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Article ; Online: Real-world effectiveness of mepolizumab in severe asthma and chronic rhinosinusitis in the United States: Impact of comorbidity and sinus surgery.

Silver, Jared / Deb, Arijita / Laliberté, François / Gao, Chi / Bhattacharyya, Neil

International forum of allergy & rhinology

2023 Volume 14, Issue 1, Page(s) 5–17

Abstract: Background: Trial data demonstrate that mepolizumab, a humanized anti-interleukin 5 monoclonal antibody, is effective for patients with severe asthma and comorbid chronic rhinosinusitis (CRS) with nasal polyps. This real-world, retrospective cohort ... ...

Abstract	Background: Trial data demonstrate that mepolizumab, a humanized anti-interleukin 5 monoclonal antibody, is effective for patients with severe asthma and comorbid chronic rhinosinusitis (CRS) with nasal polyps. This real-world, retrospective cohort study investigated mepolizumab for US patients with severe asthma and CRS with/without sinus surgery. Methods: IQVIA PharMetrics Plus claims data from baseline and follow-up (12 months before and after mepolizumab initiation) were used to analyze three patient cohorts: cohort 1 (severe asthma only); cohort 2 (severe asthma + comorbid CRS without sinus surgery); and cohort 3 (severe asthma+comorbid CRS+sinus surgery), allowing for cross-cohort comparisons. Results: The analysis included 495, 370, and 85 patients in cohort 1, cohort 2, and cohort 3, respectively. Systemic and oral corticosteroid use was lower for all cohorts after mepolizumab initiation. In cohort 3, asthma rescue inhaler and antibiotic use were lower during follow-up than baseline. Asthma exacerbations were reduced by 28% to 44% comparing follow-up versus baseline, with the largest reduction in cohort 3 (ratio of incidence rate ratio [RR] vs cohort 1: 0.76; p = 0.036). Reductions in oral corticosteroid claims were greater following mepolizumab initiation for cohort 3 versus cohort 1 (RR, 0.72; p = 0.011) and cohort 2 (RR, 0.70; p < 0.01). In cohorts 1 through 3, outpatient and emergency department visits were reduced by 1 to 2 and 0.4 to 0.6 visits annually, asthma-related and asthma exacerbation-related total costs were reduced by $387 to $2580 USD, and medical costs were reduced by $383 to $2438 USD during follow-up. Conclusions: Consistent with trial data, mepolizumab use in real-world practice shows benefits across comorbid patient cohorts with more a pronounced impact in those with severe asthma+comorbid CRS + sinus surgery.
MeSH term(s)	Humans ; United States/epidemiology ; Anti-Asthmatic Agents/therapeutic use ; Retrospective Studies ; Rhinosinusitis ; Asthma/drug therapy ; Asthma/epidemiology ; Chronic Disease ; Comorbidity ; Sinusitis/drug therapy ; Sinusitis/epidemiology ; Sinusitis/surgery ; Adrenal Cortex Hormones/therapeutic use ; Antibodies, Monoclonal, Humanized
Chemical Substances	mepolizumab (90Z2UF0E52) ; Anti-Asthmatic Agents ; Adrenal Cortex Hormones ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625826-2
ISSN	2042-6984 ; 2042-6976
ISSN (online)	2042-6984
ISSN	2042-6976
DOI	10.1002/alr.23220
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Article: Acceptability and Preferences of Dry HR HPV Self-Sampling Mailed Kits Among Canadian Women: A Cross-Sectional Study.

Ruel-Laliberté, Jessica / Jacob-Wagner, Marieve / Bestman-Smith, Julie / Paré, Josianne

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

2023 Volume 45, Issue 4, Page(s) 261–266

Abstract: Human papillomavirus (HPV), a sexually transmitted disease, is identified as the source of 99.7% of cervical cancers. Screening for cervical cancer using oncogenic HPV (high-risk [HR] HPV) detection is more sensitive than traditional cytology. However, ... ...

Abstract	Human papillomavirus (HPV), a sexually transmitted disease, is identified as the source of 99.7% of cervical cancers. Screening for cervical cancer using oncogenic HPV (high-risk [HR] HPV) detection is more sensitive than traditional cytology. However, few Canadian data exist on HR HPV self-sampling. Objective: To evaluate the acceptability of HR HPV self-sampling by patients, the percentage of correctly collected samples, the return rate of mailed kits, and the HPV positivity rate in a population sample based on different cervical cancer risk factors. Methods: We conducted an observational cross-sectional study on HPV primary cervical cancer screening with self-collected cervicovaginal samples through mail service. Results: A total of 400 kits were mailed and 310 kits were returned, making a return rate of 77.5%. Of these, 84.2% of patients were very satisfied with this method and 95.8% (297/310) of patients would choose self-sampling over cytology as their primary screening method. All patients would recommend this screening method to their friends or family members. Of the samples, 93.8% could be analyzed correctly and the HPV positivity rate was 11.7%. Conclusion: In this large and random sample, there was a strong interest in self-testing. Offering HR HPV self-sampling could increase access to cervical cancer screening. The self-screening method could also be a part of the solution to reaching under-screened populations, in particular, those who do not have a family doctor or avoid gynaecologic exams because of pain or anxiety.
MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Cross-Sectional Studies ; Papillomavirus Infections/diagnosis ; Early Detection of Cancer/methods ; Canada ; Mass Screening/methods ; Human Papillomavirus Viruses ; Papillomaviridae ; Vaginal Smears
Language	English
Publishing date	2023-03-03
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	2171082-X
ISSN	1701-2163
ISSN	1701-2163
DOI	10.1016/j.jogc.2023.02.012
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Article ; Online: Marginal Zone B-Cell Populations and Their Regulatory Potential in the Context of HIV and Other Chronic Inflammatory Conditions.

Doyon-Laliberté, Kim / Aranguren, Matheus / Poudrier, Johanne / Roger, Michel

International journal of molecular sciences

2022 Volume 23, Issue 6

Abstract: Inflammation in the context of Human Immunodeficiency Virus (HIV) establishes early and persists beyond antiretroviral therapy (ART). As such, we have shown excess B-cell activating factor (BAFF) in the blood of HIV-infected progressors, as soon as in ... ...

Abstract	Inflammation in the context of Human Immunodeficiency Virus (HIV) establishes early and persists beyond antiretroviral therapy (ART). As such, we have shown excess B-cell activating factor (BAFF) in the blood of HIV-infected progressors, as soon as in the acute phase, and despite successful ART. Excess BAFF was associated with deregulation of the B-cell compartment; notably, with increased frequencies of a population sharing features of both transitional immature (TI) and marginal zone (MZ) B-cells, we termed Marginal Zone precursor-like (MZp). We have reported similar observations with HIV-transgenic mice, Simian Immunodeficiency Virus (SIV)-infected macaques, and more recently, with HIV-infected Beninese commercial sex workers, which suggests that excess BAFF and increased frequencies of MZp B-cells are reliable markers of inflammation in the context of HIV. Importantly, we have recently shown that in healthy individuals, MZps present an important regulatory B-cell (Breg) profile and function. Herein, we wish to review our current knowledge on MZ B-cell populations, especially their Breg status, and that of other B-cell populations sharing similar features. BAFF and its analog A Proliferation-Inducing Ligand (APRIL) are important in shaping the MZ B-cell pool; moreover, the impact that excess BAFF-encountered in the context of HIV and several chronic inflammatory conditions-may exert on MZ B-cell populations, Breg and antibody producing capacities is a threat to the self-integrity of their antibody responses and immune surveillance functions. As such, deregulations of MZ B-cell populations contribute to autoimmune manifestations and the development of MZ lymphomas (MZLs) in the context of HIV and other inflammatory diseases. Therefore, further comprehending the mechanisms regulating MZ B-cell populations and their functions could be beneficial to innovative therapeutic avenues that could be deployed to restore MZ B-cell immune competence in the context of chronic inflammation involving excess BAFF.
MeSH term(s)	Animals ; B-Cell Activating Factor ; B-Lymphocytes ; HIV Infections ; Humans ; Inflammation/pathology ; Lymphoid Tissue/pathology ; Mice ; Sex Workers
Chemical Substances	B-Cell Activating Factor
Language	English
Publishing date	2022-03-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23063372
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Article: Outcome and Management of Serous Tubal Intraepithelial Carcinoma Following Opportunistic Salpingectomy: Systematic Review and Meta-Analysis.

Ruel-Laliberté, Jessica / Kasasni, Sara Medina / Oprea, Diana / Viau, Mathieu

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

2022 Volume 44, Issue 11, Page(s) 1174–1180

Abstract: Objective: Serous ovarian cancer is the most common subtype of epithelial ovarian carcinoma-the most prevalent type of ovarian cancer. High-grade serous ovarian carcinoma (HGSOC) is thought to arise from the distal fallopian tube, with a precursor ... ...

Abstract	Objective: Serous ovarian cancer is the most common subtype of epithelial ovarian carcinoma-the most prevalent type of ovarian cancer. High-grade serous ovarian carcinoma (HGSOC) is thought to arise from the distal fallopian tube, with a precursor lesion known as serous tubal intraepithelial carcinoma (STIC). STICs are found in the final pathology of a salpingectomy specimen in 10%-20% of women with a BRCA gene mutation and 1%-7% of women without a mutation. However, there is currently no official guideline and a paucity of data on the management of STICs. Data sources: We performed a systematic review following PRISMA guidelines. Five databases were searched for relevant studies on STICs. Study selection: Two independent reviewers performed the abstract and full-text screening and data extraction, with conflicts resolved through discussion with the third reviewer. The risk of bias of each study was assessed using the Newcastle-Ottawa scale. Data extraction and synthesis: Fourteen articles were included. Ninety-nine patients who were diagnosed with STIC and subsequently followed for a mean period of 55.5 months were included in this analysis. Eighty-three patients (83.9%) were BRCA mutation carriers. After the diagnosis of isolated STIC, 7 patients (7.3%) received chemotherapy and 25 (26%) underwent surgical staging. Three of the 25 patients were diagnosed with HGSOC based on the staging surgery. Nine patients were later diagnosed with HGSOC during follow-up, with an average duration of follow-up of 58.5 months between the diagnosis of STIC and the diagnosis of HGSOC. Conclusion: Based on our review of the literature, there is a 10.7% risk of having concurrent HGSOC at the time of STIC diagnosis, and the risk of developing a subsequent HGSOC is 14.5%. BRCA mutation status should be determined in cases of isolated STIC, as 83.9% of patients included in this study were found to carry BRCA mutations. We believe it is necessary to further investigate the role of surgical staging following the diagnosis of STIC.
MeSH term(s)	Humans ; Female ; Carcinoma in Situ/genetics ; Carcinoma in Situ/pathology ; Fallopian Tube Neoplasms/genetics ; Fallopian Tube Neoplasms/surgery ; Cystadenocarcinoma, Serous/pathology ; Salpingectomy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Adenocarcinoma in Situ
Language	English
Publishing date	2022-09-12
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2171082-X
ISSN	1701-2163
ISSN	1701-2163
DOI	10.1016/j.jogc.2022.08.018
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Article: Analysis and synthesis of assistive tools for insertion tasks.

Landuré, Jérôme / Gosselin, Clément / Laliberté, Thierry / Abdallah, Muhammad

Proceedings of the Institution of Mechanical Engineers. Part B, Journal of engineering manufacture

2021 Volume 235, Issue 13, Page(s) 2066–2080

Abstract: This article studies two types of assembly tasks, namely snap-fit insertions and press-fit hose insertions. Experimental data and theoretical modelling of a snap-fit assembly are used to design a tool that can perform the snap-fit task effectively. The ... ...

Abstract	This article studies two types of assembly tasks, namely snap-fit insertions and press-fit hose insertions. Experimental data and theoretical modelling of a snap-fit assembly are used to design a tool that can perform the snap-fit task effectively. The design process of the tool is presented and experimental tests developed to validate its effectiveness are described. Hose insertion experiments are then performed and the results are analyzed in order to develop strategies for the effective insertion of press-fit components in assembly tasks. A motion primitive strategy is first explored, followed by a vibration oriented strategy. Finally, a video demonstrating the experiments accompanies this paper.
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2032745-6
ISSN	2041-2975 ; 0954-4054 ; 0263-7146
ISSN (online)	2041-2975
ISSN	0954-4054 ; 0263-7146
DOI	10.1177/09544054211019655
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Article: Real-world association between systemic corticosteroid exposure and complications in US patients with severe asthma.

Casale, Thomas B / Corbridge, Thomas / Germain, Guillaume / Laliberté, François / MacKnight, Sean D / Boudreau, Julien / Duh, Mei S / Deb, Arijita

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

2024 Volume 20, Issue 1, Page(s) 25

Abstract: Background: Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications.: Objective: Evaluate the association between cumulative SCS exposure and SCS-related complications in severe asthma.! ...

Abstract	Background: Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications. Objective: Evaluate the association between cumulative SCS exposure and SCS-related complications in severe asthma. Methods: This retrospective, longitudinal study used claims data from the Optum Clinformatics Data Mart database (GSK ID: 214469). Eligible patients (≥ 12 years old) had an asthma diagnosis and were divided into two cohorts: SCS use and non/burst-SCS use. Patients in the SCS use cohort had a claim for a daily prednisone-equivalent dose ≥ 5 mg SCS following ≥ 6 months of continuous SCS use; those in the non/burst-SCS cohort had no evidence of continuous SCS use and had a non-SCS controller/rescue medication initiation claim. For each cohort, the date of the qualifying claim was the index date. SCS users were further stratified by SCS use during each quarter of follow-up: low (≤ 6 mg/day), medium (> 6-12 mg/day), high (> 12 mg/day), and continuous high (≥ 20 mg/day for 90 days). SCS-related complications were evaluated in the quarter following SCS exposure. The adjusted odds ratios (OR) of experiencing SCS-related complications during follow-up in each of the SCS use groups versus the non/burst SCS cohort were calculated using generalized estimating equations models. Results: SCS and non/burst-SCS use cohorts included 7473 and 89,281 patients (mean follow-up: 24.6 and 24.2 months), respectively. Compared with the non/burst-SCS use cohort, medium, high, and continuous high SCS use was associated with greater odds of any SCS-related complication (adjusted OR [95% confidence interval]: 1.30 [1.21, 1.39], 1.49 [1.35, 1.64] and 1.63 [1.40, 1.89], respectively) including increased acute gastrointestinal, cardiovascular, and immune system-related complications, and chronic cardiovascular, metabolic/endocrine, central nervous system, bone-/muscle-related, ophthalmologic, and hematologic/oncologic complications. Low-dose SCS use was also associated with significantly increased odds of acute gastrointestinal and immune system-related complications, and chronic bone-/muscle-related and hematologic/oncologic complications versus the non/burst-SCS use cohort. Conclusion: SCS use, even at low doses, is associated with increased risk of SCS-related complications among patients with severe asthma.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2434973-2
ISSN	1710-1492 ; 1710-1484
ISSN (online)	1710-1492
ISSN	1710-1484
DOI	10.1186/s13223-024-00882-y
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Article ; Online: Optical closure in highly absorptive coastal waters: significance of inelastic scattering processes.

Mukherjee, Soham / Hedley, John D / Fichot, Cédric G / Laliberté, Julien / Bélanger, Simon

Optics express

2023 Volume 31, Issue 21, Page(s) 35178–35199

Abstract: In hydrological optics, "optical closure" means consistency between the apparent optical properties (AOPs) determined from radiometric measurements and those derived from radiative transfer modelling based on concurrently measured inherent optical ... ...

Abstract	In hydrological optics, "optical closure" means consistency between the apparent optical properties (AOPs) determined from radiometric measurements and those derived from radiative transfer modelling based on concurrently measured inherent optical properties (IOPs) and boundary conditions (sea and sky states). Good optical closure not only provides confidence in the data quality but also informs on the adequacy of the radiative transfer parameterization. Achieving optical closure in highly absorptive coastal waters is challenging due to the low signal-to-noise ratio of radiometric measurements and uncertainties in the measurements of IOPs, namely the spectral absorption and backscattering coefficients. Here, we present an optical closure assessment using a comprehensive set of in situ IOPs acquired in highly absorptive coastal waters optically dominated by chromophoric dissolved organic matter (CDOM). The spectral remote sensing reflectance, R
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.501732
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Article: Salpingectomie bilatérale aux fins de contraception permanente : série de cas et facteurs limitant le changement de pratique.

Ruel-Laliberté, Jessica / Binette, Audrey / Bertrand, Amélie

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

2020 Volume 42, Issue 8, Page(s) 948–952

Abstract: Objective: The Society of Obstetricians and Gynaecologists of Canada (SOGC) and the Society of Gynaecologic Oncology of Canada (GOC) recommend complete removal of the fallopian tubes as a permanent contraceptive method because of its association with a ... ...

Abstract	Objective: The Society of Obstetricians and Gynaecologists of Canada (SOGC) and the Society of Gynaecologic Oncology of Canada (GOC) recommend complete removal of the fallopian tubes as a permanent contraceptive method because of its association with a reduced risk of ovarian cancer. Currently, many women are not offered bilateral salpingectomy as an alternative to tubal ligation for permanent contraception. Method: As part of a quality improvement initiative, we reviewed all cases of sterilization performed at our university centre between 1 January and 31 December 2018. A literature review of the clinical and ethical considerations that prevent clinicians from offering bilateral salpingectomy as permanent contraception is also presented. Results: The records of 111 women who underwent tubal sterilization were reviewed. Of these, 31.5% underwent bilateral salpingectomy; 46.8% underwent tubal fulguration; 12.6% underwent clip ligation; and 9.1% underwent tubal implant ligation (Essure). According to the information on file, only 36.3% of women were offered bilateral salpingectomy, and of these, 83.8% chose this method. Conclusion: Bilateral salpingectomy should be offered to all women seeking permanent contraception. The benefits and very low risks associated with this procedure should make it a first choice option.
MeSH term(s)	Canada ; Clinical Audit ; Contraception ; Female ; Humans ; Quality Improvement ; Salpingectomy ; Sterilization, Reproductive ; Sterilization, Tubal
Language	English
Publishing date	2020-04-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2171082-X
ISSN	1701-2163
ISSN	1701-2163
DOI	10.1016/j.jogc.2020.02.004
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Article ; Online: Improving Transfer of Care Between Psychiatrists and Residents: Participants' Perspective on the Implementation of a Handover Protocol in a Psychiatric Emergency.

Lafontaine, Jonathan / Casacalenda, Nicola / Perreault, Michel / Laliberté, Vincent / Milton, Diana

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

2021 Volume 46, Issue 1, Page(s) 114–119

Abstract: Objectives: Handover refers to the transfer of information from one professional to another during transitions of care. I-PASS is a mnemonic tool which stands for Illness severity; Patient summary; Action list; Situation awareness and contingency ... ...

Abstract	Objectives: Handover refers to the transfer of information from one professional to another during transitions of care. I-PASS is a mnemonic tool which stands for Illness severity; Patient summary; Action list; Situation awareness and contingency planning; and Synthesis by receiver. It was developed to standardize the handover process. Psychiatrists, nurses, and residents at the Montreal Jewish General Hospital psychiatric emergency were trained and the I-PASS handover model was implemented. Methods: Thirty-one psychiatrists, nurses, and residents participated in this quality improvement project. Participants filled a pre-training questionnaire to examine the baseline status of handovers before attending a training session on I-PASS. Participants then filled a second questionnaire assessing the perceived quality of the handover training session, as well as anticipated benefits and challenges of I-PASS prior to its implementation. Finally, following implementation, two focus groups were held to collect feedback from participants. Results: Pre-training, most participants reported that information provided during handovers was incomplete. Training was overall much appreciated. The most significant anticipated obstacle for implementing I-PASS was lack of time to properly fill out the form. Post-implementation, participants unanimously reported an improvement in the handover process. Handovers were perceived as faster, providing all key information about patients, and the perceived quality of the information was better. Conclusion: Overall, the implementation of the I-PASS handover model was much appreciated by participants, who perceived that handovers were more comprehensive, efficient, and of better quality.
MeSH term(s)	Humans ; Patient Handoff ; Psychiatry ; Quality Improvement ; Surveys and Questionnaires
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1045331-3
ISSN	1545-7230 ; 1042-9670
ISSN (online)	1545-7230
ISSN	1042-9670
DOI	10.1007/s40596-021-01472-5
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Zs.B 2043: Show issues

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Article ; Online: Representations of parenting autistic children: A critical interpretive synthesis.

Dash, Meredith J / Hamdani, Yani / Laliberte Rudman, Debbie / Teachman, Gail

Scandinavian journal of occupational therapy

2023 Volume 30, Issue 8, Page(s) 1209–1223

Abstract: Background: Many taken-for-granted expectations for parents in Western societies are situated in normative assumptions. Social constructions of 'good' parenting may be a poor fit for parents whose children's development varies from a so-called typical ... ...

Abstract	Background: Many taken-for-granted expectations for parents in Western societies are situated in normative assumptions. Social constructions of 'good' parenting may be a poor fit for parents whose children's development varies from a so-called typical trajectory. Normative assumptions about parenting can have harmful effects for parents of autistic children. Aims/objectives: This paper examines representations of parenting autistic children in contemporary research and considers the potential effects of these representations on these parents' occupational possibilities. Methods: Informed by a critical occupational perspective, a critical interpretive synthesis (CIS) of 27 research articles focussed on parenting autistic children was conducted. Findings: Three major discursive threads were identified regarding how parents of autistic children are represented in research: gendered assumptions, caregiving as all-consuming, and disruption of normative expectations of parenting. Conclusions and significance: Normative discourses about parenting were (re)produced within this body of research which may perpetuate limitations in the occupational possibilities of parents of autistic children. Critical investigation into contemporary research is necessary to challenge taken for granted expectations for parents of children with autism, to mitigate harmful effects for parents, to inform transformative OT practices and policies, and to promote equitable service provision.
MeSH term(s)	Humans ; Child ; Parenting ; Autistic Disorder ; Parents ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2144132-7
ISSN	1651-2014 ; 1103-8128
ISSN (online)	1651-2014
ISSN	1103-8128
DOI	10.1080/11038128.2023.2210802
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