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  1. Article ; Online: The bold promise of gene therapy for sickle cell disease.

    Ware, Russell E / Quinn, Charles T

    British journal of haematology

    2024  Volume 204, Issue 2, Page(s) 381–382

    MeSH term(s) Humans ; Anemia, Sickle Cell/therapy ; Hematopoietic Stem Cell Transplantation ; Genetic Therapy
    Language English
    Publishing date 2024-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Screening for haemoglobin disorders: One size may not fit all.

    Shook, Lisa M / Ware, Russell E

    British journal of haematology

    2023  Volume 204, Issue 1, Page(s) 26–28

    Abstract: Accurate laboratory screening for sickle cell disease and other haemoglobin disorders is expanding worldwide. Two new reports describe different methods and strategies for screening in Mali and Denmark, respectively, and their encouraging results suggest ...

    Abstract Accurate laboratory screening for sickle cell disease and other haemoglobin disorders is expanding worldwide. Two new reports describe different methods and strategies for screening in Mali and Denmark, respectively, and their encouraging results suggest that countries should tailor their screening programmes according to local needs, resources and opportunities. Commentary on: Guindo et al. Potential for a large-scale newborn screening strategy for sickle cell disease in Mali: a comparative diagnostic performance study of two rapid diagnostic tests (SickleScan® and HemotypeSC®) on cord blood. Br J Haematol 2024;204:337-345 and Gravholt et al. The Danish national haemoglobinopathy screening programme: report from 16 years of screening in a low-prevalence, non-endemic region. Br J Haematol 2024;204:329-336.
    MeSH term(s) Infant, Newborn ; Humans ; Hemoglobinopathies/diagnosis ; Hemoglobinopathies/epidemiology ; Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/epidemiology ; Neonatal Screening/methods ; Fetal Blood ; Hemoglobins
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reproductive equity: preserve the reserve.

    Quinn, Charles T / Ware, Russell E

    Blood

    2022  Volume 139, Issue 7, Page(s) 963–965

    MeSH term(s) Female ; Humans ; Ovary ; Reproduction
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021015021
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  4. Article ; Online: New therapeutics for children with sickle cell disease: A time for celebration, caution, or both?

    Quinn, Charles T / Ware, Russell E

    Pediatric blood & cancer

    2022  Volume 69, Issue 8, Page(s) e29805

    MeSH term(s) Anemia, Sickle Cell/therapy ; Child ; Humans
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29805
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  5. Article ; Online: Increased oxygen affinity: to have and to hold.

    Quinn, Charles T / Ware, Russell E

    Blood

    2021  Volume 138, Issue 13, Page(s) 1094–1095

    MeSH term(s) Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: There's safety in numbers.

    Ware, Russell E / Dertinger, Stephen D

    Blood

    2021  Volume 137, Issue 6, Page(s) 729–731

    MeSH term(s) Anemia, Sickle Cell ; Humans ; Hydroxyurea
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020010033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Newborn screening for sickle cell disease in sub-Saharan Africa: Is the glass half-full yet?

    Smart, Luke R / Ware, Russell E

    Pediatric blood & cancer

    2021  Volume 68, Issue 7, Page(s) e29137

    MeSH term(s) Africa South of the Sahara/epidemiology ; Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/epidemiology ; Humans ; Infant, Newborn ; Neonatal Screening
    Language English
    Publishing date 2021-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29137
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  8. Article ; Online: Microscope diagnosis of MYH9-related thrombocytopenia.

    Sadaf, Alina / Ware, Russell E

    Blood

    2021  Volume 138, Issue 11, Page(s) 1000

    MeSH term(s) Adolescent ; Female ; Humans ; Menorrhagia/complications ; Menorrhagia/genetics ; Menorrhagia/pathology ; Mutation, Missense ; Myosin Heavy Chains/genetics ; Thrombocytopenia/complications ; Thrombocytopenia/genetics ; Thrombocytopenia/pathology
    Chemical Substances MYH9 protein, human ; Myosin Heavy Chains (EC 3.6.4.1)
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021012044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Absence of hydroxyurea-induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia.

    Ware, Russell E / Dertinger, Stephen D

    British journal of haematology

    2021  Volume 194, Issue 2, Page(s) 252–266

    Abstract: Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with sickle cell anaemia (SCA). Fetal haemoglobin (HbF) induction is the primary treatment response, along with improved anaemia, reduced haemolysis, myelosuppression and ... ...

    Abstract Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with sickle cell anaemia (SCA). Fetal haemoglobin (HbF) induction is the primary treatment response, along with improved anaemia, reduced haemolysis, myelosuppression and decreased endothelial inflammation. Hydroxyurea has proven clinical efficacy for SCA - treatment significantly reduces disease manifestations and prolongs survival. Despite these recognised benefits, long-standing concerns regarding the risks of mutagenic and potentially carcinogenic drug exposure have hampered efforts for broad hydroxyurea use in SCA, although these are based largely on outdated experimental models and treatment experiences with myeloproliferative neoplasms. Consequently, many patients with SCA are not receiving this highly effective disease-modifying therapy. In this review, we describe the concept of genotoxicity and its laboratory measurements, summarise hydroxyurea-associated data from both preclinical and clinical studies, and discuss carcinogenic potential. The genotoxicity results clearly demonstrate that hydroxyurea does not directly bind DNA and is not mutagenic. Rather, its genotoxic effects are limited to indirect clastogenicity occurring in select cell types, and only when high dose and time thresholds are exceeded. This absence of mutagenic activity is consistent with the observed lack of any compelling carcinogenic potential. Since hydroxyurea therapy for SCA carries minimal carcinogenic risks, the current drug labelling should be modified accordingly, and prescribing practices should be broadened to allow better access and increased utilisation of this highly effective drug.
    MeSH term(s) Anemia, Sickle Cell/drug therapy ; Anemia, Sickle Cell/genetics ; Animals ; Antisickling Agents/adverse effects ; Antisickling Agents/therapeutic use ; DNA Damage/drug effects ; Humans ; Hydroxyurea/adverse effects ; Hydroxyurea/therapeutic use ; Mutation/drug effects ; Neoplasms/chemically induced ; Neoplasms/genetics ; Treatment Outcome
    Chemical Substances Antisickling Agents ; Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Technological Advances in Sickle Cell Disease.

    Ware, Russell E

    Blood cells, molecules & diseases

    2017  Volume 67, Page(s) 102–103

    MeSH term(s) Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/therapy ; Genomics/methods ; Genotyping Techniques ; Humans ; Hydroxyurea/therapeutic use ; Magnetic Resonance Imaging/methods
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2017-11-07
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2017.09.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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