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Article ; Online: Fusion-driven cutaneous and superficial mesenchymal and adnexal tumors-A clinicopathologic and molecular study of 15 cases, including a novel case of ACTB::ZMIZ2-rearranged adnexal carcinoma.

Dehner, Carina A / Johnson, Emma F / Wieland, Carrie N / Camilleri, Michael J / Kajdacsy-Balla, Andre / Oliveira, Andre M / Halling, Kevin C / Gupta, Sounak / Guo, Ruifeng

Journal of cutaneous pathology

2024

Abstract: Background: While the list of fusion-driven soft tissue neoplasms is expanding rapidly, their importance among cutaneous and superficial mesenchymal and adnexal neoplasms remains poorly understood. This challenge is especially evident in cases with ... ...

Abstract	Background: While the list of fusion-driven soft tissue neoplasms is expanding rapidly, their importance among cutaneous and superficial mesenchymal and adnexal neoplasms remains poorly understood. This challenge is especially evident in cases with ambiguous histopathology that are difficult to classify based on morphology. Aims: Our goal was to investigate the benefits of next-generation sequencing in diagnosing complex cutaneous neoplasms. Materials & methods: Departmental archives were searched for fusion-driven cutaneous neoplasms. Slides were retrieved and clinical information including follow-up was obtained. Results: Fifteen cases occurred in eight female and seven male patients, with a median age of 26 years (range: 1-83) at diagnosis. Tumors involved the extremities (9), scalp (5), and head and neck (1). Predominant features included myoepithelial (5), nested spindled with clear cytoplasm (2), atypical adnexal/squamoid (2), small round blue cell (2), cellular spindled (3), and fibrohistiocytic morphology (1). Most frequently encountered fusions involved EWSR1 (6) fused to ERG (1), FLI1 (1), CREB1 (2), CREM (1), PBX3 (1), followed by PLAG1 (4) with LIFR (2), TRPS1 (1) and CHCHD7. Additional fusions encountered were YAP1::NUTM1, EML4::ALK, SS18::SSX1 (2), and a novel fusion: ACTB::ZMIZ2. Integration of histologic features and molecular findings led to final diagnoses of primary cutaneous Ewing sarcoma (2), soft tissue myoepithelioma (4), cutaneous syncytial myoepithelioma (1), cutaneous adnexal carcinoma (1), porocarcinoma (1), inflammatory myofibroblastic tumor (1), synovial sarcoma (2), clear cell sarcoma (2), and angiomatoid fibrous histiocytoma (1). Discussion and conclusion: Our results show that fusion testing can be a helpful diagnostic tool, especially in cases with unusual or uncommon morphology in superficial sites. Furthermore, it can allow for the identification of potential therapeutic targets in some instances.
Language	English
Publishing date	2024-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.14610
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Article: A deep learning framework for autonomous detection and classification of Crohn's disease lesions in the small bowel and colon with capsule endoscopy.

Majtner, Tomáš / Brodersen, Jacob Broder / Herp, Jürgen / Kjeldsen, Jens / Halling, Morten Lee / Jensen, Michael Dam

Endoscopy international open

2021 Volume 9, Issue 9, Page(s) E1361–E1370

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2021-08-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-1507-4980
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Article ; Online: Bond and Equity Issuance Activity during COVID-19

Halling, Michael / Yu, Jin / Zechner, Josef

SSRN Electronic Journal ; ISSN 1556-5068

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3596114
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: How Did COVID-19 Affect Firms’ Access to Public Capital Markets?

Halling, Michael / Yu, Jin / Zechner, Josef

The Review of Corporate Finance Studies

Abstract: We find that bond issues have substantially increased since the onset of the COVID-19 crisis in calendar week 12 (March 16–20) for bonds rated A or higher, but surprisingly also for bonds rated BBB or lower In contrast to existing evidence on bond ... ...

Abstract	We find that bond issues have substantially increased since the onset of the COVID-19 crisis in calendar week 12 (March 16–20) for bonds rated A or higher, but surprisingly also for bonds rated BBB or lower In contrast to existing evidence on bond maturities in economic downturns, we document that maturities exceed those of bonds issued before by the same firms as well as the average maturities during normal times Determinants of corporate bond spreads substantially differ between COVID-19 and normal times Most prominently, asset tangibility has a highly significant negative effect on spreads during normal times During COVID-19, this is reversed, especially in industries heavily affected by lockdown measures, reflecting the inflexibility associated with fixed assets A different picture emerges for equity issues, which slowed considerably during the first 4 weeks of the pandemic, before accelerating again Capital raised during COVID-19 via equity issues is approximately 5% of capital raised via bond issues
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #630799
Database	COVID19

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Article ; Online: How Did COVID-19 Affect Firms’ Access to Public Capital Markets?*

Halling, Michael / Yu, Jin / Zechner, Josef

The Review of Corporate Finance Studies

2020 Volume 9, Issue 3, Page(s) 501–533

Abstract: Abstract We find that bond issues have substantially increased since the onset of the COVID-19 crisis in calendar week 12 (March 16–20) for bonds rated A or higher, but surprisingly also for bonds rated BBB or lower. In contrast to existing evidence on ... ...

Abstract	Abstract We find that bond issues have substantially increased since the onset of the COVID-19 crisis in calendar week 12 (March 16–20) for bonds rated A or higher, but surprisingly also for bonds rated BBB or lower. In contrast to existing evidence on bond maturities in economic downturns, we document that maturities exceed those of bonds issued before by the same firms as well as the average maturities during normal times. Determinants of corporate bond spreads substantially differ between COVID-19 and normal times. Most prominently, asset tangibility has a highly significant negative effect on spreads during normal times. During COVID-19, this is reversed, especially in industries heavily affected by lockdown measures, reflecting the inflexibility associated with fixed assets. A different picture emerges for equity issues, which slowed considerably during the first 4 weeks of the pandemic, before accelerating again. Capital raised during COVID-19 via equity issues is approximately 5% of capital raised via bond issues. (JEL G01, G32) Received: May 21, 2020; editorial decision June 17, 2020 by Editor Andrew Ellul.
Keywords	covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2650556-3
ISSN	2046-9136 ; 2046-9128
ISSN (online)	2046-9136
ISSN	2046-9128
DOI	10.1093/rcfs/cfaa008
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Article ; Online: Transcriptomic and immunophenotypic characterization of two cases of adamantinoma-like Ewing sarcoma of the thyroid gland.

Chatzopoulos, Kyriakos / Davila, Jaime I / Fadra, Numrah / Jackson, Rory A / Minn, Kay T / Sotiriou, Sotiris / Oliveira, Andre M / Erickson, Lori A / Halling, Kevin C / Rumilla, Kandelaria M / Rivera, Michael

Histopathology

2023 Volume 83, Issue 3, Page(s) 426–434

Abstract: Introduction: Adamantinoma-like Ewing sarcoma (ALES) is a rare aggressive malignancy occasionally diagnosed in the thyroid gland. ALES shows basaloid cytomorphology, expresses keratins, p63, p40, frequently CD99, and harbours the t(11;22) EWSR1::FLI1 ... ...

Abstract	Introduction: Adamantinoma-like Ewing sarcoma (ALES) is a rare aggressive malignancy occasionally diagnosed in the thyroid gland. ALES shows basaloid cytomorphology, expresses keratins, p63, p40, frequently CD99, and harbours the t(11;22) EWSR1::FLI1 translocation. There is debate on whether ALES resembles more sarcoma or carcinoma. Methods: We performed RNA sequencing from two ALES cases and compared findings with skeletal Ewing's sarcomas and nonneoplastic thyroid tissue. ALES was investigated by in situ hybridization (ISH) for high-risk human papillomavirus (HPV) DNA and immunohistochemistry for the following antigens: keratin 7, keratin 20, keratin 5, keratins (AE1/AE3 and CAM5.2), CD45, CD20, CD5, CD99, chromogranin, synaptophysin, calcitonin, thyroglobulin, PAX8, TTF1, S100, p40, p63, p16, NUT, desmin, ER, FLI1, INI1, and myogenin. Results: An uncommon EWSR1::FLI transcript with retained EWSR1 exon 8 was detected in both ALES cases. Regulators of EWSR1::FLI1 splicing (HNRNPH1, SUPT6H, SF3B1) necessary for production of a functional fusion oncoprotein, as well as 53 genes (including TNNT1, NKX2.2) activated downstream to the EWSR1::FLI1 cascade, were overexpressed. Eighty-six genes were uniquely overexpressed in ALES, most of which were related to squamous differentiation. Immunohistochemically, ALES strongly expressed keratins 5, AE1/AE3 and CAM5.2, p63, p40, p16, and focally CD99. INI1 was retained. The remaining immunostains and HPV DNA ISH were negative. Conclusion: Comparative transcriptomic profiling reveals overlapping features of ALES with skeletal Ewing's sarcoma and an epithelial carcinoma, as evidenced by immunohistochemical expression of keratin 5, p63, p40, CD99, the transcriptome profile, and detection of EWSR1::FLI1 fusion transcript by RNA sequencing.
MeSH term(s)	Humans ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/genetics ; Adamantinoma/diagnosis ; Adamantinoma/genetics ; Adamantinoma/chemistry ; Thyroid Gland/pathology ; Transcriptome ; Keratin-5/metabolism ; Papillomavirus Infections ; RNA-Binding Protein EWS/genetics ; RNA-Binding Protein EWS/metabolism ; Transcription Factors/genetics ; Carcinoma ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism
Chemical Substances	Keratin-5 ; RNA-Binding Protein EWS ; Transcription Factors ; Oncogene Proteins, Fusion
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.14961
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Zs.A 1328: Show issues

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Article: The politics of related lending

Halling, Michael / Pichler, Pegaret / Stomper, Alex

Journal of financial and quantitative analysis : JFQA Vol. 51, No. 1 , p. 333-358

2016 Volume 51, Issue 1, Page(s) 333–358

Author's details	Michael Halling, Pegaret Pichler, and Alex Stomper
Keywords	Öffentliche Bank ; Kreditgeschäft ; Kreditrisiko ; Eigentümer ; Politiker ; Gemeindefinanzen ; EU-Mitgliedschaft ; Österreich
Language	English
Publisher	Cambridge University Press
Publishing place	New York, NY [u.a.]
Document type	Article
ZDB-ID	219406-5 ; 2010249-5
ISSN	1756-6916 ; 0022-1090
ISSN (online)	1756-6916
ISSN	0022-1090
Database	ECONomics Information System

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Article ; Online: Sarcomas Harboring EWSR1::PATZ1 Fusions: A Clinicopathologic Study of 17 Cases.

Dehner, Carina A / Torres-Mora, Jorge / Gupta, Sounak / Kipp, Benjamin R / Halling, Kevin C / Chen, Shaoxiong / Warmke, Laura M / Michal, Michael / Alani, Ali / Yu, Wendong / Kovacs, Krisztian / Obeidin, Farres / Iwenofu, Obiajulu Hans / Satturwar, Swati / Meis, Jeanne M / Folpe, Andrew L

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2023 Volume 37, Issue 2, Page(s) 100400

Abstract: Soft tissue sarcomas harboring EWSR1::PATZ1 are a recently recognized entity with variable morphology and a heterogeneous immunohistochemical profile. We studied 17 such tumors. The tumors occurred in 12 men and 5 women (median age, 50 years; range, 15- ... ...

Abstract	Soft tissue sarcomas harboring EWSR1::PATZ1 are a recently recognized entity with variable morphology and a heterogeneous immunohistochemical profile. We studied 17 such tumors. The tumors occurred in 12 men and 5 women (median age, 50 years; range, 15-71 years), involved the thoracoabdominal soft tissues (14 cases; 82%), lower extremities (2 cases; 12%), and tongue (1 case; 6%), and ranged from 0.7 to 11.3 cm (median, 4.7 cm). All but 1 patient received complete surgical resection; 7 were also treated with neoadjuvant chemo/radiotherapy. All cases showed typical features of EWSR1::PATZ1 sarcoma, including uniform round to spindled cells, fibromyxoid matrix, fibrous bands, hyalinized vessels, and pseudoalveolar/microcystic spaces. Unusual features, seen in a subset of cases, included degenerative-appearing nuclear atypia, epithelioid cytomorphology, mature fat, abundant rhabdomyoblasts, high mitotic activity, and foci with increased cellularity and nuclear atypia. Positive immunohistochemical results were desmin (16/17, 94%), MyoD1 (13/14, 93%), myogenin (6/14, 43%), GFAP (10/10, 100%), S100 protein (15/17, 88%), SOX10 (7/13, 54%), keratin (10/17, 59%), CD99 (4/11, 36%), H3K27me3 (retained expression 9/9, 100%), p16 (absent expression 1/4, 25%), and p53 (wild type 3/3, 100%). Fusion events included EWSR1 exon 8::PATZ1 exon 1 (14/17, 82%), EWSR1 exon 9::PATZ1 exon 1 (2/17, 12%), and EWSR1 exon 7::PATZ1 exon 1 (1/17, 6%). No evaluated tumor had alterations of CDKN2A/B and/or TP53, or MDM2 amplification. Clinical follow-up (16 patients: median, 13.5 months; range, 1-77 months) showed distant metastases in 3 patients (1/3 at time of presentation) and no local recurrences. At the time of last follow-up, 14 patients were disease free, 1 was alive with disease, 1 was dead of disease (at 13 months), and 1 had an indeterminant pulmonary nodule. We conclude that the morphologic spectrum of EWSR1::PATZ1 is broader than has been previously appreciated. Although more long-term follow-up is needed, the prognosis of these very rare sarcomas may be more favorable than previously reported.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Sarcoma/genetics ; Sarcoma/therapy ; Sarcoma/pathology ; Transcription Factors ; RNA-Binding Protein EWS/genetics ; S100 Proteins ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/therapy ; Soft Tissue Neoplasms/pathology ; Prognosis ; Biomarkers, Tumor/genetics ; Repressor Proteins/genetics ; Kruppel-Like Transcription Factors
Chemical Substances	Transcription Factors ; RNA-Binding Protein EWS ; S100 Proteins ; Biomarkers, Tumor ; PATZ1 protein, human ; Repressor Proteins ; Kruppel-Like Transcription Factors ; EWSR1 protein, human
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1016/j.modpat.2023.100400
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Article: A deep learning framework for autonomous detection and classification of Crohnʼs disease lesions in the small bowel and colon with capsule endoscopy

Majtner, Tomáš / Brodersen, Jacob Broder / Herp, Jürgen / Kjeldsen, Jens / Halling, Morten Lee / Jensen, Michael Dam

Endoscopy International Open

2021 Volume 09, Issue 09, Page(s) E1361–E1370

Abstract: Background and study aims : Small bowel ulcerations are efficiently detected with deep learning techniques, whereas the ability to diagnose Crohnʼs disease (CD) in the colon with it is unknown. This study examined the ability of a deep learning ... ...

Abstract	Background and study aims : Small bowel ulcerations are efficiently detected with deep learning techniques, whereas the ability to diagnose Crohnʼs disease (CD) in the colon with it is unknown. This study examined the ability of a deep learning framework to detect CD lesions with pan-enteric capsule endoscopy (CE) and classify lesions of different severity. Patients and methods : CEs from patients with suspected or known CD were included in the analysis. Two experienced gastroenterologists classified anonymized images into normal mucosa, non-ulcerated inflammation, aphthous ulceration, ulcer, or fissure/extensive ulceration. An automated framework incorporating multiple ResNet-50 architectures was trained. To improve its robustness and ability to characterize lesions, image processing methods focused on texture enhancement were employed. Results : A total of 7744 images from 38 patients with CD were collected (small bowel 4972, colon 2772) of which 2748 contained at least one ulceration (small bowel 1857, colon 891). With a patient-dependent split of images for training, validation, and testing, ulcerations were diagnosed with a sensitivity, specificity, and diagnostic accuracy of 95.7 % (CI 93.4–97.4), 99.8 % (CI 99.2–100), and 98.4 % (CI 97.6–99.0), respectively. The diagnostic accuracy was 98.5 % (CI 97.5–99.2) for the small bowel and 98.1 % (CI 96.3–99.2) for the colon. Ulcerations of different severities were classified with substantial agreement (κ = 0.72). Conclusions : Our proposed framework is in excellent agreement with the clinical standard, and diagnostic accuracies are equally high for the small bowel and colon. Deep learning approaches have a great potential to help clinicians detect, localize, and determine the severity of CD with pan-enteric CE.
Language	English
Publishing date	2021-08-16
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722 ; 2196-9736
ISSN (online)	2196-9736
ISSN	2364-3722 ; 2196-9736
DOI	10.1055/a-1507-4980
Database	Thieme publisher's database

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Article ; Online: Lipocalin-2 Expression in Pancreas Adenocarcinoma Tumor Microenvironment Via Endoscopic Ultrasound Fine Needle Biopsy Is Feasible and May Reveal a Therapeutic Target.

Gleeson, Ferga C / Levy, Michael J / Jackson, Rory A / Murphy, Stephen J / Halling, Kevin C / Kipp, Benjamin R / Graham, Rondell P / Zhang, Lizhi

Pancreas

2020 Volume 49, Issue 10, Page(s) e98–e99

MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/therapy ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Feasibility Studies ; Gene Expression Profiling ; Humans ; Lipocalin-2/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; Predictive Value of Tests ; Prognosis ; Tumor Microenvironment ; Up-Regulation
Chemical Substances	Biomarkers, Tumor ; LCN2 protein, human ; Lipocalin-2
Language	English
Publishing date	2020-12-09
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001669
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