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  1. Article ; Online: Host genetic factors and susceptibility to SARS-CoV-2 infection.

    Schurr, Theodore G

    American journal of human biology : the official journal of the Human Biology Council

    2020  Volume 32, Issue 5, Page(s) e23497

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/genetics ; Genetic Predisposition to Disease ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/genetics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1025339-7
    ISSN 1520-6300 ; 1042-0533
    ISSN (online) 1520-6300
    ISSN 1042-0533
    DOI 10.1002/ajhb.23497
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  3. Article ; Online: Host genetic factors and susceptibility to SARS‐CoV ‐2 infection

    Schurr, Theodore G.

    American Journal of Human Biology

    2020  Volume 32, Issue 5

    Keywords Anatomy ; Genetics ; Ecology, Evolution, Behavior and Systematics ; Anthropology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1025339-7
    ISSN 1520-6300 ; 1042-0533
    ISSN (online) 1520-6300
    ISSN 1042-0533
    DOI 10.1002/ajhb.23497
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction: Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography.

    Kristjansson, Dana / Bohlin, Jon / Nguyen, Truc Trung / Jugessur, Astanand / Schurr, Theodore G

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 459

    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08696-1
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  5. Article ; Online: Historical genomes elucidate European settlement and the African diaspora in Delaware.

    Fleskes, Raquel E / Owsley, Douglas W / Bruwelheide, Karin S / Barca, Kathryn G / Griffith, Daniel R / Cabana, Graciela S / Schurr, Theodore G

    Current biology : CB

    2023  Volume 33, Issue 11, Page(s) 2350–2358.e7

    Abstract: ... The ... ...

    Abstract The 17
    MeSH term(s) Adult ; Child ; Humans ; Black People/genetics ; Delaware ; DNA, Mitochondrial/genetics ; Genetics, Population ; Haplotypes ; Human Migration ; White
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.04.069
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  6. Article ; Online: Phylogeographic history of mitochondrial haplogroup J in Scandinavia.

    Kristjansson, Dana / Schurr, Theodore G / Bohlin, Jon / Jugessur, Astanand

    American journal of biological anthropology

    2022  Volume 180, Issue 2, Page(s) 298–315

    Abstract: Background: Mitochondrial DNA haplogroup J is the third most frequent haplogroup in modern-day Scandinavia, although it did not originate there. To infer the genetic history of haplogroup J in Scandinavia, we examined worldwide mitogenome sequences ... ...

    Abstract Background: Mitochondrial DNA haplogroup J is the third most frequent haplogroup in modern-day Scandinavia, although it did not originate there. To infer the genetic history of haplogroup J in Scandinavia, we examined worldwide mitogenome sequences using a maximum-likelihood phylogenetic approach.
    Methods: Haplogroup J mitogenome sequences were gathered from GenBank (n = 2245) and aligned against the ancestral Reconstructed Sapiens Reference Sequence. We also analyzed haplogroup J Viking Age sequences from the European Nucleotide Archive (n = 54). Genetic distances were estimated from these data and projected onto a maximum likelihood rooted phylogenetic tree to analyze clustering and branching dates.
    Results: Haplogroup J originated approximately 42.6 kya (95% CI: 30.0-64.7), with several of its earliest branches being found within the Arabian Peninsula and Northern Africa. J1b was found most frequently in the Near East and Arabian Peninsula, while J1c occurred most frequently in Europe. Based on phylogenetic dating, subhaplogroup J1c has its early roots in the Mediterranean and Western Balkans. Otherwise, the majority of the branches found in Scandinavia are younger than those seen elsewhere, indicating that haplogroup J dispersed relatively recently into Northern Europe, most plausibly with Neolithic farmers.
    Conclusions: Haplogroup J appeared when Scandinavia was transitioning to agriculture over 6 kya, with J1c being the most common lineage there today. Changes in the distribution of haplogroup J mtDNAs were likely driven by the expansion of farming from West Asia into Southern Europe, followed by a later expansion into Scandinavia, with other J subhaplogroups appearing among Scandinavian groups as early as the Viking Age.
    MeSH term(s) Phylogeny ; Haplotypes/genetics ; Phylogeography ; Scandinavian and Nordic Countries ; Balkan Peninsula
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2692-7691
    ISSN (online) 2692-7691
    DOI 10.1002/ajpa.24666
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  7. Article ; Online: Mitochondrial genetic variation in human bioenergetics, adaptation, and adult disease.

    Friedrich, Volney K / Rubel, Meagan A / Schurr, Theodore G

    American journal of human biology : the official journal of the Human Biology Council

    2021  Volume 34, Issue 2, Page(s) e23629

    Abstract: Objectives: Mitochondria are critical for the survival of eukaryotic organisms due to their ability to produce cellular energy, which drives virtually all aspects of host biology. However, the effects of mitochondrial DNA (mtDNA) variation in relation ... ...

    Abstract Objectives: Mitochondria are critical for the survival of eukaryotic organisms due to their ability to produce cellular energy, which drives virtually all aspects of host biology. However, the effects of mitochondrial DNA (mtDNA) variation in relation to disease etiology and adaptation within contemporary global human populations remains incompletely understood.
    Methods: To develop a more holistic understanding of the role of mtDNA diversity in human adaptation, health, and disease, we investigated mitochondrial biology and bioenergetics. More specifically, we synthesized details from studies of mitochondrial function and variation in the context of haplogroup background, climatic adaptation, and oxidative disease.
    Results: The majority of studies show that mtDNA variation arose during modern human dispersal around the world. Some of these variants appear to have been positively selected for their adaptiveness in colder climates, with these sequence changes having implications for tissue-specific function and thermogenic capacity. In addition, many variants modulating energy production are also associated with damaging metabolic byproducts and mitochondrial dysfunction, which, in turn, are implicated in the onset and severity of several different adult mitochondrial diseases. Thus, mtDNA variation that governs bioenergetics, metabolism, and thermoregulation may potentially have adverse consequences for human health, depending on the genetic background and context in which it occurs.
    Conclusions: Our review suggests that the mitochondrial research field would benefit from independently replicating mtDNA haplogroup-phenotype associations across global populations, incorporating potentially confounding environmental, demographic, and disease covariates into studies of mtDNA variation, and extending association-based studies to include analyses of complete mitogenomes and assays of mitochondrial function.
    MeSH term(s) Adaptation, Physiological ; DNA, Mitochondrial/genetics ; Energy Metabolism/genetics ; Genetic Variation ; Haplotypes ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1025339-7
    ISSN 1520-6300 ; 1042-0533
    ISSN (online) 1520-6300
    ISSN 1042-0533
    DOI 10.1002/ajhb.23629
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  8. Article ; Online: Evolutionary analysis of JC polyomavirus in Misiones' population yields insight into the population dynamics of the early human dispersal in the Americas.

    Pereson, Matias J / Sanabria, Daiana J / Torres, Carolina / Liotta, Domingo J / Campos, Rodolfo H / Schurr, Theodore G / Di Lello, Federico A / Badano, Inés

    Virology

    2023  Volume 585, Page(s) 100–108

    Abstract: Background: JC polyomavirus (JCV) has an ethno-geographical distribution across human populations.: Objective: Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker.: Methods: Viral detection and ... ...

    Abstract Background: JC polyomavirus (JCV) has an ethno-geographical distribution across human populations.
    Objective: Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker.
    Methods: Viral detection and characterization was conducted by PCR amplification and evolutionary analysis of the intergenic region sequences.
    Results: 22 out of 121 samples were positive for JCV, including 5 viral lineages: MY (n = 8), Eu-a (n = 7), B1-c (n = 4), B1-b (n = 2) and Af2 (n = 1). MY sequences clustered within a branch of Native American origin that diverged from its Asian counterpart about 21,914 years ago (HPD 95% interval 15,383-30,177), followed by a sustained demographic expansion around 5000 years ago.
    Conclusions: JCV in Misiones reflects the multiethnic origin of the current population, with an important Amerindian contribution. Analysis of the MY viral lineage shows a pattern consistent with the arrival of early human migrations to the Americas and a population expansion by the pre-Columbian native societies.
    MeSH term(s) Humans ; JC Virus/genetics ; Biological Evolution ; Population Dynamics ; Human Migration ; Americas/epidemiology ; DNA, Viral/genetics
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2023.05.009
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  9. Article ; Online: Evolution and dispersal of mitochondrial DNA haplogroup U5 in Northern Europe: insights from an unsupervised learning approach to phylogeography.

    Kristjansson, Dana / Bohlin, Jon / Nguyen, Truc Trung / Jugessur, Astanand / Schurr, Theodore G

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 354

    Abstract: Background: We combined an unsupervised learning methodology for analyzing mitogenome sequences with maximum likelihood (ML) phylogenetics to make detailed inferences about the evolution and diversification of mitochondrial DNA (mtDNA) haplogroup U5, ... ...

    Abstract Background: We combined an unsupervised learning methodology for analyzing mitogenome sequences with maximum likelihood (ML) phylogenetics to make detailed inferences about the evolution and diversification of mitochondrial DNA (mtDNA) haplogroup U5, which appears at high frequencies in northern Europe.
    Methods: Haplogroup U5 mitogenome sequences were gathered from GenBank. The hierarchal Bayesian Analysis of Population Structure (hierBAPS) method was used to generate groups of sequences that were then projected onto a rooted maximum likelihood (ML) phylogenetic tree to visualize the pattern of clustering. The haplogroup statuses of the individual sequences were assessed using Haplogrep2.
    Results: A total of 23 hierBAPS groups were identified, all of which corresponded to subclades defined in Phylotree, v.17. The hierBAPS groups projected onto the ML phylogeny accurately clustered all haplotypes belonging to a specific haplogroup in accordance with Haplogrep2. By incorporating the geographic source of each sequence and subclade age estimates into this framework, inferences about the diversification of U5 mtDNAs were made. Haplogroup U5 has been present in northern Europe since the Mesolithic, and spread in both eastern and western directions, undergoing significant diversification within Scandinavia. A review of historical and archeological evidence attests to some of the population interactions contributing to this pattern.
    Conclusions: The hierBAPS algorithm accurately grouped mitogenome sequences into subclades in a phylogenetically robust manner. This analysis provided new insights into the phylogeographic structure of haplogroup U5 diversity in northern Europe, revealing a detailed perspective on the diversity of subclades in this region and their distribution in Scandinavian populations.
    MeSH term(s) Bayes Theorem ; DNA, Mitochondrial/genetics ; Europe ; Evolution, Molecular ; Genetics, Population ; Haplotypes ; Humans ; Phylogeny ; Phylogeography ; Unsupervised Machine Learning
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2022-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08572-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Contrasting maternal and paternal genetic histories among five ethnic groups from Khyber Pakhtunkhwa, Pakistan.

    Tariq, Muhammad / Ahmad, Habib / Hemphill, Brian E / Farooq, Umar / Schurr, Theodore G

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 1027

    Abstract: Northwest Pakistan has served as a point of entry to South Asia for different populations since ancient times. However, relatively little is known about the population genetic history of the people residing within this region. To better understand human ... ...

    Abstract Northwest Pakistan has served as a point of entry to South Asia for different populations since ancient times. However, relatively little is known about the population genetic history of the people residing within this region. To better understand human dispersal in the region within the broader history of the subcontinent, we analyzed mtDNA diversity in 659 and Y-chromosome diversity in 678 individuals, respectively, from five ethnic groups (Gujars, Jadoons, Syeds, Tanolis and Yousafzais), from Swabi and Buner Districts, Khyber Pakhtunkhwa Province, Pakistan. The mtDNAs of all individuals were subject to control region sequencing and SNP genotyping, while Y-chromosomes were analyzed using 54 SNPs and 19 STR loci. The majority of the mtDNAs belonged to West Eurasian haplogroups, with the rest belonging to either South or East Asian lineages. Four of the five Pakistani populations (Gujars, Jadoons, Syeds, Yousafzais) possessed strong maternal genetic affinities with other Pakistani and Central Asian populations, whereas one (Tanolis) did not. Four haplogroups (R1a, R1b, O3, L) among the 11 Y-chromosome lineages observed among these five ethnic groups contributed substantially to their paternal genetic makeup. Gujars, Syeds and Yousafzais showed strong paternal genetic affinities with other Pakistani and Central Asian populations, whereas Jadoons and Tanolis had close affinities with Turkmen populations from Central Asia and ethnic groups from northeast India. We evaluate these genetic data in the context of historical and archeological evidence to test different hypotheses concerning their origins and biological relationships.
    MeSH term(s) Chromosomes, Human, Y/genetics ; DNA, Mitochondrial/genetics ; Ethnicity/genetics ; Genetics, Population ; Haplotypes ; Humans ; Male ; Pakistan/ethnology ; Phylogeny ; Polymorphism, Single Nucleotide
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-05076-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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