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  1. Article ; Online: Endovascular Embolization of Intracranial Meningiomas.

    Lin, Michelle / Nguyen, Vincent / Mack, William J

    Neurosurgery clinics of North America

    2023  Volume 34, Issue 3, Page(s) 371–380

    Abstract: Although benign in histology, the hypervascularity and skull base location of meningiomas can make them surgically challenging lesions. Preoperative endovascular embolization with superselective microcatheterization of vascular pedicles may be ... ...

    Abstract Although benign in histology, the hypervascularity and skull base location of meningiomas can make them surgically challenging lesions. Preoperative endovascular embolization with superselective microcatheterization of vascular pedicles may be efficacious in decreasing intraoperative transfusion requirements with equivocal postoperative functional benefit. The potential benefits of preoperative embolization should be weighed against the risks of ischemic complications. Appropriate patient selection is critical. All patients should be monitored closely postembolization, and a course of steroids can be considered to minimize neurologic symptoms.
    MeSH term(s) Humans ; Meningioma/surgery ; Meningeal Neoplasms/surgery ; Skull Base ; Embolization, Therapeutic ; Endovascular Procedures
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2023.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Measuring PROMIS Asthma Impact cut point scores for identifying uncontrolled asthma in children.

    Burbank, Allison J / Lucas, Nicole / Lin, Li / Hernandez, Michelle L / Reeve, Bryce B

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 12, Page(s) 3783–3785

    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.08.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Geographic Variation in Colorectal Cancer Incidence Among Asian Americans: A Population-Based Analysis 2006-2016.

    Wang, Christina P / Lin, Jenny J / Shah, Shailja C / Kim, Michelle Kang

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2022  Volume 21, Issue 2, Page(s) 543–545.e3

    Abstract: Among Asian Americans, cancer is the leading cause of death and colorectal cancer (CRC) is the second most common cancer. ...

    Abstract Among Asian Americans, cancer is the leading cause of death and colorectal cancer (CRC) is the second most common cancer.
    MeSH term(s) Humans ; United States/epidemiology ; Asian ; Incidence ; Ethnicity ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Early Detection of Cancer
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2022.01.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rates of operative intervention and in-hospital mortality following subarachnoid hemorrhage in patients with COVID-19.

    Dallas, Jonathan / Fixman, Benjamin / Ding, Li / Lin, Michelle / Nguyen, Vincent N / Attenello, Frank J / Mack, William J

    Journal of neurosurgery

    2024  , Page(s) 1–11

    Abstract: Objective: COVID-19 had massive effects on the healthcare system and multifactorial implications for the management of intensive care unit and cerebrovascular patients. This study aimed to assess the effect of COVID-19 on the outcomes of patients with ... ...

    Abstract Objective: COVID-19 had massive effects on the healthcare system and multifactorial implications for the management of intensive care unit and cerebrovascular patients. This study aimed to assess the effect of COVID-19 on the outcomes of patients with aneurysmal subarachnoid hemorrhage (SAH).
    Methods: The National Inpatient Sample (NIS) was used to identify patients with nontraumatic SAH (ICD-10 code I60.x). Patients with nonaneurysmal cerebrovascular malformations or traumatic intracranial injuries were excluded. Only patients managed from April to December 2020 were included in the study given the availability of an ICD-10 code for COVID-19. Data on sociodemographic factors, hospital characteristics, comorbidities, NIS SAH Severity Score (NIS-SSS), surgical treatment, and death were acquired. Multivariable analysis was used to assess predictors of both surgical intervention and in-hospital mortality.
    Results: In total, 6984 patients met the study criteria, 359 (5.1%) of whom had COVID-19. Those with COVID-19 were more likely to be younger and male and had a higher All Patient Refined Diagnosis-Related Groups illness severity subclass, and NIS-SSS. Moreover, patients with COVID-19 were less likely to undergo surgery (10.0% vs 23.6%, OR 0.35, p < 0.0001) and had significantly higher mortality rates (48.2% vs 22.7%, p < 0.0001). When controlling for other variables, COVID-19 was an independent predictor of death (OR 1.67, p = 0.0002). Aneurysm surgery was performed in 1597 patients (317 open and 1280 endovascular procedures). There was no difference between the cohorts positive and negative for COVID-19 in terms of time to surgery or type of surgery.
    Conclusions: COVID-19 had significant impacts on patients with nontraumatic SAH. Specifically, patients with COVID-19 were significantly less likely to undergo surgery and had higher in-hospital mortality rates; however, for patients who did undergo procedural intervention, there was no significant difference in the type of intervention. Multiple factors, from medical acuity to healthcare system limitations, may contribute to these findings. Further retrospective research is needed to identify both specific causes of lower intervention rates and other potential nonaneurysmal causes of SAH in patients with COVID-19.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2024.1.JNS231734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Outcomes following perioperative red blood cell transfusion in patients undergoing elective major abdominal surgery: a systematic review and meta-analysis.

    Morris, Fraser J D / Fung, Yoke-Lin / Craswell, Alison / Chew, Michelle S

    British journal of anaesthesia

    2023  Volume 131, Issue 6, Page(s) 1002–1013

    Abstract: Background: Perioperative red blood cell transfusion is a double-edged sword for surgical patients. While transfusion of red cells can increase oxygen delivery by increasing haemoglobin levels, its impact on short- and long-term postoperative outcomes, ... ...

    Abstract Background: Perioperative red blood cell transfusion is a double-edged sword for surgical patients. While transfusion of red cells can increase oxygen delivery by increasing haemoglobin levels, its impact on short- and long-term postoperative outcomes, particularly in patients undergoing elective major abdominal surgery, is unclear.
    Methods: We conducted a systematic review and meta-analysis on the effect of perioperative blood transfusions on postoperative outcomes in elective major abdominal surgery. PubMed, Cochrane, and Scopus databases were searched for studies with data collected between January 1, 2000 and June 6, 2020. The primary outcome was short-term mortality, including all-cause 30-day or in-hospital mortality. Secondary outcomes included long-term all-cause mortality, any morbidity, infectious complications, overall survival, and recurrence-free survival. No randomised controlled trials were found. Thirty-nine observational studies were identified, of which 37 were included in the meta-analysis.
    Results: Perioperative blood transfusion was associated with short-term all-cause mortality (odds ratio [OR] 2.72, 95% confidence interval [CI] 1.89-3.91, P<0.001), long-term all-cause mortality (hazard ratio 1.35, 95% CI 1.09-1.67, P=0.007), any morbidity (OR 2.18, 95% CI 1.81-2.64, P<0.001), and infectious complications (OR 1.90, 95% CI 1.60-2.26, P<0.001). Perioperative blood transfusion remained associated with short-term mortality in the sensitivity analysis after excluding studies that did not control for preoperative anaemia (OR 2.27, 95% CI 1.59-3.24, P<0.001).
    Conclusions: Perioperative blood transfusion in patients undergoing elective major abdominal surgery is associated with poorer short- and long-term postoperative outcomes. This highlights the need to implement patient blood management strategies to manage and preserve the patient's own blood and reduce the need for red blood cell transfusion.
    Trial registration: PROSPERO (CRD42021254360).
    MeSH term(s) Humans ; Erythrocyte Transfusion/adverse effects ; Anemia ; Blood Transfusion ; Elective Surgical Procedures ; Hospital Mortality
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.08.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Awake ripples enhance emotional memory encoding in the human brain.

    Zhang, Haoxin / Skelin, Ivan / Ma, Shiting / Paff, Michelle / Mnatsakanyan, Lilit / Yassa, Michael A / Knight, Robert T / Lin, Jack J

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 215

    Abstract: Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory ... ...

    Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events.
    MeSH term(s) Humans ; Wakefulness/physiology ; Hippocampus/physiology ; Amygdala/physiology ; Emotions ; Electrophysiological Phenomena ; Memory Consolidation/physiology
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44295-8
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  7. Article ; Online: Development of multifocal glioblastoma after radiotherapy for craniopharyngioma: illustrative case.

    Yuan, Edith / Lin, Michelle / Min, Elliot / Liu, Kristie / Attenello, Frank J

    Journal of neurosurgery. Case lessons

    2023  Volume 5, Issue 26

    Abstract: Background: Radiation-induced glioblastoma (GBM) in patients previously treated for craniopharyngioma is a rare phenomenon. To the authors' knowledge, only seven cases have previously been documented in the literature.: Observations: Herein, the ... ...

    Abstract Background: Radiation-induced glioblastoma (GBM) in patients previously treated for craniopharyngioma is a rare phenomenon. To the authors' knowledge, only seven cases have previously been documented in the literature.
    Observations: Herein, the authors report a case of a patient presenting with a new diagnosis of multifocal GBM 15 years after having received adjuvant radiotherapy for a craniopharyngioma. Magnetic resonance imaging revealed an extensive enhancing infiltrative lesion in the right frontal lobe as well as two satellite lesions in the contralateral frontal lobe. Histopathology on biopsy was consistent with GBM.
    Lessons: Even though this case is rare, it is nevertheless important to recognize GBM as a potential side effect of radiation. Long-term follow-up in postradiation craniopharyngioma patients is crucial for early detection.
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE2377
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  8. Article ; Online: Awake ripples enhance emotional memory encoding in the human brain

    Haoxin Zhang / Ivan Skelin / Shiting Ma / Michelle Paff / Lilit Mnatsakanyan / Michael A. Yassa / Robert T. Knight / Jack J. Lin

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Volume 13

    Abstract: Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional ... ...

    Abstract Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events.
    Keywords Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Dexamethasone Intracanalicular Insert for Clinically Significant Aqueous-Deficient Dry Eye: A Randomized Controlled Trial.

    Lin, Michael / Guo, Lee / Saldanha, Ian J / VanCourt, Shanna / Zeng, Julia / Karakus, Sezen / Hessen, Michelle / Li, Gavin / Akpek, Esen K

    Ophthalmology

    2024  

    Abstract: Purpose: To evaluate a commercially available dexamethasone intracanalicular insert to treat dry eye.: Design: Single-center, double-masked, randomized controlled trial.: Participants: Patients with clinically significant aqueous-deficient dry eye ...

    Abstract Purpose: To evaluate a commercially available dexamethasone intracanalicular insert to treat dry eye.
    Design: Single-center, double-masked, randomized controlled trial.
    Participants: Patients with clinically significant aqueous-deficient dry eye [combined ocular surface staining score ≥3 (0-12), corneal fluorescein staining ≥2 (0-6), and Schirmer's wetting <10 mm at 5 minutes in both eyes] with symptoms (dryness, eye discomfort, or visual fatigue, ≥30 [0-100]) despite treatment with at least one prescription drop and deemed candidate for topical steroid.
    Methods: Seventy-five adult patients were enrolled. A 1:1 randomization sequence was used to determine which eye of each patient would receive the treatment (dexamethasone 0.4 mg intracanalicular insert with 30-day elution time) or the sham (collagen plug). The fellow eye received the opposite treatment. Patients were masked to treatment assignment. Follow-up visits (at weeks 2, 4, and 6) were performed by a masked investigator.
    Main outcome measures: Dry eye parameters and patient symptoms were used for efficacy and intraocular pressure (IOP) was used for safety assessment.
    Results: The severity of dry eye was comparable between the treatment arms (fellow eyes) at baseline. Eyes that received the dexamethasone insert had significantly less corneal staining at week 4 (mean difference [MD] -0.55, 95% confidence interval [CI] = -0.91, -0.19) and conjunctival staining at week 4 (MD -0.68, 95% CI = -1.05, -0.30) and week 6 (MD -0.34, 95% CI = -0.65, -0.02). Schirmer's wetting was comparable between the two treatment arms. Although the patients reported less dryness in eyes that received the insert at week 4 (MD -5.5, 95% CI = -11.4, 0.4), there were no statistically significant differences in any patient-reported symptoms. At week 4, dexamethasone-treated eyes were more likely to experience an IOP increase (by 5-10 mm Hg) (9 eyes vs. 1 eye; relative risk [RR] = 9.00, 95% CI = 1.14, 71.0; due to sparse events, the CI was very wide). All cases of increased IOP were managed with short-term topical beta blockers and subsided.
    Conclusions: Dexamethasone intracanalicular insert may be considered a dropless dual treatment for clinically significant aqueous-deficient dry eye when topical steroid treatment is deemed appropriate.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2024.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Commentary: Early Experience With Virtual and Synchronized Augmented Reality Platform for Preoperative Planning and Intraoperative Navigation: A Case Series.

    Yuan, Edith / Lin, Michelle / Han, Jane S / Attenello, Frank J

    Operative neurosurgery (Hagerstown, Md.)

    2021  Volume 21, Issue 5, Page(s) E457–E458

    MeSH term(s) Augmented Reality ; Humans ; Surgery, Computer-Assisted ; Virtual Reality
    Language English
    Publishing date 2021-08-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opab294
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