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Article: How COVID-19 can cause autonomic dysfunctions and postural orthostatic syndrome? A Review of mechanisms and evidence.

Hassani, Mehran / Fathi Jouzdani, Ali / Motarjem, Sara / Ranjbar, Akram / Khansari, Nakisa

Neurology and clinical neuroscience

2021 Volume 9, Issue 6, Page(s) 434–442

Abstract: Coronavirus disease 2019 (COVID-19) is a viral disease spread by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because the recent pandemic has resulted in significant morbidity and mortality, understanding various aspects of this disease ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is a viral disease spread by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because the recent pandemic has resulted in significant morbidity and mortality, understanding various aspects of this disease has become critical. SARS-CoV-2 can affect a variety of organs and systems in the body. The autonomic nervous system plays an important role in regulating body functions, and its dysfunction can cause a great deal of discomfort for patients. In this study, we focused on the effect of COVID-19 on the autonomic system and syndromes associated with it, such as postural orthostatic syndrome (POTS).
Language	English
Publishing date	2021-10-26
Publishing country	England
Document type	Journal Article ; Review
ISSN	2049-4173
ISSN	2049-4173
DOI	10.1111/ncn3.12548
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Article ; Online: Aneuploidy Rate and Stemness in Low-Level Mosaic Human Embryonic Stem Cells in the Presence/Absence of Bortezomib, Paclitaxel, and Lapatinib.

Khademi, Nazanin Sadat / Farivar, Shirin / Bazrgar, Masood / Hassani, Seyedeh-Nafiseh / Masoudi, Najmeh Sadat / Haghparast, Newsha / Rezaei Larijani, Mehran

Cells, tissues, organs

2022 Volume 213, Issue 1, Page(s) 17–23

Abstract: Human embryonic stem cells (hESCs) are predisposed to aneuploidy through continual passages. Some reports indicate more sensitivity of aneuploid hESCs cells to anticancer drugs. The present study was designed to investigate the cytotoxicity of three ... ...

Abstract	Human embryonic stem cells (hESCs) are predisposed to aneuploidy through continual passages. Some reports indicate more sensitivity of aneuploid hESCs cells to anticancer drugs. The present study was designed to investigate the cytotoxicity of three anticancer drugs (including bortezomib, paclitaxel, and lapatinib) and their effect on aneuploidy rate in hESCs. To create a low-level mosaic cell line, normal hESCs (80%) and trisomic hESCs for chromosomes 12 and 17 (20%) were mixed. The effect of the 3 mentioned anticancer drugs on the chromosomal status was assessed by metaphase spread analysis after selection of the nontoxic conditions. Expression of pluripotency genes was analyzed, and an alkaline phosphatase test was performed to assess pluripotency preservation. Our data showed that treatment with bortezomib, paclitaxel, and lapatinib was nontoxic at 0.01, 0.01, and 0.2 μ<sc>M</sc> concentrations, respectively. Alkaline phosphatase and pluripotency gene expression analyses revealed maintenance of pluripotency following treatment with above-noted nontoxic concentrations. Aneuploid cells were dominant in treated and control groups with a minimum abundance of 70%, with no significant differences between groups. Drug treatments had no negative effect on pluripotency. Insensitivity of aneuploid cells in treatment groups could be related to the specific characteristics of each cell line in response to the drug and the proliferative superiority of cells with trisomies 12 and 17.
MeSH term(s)	Humans ; Human Embryonic Stem Cells/metabolism ; Lapatinib/pharmacology ; Lapatinib/metabolism ; Bortezomib/pharmacology ; Bortezomib/metabolism ; Paclitaxel/pharmacology ; Paclitaxel/metabolism ; Alkaline Phosphatase/metabolism ; Cell Differentiation ; Aneuploidy ; Antineoplastic Agents/metabolism
Chemical Substances	Lapatinib (0VUA21238F) ; Bortezomib (69G8BD63PP) ; Paclitaxel (P88XT4IS4D) ; Alkaline Phosphatase (EC 3.1.3.1) ; Antineoplastic Agents
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1468141-9
ISSN	1422-6421 ; 1422-6405
ISSN (online)	1422-6421
ISSN	1422-6405
DOI	10.1159/000526199
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Article ; Online: The effect of flaxseed supplementation on circulating adiponectin and leptin concentration in adults: A systematic review and meta-analysis of randomized controlled trials.

Jalili, Cyrus / Pezeshki, Mehran / Askarpour, Moein / Marx, Wolfgang / Hassani, Bahar / Hadi, Amir / Ghaedi, Ehsan

Phytotherapy research : PTR

2020 Volume 34, Issue 7, Page(s) 1578–1586

Abstract: Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of flaxseed supplementation on serum adiponectin and leptin concentration.: Methods: Electronic searches were ... ...

Abstract	Objective: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of flaxseed supplementation on serum adiponectin and leptin concentration. Methods: Electronic searches were performed in PubMed, Scopus, Web of Science, and Google Scholar up to May 2019 without any restriction. All RCTs that reported the effect of flaxseed supplementation on circulating adiponectin and leptin concentration were included. A random-effects model was used to pool calculated effect sizes. Results: Nine RCTs (11 arms) were eligible to be included. Our analysis showed that flaxseed supplementation did not significantly affect adiponectin (weighted mean difference [WMD]: 0.15 μg/ml; 95% CI [-0.16, 0.47], p = .34) and leptin (WMD: 0.47 ng/ml; 95% CI [-3.10, 4.06], p = .79) concentration in comparison with control. Furthermore, subgroup analysis revealed that effects remained nonsignificant in all subgroups of trial duration, flaxseed type, and health status of participants. The pooled effect size was also robust and remained nonsignificant in the sensitivity analysis. Conclusion: Flaxseed supplementation had no significant effect on adiponectin and leptin levels in adults. However, future well-designed trials are still needed to confirm these results.
MeSH term(s)	Adiponectin/blood ; Dietary Supplements/analysis ; Flax/chemistry ; Humans ; Leptin/blood ; Randomized Controlled Trials as Topic
Chemical Substances	Adiponectin ; Leptin
Language	English
Publishing date	2020-02-12
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6634
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Article ; Online: The analysis and forecasting of male cycling time trial records established within England and Wales.

Dyer, Bryce / Hassani, Hossein / Shadi, Mehran

Journal of sports sciences

2016 Volume 34, Issue 13, Page(s) 1222–1230

Abstract: The format of cycling time trials in England, Wales and Northern Ireland, involves riders competing individually over several fixed race distances of 10-100 miles in length and using time constrained formats of 12 and 24 h in duration. Drawing on data ... ...

Abstract	The format of cycling time trials in England, Wales and Northern Ireland, involves riders competing individually over several fixed race distances of 10-100 miles in length and using time constrained formats of 12 and 24 h in duration. Drawing on data provided by the national governing body that covers the regions of England and Wales, an analysis of six male competition record progressions was undertaken to illustrate its progression. Future forecasts are then projected through use of the Singular Spectrum Analysis technique. This method has not been applied to sport-based time series data before. All six records have seen a progressive improvement and are non-linear in nature. Five records saw their highest level of record change during the 1950-1969 period. Whilst new record frequency generally has reduced since this period, the magnitude of performance improvement has generally increased. The Singular Spectrum Analysis technique successfully provided forecasted projections in the short to medium term with a high level of fit to the time series data.
MeSH term(s)	Athletic Performance/trends ; Bicycling/trends ; England ; Forecasting ; Humans ; Male ; Wales
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article
ZDB-ID	995528-8
ISSN	1466-447X ; 0264-0414
ISSN (online)	1466-447X
ISSN	0264-0414
DOI	10.1080/02640414.2015.1105378
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Article: The effect of flaxseed supplementation on circulating adiponectin and leptin concentration in adults: A systematic review and meta‐analysis of randomized controlled trials

Jalili, Cyrus / Pezeshki, Mehran / Askarpour, Moein / Marx, Wolfgang / Hassani, Bahar / Hadi, Amir / Ghaedi, Ehsan

Phytotherapy research. 2020 July, v. 34, no. 7

2020

Abstract: OBJECTIVE: Our objective was to perform a systematic review and meta‐analysis on randomized controlled trials (RCTs) assessing the effect of flaxseed supplementation on serum adiponectin and leptin concentration. METHODS: Electronic searches were ... ...

Abstract	OBJECTIVE: Our objective was to perform a systematic review and meta‐analysis on randomized controlled trials (RCTs) assessing the effect of flaxseed supplementation on serum adiponectin and leptin concentration. METHODS: Electronic searches were performed in PubMed, Scopus, Web of Science, and Google Scholar up to May 2019 without any restriction. All RCTs that reported the effect of flaxseed supplementation on circulating adiponectin and leptin concentration were included. A random‐effects model was used to pool calculated effect sizes. RESULTS: Nine RCTs (11 arms) were eligible to be included. Our analysis showed that flaxseed supplementation did not significantly affect adiponectin (weighted mean difference [WMD]: 0.15 μg/ml; 95% CI [−0.16, 0.47], p = .34) and leptin (WMD: 0.47 ng/ml; 95% CI [−3.10, 4.06], p = .79) concentration in comparison with control. Furthermore, subgroup analysis revealed that effects remained nonsignificant in all subgroups of trial duration, flaxseed type, and health status of participants. The pooled effect size was also robust and remained nonsignificant in the sensitivity analysis. CONCLUSION: Flaxseed supplementation had no significant effect on adiponectin and leptin levels in adults. However, future well‐designed trials are still needed to confirm these results.
Keywords	adiponectin ; adults ; blood serum ; duration ; health status ; leptin ; linseed ; meta-analysis ; phytotherapy ; randomized clinical trials ; research ; statistical models ; systematic review
Language	English
Dates of publication	2020-07
Size	p. 1578-1586.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	NAL-light ; REVIEW
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6634
Database	NAL-Catalogue (AGRICOLA)

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Article: Salicylic acid mediated protection of Brassica campestris sp. chinensis from saline stress via SA receptor NPR1 dependent transcriptional regulation and biosynthesis of related biochemicals

Khalid, Muhammad / Saeed-ur-Rahman / Ali, Mehran / Hassani, Danial / Rauf, Abdur / Jan, Farooq / Hui, Nan

Environmental technology & innovation. 2021 Nov., v. 24

2021

Abstract: Salt stress has a significant impact on plant physiological processes and morphology, resulting in reduced plant performance. This study aimed to evaluate the hormonal regulation of Pakchoi (Brassica campestris spp. chinensis) in response to saline ... ...

Abstract	Salt stress has a significant impact on plant physiological processes and morphology, resulting in reduced plant performance. This study aimed to evaluate the hormonal regulation of Pakchoi (Brassica campestris spp. chinensis) in response to saline stress imposition and exogenous salicylic acid application, focusing on morphological and physiological parameters. Saline stress imposition altered the concentration of endogenous hormonal levels, as demonstrated by Jasmonic acid (JA) and abscisic acid (ABA). Alterations in the level of plant hormones coincided with the enhanced reactive oxygen species (ROS) generation and proline accumulation followed by redox imbalances. Proline biosynthesis and antioxidative enzymes were significantly elevated with SA pretreatment. SA augmented stress responses are corroborated by the upregulation of SA signaling genes (NPR1 and PR-1) and with a repressive effect on the expression of JA and ABA synthesis-related genes (NCED3, MYC2, PDF1.2). Moreover, the concerted action of SA-mediated genes might be associated with upregulation of flavonoid biosynthesis pathway genes (FLS, CHS, CHI, F3H and ANS), resulting in an enhanced level of phenolic compounds in SA pre-treated plants. A substantial scavenging property is attributed to phenolic compounds for the maintenance of cellular redox status. The results suggest that SA receptor NPR1 dependent transcriptional regulation and biosynthesis of related biochemicals are collaborative processes to counteract the adverse effects of salinity and maintain plant cellular redox homeostasis.
Keywords	Brassica rapa subsp. chinensis ; Brassica rapa subsp. oleifera ; abscisic acid ; biosynthesis ; environmental technology ; flavonoids ; homeostasis ; hormonal regulation ; jasmonic acid ; proline ; reactive oxygen species ; salicylic acid ; salinity ; salt stress ; transcription (genetics)
Language	English
Dates of publication	2021-11
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2352-1864
DOI	10.1016/j.eti.2021.101950
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An Overview of the Running Performance of Athletes with Lower-Limb Amputation at the Paralympic Games 2004–2012

Hossein Hassani / Mansi Ghodsi / Mehran Shadi / Siamak Noroozi / Bryce Dyer

Sports, Vol 3, Iss 2, Pp 103-

2015 Volume 115

Abstract: This paper analyses the performances of lower-limb amputees in the 100, 200 and 400 m running events from the 2004, 2008 and 2012 Paralympic Games. In this paper, four hypotheses are pursued. In the first, it investigates whether the running performance ... ...

Abstract	This paper analyses the performances of lower-limb amputees in the 100, 200 and 400 m running events from the 2004, 2008 and 2012 Paralympic Games. In this paper, four hypotheses are pursued. In the first, it investigates whether the running performance of lower-limb amputees over three consecutive Paralympic Games has changed. In the second, it asks whether a bi-lateral amputee has a competitive advantage over a uni-lateral amputee. In the third, the effect of blade classification has been considered and we attempt to see whether amputees in various classifications have different level of performance. Finally, it is considered whether the final round of competition obtains different levels of performance in comparison to the qualification heats. Based on the outcomes of these investigations, it is proposed that future amputee-based running events should be undertaken with separate and not combined events for the T42, T43 and T44 classifications at the Paralympic Games.
Keywords	running ; paralympic games ; bi-lateral amputee ; athletes ; Sports ; GV557-1198.995 ; Recreation. Leisure ; GV1-1860 ; Geography. Anthropology. Recreation ; G
Subject code	796
Language	English
Publishing date	2015-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Statistical Perspective on Running with Prosthetic Lower-Limbs

Hossein Hassani / Mansi Ghodsi / Mehran Shadi / Siamak Noroozi / Bryce Dyer

Sports, Vol 2, Iss 4, Pp 76-

An Advantage or Disadvantage?

2014 Volume 84

Abstract: Technological developments have led to the increased use of carbon fiber and prosthetic lower-limbs in running events at the Paralympic Games. This study aims to exploit a series of statistical techniques in order to prepare a response to the vital ... ...

Abstract	Technological developments have led to the increased use of carbon fiber and prosthetic lower-limbs in running events at the Paralympic Games. This study aims to exploit a series of statistical techniques in order to prepare a response to the vital question of whether utilizing prosthetic feet can affect an athletes ability when running competitively at the Paralympics Games by comparing both within and between different classifications. The study also considers the differences between running on biological limbs and prosthetic lower-limbs from a mechanical point of view. The results from the male 100 m, 200 m and 400 m at the 2012 London Paralympic Games have been the source of this investigation. The investigation provides statistical evidence to propose that the number of prosthetic limbs used and the structure of such limbs have a significant impact on the outcome of track events at the Paralympic Games.
Keywords	Paralympic Games ; prosthetic lower-limbs ; statistical analysis ; running ; Sports ; GV557-1198.995 ; Recreation. Leisure ; GV1-1860 ; Geography. Anthropology. Recreation ; G
Subject code	796
Language	English
Publishing date	2014-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats.

Mehri, Soghra / Shahi, Mehran / Razavi, Bibi Marjan / Hassani, Faezeh Vahdati / Hosseinzadeh, Hossein

Iranian journal of basic medical sciences

2015 Volume 17, Issue 12, Page(s) 1007–1011

Abstract: Objectives: Acrylamide (ACR) has broad applications in different industries. It also forms in food during heating process. Oxidative stress has a critical role in ACR-induced neurotoxicity in both in vitro and in vivo models; therefore, the aim of the ... ...

Abstract	Objectives: Acrylamide (ACR) has broad applications in different industries. It also forms in food during heating process. Oxidative stress has a critical role in ACR-induced neurotoxicity in both in vitro and in vivo models; therefore, the aim of the current study was the evaluation of effects of thymoquinone, the main constituent of volatile oil from Nigella sativa seeds in ACR-induced neurotoxicity. Materials and methods: Male Wistar rats were treated with ACR (50 mg/kg IP) alone or with thymoquinone (TQ) (2.5, 5, 10 mg/kg IP) for 11 days. Two protocols were used in this study, A: in this one TQ and ACR were used simultaneously, B: Administration of TQ was started 1 week before ACR treatment and continued during exposure to ACR. At the end of the treatment, behavioral index (gait score) was examined for rats. After that, rats were sacrificed and molondialdehyde (MDA) as a marker of lipid peroxidation and glutathione (GSH) content were determined in cerebral cortex. Results: Exposure to ACR led to severe gait abnormalities and treatment with TQ significantly decreased abnormalities. Level of MDA was elevated in cerebral cortex after exposure to ACR while TQ treatment significantly and in a dose-dependent manner reduced lipid peroxidation. Results clearly showed that there is no significant difference between two protocols of administration of TQ. Conclusion: It suggests the neuroprotective effect of TQ in this model in part, may be because of due the antioxidant activity of this natural compound.
Language	English
Publishing date	2015-04-09
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
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Article ; Online: Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats

Soghra Mehri / Mehran Shahi / Bibi Marjan Razavi / Faezeh Vahdati Hassani / Hossein Hosseinzadeh

Iranian Journal of Basic Medical Sciences, Vol 17, Iss 12, Pp 1007-

2015 Volume 1011

Abstract: Objective(s):Acrylamide (ACR) has broad applications in different industries. It also forms in food during heating process. Oxidative stress has a critical role in ACR-induced neurotoxicity in both in vitro and in vivo models; therefore, the aim of the ... ...

Abstract	Objective(s):Acrylamide (ACR) has broad applications in different industries. It also forms in food during heating process. Oxidative stress has a critical role in ACR-induced neurotoxicity in both in vitro and in vivo models; therefore, the aim of the current study was the evaluation of effects of thymoquinone, the main constituent of volatile oil from Nigella sativa seeds in ACR-induced neurotoxicity. Materials and Methods: Male Wistar rats were treated with ACR (50 mg/kg IP) alone or with thymoquinone (TQ) (2.5, 5, 10 mg/kg IP) for 11 days. Two protocols were used in this study, A: in this one TQ and ACR were used simultaneously, B: Administration of TQ was started 1 week before ACR treatment and continued during exposure to ACR. At the end of the treatment, behavioral index (gait score) was examined for rats. After that, rats were sacrificed and molondialdehyde (MDA) as a marker of lipid peroxidation and glutathione (GSH) content were determined in cerebral cortex. Results: Exposure to ACR led to severe gait abnormalities and treatment with TQ significantly decreased abnormalities. Level of MDA was elevated in cerebral cortex after exposure to ACR while TQ treatment significantly and in a dose-dependent manner reduced lipid peroxidation. Results clearly showed that there is no significant difference between two protocols of administration of TQ. Conclusion: It suggests the neuroprotective effect of TQ in this model in part, may be because of due the antioxidant activity of this natural compound.
Keywords	Acrylamide Behavioral index Gait scores Lipid peroxidation Neurotoxicity Thymoquinone ; Medicine ; R
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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