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  1. Article ; Online: Correction: Recent progress in ITP treatment.

    Rodeghiero, Francesco

    International journal of hematology

    2023  Volume 118, Issue 1, Page(s) 151

    Language English
    Publishing date 2023-05-30
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-023-03620-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Introduction to a review series on the treatment of thrombocytopenic disorders: something old, something new.

    Rodeghiero, Francesco

    Haematologica

    2022  Volume 107, Issue 6, Page(s) 1239–1242

    MeSH term(s) Anemia ; Humans ; Leukopenia ; Thrombocytopenia/diagnosis ; Thrombocytopenia/therapy
    Language English
    Publishing date 2022-06-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.280920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recent progress in ITP treatment.

    Rodeghiero, Francesco

    International journal of hematology

    2023  Volume 117, Issue 3, Page(s) 316–330

    Abstract: In this review, the recently approved drugs avatrombopag and fostamatinib, which were not extensively covered within 2019 international recommendations for ITP, will be discussed in some detail. Avatrombopag appears more convenient than eltrombopag as it ...

    Abstract In this review, the recently approved drugs avatrombopag and fostamatinib, which were not extensively covered within 2019 international recommendations for ITP, will be discussed in some detail. Avatrombopag appears more convenient than eltrombopag as it does not require dietary restrictions or subcutaneous administration like romiplostim. However, data on quality of life (QoL) are lacking and the rate of thromboembolic events in exposed patients is not negligible. Efficacy of fostamatinib, an inhibitor of macrophagic activity, is supported by placebo-controlled trials in patients refractory to several therapies, including TPO-RA. While hypertension and diarrhea have been reported, only one minor thrombotic event occurred in 146 exposed patients. In addition, several new treatment combinations and new agents entered clinical investigation in recent years. In a UK trial, combining mycophenolate mofetil with corticosteroids as first line therapy was more effective than corticosteroids alone, but at the cost of worse QoL. No combination, including oseltamivir or all-trans retinoic acid or danazol, resulted in convincing evidence of superior efficacy and safety when used in first or later lines of treatment. Agents targeting specific mechanisms are also discussed: sutimlimab (complement inhibitor); rilzabrutinib (BTK inhibitor) and efgartigimod (modified Fc fragment inhibiting FcRn). Only efgartigimod has completed phase 3 investigation.
    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Quality of Life ; Receptors, Fc ; Recombinant Fusion Proteins/therapeutic use ; Thiazoles/therapeutic use ; Thrombopoietin/pharmacology ; Clinical Trials as Topic
    Chemical Substances avatrombopag (3H8GSZ4SQL) ; fostamatinib (SQ8A3S5101) ; Receptors, Fc ; Recombinant Fusion Proteins ; Thiazoles ; Thrombopoietin (9014-42-0)
    Language English
    Publishing date 2023-01-09
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-022-03527-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immune thrombocytopenia in myeloid and lymphoid clonal disorders: an intriguing association.

    Rodeghiero, Francesco

    Haematologica

    2021  Volume 106, Issue 5, Page(s) 1231–1233

    MeSH term(s) Cells, Cultured ; Humans ; Leukemia, Myelomonocytic, Chronic ; Myelodysplastic Syndromes ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Thrombocytopenia
    Language English
    Publishing date 2021-05-01
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2020.275933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: New therapy option for chronic immune thrombocytopenic purpura

    Rodeghiero, Francesco

    a breath of fresh air

    (European journal of haematology : Supplement ; 71)

    2009  

    Author's details guest ed.: F. Rodeghiero
    Series title European journal of haematology : Supplement ; 71
    European journal of haematology
    European journal of haematology ; Supplement
    Collection European journal of haematology
    European journal of haematology ; Supplement
    Language English
    Size 25 S. : Ill.
    Publisher Wiley
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015837756
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Cerebral microbleeds in ITP: alarming or innocent?

    Rodeghiero, Francesco

    Blood

    2020  Volume 136, Issue 25, Page(s) 2842–2844

    MeSH term(s) Adult ; Brain ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/etiology ; Humans ; Inosine Triphosphate ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/diagnosis
    Chemical Substances Inosine Triphosphate (132-06-9)
    Language English
    Publishing date 2020-12-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020008425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Thrombopoietin receptor agonist in chemotherapy-induced thrombocytopenia.

    Lozano, Maria L / Rodeghiero, Francesco

    The Lancet. Haematology

    2022  Volume 9, Issue 3, Page(s) e168–e169

    MeSH term(s) Antineoplastic Agents/adverse effects ; Humans ; Receptors, Thrombopoietin/agonists ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Thrombopoietin/adverse effects
    Chemical Substances Antineoplastic Agents ; Receptors, Thrombopoietin ; Thrombopoietin (9014-42-0)
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(22)00030-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: ITP and thrombosis: an intriguing association.

    Rodeghiero, Francesco

    Blood advances

    2017  Volume 1, Issue 24, Page(s) 2280

    Language English
    Publishing date 2017-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2876449-3
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2017007989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A hit to current "hit" wisdom: A century later, it's time for a change.

    Rodeghiero, Francesco

    American journal of hematology

    2017  Volume 92, Issue 8, Page(s) 727–729

    MeSH term(s) Cohort Studies ; Humans ; Thrombocytopenia
    Language English
    Publishing date 2017-06-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.24789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A new enemy is emerging in the fight against the SARS-CoV-2 pandemic.

    Rodeghiero, Francesco / Balduini, Carlo L

    Haematologica

    2021  Volume 106, Issue 8, Page(s) 2040–2041

    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-08-01
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.279186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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