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Article: Development and implementation of a virtual Lupus Patient Education Event during the COVID-19 pandemic.

Maheswaranathan, Mithu / English, Jessica A / Cunningham, Melissa A / Kamen, Diane L

2021 Volume 8, Issue 1

MeSH term(s)	COVID-19 ; Humans ; Lupus Erythematosus, Systemic ; Pandemics ; Patient Education as Topic ; Videoconferencing
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2779620-6
ISSN	2053-8790
ISSN	2053-8790
DOI	10.1136/lupus-2021-000493
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Article ; Online: Environmental influences on systemic lupus erythematosus expression.

Kamen, Diane L

Rheumatic diseases clinics of North America

2014 Volume 40, Issue 3, Page(s) 401–12, vii

Abstract: The etiology of systemic lupus erythematosus (SLE) is unknown, but multiple genetic, epigenetic, and environmental risk factors have been implicated. The inheritance of genes alone is not sufficient for developing SLE, suggesting the influence of ... ...

Abstract	The etiology of systemic lupus erythematosus (SLE) is unknown, but multiple genetic, epigenetic, and environmental risk factors have been implicated. The inheritance of genes alone is not sufficient for developing SLE, suggesting the influence of environmental triggers on disease expression. Despite the tremendous amount of progress in elucidating potential environmental risk factors for SLE, much more needs to be done. An interdisciplinary approach to studies of the causes and, ultimately, prevention of SLE is needed. This article reviews what is understood about the epidemiology of the relationship between environmental exposures and SLE, in addition to emerging areas of study.
MeSH term(s)	Case-Control Studies ; Diet Surveys ; Environmental Exposure/adverse effects ; Environmental Exposure/classification ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Humans ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/etiology ; Risk Factors ; Time
Language	English
Publishing date	2014-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	92118-x
ISSN	1558-3163 ; 0889-857X
ISSN (online)	1558-3163
ISSN	0889-857X
DOI	10.1016/j.rdc.2014.05.003
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Article ; Online: META-ANALYSIS OF DOLPHIN AND HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS REVEALS INFLAMMATORY SIGNATURES ASSOCIATED WITH EXPOSURE TO HIGH LEVELS OF PERFLUOROALKYL SUBSTANCES.

Wolf, Bethany J / Kamen, Diane L / Fair, Patricia / Hardiman, Gary

International journal of advances in science, engineering and technology

2021 Volume 7, Issue 3, Page(s) 66–72

Abstract: Currently a fundamental gap exists on how persistent organic pollutants affect humans especially those who consume high levels of seafood from contaminated coastal waters. There is an urgent need to better understand effects of these contaminants on ... ...

Abstract	Currently a fundamental gap exists on how persistent organic pollutants affect humans especially those who consume high levels of seafood from contaminated coastal waters. There is an urgent need to better understand effects of these contaminants on human health in coastal communities. Elevated contaminant levels in coastal seafood will give rise to increased contaminant burdens in humans who consume coastal seafood and given the toxicity of these contaminants increase risk for immune system disorders. In this paper we describe how we assessed the effects of contaminant exposures using high-throughput RNA sequencing (RNA-seq) in peripheral blood mononuclear cells from two species, dolphins and humans. This paper presents an integrated systems biology approach to understand the adverse effects of one of these CECs PFAS on both species.
Language	English
Publishing date	2021-07-05
Publishing country	India
Document type	Journal Article
ISSN	2321-9009
ISSN (online)	2321-9009
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Article ; Online: Gastrointestinal and Hepatic Disease in Systemic Lupus Erythematosus.

Brewer, Brian N / Kamen, Diane L

Rheumatic diseases clinics of North America

2017 Volume 44, Issue 1, Page(s) 165–175

Abstract: Gastrointestinal (GI) symptoms are common among patients with systemic lupus erythematosus (SLE), although only rarely are they caused by active organ system involvement from SLE itself. Rapid diagnosis and appropriate treatment of lupus enteritis and ... ...

Abstract	Gastrointestinal (GI) symptoms are common among patients with systemic lupus erythematosus (SLE), although only rarely are they caused by active organ system involvement from SLE itself. Rapid diagnosis and appropriate treatment of lupus enteritis and other GI manifestations of SLE are critical, because of the potential for organ and life-threatening complications. The 3 main variants of lupus enteritis are lupus mesenteric vasculitis, intestinal pseudo-obstruction, and protein-losing enteropathy. These GI manifestations and others in patients with SLE are reviewed here.
MeSH term(s)	Disease Management ; Early Diagnosis ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/immunology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/physiopathology ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/physiopathology
Language	English
Publishing date	2017-11-14
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	92118-x
ISSN	1558-3163 ; 0889-857X
ISSN (online)	1558-3163
ISSN	0889-857X
DOI	10.1016/j.rdc.2017.09.011
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Article ; Online: Corticosteroids in Lupus Nephritis and Central Nervous System Lupus.

Kamen, Diane L / Zollars, Eric S

Rheumatic diseases clinics of North America

2016 Volume 42, Issue 1, Page(s) 63–73, viii

Abstract: Corticosteroids are a mainstay of therapy for severe organ-threatening systemic lupus erythematosus. Lupus nephritis and central nervous system (CNS) lupus remain two of the most debilitating and potentially life-threatening manifestations of lupus. The ... ...

Abstract	Corticosteroids are a mainstay of therapy for severe organ-threatening systemic lupus erythematosus. Lupus nephritis and central nervous system (CNS) lupus remain two of the most debilitating and potentially life-threatening manifestations of lupus. The dose and duration of corticosteroids required for control of lupus nephritis and CNS lupus have never been tested in a randomized trial design, so current recommendations are based on observation and expert opinion. As more targeted individualized therapeutic approaches are developed for lupus nephritis and CNS lupus, reliance on long-term corticosteroids will decrease, as will the long-term damage and early mortality associated with their use.
MeSH term(s)	Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Glucocorticoids/administration & dosage ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/therapeutic use ; Lupus Nephritis/drug therapy ; Lupus Vasculitis, Central Nervous System/drug therapy ; Severity of Illness Index
Chemical Substances	Adrenal Cortex Hormones ; Glucocorticoids ; Immunosuppressive Agents
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	92118-x
ISSN	1558-3163 ; 0889-857X
ISSN (online)	1558-3163
ISSN	0889-857X
DOI	10.1016/j.rdc.2015.08.008
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Article ; Online: Prevalence of clinically meaningful antiphospholipid antibodies in patients with systemic lupus erythematosus varies by race and ethnicity.

Annals of the rheumatic diseases

2024 Volume 83, Issue 3, Page(s) 404–406

MeSH term(s)	Humans ; Antibodies, Antiphospholipid ; Prevalence ; Ethnicity ; Lupus Erythematosus, Systemic ; Antiphospholipid Syndrome
Chemical Substances	Antibodies, Antiphospholipid
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Letter
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard-2023-224952
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Article: A Distinct Plasma Microbiome But Not Gut Microbiome in Patients With Systemic Lupus Erythematosus Compared to Healthy Individuals.

James, Warren A / Ogunrinde, Elizabeth / Wan, Zhuang / Kamen, Diane L / Oates, Jim / Gilkeson, Gary S / Jiang, Wei

The Journal of rheumatology

2022 Volume 49, Issue 6, Page(s) 592–597

Abstract: Objective: Blood microbiome has been analyzed in cancer patients using machine learning. We aimed to study whether the plasma microbiome represents the microbial community in the gut among patients with systemic lupus erythematosus (SLE) and healthy ... ...

Abstract	Objective: Blood microbiome has been analyzed in cancer patients using machine learning. We aimed to study whether the plasma microbiome represents the microbial community in the gut among patients with systemic lupus erythematosus (SLE) and healthy controls (HCs). Methods: Paired plasma and stool samples from female patients with SLE and female HCs were assessed for microbiome composition by microbial 16S ribosomal RNA sequencing. Results: Decreased microbial alpha diversity in stool compared to plasma and distinct plasma and gut beta diversity were found in both HCs and patients with SLE. No difference in gut microbial diversity was found; however, plasma alpha diversity was decreased in patients with SLE compared to HCs. The predominant bacteria differed between plasma and stool in both groups. Although the predominant plasma and stool genus bacteria were similar in patients with SLE and HCs, some were clearly different. Conclusion: Compared to the gut, the plasma microbiome contained distinct community and greater heterogeneity, indicating that the predominant circulating microbiome may originate from sites (eg, oral or skin) other than the gastrointestinal tract. The decreased plasma but not gut alpha diversity in patients with SLE compared to HCs implies an altered plasma microbiome in SLE, which may be important for systemic immune perturbations and SLE disease pathogenesis.
MeSH term(s)	Bacteria ; Feces ; Female ; Gastrointestinal Microbiome ; Humans ; Lupus Erythematosus, Systemic ; Microbiota
Language	English
Publishing date	2022-02-15
Publishing country	Canada
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.210952
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Article ; Online: Vitamin D in lupus - new kid on the block?

Kamen, Diane L

Bulletin of the NYU hospital for joint diseases

2010 Volume 68, Issue 3, Page(s) 218–222

Abstract: Vitamin D is an essential steroid hormone, with well established effects on mineral metabolism, skeletal health, and recently established effects on the cardiovascular and immune systems. Vitamin D deficiency is highly prevalent and evidence is mounting ... ...

Abstract	Vitamin D is an essential steroid hormone, with well established effects on mineral metabolism, skeletal health, and recently established effects on the cardiovascular and immune systems. Vitamin D deficiency is highly prevalent and evidence is mounting that it contributes to the morbidity and mortality of multiple chronic diseases, including systemic lupus erythematosus (SLE). Patients with SLE avoid the sun because of photosensitive rashes and potential for disease fare, so adequate oral supplementation is critical. This review will describe the prevalence of vitamin D deficiency in patients with SLE, identify risk factors for deficiency, describe the consequences of deficiency, and review current vitamin D recommendations for patients with rheumatic diseases.
MeSH term(s)	Biomarkers/blood ; Dietary Supplements ; Humans ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/epidemiology ; Practice Guidelines as Topic ; Prevalence ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/therapeutic use ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/epidemiology
Chemical Substances	Biomarkers ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2010-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	390411-8
ISSN	1936-9727 ; 2328-5273 ; 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
ISSN (online)	1936-9727 ; 2328-5273
ISSN	1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
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Article: Protocol for virtual physical examination in an observational, longitudinal study evaluating virtual outcome measures in SLE.

Askanase, Anca D / Aranow, Cynthia / Kim, Mimi Y / Kamen, Diane L / Arriens, Cristina / Khalili, Leila / Tang, Wei / Barasch, Julia / Dall'Era, Maria / Mackay, Meggan

Lupus science & medicine

2023 Volume 10, Issue 2

Abstract: Objective: There is a lack of data on the use of telemedicine (TM) in SLE. SLE outcome measures remain complex, and clinicians and clinical trialists have raised concerns about the accuracy of virtual disease activity measures. This study evaluates the ... ...

Abstract	Objective: There is a lack of data on the use of telemedicine (TM) in SLE. SLE outcome measures remain complex, and clinicians and clinical trialists have raised concerns about the accuracy of virtual disease activity measures. This study evaluates the level of agreement between virtual SLE outcome measures and face-to-face (F2F) encounter. Here, we describe the study design, virtual physical examination protocol and demographics for the first 50 patients evaluated. Methods and analysis: This is an observational, longitudinal study of 200 patients with SLE with varying levels of disease activity from 4 academic lupus centres serving diverse populations. Each study participant will be evaluated at a baseline and a follow-up visit. At each visit, participants are evaluated by the same physician first via a videoconference-based TM and then a F2F encounter. For this protocol, virtual physical examination guidelines relying on physician-directed patient self-examination were established. SLE disease activity measures will be completed immediately after the TM encounter and repeated after the F2F encounter for each visit. The degree of agreement between TM and F2F disease activity measures will be analysed using the Bland-Altman method. An interim analysis is planned after the enrolment of the first 50 participants. Ethics and dissemination: This study has been reviewed by the Columbia University Medical Center Institutional Review Board (IRB Protocol #: AAAT6574). The full results of this study will be published after the final data analysis of 200 patients. The abrupt shift to TM visits due to the COVID-19 pandemic disrupted clinical practice and clinical trials. Establishing a high level of agreement between SLE disease activity measures obtained with videoconference TM and F2F at the same time point, will allow for improved assessment of disease activity when F2F data cannot be acquired. This information may guide both medical decision-making and provide reliable outcome measures for clinical research.
MeSH term(s)	Humans ; Longitudinal Studies ; Pandemics ; COVID-19 ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Physical Examination ; Observational Studies as Topic
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2779620-6
ISSN	2053-8790
ISSN	2053-8790
DOI	10.1136/lupus-2023-000952
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Article ; Online: A Pilot Study to Determine if Vitamin D Repletion Improves Endothelial Function in Lupus Patients.

Kamen, Diane L / Oates, Jim C

The American journal of the medical sciences

2015 Volume 350, Issue 4, Page(s) 302–307

Abstract: Background: The endothelium is important not only in regulating vascular tone but also in modulating inflammation. Patients with systemic lupus erythematosus (SLE) have deficits in these endothelial functions. Vitamin D is a nuclear hormone that ... ...

Abstract	Background: The endothelium is important not only in regulating vascular tone but also in modulating inflammation. Patients with systemic lupus erythematosus (SLE) have deficits in these endothelial functions. Vitamin D is a nuclear hormone that regulates vascular endothelial nitric oxide synthase activity and expression. Many SLE patients have insufficient levels of vitamin D. The effect of this hormone on vascular endothelial function in SLE patients is not known. This study was designed to determine the effect size of repleting vitamin D levels on endothelial function in patients with SLE and vitamin D deficiency. Methods: SLE patients with 25(OH) vitamin D (25(OH)D) levels <20 ng/mL were randomized to oral vitamin D3 (D3) doses that did or did not raise 25(OH)D levels to ≥32 ng/mL. Endothelial function was measured with flow-mediated dilation (FMD) before and after 16 weeks of vitamin D3 supplementation. Results: Half of those who achieved 25(OH)D levels of ≥32 ng/mL experienced increases in FMD, whereas none of those with continued low 25(OH)D levels did. Those with increases in FMD had significantly higher final 25(OH)D levels. Using the effect size from this study, future studies designed to test the effect of repleting 25(OH)D on FMD in vitamin D-deficient SLE patients will require 35 patients in each group. Conclusions: These results suggest a potential role for vitamin D in SLE-related endothelial dysfunction and that an adaptive, multi-arm, treat-to-target, serum-level trial design may increase the efficiency and likelihood of success of such a study.
MeSH term(s)	Administration, Oral ; Adult ; Cholecalciferol/deficiency ; Cholecalciferol/therapeutic use ; Dietary Supplements ; Endothelium/drug effects ; Female ; Humans ; Inflammation/drug therapy ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged ; Pilot Projects ; Vascular Diseases ; Vitamin D Deficiency/drug therapy
Chemical Substances	Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2015-09-05
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1097/MAJ.0000000000000556
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