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Article ; Online: Pitfalls in MRI of the Developing Pediatric Ankle.

Walter, William R / Goldman, Lauren H / Rosenberg, Zehava S

Radiographics : a review publication of the Radiological Society of North America, Inc

2020 Volume 41, Issue 1, Page(s) 210–223

Abstract: Normal skeletal development in the pediatric ankle is dynamic and often produces variable imaging appearances that are subject to misinterpretation. Radiologists must understand the underlying developmental phenomena, such as endochondral and membranous ... ...

Abstract	Normal skeletal development in the pediatric ankle is dynamic and often produces variable imaging appearances that are subject to misinterpretation. Radiologists must understand the underlying developmental phenomena, such as endochondral and membranous ossification and physeal fusion, and be familiar with their common and uncommon imaging manifestations unique to the pediatric ankle. This is especially true as the use of MRI in the evaluation of musculoskeletal trauma expands among younger populations. The authors focus on MRI evaluation of the skeletally maturing pediatric ankle and present pearls for accurately distinguishing normal findings and imaging pitfalls from true pathologic findings. The normal but often variable imaging findings of preossification, secondary ossification, and multiple ossification centers, as well as the range of bone marrow signal intensities that can be visualized within ossification centers, are described, along with tips to help differentiate these from true pathologic findings such as contusion, fracture, or tumor. The authors also review dynamic periosteal and physeal contributions to bone growth to highlight helpful distinguishing features and avoid misdiagnosis of common subperiosteal and periphyseal abnormalities. For example, the normal trilaminar appearance of the immature cortex and periosteum should not be mistaken for periosteal reaction, traumatic stripping, or subperiosteal hematoma. In addition, the physis can have several confusing but normal appearances, including normal physeal undulations (eg, Kump bump) or focal periphyseal edema, which should not be mistaken for pathologic findings such as physeal fracture, infection, or bar.
MeSH term(s)	Ankle ; Bone Diseases ; Child ; Edema ; Growth Plate ; Humans ; Magnetic Resonance Imaging
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.2021200088
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Article ; Online: Aspergillus fumigatus FhdA Transcription Factor Is Important for Mitochondrial Activity and Codon Usage Regulation during the Caspofungin Paradoxical Effect.

Colabardini, Ana Cristina / Van Rhijn, Norman / LaBella, Abigail L / Valero, Clara / Dineen, Lauren / Rokas, Antonis / Goldman, Gustavo H

Antimicrobial agents and chemotherapy

2022 Volume 66, Issue 9, Page(s) e0070122

Abstract: Aspergillus fumigatus is the main etiological agent of aspergillosis. The antifungal drug caspofungin (CSP) can be used against A. fumigatus, and CSP tolerance is observed. We have previously shown that the transcription factor FhdA is important for ... ...

Abstract	Aspergillus fumigatus is the main etiological agent of aspergillosis. The antifungal drug caspofungin (CSP) can be used against A. fumigatus, and CSP tolerance is observed. We have previously shown that the transcription factor FhdA is important for mitochondrial activity. Here, we show that FhdA regulates genes transcribed by RNA polymerase II and III. FhdA influences the expression of tRNAs that are important for mitochondrial function upon CSP. Our results show a completely novel mechanism that is impacted by CSP.
MeSH term(s)	Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Aspergillus fumigatus ; Caspofungin/pharmacology ; Codon Usage ; Echinocandins/genetics ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Lipopeptides/pharmacology ; Mitochondria/genetics ; Mitochondria/metabolism ; RNA Polymerase II/genetics ; Transcription Factors/genetics
Chemical Substances	Antifungal Agents ; Echinocandins ; Fungal Proteins ; Lipopeptides ; Transcription Factors ; RNA Polymerase II (EC 2.7.7.-) ; Caspofungin (F0XDI6ZL63)
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00701-22
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A Case Report of Cake Frosting as a Source of Copper Toxicity in a Pediatric Patient.

Tsao, Hoi See / Allister, Lauren / Chiba, Takuyo / Barkley, Jonathan / Goldman, Rose H

Clinical practice and cases in emergency medicine

2020 Volume 4, Issue 3, Page(s) 384–388

Abstract: Introduction: Copper is an uncommon source of metal toxicity in children that requires a high index of suspicion for diagnosis.: Case report: We describe the unique presentation of a 12-month-old girl who developed acute onset of vomiting and ... ...

Abstract	Introduction: Copper is an uncommon source of metal toxicity in children that requires a high index of suspicion for diagnosis. Case report: We describe the unique presentation of a 12-month-old girl who developed acute onset of vomiting and diarrhea after ingestion of a copper-contaminated birthday cake. Conclusion: This case highlights the presentation, evaluation, and management of the rare pediatric patient who presents with copper poisoning. This case also illuminates the public health implications of potential metal poisoning when using non-edible decorative products in homemade and commercially prepared baked goods.
Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Journal Article
ISSN	2474-252X
ISSN (online)	2474-252X
DOI	10.5811/cpcem.2020.7.47267
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Article ; Online: Coxiella

Loterio, Robson K / Thomas, David R / Andrade, Warrison / Lee, Yi Wei / Santos, Leonardo L / Mascarenhas, Danielle P A / Steiner, Thiago M / Chiaratto, Jéssica / Fielden, Laura F / Lopes, Leticia / Bird, Lauren E / Goldman, Gustavo H / Stojanovski, Diana / Scott, Nichollas E / Zamboni, Dario S / Newton, Hayley J

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 36, Page(s) e2308752120

Abstract: The causative agent of human Q fever, ...

Abstract	The causative agent of human Q fever,
MeSH term(s)	Humans ; Animals ; Mice ; Coxiella ; Antioxidants ; Phospholipid Hydroperoxide Glutathione Peroxidase ; Oxidative Stress ; Cell Death ; Mammals
Chemical Substances	Antioxidants ; Phospholipid Hydroperoxide Glutathione Peroxidase (EC 1.11.1.12)
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2308752120
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Article ; Online: The use of transesophageal echocardiography to predict surgical complexity scoring system for degenerative mitral valve repair.

Bhatt, Himani V / Lisann-Goldman, Lauren / Baron, Elvera L / Salter, Benjamin S / Lin, Hung-Mo / Itagaki, Shinobu / Anyanwu, Anelechi C / Adams, David H / Fischer, Gregory W / El-Eshmawi, Ahmed

Echocardiography (Mount Kisco, N.Y.)

2023 Volume 40, Issue 6, Page(s) 562–567

Abstract: Background: For severe mitral valve (MV) degenerative disease, repair is recommended. Prediction of repair complexity and referral to high volume centers can increase rates of successful repair. This study sought to demonstrate that TEE is a feasible ... ...

Abstract	Background: For severe mitral valve (MV) degenerative disease, repair is recommended. Prediction of repair complexity and referral to high volume centers can increase rates of successful repair. This study sought to demonstrate that TEE is a feasible imaging modality to predict the complexity of surgical MV repair. Methods: Two hundred TEE examinations of patients who underwent MV repair (2009-2011) were retrospectively reviewed and scored by two cardiac anesthesiologists. TEE scores were compared to surgical complexity scores, which were previously assigned based on published methods. Kappa values were reported for the agreement of TEE and surgical scores. McNemar's tests were used to test the homogeneity of the marginal probabilities of different scoring categories. Results: TEE scores were slightly lower (2[1,3]) than surgical scores (3[1,4]). The agreement was 66% between the scoring methods, with a moderate kappa (.46). Using surgical scores as the gold standard, 70%, 71%, and 46% of simple, intermediate and complex surgical scores, respectively, were correctly scored by TEE. P1, P2, P3, and A2 prolapse were easiest to identify with TEE and had the highest agreement with surgical scoring (P1 agreement 79% with kappa .55, P2 96% [kappa .8], P3 77% [kappa .51], A2 88% [kappa .6]). The lowest agreement between the two scores occurred with A1 prolapse (kappa .05) and posteromedial commissure prolapse (kappa .14). In the presence of significant disagreement, TEE scores were more likely to be of higher complexity than surgical. McNemar's test was significant for prolapse of P1 (p = .005), A1 (p = .025), A2 (p = .041), and the posteromedial commissure (p < .0001). Conclusion: TEE-based scoring is feasible for prediction of the complexity of MV surgical repair, thus allowing for preoperative stratification.
MeSH term(s)	Humans ; Echocardiography, Transesophageal/methods ; Mitral Valve/diagnostic imaging ; Mitral Valve Prolapse/surgery ; Retrospective Studies ; Echocardiography, Three-Dimensional/methods ; Mitral Valve Insufficiency/surgery ; Heart Valve Diseases ; Prolapse
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15597
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Exploring relationships among multi-disciplinary assessments for knee joint health in service members with traumatic unilateral lower limb loss: a two-year longitudinal investigation.

Wasser, Joseph G / Hendershot, Brad D / Acasio, Julian C / Dodd, Lauren D / Krupenevich, Rebecca L / Pruziner, Alison L / Miller, Ross H / Goldman, Stephen M / Valerio, Michael S / Senchak, Lien T / Murphey, Mark D / Heltzel, David A / Fazio, Michael G / Dearth, Christopher L / Hager, Nelson A

Scientific reports

2023 Volume 13, Issue 1, Page(s) 21177

Abstract: Motivated by the complex and multifactorial etiologies of osteoarthritis, here we use a comprehensive approach evaluating knee joint health after unilateral lower limb loss. Thirty-eight male Service members with traumatic, unilateral lower limb loss ( ... ...

Abstract	Motivated by the complex and multifactorial etiologies of osteoarthritis, here we use a comprehensive approach evaluating knee joint health after unilateral lower limb loss. Thirty-eight male Service members with traumatic, unilateral lower limb loss (mean age = 38 yr) participated in a prospective, two-year longitudinal study comprehensively evaluating contralateral knee joint health (i.e., clinical imaging, gait biomechanics, physiological biomarkers, and patient-reported outcomes); seventeen subsequently returned for a two-year follow-up visit. For this subset with baseline and follow-up data, outcomes were compared between timepoints, and associations evaluated between values at baseline with two-year changes in tri-compartmental joint space. Upon follow-up, knee joint health worsened, particularly among seven Service members who presented at baseline with no joint degeneration (KL = 0) but returned with evidence of degeneration (KL ≥ 1). Joint space narrowing was associated with greater patellar tilt (r[12] = 0.71, p = 0.01), external knee adduction moment (r[13] = 0.64, p = 0.02), knee adduction moment impulse (r[13] = 0.61, p = 0.03), and CTX-1 concentration (r[11] = 0.83, p = 0.001), as well as lesser KOOS
MeSH term(s)	Male ; Humans ; Adult ; Longitudinal Studies ; Prospective Studies ; Knee Joint/diagnostic imaging ; Gait/physiology ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/etiology ; Lower Extremity ; Biomechanical Phenomena
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48662-9
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Article ; Online: Clinical significance of incidental findings on coronary CT angiography: Insights from a randomized controlled trial.

Goldman, Lauren H / Lerer, Rikah / Shabrang, Cyrus / Travin, Mark I / Levsky, Jeffrey M

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2019 Volume 27, Issue 6, Page(s) 2306–2315

Abstract: Background: The effect of incidental findings from coronary computed tomography angiography (CCTA) on management has not been rigorously investigated. This study uses a control group to explore this relationship.: Methods: Analysis of data from a ... ...

Abstract	Background: The effect of incidental findings from coronary computed tomography angiography (CCTA) on management has not been rigorously investigated. This study uses a control group to explore this relationship. Methods: Analysis of data from a randomized controlled trial of acute chest pain patients admitted to telemetry was performed. Patients were randomized to undergo either CCTA (n = 200) or radionuclide myocardial perfusion imaging (MPI) (n = 200). Incidental findings were determined from imaging reports. Records were reviewed to determine subsequent management and imaging during and after hospitalization. Comparisons were performed using Fischer's exact tests. Results: 386 incidental findings were found among 187 CCTA studies. No extra-cardiac incidental findings were noted in the MPI arm, which served as an effective control group. There were significantly more non-coronary medical workups during admission in the CCTA group compared to the MPI group [20% (39) vs. 12% (23), P = 0.038]. CCTA patients underwent significantly more resting echocardiography during the inpatient workup compared to the MPI group [38% (75) vs. 18% (55), P = 0.042]. CCTA patients underwent significantly more non-contrast chest CT exams in the year following admission compared to MPI patients [14% (27) vs. 7% (13) P = 0.029]. Conclusions: Incidental findings on inpatient CCTAs performed for chest pain have a significant impact on treatment and imaging during and following hospital admission.
MeSH term(s)	Acute Pain ; Adult ; Aged ; Chest Pain ; Computed Tomography Angiography/methods ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Female ; Humans ; Incidental Findings ; Lung Diseases/complications ; Lung Diseases/diagnostic imaging ; Male ; Middle Aged ; Myocardial Perfusion Imaging/methods ; Patient Admission ; Tomography, X-Ray Computed/methods ; Treatment Outcome
Language	English
Publishing date	2019-02-20
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-019-01647-6
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Article ; Online: Does Magnetic Resonance Imaging After Diagnostic Ultrasound for Soft Tissue Masses Change Clinical Management?

Goldman, Lauren H / Perronne, Laetitia / Alaia, Erin F / Samim, Mohammad M / Hoda, Syed T / Adler, Ronald S / Burke, Christopher J

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2020 Volume 40, Issue 8, Page(s) 1515–1522

Abstract: Objectives: To evaluate whether a follow-up magnetic resonance imaging (MRI) scan performed after initial ultrasound (US) to evaluate soft tissue mass (STM) lesions of the musculoskeletal system provides additional radiologic diagnostic information and ... ...

Abstract	Objectives: To evaluate whether a follow-up magnetic resonance imaging (MRI) scan performed after initial ultrasound (US) to evaluate soft tissue mass (STM) lesions of the musculoskeletal system provides additional radiologic diagnostic information and alters clinical management. Methods: A retrospective chart review was performed of patients undergoing initial US evaluations of STMs of the axial or appendicular skeleton between November 2012 and March 2019. Patients who underwent US examinations followed by MRI for the evaluation of STM lesions were identified. For inclusion, the subsequent pathologic correlation was required from either a surgical or image-guided biopsy. Imaging studies with pathologic correlations were then reviewed by 3 musculoskeletal radiologists, who were blinded to the pathologic diagnoses. The diagnostic utility of MRI was then assessed on the basis of a 5-point grading scale, and inter-reader agreements were determined by the Fleiss κ statistic. Results: Ninety-two patients underwent MRI after US for STM evaluations. Final pathologic results were available in 42 cases. Samples were obtained by surgical excision or open biopsy (n = 34) or US-guided core biopsy (n = 8). The most common pathologic diagnoses were nerve sheath tumors (n = 9), lipomas (n = 5), and leiomyomas (n = 5). Imaging review showed that the subsequent MRI did not change the working diagnosis in 73% of cases, and the subsequent MRI was not considered to narrow the differential diagnosis in 68% of cases. There was slight inter-reader agreement for the diagnostic utility of MRI among individual cases (κ = 0.10) between the 3 readers. Conclusions: The recommendation of MRI to further evaluate STM lesions seen with US frequently fails to change the working diagnosis or provide significant diagnostic utility.
MeSH term(s)	Diagnosis, Differential ; Humans ; Image-Guided Biopsy ; Magnetic Resonance Imaging ; Retrospective Studies ; Ultrasonography
Language	English
Publishing date	2020-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.15529
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Article ; Online: Exploring relationships among multi-disciplinary assessments for knee joint health in service members with traumatic unilateral lower limb loss

Joseph G. Wasser / Brad D. Hendershot / Julian C. Acasio / Lauren D. Dodd / Rebecca L. Krupenevich / Alison L. Pruziner / Ross H. Miller / Stephen M. Goldman / Michael S. Valerio / Lien T. Senchak / Mark D. Murphey / David A. Heltzel / Michael G. Fazio / Christopher L. Dearth / Nelson A. Hager

Scientific Reports, Vol 13, Iss 1, Pp 1-

a two-year longitudinal investigation

2023 Volume 11

Abstract: Abstract Motivated by the complex and multifactorial etiologies of osteoarthritis, here we use a comprehensive approach evaluating knee joint health after unilateral lower limb loss. Thirty-eight male Service members with traumatic, unilateral lower limb ...

Abstract	Abstract Motivated by the complex and multifactorial etiologies of osteoarthritis, here we use a comprehensive approach evaluating knee joint health after unilateral lower limb loss. Thirty-eight male Service members with traumatic, unilateral lower limb loss (mean age = 38 yr) participated in a prospective, two-year longitudinal study comprehensively evaluating contralateral knee joint health (i.e., clinical imaging, gait biomechanics, physiological biomarkers, and patient-reported outcomes); seventeen subsequently returned for a two-year follow-up visit. For this subset with baseline and follow-up data, outcomes were compared between timepoints, and associations evaluated between values at baseline with two-year changes in tri-compartmental joint space. Upon follow-up, knee joint health worsened, particularly among seven Service members who presented at baseline with no joint degeneration (KL = 0) but returned with evidence of degeneration (KL ≥ 1). Joint space narrowing was associated with greater patellar tilt (r[12] = 0.71, p = 0.01), external knee adduction moment (r[13] = 0.64, p = 0.02), knee adduction moment impulse (r[13] = 0.61, p = 0.03), and CTX-1 concentration (r[11] = 0.83, p = 0.001), as well as lesser KOOSSport and VR-36General Health (r[16] = − 0.69, p = 0.01 and r[16] = − 0.69, p = 0.01, respectively). This longitudinal, multi-disciplinary investigation highlights the importance of a comprehensive approach to evaluate the fast-progressing onset of knee osteoarthritis, particularly among relatively young Service members with lower limb loss.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of Stress on Menstrual Cyclicity During the Coronavirus Disease 2019 Pandemic: A Survey Study.

Ozimek, Noelle / Velez, Karen / Anvari, Hannah / Butler, Lauren / Goldman, Kara N / Woitowich, Nicole C

Journal of women's health (2002)

2021 Volume 31, Issue 1, Page(s) 84–90

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Adult ; COVID-19 ; Cross-Sectional Studies ; Female ; Humans ; Menstrual Cycle ; Middle Aged ; Pandemics ; Periodicity ; SARS-CoV-2 ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2021-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1139774-3
ISSN	1931-843X ; 1059-7115 ; 1540-9996
ISSN (online)	1931-843X
ISSN	1059-7115 ; 1540-9996
DOI	10.1089/jwh.2021.0158
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