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Article ; Online: Potential threat of human pathogenic orthopoxviruses to public health and control strategies.

Zhang, Yongli / Zhou, Yuan / Pei, Rongjuan / Chen, Xinwen / Wang, Yun

Journal of biosafety and biosecurity

2023 Volume 5, Issue 1, Page(s) 1–7

Abstract: Orthopoxviruses (OPXVs) belong to a group of nucleo-cytoplasmic large DNA viruses. Human pathogenic OPXVs (hpOPXVs) include at least five viruses, among which smallpox virus and monkeypox virus are the most dangerous viral pathogens. Both viruses are ... ...

Abstract	Orthopoxviruses (OPXVs) belong to a group of nucleo-cytoplasmic large DNA viruses. Human pathogenic OPXVs (hpOPXVs) include at least five viruses, among which smallpox virus and monkeypox virus are the most dangerous viral pathogens. Both viruses are classified as category-one human infectious pathogens in China. Although smallpox was globally eradicated in the 1980 s, it is still a top biosecurity threat owing to the possibility of either being leaked to the outside world from a laboratory or being weaponized by terrorists. Beginning in early May 2022, a sudden outbreak of monkeypox was concurrently reported in more than 100 disparate geographical areas, representing a public health emergency of international concern, as declared by the World Health Organization (WHO). In this review, we present the reasons for hpOPXVs such as monkeypox virus presenting a potential threat to public health. We then systematically review the historical and recent development of vaccines and drugs against smallpox and monkeypox. In the final section, we highlight the importance of viromics studies as an integral part of a forward defense strategy to eliminate the potential threat to public health from emerging or re-emerging hpOPXVs and their variants.
Language	English
Publishing date	2023-01-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2588-9338
ISSN (online)	2588-9338
DOI	10.1016/j.jobb.2022.12.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential threat of human pathogenic orthopoxviruses to public health and control strategies

Yongli Zhang / Yuan Zhou / Rongjuan Pei / Xinwen Chen / Yun Wang

Journal of Biosafety and Biosecurity, Vol 5, Iss 1, Pp 1-

2023 Volume 7

Abstract	Orthopoxviruses (OPXVs) belong to a group of nucleo-cytoplasmic large DNA viruses. Human pathogenic OPXVs (hpOPXVs) include at least five viruses, among which smallpox virus and monkeypox virus are the most dangerous viral pathogens. Both viruses are classified as category-one human infectious pathogens in China. Although smallpox was globally eradicated in the 1980 s, it is still a top biosecurity threat owing to the possibility of either being leaked to the outside world from a laboratory or being weaponized by terrorists. Beginning in early May 2022, a sudden outbreak of monkeypox was concurrently reported in more than 100 disparate geographical areas, representing a public health emergency of international concern, as declared by the World Health Organization (WHO). In this review, we present the reasons for hpOPXVs such as monkeypox virus presenting a potential threat to public health. We then systematically review the historical and recent development of vaccines and drugs against smallpox and monkeypox. In the final section, we highlight the importance of viromics studies as an integral part of a forward defense strategy to eliminate the potential threat to public health from emerging or re-emerging hpOPXVs and their variants.
Keywords	Biology (General) ; QH301-705.5
Subject code	306
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vaccinia virus tiantan strain is inefficient in eliciting cross-reactive immunity against the emerging monkeypox virus strain.

Tian, Lingqian / Zhang, Yongli / Liu, Qiuhong / Ruan, Lianguo / Ren, Fuli / Han, Yang / Zhang, Yanfang / Yang, Lei / Li, Sha / Sun, Hao / Zhang, Yecheng / Zhou, Yuan / Pei, Rongjuan / Deng, Fei / Huang, Chaolin / Chen, Xinwen / Wang, Yun

Emerging microbes & infections

2024 Volume 13, Issue 1, Page(s) 2306967

MeSH term(s)	Vaccinia virus/genetics ; Monkeypox virus/genetics
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2306967
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunization of mice with vaccinia virus Tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus.

Yang, Lei / Chen, Yingshan / Li, Sha / Zhou, Yuan / Zhang, Yongli / Pei, Rongjuan / Chen, Xinwen / Wang, Yun

Virologica Sinica

2022 Volume 38, Issue 1, Page(s) 162–164

MeSH term(s)	Animals ; Mice ; Vaccinia virus ; Monkeypox virus/genetics ; Immunization ; Vaccination ; Antibodies ; Mice, Inbred BALB C
Chemical Substances	Antibodies
Language	English
Publishing date	2022-10-19
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1016/j.virs.2022.10.004
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Zs.A 4175: Show issues

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Article ; Online: Efficient assembly of a large fragment of monkeypox virus genome as a qPCR template using dual-selection based transformation-associated recombination.

Yang, Lei / Tian, Lingqian / Li, Leshan / Liu, Qiuhong / Guo, Xiang / Zhou, Yuan / Pei, Rongjuan / Chen, Xinwen / Wang, Yun

Virologica Sinica

2022 Volume 37, Issue 3, Page(s) 341–347

Abstract: Transformation-associated recombination (TAR) has been widely used to assemble large DNA constructs. One of the significant obstacles hindering assembly efficiency is the presence of error-prone DNA repair pathways in yeast, which results in vector ... ...

Abstract	Transformation-associated recombination (TAR) has been widely used to assemble large DNA constructs. One of the significant obstacles hindering assembly efficiency is the presence of error-prone DNA repair pathways in yeast, which results in vector backbone recircularization or illegitimate recombination products. To increase TAR assembly efficiency, we prepared a dual-selective TAR vector, pGFCS, by adding a P
MeSH term(s)	Cloning, Molecular ; Genetic Vectors ; Monkeypox virus/genetics ; Recombination, Genetic ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Transformation, Genetic
Language	English
Publishing date	2022-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1016/j.virs.2022.02.009
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Article ; Online: Author Correction: Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice.

Nature communications

2023 Volume 14, Issue 1, Page(s) 3969

Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39774-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ADAM15 Participates in Tick-Borne Encephalitis Virus Replication.

Yang, Qi / Pei, Rongjuan / Wang, Yun / Zhou, Yuan / Yang, Min / Chen, Xinwen / Chen, Jizheng

Journal of virology

2021 Volume 95, Issue 4

Abstract: Tick-borne encephalitis virus (TBEV), a major tick-borne viral pathogen of humans, is known to cause neurological diseases such as meningitis, encephalitis, and meningoencephalitis. However, the life cycle and pathogenesis of TBEV are not well understood. ...

Abstract	Tick-borne encephalitis virus (TBEV), a major tick-borne viral pathogen of humans, is known to cause neurological diseases such as meningitis, encephalitis, and meningoencephalitis. However, the life cycle and pathogenesis of TBEV are not well understood. Here, we show that the knockdown or knockout of ADAM15 (a disintegrin and metalloproteinase 15), a host protein involved in neuroblastoma diseases, leads to TBEV replication and assembly defects. We characterized the disintegrin domain in ADAM15 and found that the ADAM15 subcellular localization was changed following TBEV infection. RNA interference (RNAi) screen analysis confirmed ADAM's nonredundant functions and identified a specific role for ADAM15 in TBEV infection. An RNA-sequencing analysis was also conducted to understand the causal link between TBEV infection and the cellular endomembrane network, namely, the generation of replication organelles promoting viral genome replication and virus production. Our data demonstrated that TBEV infection changes ADAM15 cellular localization, which contributes to membrane reorganization and viral replication.
MeSH term(s)	ADAM Proteins/physiology ; Animals ; Chlorocebus aethiops ; Cricetinae ; Encephalitis Viruses, Tick-Borne/physiology ; Encephalitis, Tick-Borne/virology ; HEK293 Cells ; Host Microbial Interactions ; Humans ; Membrane Proteins/physiology ; Vero Cells ; Virus Replication
Chemical Substances	Membrane Proteins ; ADAM Proteins (EC 3.4.24.-) ; ADAM15 protein, human (EC 3.4.24.-)
Language	English
Publishing date	2021-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.01926-20
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Zs.A 609: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.

Tang, Jielin / Xu, Chonghui / Fu, Muqing / Liu, Canyu / Zhang, Xianwen / Zhang, Wei / Pei, Rongjuan / Wang, Yun / Zhou, Yuan / Chen, Jizheng / Miao, Zhichao / Pan, Guangjin / Yang, Qi / Chen, Xinwen

Journal of medical virology

2023 Volume 95, Issue 3, Page(s) e28610

Abstract: Tick-borne encephalitis virus (TBEV) is the causative agent of a potentially fatal neurological infection in humans. Investigating virus-host interaction is important for understanding the pathogenesis of TBEV and developing effective antiviral drugs ... ...

Abstract	Tick-borne encephalitis virus (TBEV) is the causative agent of a potentially fatal neurological infection in humans. Investigating virus-host interaction is important for understanding the pathogenesis of TBEV and developing effective antiviral drugs against this virus. Here, we report that mammalian ste20-like kinase 3 (MST3) is involved in the regulation of TBEV infection. The knockdown or knockout of MST3, but not other mammalian ste20-like kinase family members, inhibited TBEV replication. The knockdown of MST3 also significantly reduced TBEV replication in mouse primary astrocytes. Life cycle analysis indicated that MST3 remarkably impaired virion assembly efficiency and specific infectivity by respectively 59% and 95% in MST3-knockout cells. We further found that MST3 interacts with the viral proteins NS2A and prM; and MST3 enhances the interaction of NS2A-NS4A. Thus, MST3-NS2A complex plays a major role in recruiting prM-E heterodimers and NS4A and mediates the virion assembly. Additionally, we found that MST3 was biotinylated and combined with other proteins (e.g., ATG5, Sec24A, and SNX4) that are associated with the cellular membrane required for TBEV infection. Overall, our study revealed a novel function for MST3 in TBEV infection and identified as a novel host factor supporting TBEV assembly.
MeSH term(s)	Animals ; Mice ; Humans ; Encephalitis Viruses, Tick-Borne/genetics ; Viral Proteins/metabolism ; Encephalitis, Tick-Borne ; Mammals/metabolism ; Vesicular Transport Proteins
Chemical Substances	Viral Proteins ; SEC24A protein, human ; Vesicular Transport Proteins
Language	English
Publishing date	2023-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28610
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: RNA-binding motif protein 24 inhibits HBV replication in vivo.

Yao, Yong-Xuan / Chen, Yingshan / Huang, Dan / Liu, Canyu / Sun, Hao / Zhou, Yuan / Pei, Rongjuan / Wang, Yun / Wen, Zhe / Yang, Bo / Chen, Xinwen

Journal of medical virology

2023 Volume 95, Issue 7, Page(s) e28969

Abstract: Despite the extensive use of effective vaccines and antiviral drugs, chronic hepatitis B virus (HBV) infection continues to pose a serious threat to global public health. Therapies with novel mechanisms of action against HBV are being explored for ... ...

Abstract	Despite the extensive use of effective vaccines and antiviral drugs, chronic hepatitis B virus (HBV) infection continues to pose a serious threat to global public health. Therapies with novel mechanisms of action against HBV are being explored for achieving a functional cure. In this study, five murine models of HBV replication were used to investigate the inhibitory effect of RNA binding motif protein 24 (RBM24) on HBV replication. The findings revealed that RBM24 serves as a host restriction factor and suppresses HBV replication in vivo. The transient overexpression of RBM24 in hydrodynamics-based mouse models of HBV replication driven by the CMV or HBV promoters suppressed HBV replication. Additionally, the ectopic expression of RBM24 decreased viral accumulation and the levels of HBV covalently closed circular DNA (cccDNA) in an rcccDNA mouse model. The liver-directed transduction of adeno-associated viruses (AAV)-RBM24 mediated the stable hepatic expression of RBM24 in pAAV-HBV1.2 and HBV/tg mouse models, and markedly reduced the levels of HBV cccDNA and other viral indicators. Altogether, these findings revealed that RBM24 inhibits the replication of HBV in vivo, and RBM24 may be a potential therapeutic target for combating HBV infections.
MeSH term(s)	Mice ; Animals ; Hepatitis B virus ; Hepatitis B, Chronic ; Virus Replication ; Hepatitis B ; DNA, Circular ; RNA-Binding Motifs ; DNA, Viral/genetics ; DNA, Viral/metabolism
Chemical Substances	DNA, Circular ; DNA, Viral
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes.

Zhang, Yabin / Sun, Hao / Pei, Rongjuan / Mao, Binli / Zhao, Zhenyu / Li, Huihui / Lin, Yong / Lu, Kefeng

Cell discovery

2021 Volume 7, Issue 1, Page(s) 31

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown. Autophagy is an intracellular lysosomal ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown. Autophagy is an intracellular lysosomal degradation pathway for the clearance of various cargoes, including viruses. Here, we systematically screened 28 viral proteins of SARS-CoV-2 and identified that ORF3a strongly inhibited autophagic flux by blocking the fusion of autophagosomes with lysosomes. ORF3a colocalized with lysosomes and interacted with VPS39, a component of the homotypic fusion and protein sorting (HOPS) complex. The ORF3a-VPS39 interaction prohibited the binding of HOPS with RAB7, which prevented the assembly of fusion machinery, leading to the accumulation of unfused autophagosomes. These results indicated the potential mechanism by which SARS-CoV-2 escapes degradation; that is, the virus interferes with autophagosome-lysosome fusion. Furthermore, our findings will facilitate strategies targeting autophagy for conferring potential protection against the spread of SARS-CoV-2.
Language	English
Publishing date	2021-05-04
Publishing country	England
Document type	Journal Article
ISSN	2056-5968
ISSN	2056-5968
DOI	10.1038/s41421-021-00268-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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