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  1. Book ; Conference proceedings: Proceedings of the 17th Clinicopathological Conference on Renal Allograft Pathology

    Morozumi, Kunio / Yamaguchi, Yutaka / Harada, Hiroshi

    20 July 2013, Tokyo, Japan

    (Nephrology ; 19, Suppl. 3)

    2014  

    Event/congress Clinicopathological Conference on Renal Allograft Pathology (17, 2013, Tokio)
    Author's details guest ed.: Kunio Morozumi ; Yutaka Yamaguchi ; Hiroshi Harada
    Series title Nephrology ; 19, Suppl. 3
    Collection
    Language English
    Size 59 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Richmond, Victoria
    Publishing country Australia
    Document type Book ; Conference proceedings
    HBZ-ID HT018329290
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4822 -19,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Surface modification of cellulose with succinic anhydride in dimethyl sulfoxide using potassium carbonate as a catalyst.

    Harada, Nobuyuki / Uyama, Hiroshi

    Carbohydrate research

    2023  Volume 528, Page(s) 108812

    Abstract: Cellulose succinates (CSs) having degrees of substitution (DSs) ranging from 0.78 to 2.77 were successfully obtained by reacting cellulose with succinic anhydride (SA) in dimethyl sulfoxide at room temperature using a small amount of inexpensive solid ... ...

    Abstract Cellulose succinates (CSs) having degrees of substitution (DSs) ranging from 0.78 to 2.77 were successfully obtained by reacting cellulose with succinic anhydride (SA) in dimethyl sulfoxide at room temperature using a small amount of inexpensive solid potassium carbonate as a catalyst. Interestingly, CSs with higher DS values were obtained with a much smaller amount of catalyst than previously reported. Moreover, it is possible to control the DS by tailoring the reaction time and mass ratio of cellulose/SA. The hydroxyl groups at the C-6, C-2, and C-3 positions were the main esterification positions. In this process, most of the raw materials are either incorporated into the product or are recoverable. The E-factor, which reflects the sustainability of a given process, was demonstrated to be reduced by 93% by recovering the raw materials.
    MeSH term(s) Cellulose ; Succinic Anhydrides ; Dimethyl Sulfoxide ; Succinates
    Chemical Substances Cellulose (9004-34-6) ; succinic anhydride (6RF4O17Z8J) ; Succinic Anhydrides ; Dimethyl Sulfoxide (YOW8V9698H) ; potassium carbonate (BQN1B9B9HA) ; Succinates
    Language English
    Publishing date 2023-04-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2023.108812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2002/704: Show issues
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  3. Article ; Online: Meeting report: AT workshop 2023-A platform for discussing cutting-edge science in DNA damage signaling, repair, and human disorders.

    Takata, Minoru / Harada, Hiroshi

    Genes to cells : devoted to molecular & cellular mechanisms

    2023  Volume 28, Issue 9, Page(s) 642–645

    Abstract: Ataxia-telangiectasia (A-T) is a rare devastating hereditary condition, which affects multiple organ systems including cerebellar motor function as well as DNA repair, resulting in a higher incidence of cancer and immunodeficiency. The genetic defect in ... ...

    Abstract Ataxia-telangiectasia (A-T) is a rare devastating hereditary condition, which affects multiple organ systems including cerebellar motor function as well as DNA repair, resulting in a higher incidence of cancer and immunodeficiency. The genetic defect in A-T lies in ATM kinase, which is activated by DNA damage and regulates a plethora of substrates including the p53 tumor suppressor. We have organized an international meeting "The 19th Ataxia-Telangiectasia Workshop 2023 (ATW2023)" with support from the Molecular Biology Society of Japan (MBSJ) and other funders. Here, we report that ATW2023 was successfully held in Kyoto from March 2nd to 5th, 2023 with more than 150 participants traveling from all over the world, despite the still smoldering COVID-19 pandemic. In this meeting report, we will briefly describe the highlights of the meeting and would like to express our gratitude to the MBSJ for the financial support.
    MeSH term(s) Humans ; Ataxia Telangiectasia/genetics ; Ataxia Telangiectasia/pathology ; Ataxia Telangiectasia Mutated Proteins ; Pandemics ; COVID-19 ; DNA Damage ; DNA Repair ; Cell Cycle Proteins/metabolism
    Chemical Substances Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; Cell Cycle Proteins
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.13054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4539: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: [A Culture System Similar to the Embryonal Microenvironment Supports Transdifferentiation in Human Leiomyoma Cells].

    Harada, Hiroshi

    Journal of UOEH

    2019  Volume 41, Issue 2, Page(s) 193–201

    Abstract: Current research on stem cells and regenerative medicine indicates new perspectives on the relationship between differentiation and gene information. Induced pluripotent stem (iPS) cells need the artificial gene expression of the somatic cell, which is ... ...

    Abstract Current research on stem cells and regenerative medicine indicates new perspectives on the relationship between differentiation and gene information. Induced pluripotent stem (iPS) cells need the artificial gene expression of the somatic cell, which is related to initialization. Paradoxically, that means that cell differentiation depends on almost all the gene information stored precisely in the nucleus of a somatic cell, plus the transformation of gene expression. Our research team tried to identify the culture conditions in the transdifferentiation of human leiomyoma cells, closely similar to the early embryonal stage, composed of various factors (hypoxia, non-serum, and regulation of cell adhesion molecules such as Wnt/β-catenin signaling). As a result, inhibition of Wnt/β-catenin signaling under serum starvation and hypoxia induces adipocytic transdifferentiation in human leiomyoma cells. Here we explain this unique culture system, referring to the components of intracellular mechanisms and the extracellular microenvironment in embryo development.
    MeSH term(s) Cell Adhesion Molecules ; Cell Culture Techniques/methods ; Cell Differentiation/genetics ; Cellular Microenvironment ; Culture Media, Serum-Free ; Embryonic Development ; Female ; Fungal Proteins ; Humans ; Leiomyoma/pathology ; Serum ; Signal Transduction ; Wnt Proteins ; beta Catenin
    Chemical Substances Cell Adhesion Molecules ; Culture Media, Serum-Free ; Fungal Proteins ; HYR1 protein, Candida albicans ; Wnt Proteins ; beta Catenin
    Language Japanese
    Publishing date 2019-07-10
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 632724-2
    ISSN 2187-2864 ; 0387-821X
    ISSN (online) 2187-2864
    ISSN 0387-821X
    DOI 10.7888/juoeh.41.193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2868: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Lupus Nephritis Prolongs Improvement of Serositis in Systemic Lupus Erythematosus.

    Harada, Takuya / Yamashita, Hiroyuki / Nakajima, Sotaro / Kobayashi, Toshiaki / Takahashi, Hiroyuki / Kaneko, Hiroshi

    Joint bone spine

    2024  , Page(s) 105727

    Language English
    Publishing date 2024-04-04
    Publishing country France
    Document type Letter
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2024.105727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4590: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article: An operative case of gastric cancer with ectopic bile duct drainage in the lesser curvature of the stomach.

    Hashimoto, Kazuaki / Ihara, Tsukasa / Maruyama, Yuichiro / Tomisaki, Shinichi / Harada, Hiroshi

    Surgical case reports

    2024  Volume 10, Issue 1, Page(s) 67

    Abstract: Background: Among the various anomalies of the biliary system, a double common bile duct with ectopic drainage in the stomach is rare. Furthermore, ectopic bile ducts are extremely rare in gastric cancers.: Case presentation: A 67-year-old man was ... ...

    Abstract Background: Among the various anomalies of the biliary system, a double common bile duct with ectopic drainage in the stomach is rare. Furthermore, ectopic bile ducts are extremely rare in gastric cancers.
    Case presentation: A 67-year-old man was admitted to our hospital with gastric cancer and ectopic left extrahepatic bile duct drainage in the stomach. Pre-operative testing revealed no communication between the intrahepatic bile ducts. Distal gastrectomy and bile duct jejunostomy were performed. The post-operative course was uneventful, and the patient did not exhibit recurrence for 39 mo.
    Conclusions: Although it is uncertain whether sustained bile exposure from an ectopic bile duct is related to gastric cancer, short-term follow-up might be necessary because of the possibility of gastric cancer.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-024-01862-5
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  7. Article ; Online: Electron Holography Observation of Magnetic Bubbles and Stripe-shaped Domains under a Magnetic Field.

    Harada, Ken / Nakajima, Hiroshi / Shimada, Keiko / Mori, Shigeo / Takahashi, Yoshio

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 1669–1671

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.859
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  8. Article ; Online: A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent.

    Nogita, Kohei / Sugahara, Takaya / Miki, Koji / Mu, Huiying / Kobayashi, Minoru / Harada, Hiroshi / Ohe, Kouichi

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 11, Page(s) 1472–1475

    Abstract: A nickel phthalocyanine precursor bearing poly(ethylene glycol) as a turn-on contrast agent for photoacoustic imaging was prepared. The water-soluble polymeric chains were smoothly eliminated through thiol-mediated reductive aromatization in cancer cells, ...

    Abstract A nickel phthalocyanine precursor bearing poly(ethylene glycol) as a turn-on contrast agent for photoacoustic imaging was prepared. The water-soluble polymeric chains were smoothly eliminated through thiol-mediated reductive aromatization in cancer cells, enabling the detection of endogenous biological thiols
    MeSH term(s) Contrast Media ; Nickel ; Sulfhydryl Compounds ; Polyethylene Glycols ; Indoles ; Photoacoustic Techniques ; Isoindoles
    Chemical Substances phthalocyanine (V5PUF4VLGY) ; Contrast Media ; Nickel (7OV03QG267) ; Sulfhydryl Compounds ; Polyethylene Glycols (3WJQ0SDW1A) ; Indoles ; Isoindoles
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05628g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Massive Upper-extremity Edema after Transaxillary Venoarterial-extracorporeal Membrane Oxygenation.

    Saito, Shunsuke / Harada, Kenji / Funayama, Hiroshi / Kario, Kazuomi

    Internal medicine (Tokyo, Japan)

    2022  Volume 62, Issue 11, Page(s) 1695–1696

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation/adverse effects ; Extremities ; Edema/etiology ; Retrospective Studies
    Language English
    Publishing date 2022-10-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.0684-22
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    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Multiple Gastrointestinal Angiosarcoma Mimicking Kaposi's Sarcoma.

    Saiki, Takuto / Harada, Akira / Suekane, Hiroshi / Torisu, Takehiro

    Internal medicine (Tokyo, Japan)

    2022  Volume 62, Issue 17, Page(s) 2577–2578

    MeSH term(s) Humans ; Sarcoma, Kaposi/diagnosis ; Hemangiosarcoma/diagnostic imaging ; Skin Neoplasms ; Gastrointestinal Tract
    Language English
    Publishing date 2022-12-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1177-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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