LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 35

Search options

  1. Book: Periodontitis

    Santi-Rocca, Julien

    (Advances in experimental medicine and biology ; 1373)

    2022  

    Author's details Julien Santi-Rocca editor
    Series title Advances in experimental medicine and biology ; 1373
    Collection
    Language English
    Size xiii, 402 Seiten, Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT021389037
    ISBN 978-3-030-96880-9 ; 9783030968816 ; 3-030-96880-4 ; 3030968812
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1373- not available for loan Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Advances in Experimental Research About Periodontitis: Lessons from the Past, Ideas for the Future.

    Santi-Rocca, Julien

    Advances in experimental medicine and biology

    2022  Volume 1373, Page(s) 1–15

    Abstract: Periodontitis is an inflammation-driven disease triggered by microbes that affects the tissues surrounding the teeth and eventually destroys the alveolar bone, leading to tooth loss. This is probably the most precise and consensual definition of ... ...

    Abstract Periodontitis is an inflammation-driven disease triggered by microbes that affects the tissues surrounding the teeth and eventually destroys the alveolar bone, leading to tooth loss. This is probably the most precise and consensual definition of periodontitis that can be given to date. How to deal with a disease whose aetiology, pathophysiology, and therapeutic strategies are still subject to debate? In the book "Periodontitis: Advances in Experimental Research", 20 chapters aim at clarifying chosen questions left unresolved from the twentieth century, with methodologies from the twenty-first century. Here we expose the concerns authors, reviewers, and editors have raised during the writing of this book. The aim of this collaborative work is to present to a large audience the current state of experimental periodontal research, and to help decision makers think out of the box while defining future research.
    MeSH term(s) Gingivitis/complications ; Humans ; Periodontitis/therapy
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-96881-6_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Editorial: The Human Microbiota in Periodontitis.

    Hernández, Marcela / Mayer, Marcia Pinto Alves / Santi-Rocca, Julien

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 952205

    MeSH term(s) Humans ; Microbiota ; Periodontitis
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.952205
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Parasites in Periodontal Health and Disease: A Systematic Review and Meta-analysis.

    Martin-Garcia, David Felipe / Sallam, Malik / Garcia, Gabriela / Santi-Rocca, Julien

    Advances in experimental medicine and biology

    2022  Volume 1373, Page(s) 95–111

    Abstract: Background: Periodontitis is an inflammatory disease triggered by the infection of the periodontal sulcus by microbes. Together with the abundant eubacterial microbiota, at least two parasites have often been identified: the amoeba Entamoeba gingivalis ... ...

    Abstract Background: Periodontitis is an inflammatory disease triggered by the infection of the periodontal sulcus by microbes. Together with the abundant eubacterial microbiota, at least two parasites have often been identified: the amoeba Entamoeba gingivalis and the flagellate Trichomonas tenax. The role of these protists in the pathophysiology of periodontal disease remains to be deciphered. A high diversity in their measured prevalence, mainly due to methodological concerns, prevents further analysis of the aetiological link between these parasites and periodontitis.
    Methods: To determine E. gingivalis and T. tenax prevalence in periodontal pockets as compared to healthy sulci, we have conducted a systematic review, searching 3 remote databases (Pubmed, LILACS, and Google Scholar), restricting to papers in which the diagnostic of the parasite was made using molecular methods. A total of 5 studies for E. gingivalis and 2 studies for T. tenax were included for the meta-analysis.
    Results: In the periodontal pockets, the prevalence of parasites is 76.9% (95%-CI: 71.5-81.7%) for E. gingivalis and 38.6% (95%-CI: 27.2-50.0%) for T. tenax . Both parasites are more abundant in periodontal pockets as compared to healthy sulci, with a risk ratio of 3.96 (95%-CI: 1.57-9.98) for E. gingivalis and 21.82 (95%-CI: 6.71-70.96) for T. tenax . The two subtypes of E. gingivalis exhibited the same risk ratio: 3.30 (95%-CI: 1.27-8.55) for ST1 and 3.30 (95%-CI: 0.42-26.03) for ST2, but ST1 was more prevalent (70.6%, 95%-CI: 65.0-76.2%) than ST2 (43.9%, 95%-CI: 35.5-52.4%) in periodontal pockets.
    Conclusion: Altogether, the data show that parasites are more prevalent in the diseased than in the healthy. However, the differences in prevalence between species and subtypes call for more studies to be able to conclude about their individual contributions in the pathophysiology of periodontal diseases. The heterogeneity in prevalence estimation should be investigated further, in particular to make out biological from methodological heterogeneity.
    MeSH term(s) Animals ; Interleukin-1 Receptor-Like 1 Protein ; Parasites ; Periodontal Diseases/epidemiology ; Periodontal Pocket ; Periodontitis ; Porphyromonas gingivalis ; Trichomonas Infections/epidemiology
    Chemical Substances Interleukin-1 Receptor-Like 1 Protein
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-96881-6_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Membrane trafficking and remodeling at the host-parasite interface.

    Santi-Rocca, Julien / Blanchard, Nicolas

    Current opinion in microbiology

    2017  Volume 40, Page(s) 145–151

    Abstract: Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra- ...

    Abstract Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host-parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host-parasite cross-talk. Here, underscoring specificities and similarities between the T. gondii and Plasmodium contexts, we present recent findings about vacuolar membrane remodeling and its potential roles in parasite fitness and immune recognition. We review in particular the implication of tubulo-vesicular structures in trapping and/or transporting host and parasite components. Understanding how membrane remodeling influences host-pathogen interactions is expected to be critical in the battle against many intracellular pathogens beyond parasites.
    MeSH term(s) Animals ; Host-Parasite Interactions ; Humans ; Malaria/parasitology ; Malaria/physiopathology ; Plasmodium/genetics ; Plasmodium/physiology ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Toxoplasma/genetics ; Toxoplasma/physiology ; Toxoplasmosis/parasitology ; Toxoplasmosis/physiopathology ; Vacuoles/parasitology
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2017.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 51: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Multi-Parametric Evaluation of Trypanosoma cruzi Infection Outcome in Animal Models.

    Santi-Rocca, Julien / Gironès, Núria / Fresno, Manuel

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1955, Page(s) 187–202

    Abstract: Biomarkers of infection with consistent discriminating power for diagnosis and/or prognosis are keystones for efficient therapeutic management of diseases. The protozoan Trypanosoma cruzi, the etiologic agent of Chagas disease (CD), exhibits high ... ...

    Abstract Biomarkers of infection with consistent discriminating power for diagnosis and/or prognosis are keystones for efficient therapeutic management of diseases. The protozoan Trypanosoma cruzi, the etiologic agent of Chagas disease (CD), exhibits high clinical and genetic diversity, making it difficult to define biomarkers. In animal models of infection, as well as in patients, many different outcomes have been described. Thus, pathophysiogenesis parameters were highly variable in patients and even in inbred animals, which impeded reliable one-dimensional diagnosis/prognosis. To help solve those problems, an in-depth analysis of the similarities and differences in the CD caused by different parasite strains or different patient conditions is needed. Multidimensional statistics may overcome the high variability for each individual parameter in patients and even in inbred animals, revealing some pathophysiological patterns that accurately allow diagnosis of clinical and physiopathological characteristics. Here, we describe this type of method and its application to T. cruzi infection.
    MeSH term(s) Animals ; Chagas Disease/pathology ; DNA, Protozoan/analysis ; DNA, Protozoan/genetics ; Discriminant Analysis ; Disease Models, Animal ; Humans ; Linear Models ; Mice ; Polymerase Chain Reaction/methods ; Trypanosoma cruzi/genetics ; Trypanosoma cruzi/isolation & purification
    Chemical Substances DNA, Protozoan
    Language English
    Publishing date 2019-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9148-8_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Efficient Cholesterol Transport in Dendritic Cells Defines Optimal Exogenous Antigen Presentation and Toxoplasma gondii Proliferation.

    Croce, Cristina / Garrido, Facundo / Dinamarca, Sofía / Santi-Rocca, Julien / Marion, Sabrina / Blanchard, Nicolas / Mayorga, Luis S / Cebrian, Ignacio

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 837574

    Abstract: Dendritic cells are the most powerful antigen-presenting cells of the immune system. They present exogenous antigens associated with Major Histocompatibility Complex (MHC) Class II molecules through the classical pathway to stimulate CD4+ T cells, or ... ...

    Abstract Dendritic cells are the most powerful antigen-presenting cells of the immune system. They present exogenous antigens associated with Major Histocompatibility Complex (MHC) Class II molecules through the classical pathway to stimulate CD4+ T cells, or with MHC-I to activate CD8+ T lymphocytes through the cross-presentation pathway. DCs represent one of the main cellular targets during infection by
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.837574
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Membrane trafficking and remodeling at the host–parasite interface

    Santi-Rocca, Julien / Nicolas Blanchard

    Current opinion in microbiology. 2017 Dec., v. 40

    2017  

    Abstract: Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host–parasite interface. This membrane comprises intra-vacuolar and extra- ...

    Abstract Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host–parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host–parasite cross-talk. Here, underscoring specificities and similarities between the T. gondii and Plasmodium contexts, we present recent findings about vacuolar membrane remodeling and its potential roles in parasite fitness and immune recognition. We review in particular the implication of tubulo-vesicular structures in trapping and/or transporting host and parasite components. Understanding how membrane remodeling influences host–pathogen interactions is expected to be critical in the battle against many intracellular pathogens beyond parasites.
    Keywords cell membranes ; deformation ; host-pathogen relationships ; parasites ; pathogens ; physiological transport ; Plasmodium ; Toxoplasma gondii ; vacuoles
    Language English
    Dates of publication 2017-12
    Size p. 145-151.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2017.11.013
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 51: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Efficient Cholesterol Transport in Dendritic Cells Defines Optimal Exogenous Antigen Presentation and Toxoplasma gondii Proliferation

    Cristina Croce / Facundo Garrido / Sofía Dinamarca / Julien Santi-Rocca / Sabrina Marion / Nicolas Blanchard / Luis S. Mayorga / Ignacio Cebrian

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: Dendritic cells are the most powerful antigen-presenting cells of the immune system. They present exogenous antigens associated with Major Histocompatibility Complex (MHC) Class II molecules through the classical pathway to stimulate CD4+ T cells, or ... ...

    Abstract Dendritic cells are the most powerful antigen-presenting cells of the immune system. They present exogenous antigens associated with Major Histocompatibility Complex (MHC) Class II molecules through the classical pathway to stimulate CD4+ T cells, or with MHC-I to activate CD8+ T lymphocytes through the cross-presentation pathway. DCs represent one of the main cellular targets during infection by Toxoplasma gondii. This intracellular parasite incorporates essential nutrients, such as cholesterol, to grow and proliferate inside a highly specialized organelle, the parasitophorous vacuole (PV). While doing so, T. gondii modulates the host immune response through multiple interactions with proteins and lipids. Cholesterol is an important cellular component that regulates cellular physiology at the structural and functional levels. Although different studies describe the relevance of cholesterol transport for exogenous antigen presentation, the molecular mechanism underlying this process is not defined. Here, we focus our study on the inhibitor U18666A, a drug widely used to arrest multivesicular bodies biogenesis that interrupts cholesterol trafficking and changes the lipid composition of intracellular membranes. Upon bone marrow-derived DC (BMDC) treatment with U18666A, we evidenced a drastic disruption in the ability to present exogenous soluble and particulate antigens to CD4+ and CD8+ T cells. Strikingly, the presentation of T. gondii-associated antigens and parasite proliferation were hampered in treated cells. However, neither antigen uptake nor BMDC viability was significantly affected by the U18666A treatment. By contrast, this drug altered the transport of MHC-I and MHC-II molecules to the plasma membrane. Since U18666A impairs the formation of MVBs, we analyzed in T. gondii infected BMDCs the ESCRT machinery responsible for the generation of intraluminal vesicles. We observed that different MVBs markers, including ESCRT proteins, were recruited to the PV. Surprisingly, the main ESCRT-III component CHMP4b ...
    Keywords dendritic cells ; cholesterol ; intraluminal vesicles ; multivesicular bodies ; CHMP4b ; Toxoplasma gondii ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Reassessing the Role of

    Bonner, Mark / Fresno, Manuel / Gironès, Núria / Guillén, Nancy / Santi-Rocca, Julien

    Frontiers in cellular and infection microbiology

    2018  Volume 8, Page(s) 379

    Abstract: ... The ... ...

    Abstract The protozoan
    MeSH term(s) Biota ; Entamoeba/growth & development ; Entamoeba/pathogenicity ; Gingiva/microbiology ; Gingiva/parasitology ; Humans ; Periodontitis/parasitology ; Periodontitis/physiopathology
    Language English
    Publishing date 2018-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2018.00379
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top