LIVIVO - Search results -

Search results

Result 1 - 10 of total 178

Search options

Article: High time for a paradigm shift in psychiatry.

Riecher-Rössler, Anita / Studerus, Erich

World psychiatry : official journal of the World Psychiatric Association (WPA)

2016 Volume 15, Issue 2, Page(s) 131–133

Language	English
Publishing date	2016-06-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2236130-3
ISSN	2051-5545 ; 1723-8617
ISSN (online)	2051-5545
ISSN	1723-8617
DOI	10.1002/wps.20329
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Mismatch negativity generation in subjects at risk for psychosis: source analysis is more sensitive than surface electrodes in risk prediction.

Aeberli, Tina / Müller, Mario / Theodoridou, Anastasia / Hagenmuller, Florence / Seifritz, Erich / Walitza, Susanne / Rössler, Wulf / Kawohl, Wolfram / Heekeren, Karsten

Frontiers in psychiatry

2023 Volume 14, Page(s) 1130809

Abstract: Background: Deficits of mismatch negativity (MMN) in patients with schizophrenia have been demonstrated many times and there is growing evidence that alterations of MMN already exist in individuals at risk for psychosis. The present study examines ... ...

Abstract	Background: Deficits of mismatch negativity (MMN) in patients with schizophrenia have been demonstrated many times and there is growing evidence that alterations of MMN already exist in individuals at risk for psychosis. The present study examines differences in MMN between subjects fulfilling ultra-high risk (UHR) or only basic symptoms criteria and it addresses the question, if MMN source analysis can improve prediction of transition to psychosis. Methods: The MMN to duration, frequency, and intensity deviants was recorded in 50 healthy controls and 161 individuals at risk for psychosis classified into three subgroups: only basic symptoms ( Results: Significant differences in MMN generation among the four groups were revealed at surface electrodes Cz and C4 ( Conclusion: MMN activity differed significantly between subjects presenting only basic symptoms and subjects which additionally meet UHR criteria. The largest differences between groups as well as between individuals with and without transition were observed at the frontal source. The present results suggest that source analysis is more sensitive than surface electrodes in psychosis risk prediction by MMN.
Language	English
Publishing date	2023-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1130809
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Prediction of conversion to psychosis in individuals with an at-risk mental state: a brief update on recent developments.

Riecher-Rössler, Anita / Studerus, Erich

Current opinion in psychiatry

2017 Volume 30, Issue 3, Page(s) 209–219

Abstract: Purpose of review: So far, only little more than one-third of individuals classified as being at-risk for psychosis have been shown to actually convert to frank psychosis during follow-up. There have therefore been enormous efforts to improve the ... ...

Abstract	Purpose of review: So far, only little more than one-third of individuals classified as being at-risk for psychosis have been shown to actually convert to frank psychosis during follow-up. There have therefore been enormous efforts to improve the accuracy of predicting this transition. We reviewed the most recent studies in the field with the aim to clarify whether accuracy of prediction has been improved by the different research endeavors and what could be done to further improve it, and/or what alternative goals research should pursue. Recent findings: A total of 56 studies published between May 2015 and December 2016 were included, of which eight were meta-analyses. New meta-analytical evidence confirms that established instruments for checking clinical risk criteria have an excellent clinical utility in individuals referred to high-risk services. Within a such identified group of ultra-high-risk (UHR) individuals, especially Brief Limited Intermittent Psychotic Symptoms and Attenuated Psychotic Symptoms seem to predict transition. Further assessments should be performed within the UHR individuals, as risk of transition seems particularly high in those with an even higher severity of certain symptoms such as suspiciousness or anhedonia, in those with lower global or social functioning, poor neurocognitive performance or cannabis abuse. Also, electroencephalography, neuroimaging and blood biomarkers might contribute to improving individual prediction. The most promising approach certainly is a staged multidomain assessment. Risk calculators to integrate all data for an individualized prediction are being developed. Summary: Prediction of psychosis is already possible with an excellent prognostic performance based on clinical assessments. Recent studies show that this accuracy can be further improved by using multidomain approaches and modern statistics for individualized prediction. The challenge now is the translation into the clinic with a broad clinical implementation.
MeSH term(s)	Disease Progression ; Humans ; Psychotic Disorders/diagnosis ; Risk Assessment/standards
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645162-7
ISSN	1473-6578 ; 0951-7367
ISSN (online)	1473-6578
ISSN	0951-7367
DOI	10.1097/YCO.0000000000000320
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2532: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Holoprosencephaly in the genomics era.

Roessler, Erich / Hu, Ping / Muenke, Maximilian

American journal of medical genetics. Part C, Seminars in medical genetics

2018 Volume 178, Issue 2, Page(s) 165–174

Abstract: Holoprosencephaly (HPE) is the direct consequence of specific genetic and/or environmental insults interrupting the midline specification of the nascent forebrain. Such disturbances can lead to a broad range of phenotypic consequences for the brain and ... ...

Abstract	Holoprosencephaly (HPE) is the direct consequence of specific genetic and/or environmental insults interrupting the midline specification of the nascent forebrain. Such disturbances can lead to a broad range of phenotypic consequences for the brain and face in humans. This malformation sequence is remarkably common in utero (1 in 250 human fetuses), but 97% typically do not survive to birth. The precise molecular pathogenesis of HPE in these early human embryos remains largely unknown. Here, we outline our current understanding of the principal driving factors leading to HPE pathologies and elaborate our multifactorial integrated genomics approach. Overall, our understanding of the pathogenesis continues to become simpler, rather than more complicated. Genomic technologies now provide unprecedented insight into disease-associated variation, including the overall extent of genetic interactions (coding and noncoding) predicted to explain divergent phenotypes.
MeSH term(s)	Animals ; Female ; Holoprosencephaly/embryology ; Holoprosencephaly/genetics ; Humans ; Infant, Newborn ; Mutation ; Phenotype ; Pregnancy
Language	English
Publishing date	2018-05-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2108622-9
ISSN	1552-4876 ; 0148-7299 ; 1552-4868
ISSN (online)	1552-4876
ISSN	0148-7299 ; 1552-4868
DOI	10.1002/ajmg.c.31615
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1376/C: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Conference proceedings: Kardiovaskuläre Risikofaktoren und erektile Dysfunktion

Rössler, Navid / Jahnen, Matthias / Schiele, Stefan / Kron, Martina / Schulwitz, Helga / Gschwend, Jürgen Erich / Herkommer, Kathleen

2022 , Page(s) 22urobay67

Event/congress	48. Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie; Lindau; ; Österreichische Gesellschaft für Urologie und Andrologie; 2022
Keywords	Medizin, Gesundheit
Publishing date	2022-05-18
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/22urobay67
Database	German Medical Science

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Dopamine-Induced Dysconnectivity Between Salience Network and Auditory Cortex in Subjects With Psychotic-like Experiences: A Randomized Double-Blind Placebo-Controlled Study.

Rössler, Julian / Rössler, Wulf / Seifritz, Erich / Unterrassner, Lui / Wyss, Thomas / Haker, Helene / Wotruba, Diana

Schizophrenia bulletin

2019 Volume 46, Issue 3, Page(s) 732–740

Abstract: Dopamine is involved in the pathophysiology of schizophrenia. Disrupted salience processing by the salience network (SN) may be a central link between dysregulated dopamine function and psychotic symptoms. However, dopaminergic influence on the SN and ... ...

Abstract	Dopamine is involved in the pathophysiology of schizophrenia. Disrupted salience processing by the salience network (SN) may be a central link between dysregulated dopamine function and psychotic symptoms. However, dopaminergic influence on the SN and its presumed influence on psychotic and subpsychotic symptoms or psychotic-like experiences in healthy individuals remain unclear. Therefore, we investigated dopamine-induced changes in functional connectivity of the right anterior insula (rAI), a central SN hub, and their association with psychotic-like experiences. We enrolled 54 healthy, right-handed male subjects in a randomized, double-blind, cross-sectional placebo-controlled experiment. Psychotic-like experiences were assessed using the revised Exceptional Experiences Questionnaire (PAGE-R). They then received either placebo (n = 32) or 200 mg L-DOPA (n = 33), a dopamine precursor, orally and underwent resting-state functional magnetic resonance imaging. In a seed-to-voxel approach, we analyzed dopamine-induced changes in functional connectivity of the rAI and assessed the relationship between functional connectivity changes and PAGE-R score. L-DOPA reduced functional connectivity between the rAI and the left auditory cortex planum polare. In the placebo group, we found a strong negative correlation between PAGE-R score and rAI to planum polare functional connectivity; in the L-DOPA group, there was a strong positive correlation between PAGE-R score and functional connectivity between rAI and planum polare. The PAGE-R score explained about 30% of the functional connectivity variation between rAI and planum polare in the two groups. Our findings suggest that psychotic-like experiences are associated with dopamine-induced disruption of auditory input to the SN, which may lead to aberrant attribution of salience.
MeSH term(s)	Adult ; Auditory Cortex/diagnostic imaging ; Auditory Cortex/drug effects ; Auditory Cortex/metabolism ; Auditory Cortex/physiopathology ; Auditory Perception/physiology ; Connectome ; Cross-Sectional Studies ; Dopamine/metabolism ; Dopamine Agents/administration & dosage ; Dopamine Agents/pharmacology ; Double-Blind Method ; Humans ; Levodopa/administration & dosage ; Levodopa/pharmacology ; Magnetic Resonance Imaging ; Male ; Nerve Net/diagnostic imaging ; Nerve Net/drug effects ; Nerve Net/metabolism ; Nerve Net/physiopathology ; Psychotic Disorders/diagnostic imaging ; Psychotic Disorders/metabolism ; Psychotic Disorders/physiopathology ; Young Adult
Chemical Substances	Dopamine Agents ; Levodopa (46627O600J) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2019-12-20
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbz110
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1323: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development and Validation of a Dynamic Risk Prediction Model to Forecast Psychosis Onset in Patients at Clinical High Risk.

Studerus, Erich / Beck, Katharina / Fusar-Poli, Paolo / Riecher-Rössler, Anita

Schizophrenia bulletin

2019 Volume 46, Issue 2, Page(s) 252–260

Abstract: The prediction of outcomes in patients at Clinical High Risk for Psychosis (CHR-P) almost exclusively relies on static data obtained at a single snapshot in time (ie, baseline data). Although the CHR-P symptoms are intrinsically evolving over time, ... ...

Abstract	The prediction of outcomes in patients at Clinical High Risk for Psychosis (CHR-P) almost exclusively relies on static data obtained at a single snapshot in time (ie, baseline data). Although the CHR-P symptoms are intrinsically evolving over time, available prediction models cannot be dynamically updated to reflect these changes. Hence, the aim of this study was to develop and internally validate a dynamic risk prediction model (joint model) and to implement this model in a user-friendly online risk calculator. Furthermore, we aimed to explore the prognostic performance of extended dynamic risk prediction models and to compare static with dynamic prediction. One hundred ninety-six CHR-P patients were recruited as part of the "Basel Früherkennung von Psychosen" (FePsy) study. Psychopathology and transition to psychosis was assessed at regular intervals for up to 5 years using the Brief Psychiatric Rating Scale-Expanded (BPRS-E). Various specifications of joint models were compared with regard to their cross-validated prognostic performance. We developed and internally validated a joint model that predicts psychosis onset from BPRS-E disorganization and years of education at baseline and BPRS-E positive symptoms during the follow-up with good prognostic performance. The model was implemented as online risk calculator (http://www.fepsy.ch/DPRP/). The use of extended joint models slightly increased the prognostic accuracy compared to basic joint models, and dynamic models showed a higher prognostic accuracy than static models. Our results confirm that extended joint modeling could improve the prediction of psychosis in CHR-P patients. We implemented the first online risk calculator that can dynamically update psychosis risk prediction.
MeSH term(s)	Adolescent ; Adult ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Male ; Models, Theoretical ; Prognosis ; Psychotic Disorders/diagnosis ; Reproducibility of Results ; Risk Assessment/methods ; Risk Assessment/standards ; Schizophrenia/diagnosis ; Young Adult
Language	English
Publishing date	2019-07-29
Publishing country	United States
Document type	Journal Article ; Validation Study
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbz059
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1323: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Mismatch negativity generation in subjects at risk for psychosis

Aeberli, Tina / Müller, Mario / Theodoridou, Anastasia / Hagenmuller, Florence / Seifritz, Erich / Walitza, Susanne / Rössler, Wulf / Kawohl, Wolfram / Heekeren, Karsten

Frontiers in Psychiatry

Source analysis is more sensitive than surface electrodes in risk prediction

2023

Title translation	Erzeugung von Mismatch-Negativität bei Personen mit Psychoserisiko: Die Quellenanalyse ist bei der Risikovorhersage empfindlicher als Oberflächenelektroden (DeepL)
Abstract	Background: Deficits of mismatch negativity (MMN) in patients with schizophrenia have been demonstrated many times and there is growing evidence that alterations of MMN already exist in individuals at risk for psychosis. The present study examines differences in MMN between subjects fulfilling ultra-high risk (UHR) or only basic symptoms criteria and it addresses the question, if MMN source analysis can improve prediction of transition to psychosis. Methods: The MMN to duration, frequency, and intensity deviants was recorded in 50 healthy controls and 161 individuals at risk for psychosis classified into three subgroups: only basic symptoms (n = 74), only ultra-high risk (n = 13) and persons who fulfill both risk criteria (n = 74). Based on a three-source model of MMN generation, we conducted an MMN source analysis and compared the amplitudes of surface electrodes and sources among the three groups. Results: Significant differences in MMN generation among the four groups were revealed at surface electrodes Cz and C4 (p < 0.05) and at the frontal source (p < 0.001) for duration deviant stimuli. The 15 subjects from the risk groups who subsequently developed a manifest psychosis had a significantly lower MMN amplitude at frontal source (p = 0.019) without showing significant differences at surface electrodes. Low activity at frontal MMN source increased the risk of transition to manifest disease by the factor 3.12 in UHR subjects. Conclusion: MMN activity differed significantly between subjects presenting only basic symptoms and subjects which additionally meet UHR criteria. The largest differences between groups as well as between individuals with and without transition were observed at the frontal source. The present results suggest that source analysis is more sensitive than surface electrodes in psychosis risk prediction by MMN.
Keywords	At Risk Populations ; Electrical Activity ; Electrodes ; Elektrische Aktivität ; Elektroden ; Mismatch Negativity ; Mismatch-Negativität ; Prediction ; Psychose ; Psychosis ; Risikogruppen ; Vorhersage
Language	English
Document type	Article
DOI	10.3389/fpsyt.2023.1130809
Database	PSYNDEX

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Loss-of-function mutations in FGF8 can be independent risk factors for holoprosencephaly.

Hong, Sungkook / Hu, Ping / Roessler, Erich / Hu, Tommy / Muenke, Maximilian

Human molecular genetics

2018 Volume 27, Issue 11, Page(s) 1989–1998

Abstract: The utilization of next generation sequencing has been shown to accelerate gene discovery in human disease. However, our confidence in the correct disease-associations of rare variants continues to depend on functional analysis. Here, we employ a ... ...

Abstract	The utilization of next generation sequencing has been shown to accelerate gene discovery in human disease. However, our confidence in the correct disease-associations of rare variants continues to depend on functional analysis. Here, we employ a sensitive assay of human FGF8 variants in zebrafish to demonstrate that the spectrum of isoforms of FGF8 produced by alternative splicing can provide key insights into the genetic susceptibility to human malformations. In addition, we describe novel mutations in the FGF core structure that have both subtle and profound effects on ligand posttranslational processing and biological activity. Finally, we solve a case of apparent digenic inheritance of novel variants in SHH and FGF8, two genes known to functionally coregulate each other in the developing forebrain, as a simpler case of FGF8 diminished function.
MeSH term(s)	Alternative Splicing/genetics ; Animals ; Fibroblast Growth Factor 8/genetics ; Fibroblast Growth Factors/genetics ; Gene Expression Regulation, Developmental ; Genetic Predisposition to Disease ; Hedgehog Proteins/genetics ; Holoprosencephaly/genetics ; Holoprosencephaly/physiopathology ; Humans ; In Situ Hybridization ; Mutation/genetics ; Risk Factors ; Signal Transduction/genetics ; Zebrafish/genetics ; Zebrafish Proteins/genetics
Chemical Substances	FGF8 protein, human ; Hedgehog Proteins ; Zebrafish Proteins ; fgf8a protein, zebrafish ; Fibroblast Growth Factor 8 (148997-75-5) ; Fibroblast Growth Factors (62031-54-3)
Language	English
Publishing date	2018-04-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddy106
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3469: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Latent state-trait structure of BPRS subscales in clinical high-risk state and first episode psychosis.

Hochstrasser, Lisa / Studerus, Erich / Riecher-Rössler, Anita / Schimmelmann, Benno G / Lambert, Martin / Lang, Undine E / Borgwardt, Stefan / Stieglitz, Rolf-Dieter / Huber, Christian G

Scientific reports

2022 Volume 12, Issue 1, Page(s) 6652

Abstract: To investigate the longitudinal latent state-trait structure of the different dimensions of psychosis symptoms in clinical high-risk state (CHRS) and first episode psychosis (FEP) individuals over a one year time-span. This paper examines if the symptom ... ...

Abstract	To investigate the longitudinal latent state-trait structure of the different dimensions of psychosis symptoms in clinical high-risk state (CHRS) and first episode psychosis (FEP) individuals over a one year time-span. This paper examines if the symptom clusters Positive Symptoms, Negative Symptoms, Affectivity, Resistance, Activation, and Excitement according to the Brief Psychiatric Rating Scale (BPRS) differ in their trait and state characters in 196 CHRS and 131 FEP individuals. Statistical analysis was performed using latent state-trait analysis. On average, trait differences accounted for 72.2% of Positive Symptoms, 81.1% of Negative Symptoms, 57.0% of Affectivity, and 69.2% of Activation, whereas 15.0% of the variance of Resistance and 13.2% of the variance of Excitement were explained by trait differences. Explorative analyses showed a trait components' increase of 0.408 in Positive Symptoms from baseline up to the 9th month and an increase of 0.521 in Affectivity from baseline up to the 6th month. Negative Symptoms had the highest trait component levels of all subscales between baseline and 6 months. The finding that an increasing proportion of psychosis symptoms is persisting over time underlines the importance of early intervention programs in individuals with psychotic disorders.
MeSH term(s)	Brief Psychiatric Rating Scale ; Humans ; Psychiatric Status Rating Scales ; Psychotic Disorders/diagnosis ; Psychotic Disorders/psychology
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-10207-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito