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  1. Article ; Online: Exercise FITT-V during pregnancy: Association with birth outcomes.

    Claiborne, Alex / Wisseman, Breanna / Kern, Kara / Steen, Dylan / Jevtovic, Filip / McDonald, Samantha / Strom, Cody / Newton, Edward / Isler, Christy / Devente, James / Mouro, Steven / Collier, David / Kuehn, Devon / Kelley, George A / May, Linda E

    Birth defects research

    2024  Volume 116, Issue 4, Page(s) e2340

    Abstract: ... time, and volume (FITT-V) were assessed in supervised sessions throughout pregnancy. Gestational age ... regressions and Pearson correlations determined associations between FITT-V and birth outcomes.: Results ...

    Abstract Background: Prenatal exercise improves birth outcomes, but research into exercise dose-response effects is limited.
    Methods: This study is a retrospective, secondary analysis of pooled data from three blinded, prospective, randomized controlled trials. Prenatal exercise frequency, intensity, type, time, and volume (FITT-V) were assessed in supervised sessions throughout pregnancy. Gestational age (GA), neonatal resting heart rate (rHR), morphometrics (body circumferences, weight-to-length and ponderal index) Apgar and reflex scores, and placental measures were obtained at birth. Stepwise regressions and Pearson correlations determined associations between FITT-V and birth outcomes.
    Results: Prenatal exercise frequency reduces ponderal index (R
    Conclusions: Prenatal exercise is positively related to birth and placental outcomes in a dose-dependent manner.
    MeSH term(s) Humans ; Female ; Pregnancy ; Exercise/physiology ; Pregnancy Outcome ; Adult ; Gestational Age ; Infant, Newborn ; Retrospective Studies ; Birth Weight ; Placenta/physiology ; Prospective Studies
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2104792-3
    ISSN 2472-1727
    ISSN (online) 2472-1727
    DOI 10.1002/bdr2.2340
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  2. Article ; Online: A P(V) platform for oligonucleotide synthesis.

    Huang, Yazhong / Knouse, Kyle W / Qiu, Shenjie / Hao, Wei / Padial, Natalia M / Vantourout, Julien C / Zheng, Bin / Mercer, Stephen E / Lopez-Ogalla, Javier / Narayan, Rohan / Olson, Richard E / Blackmond, Donna G / Eastgate, Martin D / Schmidt, Michael A / McDonald, Ivar M / Baran, Phil S

    Science (New York, N.Y.)

    2021  Volume 373, Issue 6560, Page(s) 1265–1270

    Abstract: ... We report a flexible and efficient [P(V)]–based platform that can install a wide variety of phosphate ...

    Abstract The promise of gene-based therapies is being realized at an accelerated pace, with more than 155 active clinical trials and multiple U.S. Food and Drug Administration approvals for therapeutic oligonucleotides, by far most of which contain modified phosphate linkages. These unnatural linkages have desirable biological and physical properties but are often accessed with difficulty using phosphoramidite chemistry. We report a flexible and efficient [P(V)]–based platform that can install a wide variety of phosphate linkages at will into oligonucleotides. This approach uses readily accessible reagents and can install not only stereodefined or racemic thiophosphates but any combination of (
    MeSH term(s) Oligonucleotides/chemical synthesis
    Chemical Substances Oligonucleotides
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abi9727
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  3. Article ; Online: Cyclotrimerization of Acetylene under Thermal Conditions: Gas-Phase Kinetics of V

    McDonald, David C / Sweeny, Brendan C / Viggiano, Albert A / Ard, Shaun G / Shuman, Nicholas S

    The journal of physical chemistry. A

    2021  Volume 125, Issue 42, Page(s) 9327–9337

    Abstract: The kinetics of successive reactions of acetylene ( ... ...

    Abstract The kinetics of successive reactions of acetylene (C
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.1c06439
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  4. Article: Imaging for precision medicine: can V-P SPECT measure mepolizumab response in asthma?

    McDonald, Vanessa M / Urroz, Paola D / Bajc, Marika / Rutherford, Natalie / Brooker, Bree / Gibson, Peter G

    Respirology case reports

    2021  Volume 9, Issue 3, Page(s) e00717

    Abstract: ... single photon emission computed tomography (V-P SPECT). In this series, patients with severe asthma received mepolizumab treatment ... with clinical outcomes recorded at commencement and at approximately 16 weeks post-treatment initiation. V-P ... perfusion, and its ability to assess treatment responsiveness. V-P SPECT shows promise as an objective ...

    Abstract Monoclonal antibody therapies are effective for many but not all people with severe asthma. Precision medicine guides treatment selection using biomarkers to select patients most likely to respond according to their inflammatory endotypes. However, when assessing response to treatment, greater precision is required. We report a case series describing treatment response to mepolizumab in four severe asthma patients, assessed by traditional methods and with objective ventilation/perfusion single photon emission computed tomography (V-P SPECT). In this series, patients with severe asthma received mepolizumab treatment with clinical outcomes recorded at commencement and at approximately 16 weeks post-treatment initiation. V-P SPECT imaging was performed before and after treatment to determine ventilation heterogeneity and perfusion, and its ability to assess treatment responsiveness. V-P SPECT shows promise as an objective measure to assess lung ventilation and perfusion to observe and assess responsiveness to mepolizumab. With quantification, this measure may allow better precision in determining treatment improvements.
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.717
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  5. Article: A comparison of grazing v. zero-grazing on early-lactation dairy cow performance

    Holohan, C. / Mulligan, F. J. / Pierce, K. M. / Somers, J. / Walsh, N. A. / McDonald, M. / Lynch, M. B.

    Journal of agricultural science. 20222022 Feb. 19, Apr. 19, v. 160, no. 1-2

    2022  

    Abstract: To overcome grass supply shortages on the main grazing block, some pasture-based dairy farmers are using zero-grazing (also known as ‘cut and carry’), whereby cows are periodically housed and fed fresh grass harvested from external land blocks. To ... ...

    Abstract To overcome grass supply shortages on the main grazing block, some pasture-based dairy farmers are using zero-grazing (also known as ‘cut and carry’), whereby cows are periodically housed and fed fresh grass harvested from external land blocks. To determine the effect of zero-grazing on cow performance, two early-lactation experiments were conducted with autumn and spring-calving dairy cows. Cows were assigned to one of two treatments in a randomized complete block design. The two treatments were zero-grazing (ZG) and grazing (G). The ZG group were housed and fed zero-grazed grass, while the G group grazed outdoors at pasture. Both treatments were fed perennial ryegrass (Lolium perenne L.) from the same paddock. In experiment 1, 24 Holstein Friesian cows (n = 12) were studied over a 35-day experimental period in autumn and offered fresh grass, grass silage, ground maize and concentrates. In experiment 2, 30 Holstein Friesian cows (n = 15) were studied over a 42-day experimental period and offered fresh grass and concentrates. Average dry matter intake and milk yield was similar for ZG and G in both experiments. Likewise, ZG did not have an effect on milk composition, body condition or locomotion. Zero-grazing had no effect on total nitrogen excretion or nitrogen utilization efficiency in either experiment, or on rumen pH and ammonia concentration in experiment 1. While zero-grazing may enable farmers to supply fresh grass to early-lactation cows in spring and autumn, results from this study suggest that there are no additional benefits to cow performance in comparison to well-managed grazed grass.
    Keywords Holstein ; Lolium perenne ; agricultural sciences ; ammonia ; autumn ; body condition ; corn ; dairy cows ; dry matter intake ; early lactation ; excretion ; grass silage ; grasses ; locomotion ; milk composition ; milk yield ; nutrient use efficiency ; pH ; pastures ; spring ; total nitrogen
    Language English
    Dates of publication 2022-0419
    Size p. 127-136.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 1498349-7
    ISSN 1469-5146 ; 0021-8596
    ISSN (online) 1469-5146
    ISSN 0021-8596
    DOI 10.1017/S0021859622000089
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Unlocking P(V): Reagents for chiral phosphorothioate synthesis.

    Knouse, Kyle W / deGruyter, Justine N / Schmidt, Michael A / Zheng, Bin / Vantourout, Julien C / Kingston, Cian / Mercer, Stephen E / Mcdonald, Ivar M / Olson, Richard E / Zhu, Ye / Hang, Chao / Zhu, Jason / Yuan, Changxia / Wang, Qinggang / Park, Peter / Eastgate, Martin D / Baran, Phil S

    Science (New York, N.Y.)

    2018  Volume 361, Issue 6408, Page(s) 1234–1238

    Abstract: ... the invention of a P(V)-based reagent platform for programmable, traceless, diastereoselective phosphorus-sulfur ...

    Abstract Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic use of phosphorus(III) [P(III)]-based reagent systems as the sole practical means of oligonucleotide assembly. A fundamentally different approach is described herein: the invention of a P(V)-based reagent platform for programmable, traceless, diastereoselective phosphorus-sulfur incorporation. The power of this reagent system is demonstrated through the robust and stereocontrolled synthesis of various nucleotidic architectures, including ASOs and CDNs, via an efficient, inexpensive, and operationally simple protocol.
    MeSH term(s) Genetic Therapy ; Isomerism ; Nucleotides/chemistry ; Phosphorothioate Oligonucleotides/chemical synthesis ; Phosphorothioate Oligonucleotides/chemistry ; Phosphorothioate Oligonucleotides/therapeutic use ; Sulfur/chemistry
    Chemical Substances Nucleotides ; Phosphorothioate Oligonucleotides ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2018-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aau3369
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  7. Article: Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing Strategies.

    Knouse, Kyle W / Flood, Dillon T / Vantourout, Julien C / Schmidt, Michael A / Mcdonald, Ivar M / Eastgate, Martin D / Baran, Phil S

    ACS central science

    2021  Volume 7, Issue 9, Page(s) 1473–1485

    Abstract: ... natural moieties; existing as ionized species in a stable P(V)-oxidation state, they are endowed with high ... and condensation chemistry, organic chemistry has not fully embraced the potential of P(V) reagents ... from our laboratories suggesting that numerous exciting opportunities for P(V) chemistry exist at the nexus ...

    Abstract Phosphate linkages govern life as we know it. Their unique properties provide the foundation for many natural systems from cell biology and biosynthesis to the backbone of nucleic acids. Phosphates are ideal natural moieties; existing as ionized species in a stable P(V)-oxidation state, they are endowed with high stability but exhibit enzymatically unlockable potential. Despite intense interest in phosphorus catalysis and condensation chemistry, organic chemistry has not fully embraced the potential of P(V) reagents. To be sure, within the world of chemical oligonucleotide synthesis, modern approaches utilize P(III) reagent systems to create phosphate linkages and their analogs. In this Outlook, we present recent studies from our laboratories suggesting that numerous exciting opportunities for P(V) chemistry exist at the nexus of organic synthesis and biochemistry. Applications to the synthesis of stereopure antisense oligonucleotides, cyclic dinucleotides, methylphosphonates, and phosphines are reviewed as well as chemoselective modification to peptides, proteins, and nucleic acids. Finally, an outlook into what may be possible in the future with P(V) chemistry is previewed, suggesting these examples represent just the tip of the iceberg.
    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.1c00487
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  8. Article ; Online: Quantifying the Competition between Intersystem Crossing and Spin-Conserved Pathways in the Thermal Reaction of V

    Ard, Shaun G / Sweeny, Brendan C / McDonald, David C / Viggiano, Albert A / Shuman, Nicholas S

    The journal of physical chemistry. A

    2019  Volume 124, Issue 1, Page(s) 30–38

    Abstract: The kinetics of V ...

    Abstract The kinetics of V
    Language English
    Publishing date 2019-12-17
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.9b09235
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  9. Article ; Online: Futility of testing for factor V Leiden.

    Favaloro, Emmanuel J / McDonald, David

    Blood transfusion = Trasfusione del sangue

    2012  Volume 10, Issue 3, Page(s) 260–263

    MeSH term(s) Activated Protein C Resistance/genetics ; Factor V/genetics ; Genes, Dominant ; Genetic Testing ; Humans ; Mutation, Missense ; Quantitative Trait, Heritable
    Chemical Substances factor V Leiden ; Factor V (9001-24-5)
    Language English
    Publishing date 2012-08-13
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/2012.0097-12
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  10. Article ; Online: Role of RNase H enzymes in maintaining genome stability in Escherichia coli expressing a steric-gate mutant of pol V

    Walsh, Erin / Henrikus, Sarah S / Vaisman, Alexandra / Makiela-Dzbenska, Karolina / Armstrong, Thomas J / Łazowski, Krystian / McDonald, John P / Goodman, Myron F / van Oijen, Antoine M / Jonczyk, Piotr / Fijalkowska, Iwona J / Robinson, Andrew / Woodgate, Roger

    DNA repair

    2019  Volume 84, Page(s) 102685

    Abstract: pol V ...

    Abstract pol V
    MeSH term(s) DNA Repair ; DNA-Directed DNA Polymerase/chemistry ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Escherichia coli ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Genomic Instability ; Mutation ; Protein Domains ; Ribonucleotides/genetics ; Ribonucleotides/metabolism
    Chemical Substances Escherichia coli Proteins ; Ribonucleotides ; DNA polymerase V, E coli (EC 2.7.7.7) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
    Language English
    Publishing date 2019-08-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2019.102685
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