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  1. Article ; Online: Poor Performance of Masks Secured Using Ear Loops.

    Yung, Chee Fu

    JAMA internal medicine

    2020  Volume 181, Issue 2, Page(s) 294

    MeSH term(s) COVID-19 ; Humans ; Masks ; SARS-CoV-2
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.6393
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  2. Article ; Online: Estimation of trajectory of protective efficacy in infectious disease prevention trials using recurrent event times.

    Cheung, Yin Bun / Ma, Xiangmei / Lam, K F / Yung, Chee Fu / Milligan, Paul

    Statistics in medicine

    2024  Volume 43, Issue 9, Page(s) 1759–1773

    Abstract: In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to ... ...

    Abstract In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one-off or continual intervention. Accurate information on the trajectory of the level of protective efficacy over time facilitates informed clinical recommendations and implementation strategies, for example, with respect to the timing of administration of the doses. Based on concepts from pharmacokinetic and pharmacodynamic modeling, we propose a non-linear function for modeling the trajectory after each dose. The cumulative effect of multiple doses of the products is captured by an additive series of the function. The model has the advantages of parsimony and interpretability, while remaining flexible in capturing features of the trajectories. We incorporate this series into the Andersen-Gill model for analysis of recurrent event time data and compare it with alternative parametric and non-parametric functions. We use data on clinical malaria disease episodes from a trial of four doses of an anti-malarial drug combination for chemoprevention to illustrate, and evaluate the performance of the methods using simulation. The proposed method out-performed the alternatives in the analysis of real data in terms of Akaike and Bayesian Information Criterion. It also accurately captured the features of the protective efficacy trajectory such as the area under curve in simulations. The proposed method has strong potential to enhance the evaluation of disease prevention measures and improve their implementation strategies.
    MeSH term(s) Humans ; Bayes Theorem ; Antimalarials ; Malaria/drug therapy ; Computer Simulation ; Communicable Diseases
    Chemical Substances Antimalarials
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.10049
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  3. Article: Combating a resurgence of poliomyelitis through public health surveillance and vaccination.

    Chong, Chia Yin / Kam, Kai Qian / Yung, Chee Fu

    Annals of the Academy of Medicine, Singapore

    2022  Volume 52, Issue 1, Page(s) 17–26

    Abstract: Poliomyelitis, or polio, is a highly infectious disease and can result in permanent flaccid paralysis of the limbs. Singapore was certified polio-free by the World Health Organization (WHO) on 29 October 2000, together with 36 other countries in the ... ...

    Abstract Poliomyelitis, or polio, is a highly infectious disease and can result in permanent flaccid paralysis of the limbs. Singapore was certified polio-free by the World Health Organization (WHO) on 29 October 2000, together with 36 other countries in the Western Pacific Region. The last imported case of polio in Singapore was in 2006. Fortunately, polio is vaccine-preventable-the world saw the global eradication of wild poliovirus types 2 and 3 achieved in 2015 and 2019, respectively. However, in late 2022, a resurgence of paralytic polio cases from vaccine-derived poliovirus (VDPV) was detected in countries like Israel and the US (specifically, New York); VDPV was also detected during routine sewage water surveillance with no paralysis cases in London, UK. Without global eradication, there is a risk of re-infection from importation and spread of wild poliovirus or VDPV, or new emergence and circulation of VDPV. During the COVID-19 pandemic, worldwide routine childhood vaccination coverage fell by 5% to 81% in 2020-2021. Fortunately, Singapore has maintained a constantly high vaccination coverage of 96% among 1-year-old children as recorded in 2021. All countries must ensure high poliovirus vaccination coverage in their population to eradicate poliovirus globally, and appropriate interventions must be taken to rectify this if the coverage falters. In 2020, WHO approved the emergency use listing of a novel oral polio vaccine type 2 for countries experiencing circulating VDPV type 2 outbreaks. Environmental and wastewater surveillance should be implemented to allow early detection of "silent" poliovirus transmission in the population, instead of relying on clinical surveillance of acute flaccid paralysis based on case definition alone.
    MeSH term(s) Child ; Humans ; Infant ; Public Health Surveillance ; Pandemics ; Wastewater ; Wastewater-Based Epidemiological Monitoring ; COVID-19/epidemiology ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Poliovirus ; Poliovirus Vaccine, Oral ; Vaccination ; Global Health
    Chemical Substances Wastewater ; Poliovirus Vaccine, Oral
    Language English
    Publishing date 2022-12-27
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    DOI 10.47102/annals-acadmedsg.2022390
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  4. Article ; Online: Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination.

    Chong, Chia-Yin / Kam, Kai-Qian / Zhang, Jinyan / Bertoletti, Antonio / Hariharaputran, Smrithi / Sultana, Rehena / Piragasam, Rupini / Mah, Yun-Yan / Tan, Chee-Wah / Wang, Linfa / Yung, Chee-Fu

    Vaccine

    2024  Volume 42, Issue 12, Page(s) 2951–2954

    Abstract: Heterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent ... ...

    Abstract Heterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent boosters with 2 doses of Sinovac-CoronaVac vaccines achieved neutralizing antibody levels which were comparable to those who had received 2 doses of Pfizer-BNT162b2 vaccines followed by 1 dose of Sinovac-CoronaVac vaccination. Adolescents with 1 Pfizer-BNT162b2 followed by 2 Sinovac-CoronaVac vaccines developed T-cell responses against broad peptides including membrane, nucleoprotein 1 and 2 but levels were highest for Spike protein and lasted until day 150 post-vaccination.
    MeSH term(s) Adolescent ; Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine/adverse effects ; Vaccination/adverse effects ; Vaccines, Inactivated/adverse effects ; Child
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; sinovac COVID-19 vaccine ; Vaccines, Inactivated
    Language English
    Publishing date 2024-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.04.011
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  5. Article ; Online: Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5.

    Tan, Chee-Wah / Lim, Beng-Lee / Young, Barnaby E / Yeoh, Aileen Ying-Yan / Yung, Chee-Fu / Yap, Wee-Chee / Althaus, Thomas / Chia, Wan-Ni / Zhu, Feng / Lye, David Chien / Wang, Lin-Fa

    The Lancet. Microbe

    2022  Volume 3, Issue 12, Page(s) e898

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00220-8
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  6. Article ; Online: Non-specific effects of childhood vaccines.

    Yung, Chee Fu

    BMJ (Clinical research ed.)

    2016  Volume 355, Page(s) i5434

    MeSH term(s) BCG Vaccine/administration & dosage ; BCG Vaccine/immunology ; Child, Preschool ; Communicable Disease Control/organization & administration ; Diphtheria-Tetanus-Pertussis Vaccine/administration & dosage ; Diphtheria-Tetanus-Pertussis Vaccine/immunology ; Female ; Humans ; Immunity, Heterologous/immunology ; Infant ; Male ; Measles Vaccine/administration & dosage ; Measles Vaccine/immunology ; Pediatrics ; Reproducibility of Results ; Risk Assessment ; Sensitivity and Specificity ; Vaccination/standards ; World Health Organization
    Chemical Substances BCG Vaccine ; Diphtheria-Tetanus-Pertussis Vaccine ; Measles Vaccine
    Language English
    Publishing date 2016-10-13
    Publishing country England
    Document type Comparative Study ; Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.i5434
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  7. Article ; Online: Ebola: evaluating vaccines during epidemics.

    Yung, Chee Fu

    BMJ (Clinical research ed.)

    2015  Volume 351, Page(s) h3861

    MeSH term(s) Disease Outbreaks/prevention & control ; Ebola Vaccines ; Female ; Hemorrhagic Fever, Ebola/prevention & control ; Humans ; Male ; Vaccination/methods
    Chemical Substances Ebola Vaccines
    Language English
    Publishing date 2015-07-29
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.h3861
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  8. Article ; Online: A 12 year outbreak of scarlet fever in Singapore.

    Yung, Chee Fu / Thoon, Koh Cheng

    The Lancet. Infectious diseases

    2018  Volume 18, Issue 9, Page(s) 942

    MeSH term(s) China ; Disease Outbreaks ; Humans ; Scarlet Fever/epidemiology ; Singapore
    Language English
    Publishing date 2018-08-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(18)30464-X
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  9. Article ; Online: A country-specific model of COVID-19 vaccination coverage needed for herd immunity in adult only or population wide vaccination programme.

    Goh, Fang Ting / Chew, Yi Zhen / Tam, Clarence C / Yung, Chee Fu / Clapham, Hannah

    Epidemics

    2022  Volume 39, Page(s) 100581

    Abstract: We present a country specific method to calculate the COVID-19 vaccination coverage needed for herd immunity by considering age structure, age group-specific contact patterns, relative infectivity and susceptibility of children to adults, vaccination ... ...

    Abstract We present a country specific method to calculate the COVID-19 vaccination coverage needed for herd immunity by considering age structure, age group-specific contact patterns, relative infectivity and susceptibility of children to adults, vaccination effectiveness and seroprevalence prior to vaccination. We find that across all six countries, vaccination of adults age 60 and above has little impact on R
    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Humans ; Immunity, Herd ; Middle Aged ; Seroepidemiologic Studies ; Vaccination/methods ; Vaccination Coverage
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-05-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467993-8
    ISSN 1878-0067 ; 1755-4365
    ISSN (online) 1878-0067
    ISSN 1755-4365
    DOI 10.1016/j.epidem.2022.100581
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  10. Article ; Online: Modelling non-linear patterns of time-varying intervention effects on recurrent events in infectious disease prevention studies.

    Cheung, Yin Bun / Ma, Xiangmei / Lam, K F / Yung, Chee Fu / Milligan, Paul

    Journal of biopharmaceutical statistics

    2022  Volume 33, Issue 2, Page(s) 220–233

    Abstract: Protective efficacy of vaccines and pharmaceutical products for prevention of infectious diseases usually vary over time. Information on the trajectory of the level of protection is valuable. We consider a parsimonious, non-linear and non-monotonic ... ...

    Abstract Protective efficacy of vaccines and pharmaceutical products for prevention of infectious diseases usually vary over time. Information on the trajectory of the level of protection is valuable. We consider a parsimonious, non-linear and non-monotonic function for modelling time-varying intervention effects and compare it with several alternatives. The cumulative effects of multiple doses of intervention over time can be captured by an additive series of the function. We apply it to the Andersen-Gill model for analysis of recurrent time-to-event data. We re-analyze data from a trial of intermittent preventive treatment for malaria to illustrate and evaluate the method by simulation.
    MeSH term(s) Humans ; Computer Simulation ; Communicable Diseases ; Vaccines ; Recurrence
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1131763-2
    ISSN 1520-5711 ; 1054-3406
    ISSN (online) 1520-5711
    ISSN 1054-3406
    DOI 10.1080/10543406.2022.2108826
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