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Article: Temperature dependent specific heat capacity (Cp) of G-actin and talin or talin-vinculin bound to G-actin.

Goldmann, W H / Isenberg, G

1992 Volume 20, Issue 3, Page(s) 273S

MeSH term(s)	Actins/chemistry ; Actins/metabolism ; Animals ; Calorimetry, Differential Scanning/methods ; Muscles/metabolism ; Protein Binding ; Rabbits ; Talin/chemistry ; Talin/metabolism ; Vinculin/chemistry ; Vinculin/metabolism
Chemical Substances	Actins ; Talin ; Vinculin (125361-02-6)
Language	English
Publishing date	1992-08
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/bst020273s
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Article: Thermodynamics of talin and talin-vinculin binding to G-actin.

Goldmann, W H / Kaufmann, S / Isenberg, G

Biochemical Society transactions

1992 Volume 20, Issue 1, Page(s) 50S

MeSH term(s)	Actins/chemistry ; Actins/metabolism ; Calorimetry ; Drug Stability ; Kinetics ; Protein Binding ; Protein Conformation ; Spectrometry, Fluorescence/methods ; Talin/chemistry ; Talin/metabolism ; Thermodynamics ; Vinculin/chemistry ; Vinculin/metabolism
Chemical Substances	Actins ; Talin ; Vinculin (125361-02-6)
Language	English
Publishing date	1992-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/bst020050s
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Article: Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein.

Inoue, R / Isenberg, G

The American journal of physiology

1990 Volume 258, Issue 6 Pt 1, Page(s) C1173–8

Abstract: ... a nonselective cation channel (G. D. Benham, T. B. Bolton, and R. J. Lang. Nature Lond. 316: 345-347, 1985; R ... that occupation of the muscarinic receptor by ACh couples to channel activation via a G protein; the coupling ...

Abstract	Acetylcholine (ACh) depolarizes the membrane of mammalian intestinal myocytes by activating a nonselective cation channel (G. D. Benham, T. B. Bolton, and R. J. Lang. Nature Lond. 316: 345-347, 1985; R. Inoue, K. Kitamura, and H. Kuriyama. Pfluegers Arch. 410: 69-74, 1987). Here, we present evidence that occupation of the muscarinic receptor by ACh couples to channel activation via a G protein; the coupling can be blocked by pertussis toxin or by intracellular guanosine 5'-O-(2-thio-diphosphate) (GDP beta S), whereas intracellular guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) activates the channel in the absence of ACh. The currents, activated by either ACh or GTP gamma S, are nonadditive, conduct sodium ions, and are similar in their voltage dependence and facilitation by submicromolar calcium ions in the cytosol.
MeSH term(s)	Acetylcholine/pharmacology ; Animals ; Cells, Cultured ; Electric Conductivity ; GTP-Binding Proteins/physiology ; Guanosine 5'-O-(3-Thiotriphosphate) ; Guanosine Diphosphate/analogs & derivatives ; Guanosine Diphosphate/pharmacology ; Guanosine Triphosphate/analogs & derivatives ; Guanosine Triphosphate/pharmacology ; Guinea Pigs ; Ileum/drug effects ; Ileum/physiology ; Ion Channels/drug effects ; Ion Channels/physiology ; Kinetics ; Membrane Potentials/drug effects ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Pertussis Toxin ; Receptors, Muscarinic/drug effects ; Receptors, Muscarinic/physiology ; Thionucleotides/pharmacology ; Virulence Factors, Bordetella/pharmacology
Chemical Substances	Ion Channels ; Receptors, Muscarinic ; Thionucleotides ; Virulence Factors, Bordetella ; guanosine 5'-O-(2-thiotriphosphate) ; Guanosine Diphosphate (146-91-8) ; Guanosine 5'-O-(3-Thiotriphosphate) (37589-80-3) ; guanosine 5'-O-(2-thiodiphosphate) (71376-97-1) ; Guanosine Triphosphate (86-01-1) ; Pertussis Toxin (EC 2.4.2.31) ; GTP-Binding Proteins (EC 3.6.1.-) ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	1990-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2948-8
ISSN	0002-9513
ISSN	0002-9513
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Article ; Online: Endoscopic Treatment of Small Bowel Bleeding.

Damjanovska, Sofi / Isenberg, Gerard

Gastrointestinal endoscopy clinics of North America

2023 Volume 34, Issue 2, Page(s) 331–343

Abstract: Approximately 5% of all gastrointestinal (GI) bleeding originates from the small bowel. Endoscopic therapy of small bowel bleeding should only be undertaken after consideration of the different options, and the risks, benefits, and alternatives of each ... ...

Abstract	Approximately 5% of all gastrointestinal (GI) bleeding originates from the small bowel. Endoscopic therapy of small bowel bleeding should only be undertaken after consideration of the different options, and the risks, benefits, and alternatives of each option. Endoscopic therapy options for small bowel bleeding are like those treatments used for other forms of bleeding in the upper and lower GI tract. Available endoscopic treatment options include thermal therapy (eg, argon plasma coagulation and bipolar cautery), mechanical therapy (eg, hemoclips), and medical therapy (eg, diluted epinephrine injection). Patients with complicated comorbidities would benefit from evaluation and planning of available treatment options, including conservative and/or medical treatments, beyond endoscopic therapy.
MeSH term(s)	Humans ; Endoscopy, Gastrointestinal/adverse effects ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Intestine, Small/surgery ; Capsule Endoscopy ; Epinephrine/therapeutic use
Chemical Substances	Epinephrine (YKH834O4BH)
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1313994-0
ISSN	1558-1950 ; 1052-5157
ISSN (online)	1558-1950
ISSN	1052-5157
DOI	10.1016/j.giec.2023.09.007
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Article ; Online: Using Exploratory Structural Equation Modeling to Examine Caregiver Distress and Its Contributors.

Li, Wenshan / Manuel, Douglas G / Isenberg, Sarina R / Tanuseputro, Peter

Journal of the American Medical Directors Association

2024 Volume 25, Issue 5, Page(s) 817–825.e5

Abstract: Objectives: To develop and test the direct and indirect associations between caregiver distress and its many contributing factors and covariates.: Design: Analysis using data from a national, cross-sectional survey of Canadian caregivers.: Setting ... ...

Abstract	Objectives: To develop and test the direct and indirect associations between caregiver distress and its many contributing factors and covariates. Design: Analysis using data from a national, cross-sectional survey of Canadian caregivers. Setting and participants: A total of 6502 respondents of the 2012 General Social Survey-Caregiving and Care-receiving who self-identified as a caregiver. Methods: We used exploratory structural equation modeling to achieve our aims. Based on literature review, we hypothesized a structural model of 5 caregiving factors that contribute to distress: caregiving burden, caregiving network and support, disruptions of family and social life, positive emotional experiences, and caregiving history. Survey items hypothesized to measure each latent factor were modeled using exploratory factor analysis (EFA). After establishing a well-fit EFA model, structural equation modeling was performed to examine the relationships between caregiving factors and caregiver distress while controlling for covariates such as caregiver's and care-recipient's sociodemographic characteristics and kinship. Results: EFA established a well-fit model that represented caregiver distress and its 5 contributing factors as hypothesized. Although all 5 had significant effects on caregiver distress, disruptions of family and social life contributed the most (β = 0.462), almost 3 times that of caregiving burden (β = 0.162). Positive emotional experiences also substantially reduced distress (β = -0.310). Conclusions and implications: Understanding the multifaceted nature of caregiver distress is crucial for developing effective strategies to support caregivers. In addition to reducing caregiving burden, having flexible resources and policies to minimize disruptions to caregivers' families (eg, flexible work policies; family-oriented education, training, and counseling) and enhance the positive aspects of caregiving may more effectively reduce distress.
MeSH term(s)	Humans ; Male ; Caregivers/psychology ; Female ; Cross-Sectional Studies ; Middle Aged ; Canada ; Aged ; Latent Class Analysis ; Adult ; Surveys and Questionnaires ; Stress, Psychological ; Caregiver Burden/psychology ; Factor Analysis, Statistical ; Psychological Distress ; Social Support
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2023.12.019
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Zs.A 5971: Show issues

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Article: Adaptive evolution of G-protein coupled receptor genes.

Yokoyama, S / Isenberg, K E / Wright, A F

Molecular biology and evolution

1989 Volume 6, Issue 4, Page(s) 342–353

Abstract: The phylogeny and patterns of nucleotide substitutions in the visual pigment genes, adrenergic receptor genes, muscarinic receptor genes, and in the human mas oncogene were studied by comparing their DNA sequences. The evolutionary tree obtained shows ... ...

Abstract	The phylogeny and patterns of nucleotide substitutions in the visual pigment genes, adrenergic receptor genes, muscarinic receptor genes, and in the human mas oncogene were studied by comparing their DNA sequences. The evolutionary tree obtained shows that the visual pigment genes and mas oncogene form one cluster and that the receptor genes form another. In the evolution of rhodopsin genes, synonymous substitutions outnumber nonsynonymous substitutions. This is consistent with the neutral theory of molecular evolution. However, the early evolutionary stages of alpha- and beta-adrenergic and muscarinic receptors are notable for significantly more nonsynonymous substitutions than synonymous substitutions, suggesting the acquisition of novel functional adaptations. Variable rates of nonsynonymous changes in different domains of these proteins reveal DNA segments that might have been important in their functional adaptations.
MeSH term(s)	Amino Acids ; Animals ; Cricetinae ; DNA/genetics ; Drosophila/genetics ; GTP-Binding Proteins/genetics ; Humans ; Multigene Family ; Neoplasm Proteins/genetics ; Phylogeny ; Proto-Oncogene Proteins/genetics ; Proto-Oncogenes ; Rats ; Receptors, Adrenergic/genetics ; Receptors, G-Protein-Coupled ; Receptors, Muscarinic/genetics ; Retinal Pigments/genetics ; Rhodopsin/genetics ; Sequence Homology, Nucleic Acid ; Swine ; Turkeys
Chemical Substances	Amino Acids ; Neoplasm Proteins ; Proto-Oncogene Proteins ; Receptors, Adrenergic ; Receptors, G-Protein-Coupled ; Receptors, Muscarinic ; Retinal Pigments ; proto-oncogene proteins c-mas-1 ; DNA (9007-49-2) ; Rhodopsin (9009-81-8) ; GTP-Binding Proteins (EC 3.6.1.-)
Language	English
Publishing date	1989-07
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	998579-7
ISSN	1537-1719 ; 0737-4038
ISSN (online)	1537-1719
ISSN	0737-4038
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Zs.A 2137: Show issues

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Book: Modern optics, electronics and high precision techniques in cell biology

Isenberg, Gerhard

1998

Author's details	G. Isenberg (ed.)
Keywords	Cytologie ; Messtechnik
Subject	Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle
Language	English
Size	VIII, 261 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	Berlin u.a.
Document type	Book
HBZ-ID	HT008055672
ISBN	3-540-62673-5 ; 978-3-540-62673-2
Database	Catalogue ZB MED Medicine, Health

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1998 A 7438	order for loan	Magazin

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Article ; Online: Patients on Antithrombotic Agents with Small Bowel Bleeding -Yield of Small Bowel Capsule Endoscopy and Subsequent Management.

Damjanovska, Sofi / Karb, Daniel / Chen, Allen / Margevicius, Seunghee / Fu, Pingfu / Isenberg, Gerard

Digestive diseases and sciences

2024

Abstract: Background and aims: Small bowel gastrointestinal bleeding (GIB) is associated with multiple blood transfusions, prolonged and/or multiple hospital admissions, utilization of significant healthcare resources, and negative effects on patient quality of ... ...

Abstract	Background and aims: Small bowel gastrointestinal bleeding (GIB) is associated with multiple blood transfusions, prolonged and/or multiple hospital admissions, utilization of significant healthcare resources, and negative effects on patient quality of life. There is a well-recognized association between antithrombotic medications and small bowel GIB. We aimed to identify the diagnostic yield of small bowel capsule endoscopy (SBCE) in patients on antithrombotic medications and the impact of SBCE on treatment course. Methods: The electronic medical records of nineteen hundred eighty-six patients undergoing SBCE were retrospectively reviewed. Results: The diagnostic yield for detecting stigmata of recent bleeding and/or actively bleeding lesions in SBCE was higher in patients that were on antiplatelet agents (21.6%), patients on anticoagulation (22.5%), and in patients that had their SBCE performed while they were inpatient (21.8%), when compared to the patients not on antiplatelet agents (12.1%), patients not on anticoagulation (13.5%), and with patients that had their SBCE performed in the outpatient setting (12%). Of 318 patients who had stigmata of recent bleeding and/or actively bleeding lesion(s) identified on SBCE, SBCE findings prompted endoscopic evaluation (small bowel enteroscopy, esophagogastroduodenoscopy (EGD), and/or colonoscopy) in 25.2%, with endoscopic hemostasis attempted in 52.5%. Conclusions: Our study, the largest conducted to date, emphasizes the importance of performing SBCE as part of the evaluation for suspected small bowel bleeding, particularly in patients taking antithrombotic therapy, and especially during their inpatient hospital stay.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-024-08433-6
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Article: Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype.

Ehrenstein, M R / Longhurst, C M / Latchman, D S / Isenberg, D A

The Journal of clinical investigation

1994 Volume 93, Issue 4, Page(s) 1787–1797

Abstract: This study analyzed the distribution of an idiotype, B3-Id, in patients with active SLE, classified according to organ involvement, normal controls, and other autoimmune rheumatic diseases. A polyclonal anti-idiotype was raised by immunizing a rabbit ... ...

Abstract	This study analyzed the distribution of an idiotype, B3-Id, in patients with active SLE, classified according to organ involvement, normal controls, and other autoimmune rheumatic diseases. A polyclonal anti-idiotype was raised by immunizing a rabbit with a monoclonal IgG anti-double-stranded (ds) DNA antibody, B3, generated from a patient with SLE who had active arthritis. The idiotype is present on the lambda chain and is at or near the binding site for double-stranded DNA. The lambda chain, which was characterized by nucleotide sequencing, was 90% homologous to the V lambda 2.1 germline, which is known to be involved in coding for nephritogenic anti-DNA antibodies carrying the 8.12 idiotype. There were four changes to positively charged amino acids, known to be involved in DNA binding, in the complementarity determining regions of B3 lambda chain compared with a non-DNA binding, 8.12 positive antibody, PV11. Only one change to a positively charged amino acid occurs in the heavy chain of B3, which is 93.5% homologous to VH-26. The B3-Id was present on IgG antibodies in the serum of 20% of patients with SLE but was not found in the normal controls. Within the SLE group, there is a statistically significant association of B3-Id on IgG in the arthritis group (42%) compared to the other manifestations (9%) (P < 0.001). In four B3-Id-positive SLE patients tested serially, the level of B3-Id reflected the arthritis disease activity more closely than the overall disease activity (P < 0.05). The B3-Id was also present on IgM antibodies in one third of patients with rheumatoid arthritis. This idiotype is the first to be derived from a human monoclonal anti-DNA antibody of the IgG class, the isotype associated with active disease. Sequence analysis shows that positively charged amino acids on the lambda chain may contribute to DNA binding.
MeSH term(s)	Adult ; Amino Acid Sequence ; Antibodies, Anti-Idiotypic/immunology ; Antibodies, Antinuclear/blood ; Antibodies, Antinuclear/genetics ; Antibodies, Monoclonal/blood ; Antibodies, Monoclonal/genetics ; Base Sequence ; DNA/immunology ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/genetics ; Immunoglobulin Idiotypes/blood ; Immunoglobulin Idiotypes/genetics ; Lupus Erythematosus, Systemic/immunology ; Male ; Middle Aged ; Molecular Sequence Data
Chemical Substances	Antibodies, Anti-Idiotypic ; Antibodies, Antinuclear ; Antibodies, Monoclonal ; Immunoglobulin G ; Immunoglobulin Idiotypes ; DNA (9007-49-2)
Language	English
Publishing date	1994-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI117164
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Book: Cytoskeleton proteins

Isenberg, Gerhard

a purification manual

(Springer lab manual)

1995

Author's details	G. Isenberg
Series title	Springer lab manual
Keywords	Cytoskeletal Proteins / isolation & purification / laboratory manuals ; Zellskelett ; Proteine ; Isolierung
Subject	Cytoskelett ; Zytoskelett ; Isolation ; Eiweiss ; Protein
Language	English
Size	267 S.
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT006732262
ISBN	3-540-59054-4 ; 978-3-540-59054-5
Database	Catalogue ZB MED Medicine, Health

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1996 A 698	order for loan	Magazin

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