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  1. Book ; Thesis: Immobilisierungstechnik nach Hüftgelenk-rekonstruierenden Eingriffen

    Pisecky, Lorenz / Klotz, Matthias C. M.

    Ergebnisse von zehn Jahren Becken-Bein-Gips. Besteht Bedarf an alternativer Lagerungstechnik?

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Lorenz Pisecky ; Doktorvater: Herr Priv.-Doz. Dr. med. Matthias C. Klotz
    Language German
    Size 136 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    HBZ-ID HT021733291
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2023 E 395 order for loan Magazin

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  2. Article ; Online: Candida albicans Hyphal Morphogenesis within Macrophages Does Not Require Carbon Dioxide or pH-Sensing Pathways.

    Wilson, Hannah B / Lorenz, Michael C

    Infection and immunity

    2023  Volume 91, Issue 5, Page(s) e0008723

    Abstract: The opportunistic fungal pathogen Candida albicans has evolved a variety of mechanisms for surviving inside and escaping macrophages, including the initiation of filamentous growth. Although several distinct models have been proposed to explain this ... ...

    Abstract The opportunistic fungal pathogen Candida albicans has evolved a variety of mechanisms for surviving inside and escaping macrophages, including the initiation of filamentous growth. Although several distinct models have been proposed to explain this process at the molecular level, the signals driving hyphal morphogenesis in this context have yet to be clarified. Here, we evaluate the following three molecular signals as potential hyphal inducers within macrophage phagosomes: CO
    MeSH term(s) Candida albicans/metabolism ; Carbon Dioxide/metabolism ; Macrophages/microbiology ; Morphogenesis ; Hydrogen-Ion Concentration ; Hyphae ; Fungal Proteins/genetics ; Fungal Proteins/metabolism
    Chemical Substances Carbon Dioxide (142M471B3J) ; Fungal Proteins
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00087-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Candida auris

    Miramón, Pedro / Pountain, Andrew W / Lorenz, Michael C

    Infection and immunity

    2023  Volume 91, Issue 11, Page(s) e0027423

    Abstract: The pathogenic ... ...

    Abstract The pathogenic yeast
    MeSH term(s) Candida/genetics ; Candida auris ; Candida albicans ; Antifungal Agents/therapeutic use ; Macrophages/microbiology ; Candida parapsilosis
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00274-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Book: Strabismus - new concepts in pathophysiology, diagnosis, and treatment

    Brodsky, Michael C. / Lorenz, Birgit

    (Pediatric ophthalmology, neuro-ophthalmology, genetics ; 3)

    2010  

    Author's details ed. Birgit Lorenz ; Michael C. Brodsky
    Series title Pediatric ophthalmology, neuro-ophthalmology, genetics ; 3
    Collection
    Keywords Strabismus / diagnosis ; Strabismus / genetics ; Strabismus / therapy ; Child ; Infant
    Language German
    Size XVI, 231 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note Zählung stammt vom Buchrücken
    HBZ-ID HT017045057
    ISBN 978-3-540-85850-8 ; 9783540858515 ; 3-540-85850-4 ; 3540858512
    Database Catalogue ZB MED Medicine, Health

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    2011 A 4876 order for loan Magazin

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  5. Article ; Online: Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis.

    Guha, Shantanu / Cristy, Shane A / Buda De Cesare, Giuseppe / Cruz, Melissa R / Lorenz, Michael C / Garsin, Danielle A

    mBio

    2024  , Page(s) e0057024

    Abstract: Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by : Importance: Since the early 1980s, the incidence of ... ...

    Abstract Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by
    Importance: Since the early 1980s, the incidence of disseminated life-threatening fungal infections has been on the rise. Worldwide,
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00570-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multiple Alternative Carbon Pathways Combine To Promote Candida albicans Stress Resistance, Immune Interactions, and Virulence.

    Williams, Robert B / Lorenz, Michael C

    mBio

    2020  Volume 11, Issue 1

    Abstract: The phagocytic cells of the innate immune system are an essential first line of antimicrobial defense, and ... ...

    Abstract The phagocytic cells of the innate immune system are an essential first line of antimicrobial defense, and yet
    MeSH term(s) Animals ; Candida albicans/immunology ; Candida albicans/metabolism ; Candida albicans/pathogenicity ; Carbon/metabolism ; Cell Line ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Glucose/metabolism ; Host-Pathogen Interactions ; Macrophages/microbiology ; Metabolic Networks and Pathways ; Mice ; Oxidative Stress ; Phagosomes/metabolism ; Virulence
    Chemical Substances Fungal Proteins ; Carbon (7440-44-0) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.03070-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Application of Ion Chromatography for the Reliable Quantification of Ammonium in Electrochemical Ammonia Synthesis Experiments: A Practical Guide.

    Bragulla, Sebastian C H / Lorenz, Julian / Harms, Corinna / Wark, Michael / Friedrich, K Andreas

    ChemSusChem

    2023  Volume 16, Issue 13, Page(s) e202202211

    Abstract: Assessing novel electrocatalysts for the electrochemical ammonia synthesis (EAS) requires reliable quantitative trace analysis of electrochemically produced ammonia to infer activity and selectivity. This study concerns the development of an ion ... ...

    Abstract Assessing novel electrocatalysts for the electrochemical ammonia synthesis (EAS) requires reliable quantitative trace analysis of electrochemically produced ammonia to infer activity and selectivity. This study concerns the development of an ion chromatography (IC) method for quantitative trace analysis of ammonium in 0.1 M sulfuric acid electrolyte, which is applied to EAS gas-diffusion electrode (GDE) experiments with commercial chromium nitride as electrocatalyst. The developed IC method is highly sensitive, versatile, and reliable, achieving a limit of quantification (LOQ) of 6 μg l
    MeSH term(s) Ammonia ; Ammonium Compounds ; Chromatography/methods ; Sulfuric Acids
    Chemical Substances Ammonia (7664-41-7) ; sulfuric acid (O40UQP6WCF) ; Ammonium Compounds ; Sulfuric Acids
    Language English
    Publishing date 2023-05-05
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202202211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Conference proceedings: Proceedings of the 11th International Congress on the Archaeology of the Ancient Near East

    Otto, Adelheid / Herles, Michael / Kaniuth, Kai / Korn, Lorenz / Heidenreich, Anja

    Vol. 2: Field Reports. Islamic Archaeology

    2020  

    Keywords Ancient history: to c 500 CE ; History ; Classical Studies
    Language English
    Size 1 Online-Ressource
    Publisher Harrassowitz Verlag
    Document type Book ; Online ; Conference proceedings
    Note English
    HBZ-ID HT030612194
    ISBN 9783447113670 ; 3447113677
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: Charcot Neuroarthropathy Is Associated With Higher Rates of Phantom Limb After Lower Extremity Amputation.

    Nam, Hannah H / Martinazzi, Brandon J / Lorenz, F Jeffrey / Kirchner, Gregory J / Bonaddio, Vincenzo / Adeyemo, Adeshina / Walley, Kempland C / Aynardi, Michael C

    Foot & ankle specialist

    2024  , Page(s) 19386400241230597

    Abstract: Background: The incidence of phantom limb pain in patients with Charcot neuroarthropathy who undergo major amputation is not well described. The purpose of this study was to determine whether patients with Charcot neuroarthropathy and diabetes who ... ...

    Abstract Background: The incidence of phantom limb pain in patients with Charcot neuroarthropathy who undergo major amputation is not well described. The purpose of this study was to determine whether patients with Charcot neuroarthropathy and diabetes who underwent either a below-knee amputation (BKA) or above-knee amputation (AKA) had an increased rate of phantom limb pain compared with those with a diagnosis of diabetes alone.
    Methods: Using international classification of disease (ICD) and common procedural terminology (CPT) codes, the TriNetX research database identified 10 239 patients who underwent BKA and 6122 who underwent AKA between 2012 and 2022. Diabetic patients with and without Charcot neuroarthropathy were compared in terms of demographics and relative risk of developing phantom limb pain after AKA or BKA.
    Results: Age, sex, ethnicity, and race did not significantly differ between groups. Charcot neuroarthropathy was associated with significantly increased risk of phantom limb pain following both BKA (risk ratio [RR]: 1.2, 95% confidence interval [CI]: 1.1-1.3, P < .01) and AKA (RR: 1.6, 95% CI: 1.2-2.3, P < .0068).
    Conclusion: Our results indicate that patients with a coexisting diagnosis of Charcot neuroarthropathy who require BKA or AKA may have an increased risk of developing phantom limb pain.
    Levels of evidence: Level III.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2488579-4
    ISSN 1938-7636 ; 1938-6400
    ISSN (online) 1938-7636
    ISSN 1938-6400
    DOI 10.1177/19386400241230597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7037: Show issues Location:
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  10. Article ; Online: Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration.

    de Luzy, Isabelle R / Lee, Michael K / Mobley, William C / Studer, Lorenz

    Nature aging

    2024  Volume 4, Issue 3, Page(s) 309–318

    Abstract: Age remains the central risk factor for many neurodegenerative diseases including Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. Although the mechanisms of aging are complex, the age-related accumulation of senescent cells in ...

    Abstract Age remains the central risk factor for many neurodegenerative diseases including Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. Although the mechanisms of aging are complex, the age-related accumulation of senescent cells in neurodegeneration is well documented and their clearance can alleviate disease-related features in preclinical models. Senescence-like characteristics are observed in both neuronal and glial lineages, but their relative contribution to aging and neurodegeneration remains unclear. Human pluripotent stem cell-derived neurons provide an experimental model system to induce neuronal senescence. However, the extensive heterogeneity in the profile of senescent neurons and the methods to assess senescence remain major challenges. Here, we review the evidence of cellular senescence in neuronal aging and disease, discuss human pluripotent stem cell-based model systems used to investigate neuronal senescence and propose a panel of cellular and molecular hallmarks to characterize senescent neurons. Understanding the role of neuronal senescence may yield novel therapeutic opportunities in neurodegenerative disease.
    MeSH term(s) Humans ; Neurodegenerative Diseases ; Aging ; Cellular Senescence/physiology ; Neurons ; Pluripotent Stem Cells
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-024-00586-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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