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  1. Book ; Online: NTM - The New Uber-Bugs

    Dartois, Veronique / Sizemore, Christine / Dick, Thomas

    2019  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; NTM ; Non-TB mycobacteria ; Non-tuberculous mycobacteria ; Environmental mycobacteria ; lung disease ; antimicrobial resistance
    Size 1 electronic resource (240 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230073
    ISBN 9782889630127 ; 2889630129
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Geochemistry measured on sediment core GeoB12309-5, supplementary data to: Wilhelms-Dick, Dorothee; Westerhold, Thomas; Röhl, Ursula; Wilhelms, Frank; Vogt, Christoph; Hanebuth, Till J J; Römmermann, Helge; Kriews, Michael; Kasten, Sabine (2012): A comparison of mm scale resolution techniques for element analysis in sediment cores. Journal of Analytical Atomic Spectrometry

    Wilhelms-Dick, Dorothee / Hanebuth, Till J J / Kasten, Sabine / Kriews, Michael / Röhl, Ursula / Römmermann, Helge / Vogt, Christoph / Westerhold, Thomas / Wilhelms, Frank

    2012  

    Abstract: Laminated sediment records from the oxygen minimum zone in the Arabian Sea offer unique ultrahigh-resolution archives for deciphering climate variability in the Arabian Sea region. Although numerous analytical techniques are available it has become ... ...

    Abstract Laminated sediment records from the oxygen minimum zone in the Arabian Sea offer unique ultrahigh-resolution archives for deciphering climate variability in the Arabian Sea region. Although numerous analytical techniques are available it has become increasingly popular during the past decade to analyze relative variations of sediment cores' chemical signature by non-destructive X-ray fluorescence (XRF) core scanning. We carefully selected an approximately 5 m long sediment core from the northern Arabian Sea (GeoB12309-5: 24°52.3' N; 62°59.9' E, 956 m water depth) for a detailed, comparative study of high-resolution techniques, namely non-destructive XRF core scanning (0.8 mm resolution) and ICP-MS/OES analysis on carefully selected, discrete samples (1 mm resolution). The aim of our study was to more precisely define suitable chemical elements that can be accurately analyzed and to determine which elemental ratios can be interpretated down to sub-millimeter-scale resolutions. Applying the Student's t-test our results show significantly correlating (1% significance level) elemental patterns for all S, Ca, Fe, Zr, Rb, and Sr, as well as the K/Ca, Fe/Ti and Ti/Al ratios that are all related to distinct lithological changes. After careful consideration of all errors for the ICP analysis we further provide respective factors of XRF Core Scanner software error's underestimation by applying Chi-square-tests, which is especially relevant for elements with high count rates. As demonstrated by these new, ultra-high resolution data core scanning has major advantages (high-speed, low costs, few sample preparation steps) and represents an increasingly required alternative over the time consuming, expensive, elaborative, and destructive wet chemical analyses (e.g., by ICP-MS/OES after acid digestions), and meanwhile also provides high-quality data in unprecedented resolution.
    Language English
    Dates of publication 2012-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1039/C2JA30148B
    DOI 10.1594/PANGAEA.770427
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article: Obituary: Stephen Thomas Moss (1943-2001): leading fungal ultrastructuralist and promoter of mycology

    Dick, M.W

    Mycological research. 2004 Feb., v. 108, pt. 2

    2004  

    Keywords agricultural history ; mycology ; Zygomycota ; Ascomycota ; fungal anatomy ; ultrastructure
    Language English
    Dates of publication 2004-02
    Size p. 214-220.
    Document type Article
    ZDB-ID 1478365-4
    ISSN 1469-8102 ; 0953-7562
    ISSN (online) 1469-8102
    ISSN 0953-7562
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease.

    Dartois, Véronique / Dick, Thomas

    Nature reviews. Drug discovery

    2024  

    Abstract: Tuberculosis (TB) drug discovery and development has undergone nothing short of a revolution over the past 20 years. Successful public-private partnerships and sustained funding have delivered a much-improved understanding of mycobacterial disease ... ...

    Abstract Tuberculosis (TB) drug discovery and development has undergone nothing short of a revolution over the past 20 years. Successful public-private partnerships and sustained funding have delivered a much-improved understanding of mycobacterial disease biology and pharmacology and a healthy pipeline that can tolerate inevitable attrition. Preclinical and clinical development has evolved from decade-old concepts to adaptive designs that permit rapid evaluation of regimens that might greatly shorten treatment duration over the next decade. But the past 20 years also saw the rise of a fatal and difficult-to-cure lung disease caused by nontuberculous mycobacteria (NTM), for which the drug development pipeline is nearly empty. Here, we discuss the similarities and differences between TB and NTM lung diseases, compare the preclinical and clinical advances, and identify major knowledge gaps and areas of cross-fertilization. We argue that applying paradigms and networks that have proved successful for TB, from basic research to clinical trials, will help to populate the pipeline and accelerate curative regimen development for NTM disease.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-024-00897-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 334: Show issues
    Zs.MG 63: Show issues

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  5. Article: Rifabutin: A Repurposing Candidate for

    Dick, Thomas

    Frontiers in microbiology

    2020  Volume 11, Page(s) 371

    Language English
    Publishing date 2020-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.00371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Conference proceedings ; E-Book: Altern: Biologie und Chancen

    Ho, Anthony Dick / Holstein, Thomas W. / Häfner, Heinz

    Alter und Altern individuell, kollektiv und die Folgen

    (Schriften der Mathematisch-naturwissenschaftlichen Klasse ; 27 ; Alter und Altern ; 4 ; Springer eBook Collection ; Research)

    2022  

    Event/congress Altern: Biologie und Chancen (2019, Heidelberg)
    Author's details Anthony D. Ho, Thomas W. Holstein, Heinz Häfner (Hrsg.)
    Series title Schriften der Mathematisch-naturwissenschaftlichen Klasse ; 27
    Alter und Altern ; 4
    Springer eBook Collection
    Research
    Schriften der Mathematisch-Naturwissenschaftliche Klasse / Heidelberger Akademie der Wissenschaften
    Collection Schriften der Mathematisch-Naturwissenschaftliche Klasse / Heidelberger Akademie der Wissenschaften
    Keywords Developmental biology ; Aging ; Evolutionary developmental biology
    Language German
    Size 1 Online-Ressource (XXIX, 229 Seiten), Illustrationen
    Publisher Springer Spektrum
    Publishing place Wiesbaden
    Publishing country Germany
    Document type Book ; Online ; Conference proceedings ; E-Book
    Note "Mit dem Titel "Altern: Biologie und Chancen" richtete die Heidelberger Akademie der Wissenschaften vom 28. März bis 30. März 2019 das interdisziplinäre Symposium aus." (Vorwort, S. VII)
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021447942
    ISBN 978-3-658-34859-5 ; 9783658348588 ; 3-658-34859-3 ; 3658348585
    DOI 10.1007/978-3-658-34859-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article: Der Literat und der Naturforscher. Wilhelm Heinse und Samuel Thomas Soemmerring

    Dick, M

    Mann G, Dumont F, ed: Samuel Thomas Soemmerring und die Gelehrten der Goethezeit

    1985  

    Author's details M. Dick
    MeSH term(s) Literature/history ; Science/history ; History, Modern 1601-
    Keywords Germany
    Language German
    Size p. 203-228.
    Publisher Fischer
    Publishing place Stuttgart
    Document type Article
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Why Matter Matters: Fast-Tracking

    Ganapathy, Uday S / Dick, Thomas

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 20

    Abstract: Unlike Tuberculosis (TB), ...

    Abstract Unlike Tuberculosis (TB),
    MeSH term(s) Humans ; Mycobacterium abscessus ; Mycobacterium ; Drug Discovery ; Mycobacterium Infections, Nontuberculous/drug therapy ; Tuberculosis ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27206948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue.

    Dartois, Véronique / Dick, Thomas

    The Journal of experimental medicine

    2022  Volume 219, Issue 6

    Abstract: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is treated with multiple repurposed drugs. Chemotherapy is long and often toxic, includes parenteral drugs, and suffers from poor cure rates. There is an urgent need for more efficacious, tolerated, ...

    Abstract Nontuberculous mycobacterial pulmonary disease (NTM-PD) is treated with multiple repurposed drugs. Chemotherapy is long and often toxic, includes parenteral drugs, and suffers from poor cure rates. There is an urgent need for more efficacious, tolerated, and oral antibiotics optimized towards the treatment of NTM-PD, adapted to the spectrum of disease. In contrast to the empty NTM pipeline, drug development for the related tuberculosis lung disease has experienced a renaissance. Here, we argue that applying lessons learned from tuberculosis will facilitate the discovery of curative oral regimens for NTM-PD.
    MeSH term(s) Drug Development ; Humans ; Lung ; Lung Diseases/drug therapy ; Lung Diseases/microbiology ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/microbiology ; Pneumonia ; Tuberculosis
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20220445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.107: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 45: Show issues

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  10. Article: Correction: Abiotic microcompartments form when neighbouring droplets fuse: an electrochemiluminescence investigation.

    Voci, Silvia / Clarke, Thomas B / Dick, Jeffrey E

    Chemical science

    2023  Volume 14, Issue 27, Page(s) 7595

    Abstract: This corrects the article DOI: 10.1039/D2SC06553C.]. ...

    Abstract [This corrects the article DOI: 10.1039/D2SC06553C.].
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc90104a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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