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Article ; Online: Reply to B. Zhao et al.

Polley, Mei-Yin C / Gorlia, Thierry / Lassman, Andy B / van den Bent, Martin J

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 41, Issue 4, Page(s) 934–935

Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.01874
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Dysregulated monocyte-derived macrophage response to Group B

Ravi, Denho / Ntinopoulou, Erato / Guetta, Nessim / Weier, Manuela / Vogel, Verena / Spellerberg, Barbara / Sendi, Parham / Gremlich, Sandrine / Roger, Thierry / Giannoni, Eric

Frontiers in immunology

2023 Volume 14, Page(s) 1268804

Abstract: Introduction: Streptococcus agalactiae: Methods: Monocytes from umbilical cord blood of healthy term newborns and from peripheral blood of healthy adult subjects were cultured with M-CSF to induce MDMs. M-CSF-MDMs, GM-CSF- and IFNγ-activated MDMs ... ...

Abstract	Introduction: Streptococcus agalactiae Methods: Monocytes from umbilical cord blood of healthy term newborns and from peripheral blood of healthy adult subjects were cultured with M-CSF to induce MDMs. M-CSF-MDMs, GM-CSF- and IFNγ-activated MDMs were exposed to GBS COH1, a reference strain for neonatal sepsis. Results: GBS induced a greater release of IL-1β, IL-6, IL-10, IL-12p70 and IL-23 in newborn compared to adult MDMs, while IL-18, IL-21, IL-22, TNF, RANTES/CCL5, MCP-1/CCL2 and IL-8/CXCL8 were released at similar levels. MDM responses to GBS were strongly influenced by conditions of activation and were distinct from those to synthetic bacterial lipopeptides and lipopolysaccharides. Under similar conditions of opsonization, newborn MDMs phagocytosed and killed GBS as efficiently as adult MDMs. Discussion: Altogether, the production of excessive levels of Th1- (IL-12p70), Th17-related (IL-1β, IL-6, IL-23) and anti-inflammatory (IL-10) cytokines is consistent with a dysregulated response to GBS in newborns. The high responsiveness of newborn MDMs may play a role in the progression of GBS infection in newborns, possibly contributing to the development of life-threatening organ dysfunction.
MeSH term(s)	Adult ; Infant, Newborn ; Humans ; Interleukin-10 ; Macrophage Colony-Stimulating Factor ; Interleukin-6 ; Neonatal Sepsis ; Streptococcus agalactiae ; Macrophages ; Interleukin-12 ; Interleukin-23
Chemical Substances	Interleukin-10 (130068-27-8) ; Macrophage Colony-Stimulating Factor (81627-83-0) ; Interleukin-6 ; Interleukin-12 (187348-17-0) ; Interleukin-23
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1268804
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Article ; Online: Regulatory T and B cells in pediatric Henoch-Schönlein purpura: friends or foes?

Filleron, Anne / Cezar, Renaud / Fila, Marc / Protsenko, Nastassja / Van Den Hende, Kathleen / Jeziorski, Eric / Occean, Bob / Chevallier, Thierry / Corbeau, Pierre / Tran, Tu Anh

Arthritis research & therapy

2024 Volume 26, Issue 1, Page(s) 52

Abstract: ... Treg), T helper 3 (Th3), and regulatory B cell (Breg) subpopulations that might intervene ...

Abstract	Background and objectives: Henoch-Schönlein purpura (HSP) is the most common immunoglobulin A-mediated systemic vasculitis in childhood. We studied immune dysregulation in HSP by analyzing regulatory T (Treg), T helper 3 (Th3), and regulatory B cell (Breg) subpopulations that might intervene in immune activation, IgA production, and HSP clinical manifestations. Methods: This prospective study included 3 groups of children: 30 HSP on acute phase, 30 HSP on remission, and 40 healthy controls (HCs) matched on age. Treg, Breg, and Th3 were analyzed by flow cytometry. Serum immunoglobulin and cytokine levels were quantified by ELISA and Luminex. Results: Treg frequencies were higher in acute HSP than in remitting HSP and HCs (6.53% [4.24; 9.21] vs. 4.33% [3.6; 5.66], p = 0.002, and vs. 4.45% [3.01; 6.6], p = 0.003, respectively). Activated Th3 cells (FoxP3 + Th3 cells) tend to be more abundant in HSP than in HCs (78.43% [50.62; 80.84] vs. 43.30% [40.20; 49.32], p = 0.135). Serum IgA, IL-17, and latency-associated peptide (a marker of the anti-inflammatory cytokine TGF-beta production) were significantly and inflammatory cytokines TNF-alpha, IL-1-beta, and IL-6 were non-significantly higher in HSP than HCs. Bregs were identical between the groups, but, in patients with renal impairment, Breg percentage was lower compared to those without. Treg removal in PBMC culture resulted in an increase in IgA production in HSP proving a negative regulatory role of Tregs on IgA production. Conclusions: In pediatric HSP, immune activation persists in spite of an increase in Th3 and Tregs. Th3 could be involved in IgA hyperproduction, inefficiently downregulated by Tregs. Lack of Bregs appears linked to renal impairment.
MeSH term(s)	Child ; Humans ; IgA Vasculitis ; Leukocytes, Mononuclear ; Prospective Studies ; Cytokines ; Immunoglobulin A
Chemical Substances	Cytokines ; Immunoglobulin A
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-024-03278-w
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Zs.A 5490: Show issues

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Article ; Online: Hepatitis B Delta: assessment of the knowledge and practices of hepato-gastroenterologists practicing in non-academic settings in France.

Cadranel, Jean-François D / Zougmoré, Honoré T / Efole, Jean-René Ngele / Hanslik, Bertrand / Causse, Xavier / Rosa, Isabelle / Lemaitre, Caroline / Mokhtari, Camélia / Baron, Aurore / Thevenot, Thierry / Medmoun, Mourad / Smadhi, Ryad / Fantognon, Gildas / Remy, André J / Macaigne, Gilles / Arondel, Yves / Arpurt, Jean-Pierre / Bellaiche, Guy / Bourlière, Marc /

De Kerguenec, Caroline / Heluwaert, Frédéric / Verlynde, Juliette / Halfon, Philippe / Roulot, Dominique / Carrier, Paul / Loustaud-Ratti, Véronique / Lemagoarou, Tristan

European journal of gastroenterology & hepatology

2024 Volume 36, Issue 6, Page(s) 735–741

Abstract: Background: Data on the management of Hepatitis B-Delta (HB-D) by hepatogastroenterologists (HGs ...

Abstract	Background: Data on the management of Hepatitis B-Delta (HB-D) by hepatogastroenterologists (HGs) practicing in nonacademic hospitals or private practices are unknown in France. Objective: We aimed to evaluate the knowledge and practices of HGs practicing in nonacademic settings regarding HB-D. Methods: A Google form document was sent to those HGs from May to September 2021. Results: A total of 130 HGs (mean age, 45 years) have participated in this survey. Among HBsAg-positive patients, Delta infection was sought in only 89% of cases. Liver fibrosis was assessed using FibroScan in 77% of the cases and by liver biopsy in 81% of the cases. A treatment was proposed for patients with >F2 liver fibrosis in 49% of the cases regardless of transaminase levels and for all the patients by 39% of HGs. Responding HGs proposed a treatment using pegylated interferon in 50% of cases, bulevirtide in 45% of cases and a combination of pegylated interferon and bulevirtide in 40.5% of cases. Among the criteria to evaluate the treatment efficacy, a decrease or a normalization of transaminases was retained by 89% of responding HGs, a reduction of liver fibrosis score for 70% of them, an undetectable delta RNA and HBsAg for 55% of them and a 2 log 10 decline in delta viremia for 62% of the cases. Conclusion: Hepatitis Delta screening was not systematically performed in HBsAg-positive patients despite the probable awareness and knowledge of the few responders who were able to prescribe treatments of hepatitis delta.
MeSH term(s)	Humans ; France ; Middle Aged ; Female ; Male ; Antiviral Agents/therapeutic use ; Practice Patterns, Physicians'/statistics & numerical data ; Gastroenterology ; Gastroenterologists ; Liver Cirrhosis/virology ; Adult ; Health Knowledge, Attitudes, Practice ; Hepatitis Delta Virus/isolation & purification ; Hepatitis Delta Virus/genetics ; Biopsy ; Hepatitis B Surface Antigens/blood
Chemical Substances	Antiviral Agents ; Hepatitis B Surface Antigens
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002707
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Zs.A 2932: Show issues

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Article ; Online: The aminopeptidase B (Ap-B) is phosphorylated in HEK293 cells.

Adicéam, Emilie / Devakumaran, Sarujan / Cadel, Sandrine / Foulon, Thierry / Ghelis, Thanos

Biochimie

2022 Volume 201, Page(s) 204–212

Abstract: ... phosphorylation. Aminopeptidase B (Ap-B), a M1 metallopeptidase, hydrolyses the peptide bond on the carbonyl side ...

Abstract	Proteolysis is a post-translational modification (PTM) that affects the whole proteome. First regarded as only destructive, it is more precise than expected. It is finely regulated by other PTMs like phosphorylation. Aminopeptidase B (Ap-B), a M1 metallopeptidase, hydrolyses the peptide bond on the carbonyl side of basic residues at the NH
MeSH term(s)	Alkaline Phosphatase/metabolism ; Aminopeptidases/chemistry ; Diamond/metabolism ; HEK293 Cells ; Humans ; Peptides/chemistry ; Phosphorylation ; Protein Processing, Post-Translational ; Proteome/metabolism
Chemical Substances	Peptides ; Proteome ; Diamond (7782-40-3) ; Alkaline Phosphatase (EC 3.1.3.1) ; Aminopeptidases (EC 3.4.11.-) ; aminopeptidase B (EC 3.4.11.6)
Language	English
Publishing date	2022-08-08
Publishing country	France
Document type	Journal Article
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2022.07.010
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Uc I Zs.135: Show issues

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Article ; Online: Degradation of aflatoxin B

Liu, Yingli / Mao, Huijia / Woldemariam Yohannes, Kalekristos / Wan, Zhen / Cao, Yating / Tron, Thierry / Lin, Junfang / Jiang, Yixuan / Li, Hongyan / Wang, Jing

Food research international (Ottawa, Ont.)

2021 Volume 145, Page(s) 110418

Abstract: Aflatoxin B ...

Abstract	Aflatoxin B
MeSH term(s)	Aflatoxin B1 ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Humans ; Laccase ; Saccharomyces cerevisiae ; Tandem Mass Spectrometry ; Trametes
Chemical Substances	Aflatoxin B1 (9N2N2Y55MH) ; Laccase (EC 1.10.3.2)
Language	English
Publishing date	2021-05-19
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2021.110418
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Article ; Online: Transcriptomic Analysis of Livers of Inactive Carriers of Hepatitis B Virus With Distinct Expression of Hepatitis B Surface Antigen.

Rico Montanari, Noe / Ramirez, Ricardo / Van Buuren, Nick / van den Bosch, Thierry P P / Doukas, Michail / Debes, Jose D / Feierbach, Becket / Boonstra, Andre

The Journal of infectious diseases

2021 Volume 225, Issue 6, Page(s) 1081–1090

Abstract: Inactive carrier phases in chronic hepatitis B virus (HBV) infection present minimal liver disease ... responsible remain elusive. Moreover, hepatitis B surface antigen (HBsAg) production-hypothesized to modulate ...

Abstract	Inactive carrier phases in chronic hepatitis B virus (HBV) infection present minimal liver disease and HBV replication activity suggesting partial immune reconstitution, although the mechanisms responsible remain elusive. Moreover, hepatitis B surface antigen (HBsAg) production-hypothesized to modulate the immune response-is unaltered. In the current study, we assessed the intrahepatic transcriptome in inactive carriers of HBV versus healthy liver donors, including in the context of diverse HBsAg levels (serum and liver), to better understand the phenomenon of immune control. We found a deregulated liver transcriptome in inactive carriers compared with healthy controls, despite normal liver function. Moreover, diverse HBsAg levels have minimal impact on the liver transcriptome in inactive carriers, although gene correlation analysis revealed that leukocyte activation, recruitment, and innate responses genes were correlated with liver HBsAg levels. These findings provide more insight into the mechanisms underlying anti-HBV strategies currently under development, aimed at interfering with HBsAg production or inducing a state of immune control.
MeSH term(s)	Carrier State ; DNA, Viral ; Hepatitis B/genetics ; Hepatitis B Surface Antigens/genetics ; Hepatitis B virus/genetics ; Hepatitis B, Chronic ; Humans ; Liver ; Transcriptome
Chemical Substances	DNA, Viral ; Hepatitis B Surface Antigens
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab381
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Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

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Article: Subclinical proximal tubulopathy in hepatitis B: The roles of nucleot(s)ide analogue treatment and the hepatitis B virus.

Brayette, Anaïs / Essig, Marie / Carrier, Paul / Debette-Gratien, Marilyne / Labrunie, Anaïs / Alain, Sophie / Maynard, Marianne / Ganne-Carrié, Nathalie / Nguyen-Khac, Eric / Pinet, Pauline / De Ledinghen, Victor / Renou, Christophe / Mathurin, Philippe / Vanlemmens, Claire / Di Martino, Vincent / Gervais, Anne / Foucher, Juliette / Isabelle, Fouchard-Hubert / Vergniol, Julien /

World journal of hepatology

2021 Volume 12, Issue 12, Page(s) 1326–1340

Abstract: Background: The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity, such as estimated glomerular filtration rate (eGFR) and phosphatemia, are late markers of proximal tubulopathy. Multiple early markers are available, but ... ...

Abstract	Background: The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity, such as estimated glomerular filtration rate (eGFR) and phosphatemia, are late markers of proximal tubulopathy. Multiple early markers are available, but no consensus exists on their use. Aim: To determine the 24 mo prevalence of subclinical proximal tubulopathy (SPT), as defined with early biomarkers, in treated Methods: A prospective, non-randomized, multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was conducted. The patients were separated into three groups: Naïve, starting entecavir (ETV) treatment, or starting tenofovir disoproxil (TDF) treatment. Data on the early markers of SPT, the eGFR and phosphatemia, were collected quarterly. SPT was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%. The prevalence and cumulative incidence of SPT at month 24 (M24) were calculated. Quantitative data were analyzed using analyses of variance or Kruskal-Wallis tests, whereas chi-squared or Fisher's exact tests were used to analyze qualitative data. Multivariate analyses were used to adjust for any potential confounding factors. Results: Of the 196 patients analyzed, 138 (84 naïve, 28 starting ETV, and 26 starting TDF) had no SPT at inclusion. At M24, the prevalence of SPT was not statistically different between naïve and either treated group (21.1% Conclusion: The prevalence and incidence of SPT was higher in TDF-treated patients compared to naïve patients. SPT in the naïve population suggests that HBV can induce renal tubular toxicity.
Language	English
Publishing date	2021-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573703-X
ISSN	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v12.i12.1326
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Article ; Online: Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation?

Ghergus, Dana / Martin, Mickaël / Knapp, Anne-Marie / Delmotte, Fabien / Joublin-Delavat, Aurélie / Jung, Sophie / Schickel, Jean-Nicolas / Mendel, Isabelle / Dupuis, Arnaud / Drénou, Bernard / Ghesquières, Hervé / Salles, Gilles / Baseggio, Lucile / Herbrecht, Raoul / Korganow, Anne-Sophie / Vallat, Laurent / Soulas-Sprauel, Pauline / Meffre, Eric / Martin, Thierry

American journal of hematology

2023 Volume 99, Issue 1, Page(s) 48–56

Abstract: ZAP70 has a prognostic value in chronic lymphocytic leukemia (CLL), through altered B-cell receptor ... B cells, and this phenomenon is poorly understood. Here, we show, using flow cytometry, that a substantial ... percentage of CD5- nonmalignant B cells from CLL patients expresses ZAP70 compared with CD5- B ...

Abstract	ZAP70 has a prognostic value in chronic lymphocytic leukemia (CLL), through altered B-cell receptor signaling, which is important in CLL pathogenesis. A good correlation between ZAP70 expression in CLL cells and the occurrence of autoimmune phenomena has been reported. Yet, the great majority of CLL-associated autoimmune cytopenia is due to polyclonal immunoglobulin (Ig) G synthesized by nonmalignant B cells, and this phenomenon is poorly understood. Here, we show, using flow cytometry, that a substantial percentage of CD5- nonmalignant B cells from CLL patients expresses ZAP70 compared with CD5- B cells from healthy subjects. This ZAP70 expression in normal B cells from CLL patients was also evidenced by the detection of ZAP70 mRNA at single-cell level with polyclonal Ig heavy- and light-chain gene transcripts. ZAP70+ normal B cells belong to various B-cell subsets and their presence in the naïve B-cell subset suggests that ZAP70 expression may occur during early B-cell development in CLL patients and potentially before malignant transformation. The presence of ZAP70+ normal B cells is associated with autoimmune cytopenia in CLL patients in our cohort of patients, and recombinant antibodies produced from these ZAP70+ nonmalignant B cells were frequently autoreactive including anti-platelet reactivity. These results provide a better understanding of the implication of ZAP70 in CLL leukemogenesis and the mechanisms of autoimmune complications of CLL.
MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Autoimmunity ; B-Lymphocytes ; Flow Cytometry ; Prognosis ; ZAP-70 Protein-Tyrosine Kinase/genetics ; ZAP-70 Protein-Tyrosine Kinase/metabolism
Chemical Substances	ZAP70 protein, human (EC 2.7.10.2) ; ZAP-70 Protein-Tyrosine Kinase (EC 2.7.10.2)
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.27137
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Zs.A 1251: Show issues

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Article ; Online: Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis.

Ponzetto, Ester / Delhez, Quentin / Hoppenbrouwers, Maarten / De Schryver, Nicolas / Serck, Nicolas / Dugernier, Thierry / Duray, Marie-Céline / Gressens, Benjamin / Vinetti, Marco / Sips, Gregorius J / van Kampen, Jeroen / GeurtsvanKessel, Corine H / van Boheemen, Sander

The American journal of tropical medicine and hygiene

2023 Volume 109, Issue 6, Page(s) 1277–1281

Abstract: Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic ...

Abstract	Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54 years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient's cerebrospinal fluid. Phylogenetic analysis showed significant divergence in the clustering of this particular BV strain compared with other known BVs. Therefore, additional efforts are needed to obtain a broader sequence landscape from BVs circulating in monkeys.
MeSH term(s)	Animals ; Humans ; Herpesvirus 1, Cercopithecine/genetics ; Macaca ; Meningoencephalitis/complications ; Phylogeny ; Zoonoses ; Female ; Aged
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.23-0253
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