LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 97

Search options

  1. Article ; Online: Golgi bypass of ciliary proteins.

    Witzgall, Ralph

    Seminars in cell & developmental biology

    2018  Volume 83, Page(s) 51–58

    Abstract: Primary cilia represent small, yet distinct compartments of the plasma membrane. They are speculated to exercise chemo- and mechanosensory functions and to serve as signaling hubs for crucial pathways such as the Wnt and hedgehog cascades. It is ... ...

    Abstract Primary cilia represent small, yet distinct compartments of the plasma membrane. They are speculated to exercise chemo- and mechanosensory functions and to serve as signaling hubs for crucial pathways such as the Wnt and hedgehog cascades. It is therefore necessary that specific integral membrane proteins, in particular sensors and receptors, are sorted to the cilium and not to the surrounding somatic plasma membrane upon being synthesized at the rough endoplasmic reticulum. Apparently no singular "zip code" for the primary cilium exists but rather several ciliary targeting signals whose biochemical and cell biological implications are just about being unravelled. Among the better understood proteins residing in the primary cilium is polycystin-2 which is mutated in patients suffering from autosomal-dominant polycystic kidney disease. A special case in the context of this review concerns the connecting cilium which serves as the trafficking pathway for proteins involved in visual sensation of retinal photoreceptor cells. In order to efficiently capture photons, the photopigments are organized in discs or membrane invaginations. Mutations in certain proteins involved in these processes lead to retinal degeneration and ultimately to blindness. One example is peripherin/rds which is mutated in the rds (retinal degeneration slow) mouse. The trafficking of peripherin/rds from the inner to the outer segment of photoreceptor cells by way of the connecting cilium also seems to diverge at the Golgi apparatus, and the routes of polycystin-2 and peripherin/rds may represent paradigms of ciliary proteins for the type IV pathway of unconventional protein "secretion". This review is part of a special issue of Seminars in Cell and Developmental Biology edited by Walter Nickel and Catherine Rabouille.
    MeSH term(s) Cilia/metabolism ; Golgi Apparatus/metabolism ; Humans ; Protein Transport/physiology
    Language English
    Publishing date 2018-03-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2018.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Nail-patella syndrome.

    Witzgall, Ralph

    Pflugers Archiv : European journal of physiology

    2017  Volume 469, Issue 7-8, Page(s) 927–936

    Abstract: The pathognomonic symptoms of patients with nail-patella syndrome are their small or absent patellae and dysplastic or absent finger- and toenails. Many of the patients suffer from renal symptoms which also affect their prognosis. In 1998, mutations in ... ...

    Abstract The pathognomonic symptoms of patients with nail-patella syndrome are their small or absent patellae and dysplastic or absent finger- and toenails. Many of the patients suffer from renal symptoms which also affect their prognosis. In 1998, mutations in the gene encoding the transcription factor LMX1B were identified as underlying this autosomal-dominant disease. The LMX1B gene is expressed in a variety of tissues, and the symptoms are reflected nicely by its expression pattern. LMX1B is essential for dorso-ventral pattern formation in the limbs, for differentiation of the anterior portions of the eyes, for development of certain neuron populations in the central nervous system, and for the differentiation and maintenance of podocytes. Accordingly, kidney biopsies of patients with nail-patella syndrome show an altered podocyte structure and defects in the glomerular basement membrane. Recent evidence suggests that LMX1B regulates genes which encode proteins associated with the actin cytoskeleton.
    Language English
    Publishing date 2017-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-017-2013-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Book ; Online ; Thesis: Structural and functional analyses of polycystins

    Brunner, Katrin [Verfasser] / Witzgall, Ralph [Akademischer Betreuer]

    2022  

    Author's details Katrin Brunner ; Betreuer: Ralph Witzgall
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    More links

    Kategorien

  4. Article ; Online: Impact of interferon-γ on the target cell tropism of nanoparticles.

    Zimmer, Oliver / Walter, Melanie / Remmert, Marius / Maier, Olga / Witzgall, Ralph / Goepferich, Achim

    Journal of controlled release : official journal of the Controlled Release Society

    2023  Volume 362, Page(s) 325–341

    Abstract: Interferon-γ (IFN-γ) is well known to reduce the infectivity of viral pathogens by altering their tissue tropism. This effect is induced by upregulation of cholesterol 25-hydroxylase (CH25H). Given the similarity of viral pathogens and ligand- ... ...

    Abstract Interferon-γ (IFN-γ) is well known to reduce the infectivity of viral pathogens by altering their tissue tropism. This effect is induced by upregulation of cholesterol 25-hydroxylase (CH25H). Given the similarity of viral pathogens and ligand-functionalized nanoparticles in the underlying strategy of receptor-mediated cell recognition, it appears conceivable that IFN-γ exceeds similar effects on nanoparticles. Concretely, IFN-γ-induced activation of CH25H could decrease nanoparticle avidity for target cells via depletion of clathrin-coated pits. We hypothesized that this effect would cause deterioration of target-cell specific accumulation of nanoparticles. To prove our hypothesis, we investigated the cell tropism of angiotensin II functionalized nanoparticles (NP
    Language English
    Publishing date 2023-09-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2023.08.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Book ; Online ; Thesis: Role of microRNAs in podocyte structure and function

    Meisinger, Sandra [Verfasser] / Witzgall, Ralph [Akademischer Betreuer]

    2022  

    Author's details Sandra Meisinger ; Betreuer: Ralph Witzgall
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    More links

    Kategorien

  6. Book ; Thesis: Klonierung der p55-Untereinheit des menschlichen IL-2-Rezeptors

    Witzgall, Ralph

    Expression in Fibroblasten-Zellinien der Maus und Analyse des Expressionsverhaltens in Escherichia coli

    1990  

    Author's details vorgelegt von Ralph Witzgall
    Size 2 Mikrofiches : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1990
    Note Manuskript: Getr. Zählung : Ill., graph. Darst.
    HBZ-ID HT003862388
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  7. Book ; Online ; Thesis: Correlative light and electron microscopy to study ciliogenesis

    Bürger, Korbinian [Verfasser] / Witzgall, Ralph [Akademischer Betreuer]

    2022  

    Author's details Korbinian Bürger ; Betreuer: Ralph Witzgall
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    More links

    Kategorien

  8. Article ; Online: Mesangial cells regulate the single nephron GFR and preserve the integrity of the glomerular filtration barrier: An intravital multiphoton microscopy study.

    Ziegler, Vera / Fremter, Katharina / Helmchen, Julia / Witzgall, Ralph / Castrop, Hayo

    Acta physiologica (Oxford, England)

    2021  Volume 231, Issue 4, Page(s) e13592

    Abstract: Aim: The intraglomerular mesangial cells are located between the glomerular capillaries. Here we hypothesized that mesangial cells regulate the single nephron glomerular filtration rate (snGFR) and that mesangial cells support the integrity of the ... ...

    Abstract Aim: The intraglomerular mesangial cells are located between the glomerular capillaries. Here we hypothesized that mesangial cells regulate the single nephron glomerular filtration rate (snGFR) and that mesangial cells support the integrity of the glomerular filtration barrier.
    Methods: We assessed the function of mesangial cells in vivo by multiphoton microscopy. Mesangial cells were depleted in Munich Wistar Froemter rats using the Thy1.1 antibody model.
    Results: The Thy1.1 antibody caused the cell-specific loss of 82 ± 3% of mesangial cells. After mesangial cell depletion, the baseline snGFR was reduced to 12.0 ± 1.2 vs 32.4 ± 3.2 nL/min in controls. In control rats, the snGFR decreased after angiotensin II infusion by 61 ± 3% (P = .004), whereas it remained unchanged in Thy1.1-treated rats. The changes in the snGFR after angiotensin II infusion in control rats were accompanied by the marked rotation of the capillary loops within Bowman's space. This phenomenon was absent in anti-Thy1.1-treated rats. The glomerular sieving coefficient (GSC
    Conclusion: Our data suggest that mesangial cells actively contribute to the regulation of the snGFR. Furthermore, mesangial cells are crucially involved in maintaining the integrity of the glomerular filtration barrier, in part by modulating the thickness of the glomerular basement membrane.
    MeSH term(s) Animals ; Glomerular Filtration Barrier ; Glomerular Filtration Rate ; Mesangial Cells ; Microscopy ; Nephrons ; Rats ; Rats, Wistar
    Language English
    Publishing date 2021-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13592
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Book ; Online ; Thesis: Regulation of the actin cytoskeleton in podocytes by the transcription factor LMX1B

    Setzer, Markus [Verfasser] / Witzgall, Ralph [Akademischer Betreuer]

    2020  

    Author's details Markus Setzer ; Betreuer: Ralph Witzgall
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    More links

    Kategorien

  10. Book ; Online ; Thesis: Charakterisierung von Polycystin-2 in Hinblick auf eine potentielle Beteiligung an der Regulation des Tubulusdurchmessers, anhand von Knock-In-Mäusen und Ca²⁺-Imaging

    Schober, Michael Philipp [Verfasser] / Witzgall, Ralph [Akademischer Betreuer]

    2020  

    Author's details Michael Philipp Schober ; Betreuer: Ralph Witzgall
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    More links

    Kategorien

To top