitis (AD) is a common inflammatory and pruritic allergic skin disease in humans and dogs worldwide. The pathogenesis of AD is multifactorial, immunologically complex, and may involve genetic factors, epidermal barrier dysfunction, microbiome changes, immune dysregulation, and allergic sensitization. Across species, prevalence of AD is on the rise. At present, there is no cure for canine AD (CAD). The treatment for CAD is multifaceted and aimed at controlling the pruritus, associated inflammation, and infections, repairing the skin barrier function, and dietary management. This review presents data on prevalence, impact, and complex immunological interactions in AD with a focus on subsequent management of the disease in the canine population. A multimodal approach for management of CAD to address varying clinical signs and responses to therapies is discussed.
    Language English
    Publishing date 2024-02-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2708944-7
    ISSN 2230-2034 ; 2230-2034
    ISSN (online) 2230-2034
    ISSN 2230-2034
    DOI 10.2147/VMRR.S412570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Isolierung, Phänotypisierung und molekularbiologische Charakterisierung von CD56-+-Zellen aus Nabelschnurblut

    Drechsler, Yvonne

    2001  

    Title variant Isolierung, Phänotypisierung und molekularbiologische Charakterisierung von CD56 + Zellen aus Nabelschnurblut
    Author's details vorgelegt von Yvonne Drechsler, geb. Brockmann
    Language German
    Size 161 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2001
    HBZ-ID HT013106973
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 D 2914 order for loan Magazin

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  3. Article: Zubereitung von Parenteralia auf einer neonatologischen Intensivstation. Umsetzung der Empfehlungen der Arbeitsgruppe KRINKO-BfArM-RKI durch die Krankenhausapotheke

    Drechsler, André / Koch, Gabriele / Thome, Ulrich / Remane, Yvonne

    Krankenhauspharmazie

    2023  Volume 44, Issue 2, Page(s) 56

    Language German
    Document type Article
    ZDB-ID 138842-3
    ISSN 0173-7597
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Unique Cell Subpopulations and Disease Progression Markers in Canines with Atopic Dermatitis.

    Sparling, Brandi A / Moss, Nicholas / Kaur, Gagandeep / Clark, David / Hawkins, R David / Drechsler, Yvonne

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 7, Page(s) 1379–1388

    Abstract: Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with unclear molecular and cellular contributions behind the complex etiology. To unravel these differences between healthy control and AD skin we employed single-cell transcriptomics, ...

    Abstract Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with unclear molecular and cellular contributions behind the complex etiology. To unravel these differences between healthy control and AD skin we employed single-cell transcriptomics, utilizing the canine AD model for its resemblance to human clinical and molecular phenotypes. In this study, we show that there are overall increases in keratinocytes and T cells and decreases in fibroblast populations in AD dogs. Within immune cell types, we identified an enriched γδ T cell population in AD, which may contribute to cutaneous inflammation. A prominent
    MeSH term(s) Animals ; Dermatitis, Atopic ; Disease Progression ; Dogs ; Epidermis/metabolism ; Humans ; Keratinocytes/metabolism ; Skin/metabolism
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 28: Show issues

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  5. Article ; Online: Immunoglobulin-like receptors in chickens: identification, functional characterization, and renaming to cluster homolog of immunoglobulin-like receptors.

    Sparling, Brandi A / Ng, Theros T / Carlo-Allende, Anaid / McCarthy, Fiona M / Taylor, Robert L / Drechsler, Yvonne

    Poultry science

    2023  Volume 103, Issue 2, Page(s) 103292

    Abstract: The cluster homolog of immunoglobulin-like receptors (CHIRs), previously known as the "chicken homolog of immunogloublin-like receptors," represents is a large group of transmembrane glycoproteins that direct the immune response. However, the full ... ...

    Abstract The cluster homolog of immunoglobulin-like receptors (CHIRs), previously known as the "chicken homolog of immunogloublin-like receptors," represents is a large group of transmembrane glycoproteins that direct the immune response. However, the full repertoire of putatively activating, inhibitory, or dual function CHIRA, CHIRB, and CHIRAB on chickens' immune responses is poorly understood. Herein, the study objective was to determine the genes encoding CHIR proteins and predict their function by searching canonical protein structure. A bioinformatics pipeline based on previous work was employed to search for the CHIRs from the newly updated broiler and layer genomes. The categorization into CHIRA, CHIRB, and CHIRAB types was assigned through motif searches, multiple sequence alignment, and phylogeny. In total, 150 protein-encoding genes on Chromosome 31 were identified as CHIRs. Gene members of each functional group (CHIRA, CHIRB, CHIRAB) were classified in accordance with previously recognized proteins. The genes were renamed to "cluster homolog of immunoglobulin-like receptors" (CHIRs) to allow for the naming of orthologous genes in other avian species. Additionally, expression analysis of the classified CHIRs across various reinforces their importance as immune regulators and activation in inflammatory tissues. Furthermore, over 1,000 diverse and rare CHIRs variants associated with differential Marek's disease response (P < 0.05) emphasize the impact of CHIRs on shaping avian immune responses in diverse contexts. The practical applications of these findings encompass advancing immunology, improving poultry health management, optimizing breeding programs for disease resistance, and enhancing overall animal health through a deeper understanding of the roles and functions of CHIRA, CHIRB, and CHIRAB types in avian immune responses.
    MeSH term(s) Animals ; Chickens/genetics ; Genome ; Phylogeny ; Marek Disease ; Immunoglobulins/genetics
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2023.103292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Transcriptomes of an Array of Chicken Ovary, Intestinal, and Immune Cells and Tissues.

    Overbey, Eliah G / Ng, Theros T / Catini, Pietro / Griggs, Lisa M / Stewart, Paul / Tkalcic, Suzana / Hawkins, R David / Drechsler, Yvonne

    Frontiers in genetics

    2021  Volume 12, Page(s) 664424

    Abstract: While the chicken ( ...

    Abstract While the chicken (
    Language English
    Publishing date 2021-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.664424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection.

    Drechsler, Yvonne / Vasconcelos, Elton J R / Griggs, Lisa M / Diniz, Pedro P P V / Collisson, Ellen

    Cells

    2020  Volume 9, Issue 6

    Abstract: Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the ... ...

    Abstract Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate not only in enterocytes of the intestines but also in monocytes, subsequently systemically transporting the virus. The immune status and genetics of affected cats certainly play an important role in the pathogenesis. Considering the importance of genetics and host immune responses in viral infections, the goal of this study was to elucidate host gene expression in macrophages using RNA sequencing. Macrophages from healthy male cats infected with FIPV 79-1146 ex vivo displayed a differential host gene expression. Despite the virus uptake, aligned viral reads did not increase from 2 to 17 h. The overlap of host gene expression among macrophages from different cats was limited, even though viral transcripts were detected in the cells. Interestingly, some of the downregulated genes in all macrophages were involved in immune signaling, while some upregulated genes common for all cats were found to be inhibiting immune activation. Our results highlight individual host responses playing an important role, consistent with the fact that few cats develop feline infectious peritonitis despite a common presence of enteric FCoV.
    MeSH term(s) Animals ; Cats ; Cell Line ; Coronavirus, Feline/genetics ; Coronavirus, Feline/immunology ; Feline Infectious Peritonitis/immunology ; Feline Infectious Peritonitis/pathology ; Feline Infectious Peritonitis/virology ; Gene Expression Regulation ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Macrophages/cytology ; Macrophages/immunology ; Monocytes/cytology ; Monocytes/immunology ; RNA, Viral/isolation & purification ; Sequence Analysis, RNA ; Transcriptome/genetics
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9061431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: CRFK and Primary Macrophages Transcriptomes in Response to Feline Coronavirus Infection Differ Significantly.

    Drechsler, Yvonne / Vasconcelos, Elton J R / Griggs, Lisa M / Diniz, Pedro P P V

    Frontiers in genetics

    2020  Volume 11, Page(s) 584744

    Abstract: Coronaviruses are highly infectious and common in many species, including in humans, and agricultural and domestic animals. Host responses play an important role in viral entry, replication, assembly, and pathogenesis, although much is still to be ... ...

    Abstract Coronaviruses are highly infectious and common in many species, including in humans, and agricultural and domestic animals. Host responses play an important role in viral entry, replication, assembly, and pathogenesis, although much is still to be understood, particularly host-virus interactions. Feline coronavirus is highly contagious, and ubiquitous in virtually all cat populations. Host-pathogen interactions have not been studied extensively due to the complex pathogenesis and development of clinical disease. Few studies have investigated cellular host responses to feline coronavirus infection, particularly at early time points. Transcriptome studies based on next-generation sequencing have the potential to elucidate the early responses of cells after viral infection and, consequently, give further insight into the pathogenesis of viruses. The current study aims to characterize and compare the viral- and immune-related differentially expressed genes in response to the coronavirus FIPV across different time points in a cell line which is permissive for productive replication versus primary cells implicated in pathogenesis. When comparing host responses in Crandell-Rees Feline Kidney (CRFK) cells to primary macrophages, many differences were observed with regards to expressed genes and their enrichments for both KEGG pathways and GO terms. CRFK cells which are permissive for productive replication of feline infectious peritonitis virus, showed induction of a large network of immunological and virally induced pathways. In contrast, Macrophages did not show similar host responses, with stronger pathway enrichment in downregulated transcripts. This study provides insights to better understand gene transcription in immune cells compared to epithelial cells discerning pathways relevant to pathogenesis in the early stages of infection.
    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.584744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds.

    Collisson, Ellen / Griggs, Lisa / Drechsler, Yvonne

    Developmental and comparative immunology

    2016  Volume 67, Page(s) 249–256

    Abstract: Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte ... ...

    Abstract Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte activation measured by IFNγ release was significantly higher in B2 versus B19 haplotypes. AIV infection of macrophages was required to activate T lymphocytes and prior in vivo exposure of chickens to NP AIV plasmid enhanced responses to infected macrophages. This study suggests that the demonstrated T lymphocyte activation is in part due to antigen presentation by the macrophages as well as cytokine release by the infected macrophages, with B2 haplotypes showing stronger activation. These responses were present both in CD4 and CD8 T lymphocytes. In contrast, T lymphocytes stimulated by ConA showed greater IFNγ release of B19 haplotype cells, further indicating the greater responses in B2 haplotypes to infection is due to macrophages, but not T cells. In summary, resistance of B2 haplotype chickens appears to be directly linked to a more vigorous innate immune response and the role macrophages play in activating adaptive immunity.
    MeSH term(s) Adaptive Immunity ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Chickens/immunology ; Disease Susceptibility ; Haplotypes ; Immunity, Innate ; Influenza in Birds/immunology ; Lymphocyte Activation ; Macrophages/immunology ; Macrophages/virology ; Orthomyxoviridae/immunology ; Paracrine Communication ; Species Specificity
    Keywords covid19
    Language English
    Publishing date 2016-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2016.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1327: Show issues Location:
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  10. Article ; Online: Neutrophils in atherosclerosis: from mice to man.

    Döring, Yvonne / Drechsler, Maik / Soehnlein, Oliver / Weber, Christian

    Arteriosclerosis, thrombosis, and vascular biology

    2015  Volume 35, Issue 2, Page(s) 288–295

    Abstract: Infiltration of leukocyte subsets is a driving force of atherosclerotic lesion growth, and during the past decade, neutrophils have received growing attention in chronic inflammatory processes, such as atherosclerosis. Equipped with various ready to be ... ...

    Abstract Infiltration of leukocyte subsets is a driving force of atherosclerotic lesion growth, and during the past decade, neutrophils have received growing attention in chronic inflammatory processes, such as atherosclerosis. Equipped with various ready to be released mediators, evolved to fight invading pathogens, neutrophils may also hold key functions in affecting sterile inflammation, such as in atherosclerosis. Many of their secretion products might instruct or activate other immune cells (particularly monocytes) to, for example, enter atherosclerotic lesions or release proinflammatory mediators. Despite the emerging evidence for the mechanistic contribution of neutrophils to early atherosclerosis in mice, their role in human atherogenesis, atheroprogression, and atherosclerotic plaque destabilization is still poorly understood. This brief review will summarize latest findings on the role of neutrophils in atherosclerosis and will pay special attention to studies describing a translation approach by combining measurements in mouse and human.
    MeSH term(s) Animals ; Atherosclerosis/immunology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Disease Models, Animal ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Mice ; Neutrophils/immunology ; Neutrophils/metabolism ; Phenotype ; Signal Transduction ; Translational Medical Research
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.114.303564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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