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  1. Book: Pierre Bayle

    Bost, Hubert

    2006  

    Author's details Hubert Bost
    Keywords Authors, French ; Philosophers
    Language French
    Size 684 S.
    Publisher Fayard
    Publishing place Paris
    Document type Book
    Note Bibliogr. und Literaturverz. S. [521] - 542
    ISBN 2213625921 ; 9782213625928
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Conference proceedings: Pierre Bayle, citoyen du monde

    Bost, Hubert

    de l'enfant du Carla à l'auteur du dictionnaire ; actes du colloque du Carla-Bayle (13 - 15 septembre 1996)

    (Vie des Huguenots ; 4)

    1999  

    Institution Colloque International Pierre Bayle, Citoyen du Monde: de l'Enfant du Carla à l'Auteur du Dictionnaire
    Event/congress Colloque International Pierre Bayle, Citoyen du Monde: de l'Enfant du Carla à l'Auteur du Dictionnaire (1996.09.13-15, Carla-BayleAriège) ; Colloque du Carla-Bayle (1996.09.13-15, Carla-BayleAriège)
    Author's details [Colloque International Pierre Bayle, Citoyen du Monde: de l'Enfant du Carla à l'Auteur du Dictionnaire]. Réunis par Hubert Bost
    Series title Vie des Huguenots ; 4
    Language French
    Size 379 S, Ill
    Publisher Champion u.a.
    Publishing place Paris
    Document type Book ; Conference proceedings
    ISBN 2745300660 ; 9782745300669
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book ; Thesis: Un "Intellectuel" avant la lettre: le journaliste Pierre Bayle

    Bost, Hubert

    (1647-1706) ; l'actualité religieuse dans les Nouvelles de la République des lettres (1684-1687)

    (Études de l'Institut Pierre Bayle ; 23)

    1994  

    Author's details Hubert Bost
    Series title Études de l'Institut Pierre Bayle ; 23
    Language French
    Size XI, 584 S, Ill
    Publisher APA-Holland Univ. Press
    Publishing place Amsterdam u.a.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Montpellier, 1991
    ISBN 9030210338 ; 9789030210337
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Online: L'Empire romain et les sociétés provinciales

    Bost, Jean-Pierre

    2009  

    Abstract: Jean-Pierre Bost a été professeur d'Histoire ancienne et d'Antiquités nationales à l'Université ...

    Abstract Jean-Pierre Bost a été professeur d'Histoire ancienne et d'Antiquités nationales à l'Université de Bordeaux 3 (Institut Ausonius). Il est l'auteur d'une œuvre de premier plan dans le domaine de l'histoire romaine et plus spécialement dans celui de l'Aquitaine et de la péninsule Ibérique antiques. Il fait partie de cette génération de chercheurs qui a su manier avec une égale aisance toutes les disciplines de la science historique, l'archéologie, l'épigraphie et la numismatique. Il a contribué au long et patient travail d'élaboration de plusieurs grands corpus de sources

    son érudition et la finesse de ses analyses ont permis de renouveler bien des perspectives de recherche

    enfin, il a su, par la simplicité et la qualité de son écriture, susciter l'intérêt d'un public plus large que celui des seuls spécialistes. C'est à la fois la diversité et la richesse de ce parcours d'historien que ce livre veut illustrer à travers un choix d'articles et de contributions qui en retracent les apports essentiels et en révèlent toute la fécondité
    Keywords History (General)
    Size 1 electronic resource ( pages)
    Publisher Ausonius Éditions
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT020320822
    ISBN 9782356133106 ; 2356133100
    DOI 10.4000/books.ausonius.8426
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Dissecting viral infections, one cell at a time, by single-cell technologies.

    Bost, Pierre / Drayman, Nir

    Microbes and infection

    2023  , Page(s) 105268

    Abstract: The meteoric rise of single-cell genomic technologies, especially of single-cell RNA-sequencing (scRNA-seq), has revolutionized several fields of cellular biology, especially immunology, oncology, neuroscience and developmental biology. While the field ... ...

    Abstract The meteoric rise of single-cell genomic technologies, especially of single-cell RNA-sequencing (scRNA-seq), has revolutionized several fields of cellular biology, especially immunology, oncology, neuroscience and developmental biology. While the field of virology has been relatively slow to adopt these technological advances, many works have shed new light on the fascinating interactions of viruses with their hosts using single cell technologies. One clear example is the multitude of studies dissecting viral infections by single-cell sequencing technologies during the recent COVID-19 pandemic. In this review we will detail the advantages of studying viral infections at a single-cell level, how scRNA-seq technologies can be used to achieve this goal and the associated technical limitations, challenges and solutions. We will highlight recent biological discoveries and breakthroughs in virology enabled by single-cell analyses and will end by discussing possible future directions of the field. Given the rate of publications in this exciting new frontier of virology, we have likely missed some important works and we apologize in advance to the researchers whose work we have failed to cite.
    Language English
    Publishing date 2023-11-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2023.105268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Optimizing multiplexed imaging experimental design through tissue spatial segregation estimation.

    Bost, Pierre / Schulz, Daniel / Engler, Stefanie / Wasserfall, Clive / Bodenmiller, Bernd

    Nature methods

    2022  Volume 20, Issue 3, Page(s) 418–423

    Abstract: Recent advances in multiplexed imaging methods allow simultaneous detection of dozens of proteins and hundreds of RNAs, enabling deep spatial characterization of both healthy and diseased tissues. Parameters for the design of optimal multiplex imaging ... ...

    Abstract Recent advances in multiplexed imaging methods allow simultaneous detection of dozens of proteins and hundreds of RNAs, enabling deep spatial characterization of both healthy and diseased tissues. Parameters for the design of optimal multiplex imaging studies, especially those estimating how much area has to be imaged to capture all cell phenotype clusters, are lacking. Here, using a spatial transcriptomic atlas of healthy and tumor human tissues, we developed a statistical framework that determines the number and area of fields of view necessary to accurately identify all cell phenotypes that are part of a tissue. Using this strategy on imaging mass cytometry data, we identified a measurement of tissue spatial segregation that enables optimal experimental design. This strategy will enable an improved design of multiplexed imaging studies.
    MeSH term(s) Humans ; Research Design ; Diagnostic Imaging ; RNA ; Neoplasms/diagnostic imaging
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-022-01692-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Security-Efficiency Tradeoffs in Searchable Encryption

    Bost Raphael / Fouque Pierre-Alain

    Proceedings on Privacy Enhancing Technologies, Vol 2019, Iss 4, Pp 132-

    2019  Volume 151

    Abstract: Besides their security, the efficiency of searchable encryption schemes is a major criteria when it comes to their adoption: in order to replace an unencrypted database by a more secure construction, it must scale to the systems which rely on it. ... ...

    Abstract Besides their security, the efficiency of searchable encryption schemes is a major criteria when it comes to their adoption: in order to replace an unencrypted database by a more secure construction, it must scale to the systems which rely on it. Unfortunately, the relationship between the efficiency and the security of searchable encryption has not been widely studied, and the minimum cost of some crucial security properties is still unclear.
    Keywords searchable encryption ; lower bounds ; Ethics ; BJ1-1725 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Author Correction: A shared disease-associated oligodendrocyte signature among multiple CNS pathologies.

    Kenigsbuch, Mor / Bost, Pierre / Halevi, Shahar / Chang, Yuzhou / Chen, Shuo / Ma, Qin / Hajbi, Renana / Schwikowski, Benno / Bodenmiller, Bernd / Fu, Hongjun / Schwartz, Michal / Amit, Ido

    Nature neuroscience

    2023  Volume 26, Issue 3, Page(s) 528

    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-023-01266-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4891: Show issues Location:
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    Zs.MG 67: Show issues

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  9. Article ; Online: Cell-specific targeting of extracellular vesicles through engineering the glycocalyx.

    Zheng, Wenyi / He, Rui / Liang, Xiuming / Roudi, Samantha / Bost, Jeremy / Coly, Pierre-Michael / van Niel, Guillaume / Andaloussi, Samir E L

    Journal of extracellular vesicles

    2022  Volume 11, Issue 12, Page(s) e12290

    Abstract: Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity. Available methods to improve the tissue specificity of EVs ... ...

    Abstract Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity. Available methods to improve the tissue specificity of EVs predominantly rely on surface display of proteins and peptides, largely overlooking the dense glycocalyx that constitutes the outermost layer of EVs. In the present study, we report a reconfigurable glycoengineering strategy that can endogenously display glycans of interest on EV surface. Briefly, EV producer cells are genetically engineered to co-express a glycosylation domain (GD) inserted into the large extracellular loop of CD63 (a well-studied EV scaffold protein) and fucosyltransferase VII (FUT7) or IX (FUT9), so that the engineered EVs display the glycan of interest. Through this strategy, we showcase surface display of two types of glycan ligands, sialyl Lewis X (sLeX) and Lewis X, on EVs and achieve high specificity towards activated endothelial cells and dendritic cells, respectively. Moreover, the endothelial cell-targeting properties of sLeX-EVs were combined with the intrinsic therapeutic effects of mesenchymal stem cells (MSCs), leading to enhanced attenuation of endothelial damage. In summary, this study presents a reconfigurable glycoengineering strategy to produce EVs with strong cellular specificity and highlights the glycocalyx as an exploitable trait for engineering EVs.
    MeSH term(s) Glycocalyx ; Endothelial Cells ; Extracellular Vesicles ; Protein Transport ; Cell Movement ; Sialyl Lewis X Antigen
    Chemical Substances Sialyl Lewis X Antigen
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2683797-3
    ISSN 2001-3078 ; 2001-3078
    ISSN (online) 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Histological features of liver disease development in the Atp7b

    Lavrut, Pierre-Marie / Guillaud, Olivier / Dumortier, Jérôme / Mintz, Elisabeth / Brun, Virginie / Heissat, Sophie / Couchonnal Bedoya, Eduardo / Lachaux, Alain / Bost, Muriel / Hervieu, Valerie

    Journal of clinical pathology

    2023  

    Abstract: Aims: Wilson's disease (WD) is caused by mutations in the ATP7B gene, resulting in copper accumulation and toxicity in liver and brain tissues. Due to the initial asymptomatic liver involvement, the progression of liver injuries in WD stays primarily ... ...

    Abstract Aims: Wilson's disease (WD) is caused by mutations in the ATP7B gene, resulting in copper accumulation and toxicity in liver and brain tissues. Due to the initial asymptomatic liver involvement, the progression of liver injuries in WD stays primarily unknown. Atp7b-/- knockout mice have been shown to be an appropriate model of WD for liver involvement.
    Methods: A total of 138 Atp7b-/- mice were included and separated into five groups according to age as follows: 6, 20, 39 and 50 weeks without treatment, and 50 weeks with copper chelator treatment from 39 to 50 weeks of age and compared with 101 wild-type (WT) mice at the same stages. The evolution of histological liver lesions was analysed and compared between groups.
    Results: Significant changes were observed in Atp7b-/- mice compared with WT. Copper deposits in hepatocytes appeared as early as 6 weeks but no significant increase over time was observed. Inflammation appeared as early as 6 weeks and progressed henceforth. Lobular and periportal acidophilic bodies appeared after 20 weeks. Significant atypia was also observed at 20 weeks and increased over time to reach a severe stage at 39 weeks. Fibrosis also became apparent at 20 weeks, progressing subsequently to precirrhotic stages at 50 weeks. Copper content, inflammation and fibrosis scores were significantly reduced in the treated group. No bile duct lesions or dysplastic changes were noted.
    Conclusions: Copper accumulation leads to progressive changes in Atp7b-/- mice regarding inflammation, fibrosis and atypia. The severity of liver damage is lessened by chelation therapy.
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jcp-2023-209190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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