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  1. Article ; Online: Accuracy of the Discriminatory Ability of Combined Fecal Microbiota Panel in the Early Detection of Patients with Colorectal Cancer.

    Amini, Maedeh / Rezasoltani, Sama / Asadzadeh Aghdaei, Hamid / Pourhoseingholi, Mohamad Amin / Zali, Mohammad Reza

    Journal of gastrointestinal cancer

    2023  

    Abstract: Background: Colorectal cancer (CRC) screening and detecting it at an early stage is an effective way to decrease mortality from CRC. Colonoscopy, considered the gold standard (GS) for diagnosing the disease in many countries, has several limitations. ... ...

    Abstract Background: Colorectal cancer (CRC) screening and detecting it at an early stage is an effective way to decrease mortality from CRC. Colonoscopy, considered the gold standard (GS) for diagnosing the disease in many countries, has several limitations. Therefore, the main focus of this literature is to investigate the ability of combining candidate gut microbiota for early diagnosis of CRC, both in the presence and absence of GS test outcomes.
    Methods: We analyzed the data derived from a case-control study, including 83 screening colonoscopies conducted on subjects aged 18-92 years in Tehran, Iran. The candidate gut microbiota including, ETBF, Enterococcus faecalis, and Porphyromonas gingivalis were quantified in samples using absolute qRT PCR. The Bayesian latent class model (LCM) was employed to combine the values from the multiple bacterial markers in order to optimize the discriminatory ability compared with a single marker.
    Results: Based on Bayesian logistic regression, we discovered that family history of CRC, physical activity, cigarette smoking, and food diet were all significantly associated with an increased risk of CRC. When comparing ETBF and E. faecalis to P. gingivalis, we have observed that P. gingivalis exhibited greater predictive power in detecting high-risk individuals with CRC. As such, the sensitivity, specificity, and the area under the receiver-operating characteristics curve of combining ETBF, E. faecalis, and P. gingivalis were 98%, 96%, and 0.97, respectively.
    Conclusions: This study suggests that the combined use of the three markers markedly improves classification performance compared to pairwise combinations, as well as individual markers, both with and without GS test outcomes. Noticeably, the triple composition of the fecal markers may serve as a reliable non-invasive indicator for the early prediction of CRC.
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-023-00962-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Correction to: 16 S rRNA sequencing analysis of the oral and fecal microbiota in colorectal cancer positives versus colorectal cancer negatives in Iranian population.

    Rezasoltani, Sama / Looha, Mehdi Azizmohammad / Aghdaei, Hamid Asadzadeh / Jasemi, Seyedesomayeh / Sechi, Leonardo Antonio / Gazouli, Maria / Sadeghi, Amir / Torkashvand, Shirin / Baniali, Reyhaneh / Schlüter, Hartmut / Zali, Mohammad Reza / Feizabadi, Mohammad Mehdi

    Gut pathogens

    2024  Volume 16, Issue 1, Page(s) 15

    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2478277-4
    ISSN 1757-4749
    ISSN 1757-4749
    DOI 10.1186/s13099-024-00607-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Detoxification of aflatoxin M1 by probiotics

    Rezasoltani, Sama / Amir Ebrahimi, Niloufar / Khadivi Boroujeni, Reza / Asadzadeh Aghdaei, Hamid / Norouzinia, Mohsen

    Gastroenterology and hepatology from bed to bench

    2022  Volume 15, Issue 3, Page(s) 263–270

    Abstract: Aim: The current study aimed to remove aflatoxin from reconstituted milk by adding three probiotics, namely : Background: Aflatoxins are poisonous substances produced by certain kinds of fungi that are found naturally all over the world. They can ... ...

    Abstract Aim: The current study aimed to remove aflatoxin from reconstituted milk by adding three probiotics, namely
    Background: Aflatoxins are poisonous substances produced by certain kinds of fungi that are found naturally all over the world. They can contaminate food crops and pose a serious health threat to humans and livestock. Microbial detoxification is one method of eliminating aflatoxins, including aflatoxin M1.
    Methods: For this purpose, about 109 and 107 cfu/ml of
    Results: The results showed that the highest amount of aflatoxin M1 removal was related to
    Conclusion: The results revealed the possibility of using
    Language English
    Publishing date 2022-10-14
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    DOI 10.22037/ghfbb.v15i3.2402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: 16S rRNA sequencing analysis of the oral and fecal microbiota in colorectal cancer positives versus colorectal cancer negatives in Iranian population.

    Rezasoltani, Sama / Azizmohammad Looha, Mehdi / Asadzadeh Aghdaei, Hamid / Jasemi, Seyedesomayeh / Sechi, Leonardo Antonio / Gazouli, Maria / Sadeghi, Amir / Torkashvand, Shirin / Baniali, Reyhaneh / Schlüter, Hartmut / Zali, Mohammad Reza / Feizabadi, Mohammad Mehdi

    Gut pathogens

    2024  Volume 16, Issue 1, Page(s) 9

    Abstract: Background: Colorectal cancer (CRC) poses a significant healthcare challenge, accounting for nearly 6.1% of global cancer cases. Early detection, facilitated by population screening utilizing innovative biomarkers, is pivotal for mitigating CRC ... ...

    Abstract Background: Colorectal cancer (CRC) poses a significant healthcare challenge, accounting for nearly 6.1% of global cancer cases. Early detection, facilitated by population screening utilizing innovative biomarkers, is pivotal for mitigating CRC incidence. This study aims to scrutinize the fecal and salivary microbiomes of CRC-positive individuals (CPs) in comparison to CRC-negative counterparts (CNs) to enhance early CRC diagnosis through microbial biomarkers.
    Material and methods: A total of 80 oral and stool samples were collected from Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, encompassing both CPs and CNs undergoing screening. Microbial profiling was conducted using 16S rRNA sequencing assays, employing the Nextera XT Index Kit on an Illumina NovaSeq platform.
    Results: Distinct microbial profiles were observed in saliva and stool samples of CPs, diverging significantly from those of CNs at various taxonomic levels, including phylum, family, and species. Saliva samples from CPs exhibited abundance of Calothrix parietina, Granulicatella adiacens, Rothia dentocariosa, and Rothia mucilaginosa, absent in CNs. Additionally, Lachnospiraceae and Prevotellaceae were markedly higher in CPs' feces, while the Fusobacteria phylum was significantly elevated in CPs' saliva. Conversely, the non-pathogenic bacterium Akkermansia muciniphila exhibited a significant decrease in CPs' fecal samples compared to CNs.
    Conclusion: Through meticulous selection of saliva and stool microbes based on Mean Decrease GINI values and employing logistic regression for saliva and support vector machine models for stool, we successfully developed a microbiota test with heightened sensitivity and specificity for early CRC detection.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2478277-4
    ISSN 1757-4749
    ISSN 1757-4749
    DOI 10.1186/s13099-024-00604-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors.

    Rezasoltani, Sama / Yadegar, Abbas / Asadzadeh Aghdaei, Hamid / Reza Zali, Mohammad

    Cancer medicine

    2020  Volume 10, Issue 3, Page(s) 1141–1154

    Abstract: The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in preserving homeostasis at the intestinal host-microbial interface. Conversely, specific gut microbiota may be altered during various pathological conditions and ... ...

    Abstract The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in preserving homeostasis at the intestinal host-microbial interface. Conversely, specific gut microbiota may be altered during various pathological conditions and produce a number of toxic compounds and oncoproteins, in turn, to induce both inflammatory response and carcinogenesis. Recently, promising findings have been documented toward the implementation of certain intestinal microbiome in the next era of cancer biology and cancer immunotherapy. Notably, intestinal microbiota can cooperate with immune checkpoint inhibitors (ICIs) of its host, especially in enhancing the efficacy of programmed death 1 (PD-1) protein and its ligand programmed death ligand 1 (PD-L1) blockade therapy for cancer. Herein, we review the dual function of gut microbiota in triggering GI cancers, its association with host immunity and its beneficial functions in modulation of cancer immunotherapy responses. Furthermore, we consider the significance of gut microbiota as a potential biomarker for predicting the efficacy of cancer immunotherapy. Finally, we summarize the relevant limitations that affect the effectiveness and clinical applications of gut microbiome in response to immunotherapy.
    MeSH term(s) Animals ; Gastrointestinal Microbiome/immunology ; Homeostasis ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy/methods ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/microbiology
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-12-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2045-7634
    ISSN (online) 2045-7634
    DOI 10.1002/cam4.3694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool.

    Sammallahti, Heidelinde / Sarhadi, Virinder Kaur / Kokkola, Arto / Ghanbari, Reza / Rezasoltani, Sama / Asadzadeh Aghdaei, Hamid / Puolakkainen, Pauli / Knuutila, Sakari

    Biomolecules

    2022  Volume 12, Issue 5

    Abstract: Pancreatic cancer (PC) is an aggressive malignancy with a dismal prognosis. To improve patient survival, the development of screening methods for early diagnosis is pivotal. Oncogenomic alterations present in tumor tissue are a suitable target for non- ... ...

    Abstract Pancreatic cancer (PC) is an aggressive malignancy with a dismal prognosis. To improve patient survival, the development of screening methods for early diagnosis is pivotal. Oncogenomic alterations present in tumor tissue are a suitable target for non-invasive screening efforts, as they can be detected in tumor-derived cells, cell-free nucleic acids, and extracellular vesicles, which are present in several body fluids. Since stool is an easily accessible source, which enables convenient and cost-effective sampling, it could be utilized for the screening of these traces. Herein, we explore the various oncogenomic changes that have been detected in PC tissue, such as chromosomal aberrations, mutations in driver genes, epigenetic alterations, and differentially expressed non-coding RNA. In addition, we briefly look into the role of altered gut microbiota in PC and their possible associations with oncogenomic changes. We also review the findings of genomic alterations in stool of PC patients, and the potentials and challenges of their future use for the development of stool screening tools, including the possible combination of genomic and microbiota markers.
    MeSH term(s) Feces ; Gastrointestinal Microbiome ; Humans ; Mass Screening ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12050652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Expression of Toll-Like Receptors 2, 4 and 5 in Relation to Gut Microbiota in Colon Neoplasm Patients with and without Inflammatory Bowel Disease.

    Asadzadeh Aghdaei, Hamid / Rezasoltani, Sama / Olfatifar, Meisam / Nazemalhosseini Mojarad, Ehsan / Sherkat, Ghazal / Yadegar, Abbas / Feizabadi, Mohammad Mehdi / Zali, Mohammad Reza

    Avicenna journal of medical biotechnology

    2022  Volume 14, Issue 3, Page(s) 188–195

    Abstract: Background: Toll-Like Receptors (TLRs) are the critical mediators of inflammatory routs in the gut, which play an essential role in regulating the immune responses towards various ligands derived from pathogenic bacteria. Also, TLR signaling has been ... ...

    Abstract Background: Toll-Like Receptors (TLRs) are the critical mediators of inflammatory routs in the gut, which play an essential role in regulating the immune responses towards various ligands derived from pathogenic bacteria. Also, TLR signaling has been implicated in the development of Inflammatory Bowel Disease (IBD), Adenomatous Polyp (AP), and Colorectal Cancer (CRC). Here, we aimed to examine the expression of some TLRs concerning certain fecal bacteria in AP and CRC patients with and without IBD.
    Methods: This case-control study collected fecal and colonic tissue samples from 93 patients versus Normal Controls (NC)
    Results: Compared to NC individuals, in AP and CRC patients, the mRNA expressions of TLR4 and TLR2 were significantly increased while TLR5 was decreased. A meaningful association between TLRs mRNA expression levels and the abundance of some selected fecal bacteria was detected. Also, there was a significant relationship between participant's food regimes, smoking habit and intestinal TLRs expression.
    Conclusion: Our study proposed the important role of TLRs during adenomatous and CRC formation. Alterations in TLRs expression associated with certain gut bacteria may contribute to disease development.
    Language English
    Publishing date 2022-08-18
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2520683-7
    ISSN 2008-4625 ; 2008-2835
    ISSN (online) 2008-4625
    ISSN 2008-2835
    DOI 10.18502/ajmb.v14i3.9825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The necessity of gut microbiome characterization in diseases prevention and therapy.

    Rezasoltani, Sama / Nazemalhosseini Mojarrad, Ehsan / Norouzinia, Mohsen / Asadzadeh Aghdaei, Hamid

    Gastroenterology and hepatology from bed to bench

    2017  Volume 10, Issue 2, Page(s) 150–151

    Language English
    Publishing date 2017-05-09
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Antimicrobial Resistance as a Hidden Menace Lurking Behind the COVID-19 Outbreak: The Global Impacts of Too Much Hygiene on AMR.

    Rezasoltani, Sama / Yadegar, Abbas / Hatami, Behzad / Asadzadeh Aghdaei, Hamid / Zali, Mohammad Reza

    Frontiers in microbiology

    2020  Volume 11, Page(s) 590683

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus that was recently discovered in 2019. While the world is working hard to overcome and control the coronavirus disease 2019 (COVID-19) pandemic, it is also crucial to be ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus that was recently discovered in 2019. While the world is working hard to overcome and control the coronavirus disease 2019 (COVID-19) pandemic, it is also crucial to be prepared for the great impacts of this outbreak on the development of antimicrobial resistance (AMR). It is predicted that inappropriate and too much use of antibiotics, biocides, and disinfectants during this pandemic may raise disastrous effects on antibiotic stewardship programs and AMR control all around the world. Furthermore, the use of certain antibiotics alone or in combination with antiviral agents or other medications for the treatment of secondary bacterial infections among COVID-19 patients may be regarded as a major factor that negatively affects host immune response by disrupting mitochondrial function and activity. Herein, we suggest that the current management strategies to control AMR and prioritize antibiotic stewardship schemes should be extremely highlighted in relation to the COVID-19 outbreak. The rising concerns about excessive use of antimicrobials and biocides and taking too much hygiene also need to be addressed during this pandemic due to their impacts on AMR, public health, and the environment.
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.590683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: How Patients With Chronic Liver Diseases Succeed to Deal With COVID-19?

    Rezasoltani, Sama / Hatami, Behzad / Yadegar, Abbas / Asadzadeh Aghdaei, Hamid / Zali, Mohammad Reza

    Frontiers in medicine

    2020  Volume 7, Page(s) 398

    Abstract: The human pathogenic coronaviruses cause infections of the respiratory tract from mild to severe ranges. Mild cases may look like the common cold, while cases with severe disease may represent severe acute respiratory syndrome (SARS), Middle East ... ...

    Abstract The human pathogenic coronaviruses cause infections of the respiratory tract from mild to severe ranges. Mild cases may look like the common cold, while cases with severe disease may represent severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19). Currently, COVID-19 is a rapidly emerging infection and the number of COVID-19 cases and its associated deaths are quickly growing around the world. COVID-19 infection can involve multiple body organs other than respiratory tract and lungs such as liver. It is hypothesized that COVID-19-associated liver injury can hamper the host drug metabolism and excretion. Liver involvement present with the elevation of enzymatic levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) accompanied by enhanced total bilirubin and decreased albumin levels has been reported in COVID-19 cases. One of the major concerns during COVID-19 outbreak is the population with a history of pre-existing liver disorders including viral hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), autoimmune hepatitis, hepatic compensated, and decompensated cirrhosis. Herein, we discussed the probable correlation between COVID-19 infection and liver damages, particularly chronic and pre-existing liver diseases during COVID-19 outbreak. Furthermore, we explained about the liver transplant recipients and post-transplant drugs used in patients with COVID-19 infection. Finally, we discussed about the therapeutic medications administered in COVID-19 patients with underlying liver injuries and their significant considerations.
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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