LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 68

Search options

  1. Book: African skin and hair disorders

    Khumalo, Nonhlanhla P.

    (Dermatologic clinics of North America; 32,2 ; 32,2)

    2014  

    Author's details ed. Nonhlanhla P. Khumalo
    Series title Dermatologic clinics of North America; 32,2 ; 32,2
    Dermatologic clinics
    Dermatologic clinics of North America; 32,2
    Collection Dermatologic clinics
    Dermatologic clinics of North America; 32,2
    Language English
    Size XII S., S. 114 - 254 : zahlr. Ill.
    Publisher Elsevier
    Publishing place Philadelphia, Pa. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018303863
    ISBN 978-0-323-28997-9 ; 0-323-28997-5
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 851 -32,2- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Correction: Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration.

    Foroushani, Fatemeh Tavakoli / Dzobo, Kevin / Khumalo, Nonhlanhla P / Mora, Vanessa Zamora / Mezerville, Roberto de / Bayat, Ardeshir

    Biomaterials research

    2023  Volume 27, Issue 1, Page(s) 95

    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2775188-0
    ISSN 2055-7124 ; 1226-4601
    ISSN (online) 2055-7124
    ISSN 1226-4601
    DOI 10.1186/s40824-023-00437-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Androgenetic alopecia: An update.

    Ntshingila, Sincengile / Oputu, Ogheneochuko / Arowolo, Afolake T / Khumalo, Nonhlanhla P

    JAAD international

    2023  Volume 13, Page(s) 150–158

    Abstract: Androgenetic alopecia (AGA) is the most common nonscarring alopecia and is characterised by distinct gradual patterned hair loss. AGA is mediated by genetic predisposition and excessive follicular sensitivity to androgens, mainly in males, leading to the ...

    Abstract Androgenetic alopecia (AGA) is the most common nonscarring alopecia and is characterised by distinct gradual patterned hair loss. AGA is mediated by genetic predisposition and excessive follicular sensitivity to androgens, mainly in males, leading to the progressive conversion of scalp terminal hair into vellus hair. Although highly prevalent, it is not fatal but may have a severe psychosocial impact, especially on females and younger males. Significant advances have been made in understanding AGA's epidemiology and pathophysiology, but only 2 drugs remain approved by the FDA - finasteride and minoxidil. Prolonged use of these drugs, is a prerequisite for enhanced treatment response. However, this leads to poor medication adherence and adverse effects from extended use eg, the "postfinasteride syndrome" which persists beyond stopping the drug. Hence, there is a need for research on more effective alternative treatments for AGA, with fewer side effects. This paper reviewed recent advances in AGA pathophysiology and its treatment options. The recently characterized structure of type 2, 5-alpha reductase holds significance in comprehending present and prospective treatments of AGA.
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2023.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Cross-disciplinary synergy

    Nonhlanhla P. Khumalo / Sarasvathie Reddy

    The Journal for Transdisciplinary Research in Southern Africa, Vol 17, Iss 1, Pp e1-e

    First-year students’ experiences of learning academic writing through integrated writing support at a University of Technology

    2021  Volume 10

    Abstract: An important role in socialising first-year students into universities is initiating them into different conventions of academic writing. Support programmes, such as writing centres, have been established in several South African universities to help ... ...

    Abstract An important role in socialising first-year students into universities is initiating them into different conventions of academic writing. Support programmes, such as writing centres, have been established in several South African universities to help students with this objective and the broader issue of academic literacy. The assumption is that such interventions bridge the articulation gap between basic and higher education phases and expedite academic success. This article draws from a larger PhD study that explored nursing students’ experiences of developing their academic writing skills at the writing centre. The focus of this article is on understanding first-year nursing students’ experiences of learning academic writing through the integrated writing interventions of language and discipline practices at a writing centre based at the Durban University of Technology (DUT). These students were regarded as relevant because their curriculum incorporates a more structured academic writing component with the writing centre. The study adopted the Academic Literacies Model (ALM), which fosters a social view of academic writing and advocates for integrated support to the teaching and learning of academic writing. Guided by the qualitative constructivist paradigm, phenomenography was adopted as a research methodology. Data were analysed according to phenomenographic categories. Whilst the study uncovered various factors influencing the development of academic writing amongst the target population, there was a clear need for shifting from interdisciplinary (at least two disciplines) to a transdisciplinary (more than two disciplines) academic literacy approach to students’ learning experiences. As such, the article recommends the intentional inclusion of various stakeholders (writing centre practitioners, discipline lecturers, clinical and academic support staff) to mitigate students’ writing challenges and develop sustainable and relevant academic literacy practices.
    Keywords academic literacies ; academic writing ; extended curriculum programme ; writing centres ; phenomenography ; Science ; Q ; Social Sciences ; H
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher AOSIS
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Genetics and Epigenetics of Keloids.

    Nyika, Dennias Tonderai / Khumalo, Nonhlanhla P / Bayat, Ardeshir

    Advances in wound care

    2021  Volume 11, Issue 4, Page(s) 192–201

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) DNA Methylation/genetics ; Epigenesis, Genetic ; Epigenomics ; Humans ; Keloid/genetics ; Keloid/pathology ; Keloid/therapy ; Quality of Life
    Language English
    Publishing date 2021-12-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650541-1
    ISSN 2162-1934 ; 2162-1918
    ISSN (online) 2162-1934
    ISSN 2162-1918
    DOI 10.1089/wound.2021.0094
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: An in silico approach to the identification of potential proteomic and genomic diagnostic biomarkers for primary cicatricial alopecia.

    Sikhakhane, Thandeka N / Adeola, Henry A / Khumalo, Nonhlanhla P

    Experimental dermatology

    2021  Volume 31, Issue 3, Page(s) 437–438

    MeSH term(s) Alopecia/diagnosis ; Alopecia/genetics ; Biomarkers ; Cicatrix/genetics ; Cicatrix/pathology ; Genomics ; Humans ; Proteomics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-10-29
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14477
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: FAM111B dysregulation promotes malignancy in fibrosarcoma and POIKTMP and a low-cost method for its mutation screening.

    Rhoda, Cenza / Sunda, Falone / Kidzeru, Elvis / Khumalo, Nonhlanhla P / Arowolo, Afolake

    Cancer treatment and research communications

    2023  Volume 34, Page(s) 100679

    Abstract: ... gene mutation: NM_198947.4: c.1861T>G (p. Tyr621Asp or Y621D) by qPCR and western blot. The cellular function ... markedly downregulated (p ≤ 0.05) in the POIKTMP-patient's fibroblasts. The PCR-RFLP method successfully ...

    Abstract Introduction: Mutations in the uncharacterised human FAM111B gene are associated with POIKTMP, a rare multi-organ fibrosing disease. Recent studies also reported the overexpression of FAM111B in specific cancers. Moreover, FAM111B mutation screening may prove expensive in under-resourced facilities. Therefore, this study investigated its cellular function and dysfunction and described an inexpensive mutation screening method.
    Materials and methods: FAM111B expression was assessed in silico and validated in vitro in cell lines and primary skin fibroblasts from a South African POIKTMP-patient with the heterozygous FAM111B gene mutation: NM_198947.4: c.1861T>G (p. Tyr621Asp or Y621D) by qPCR and western blot. The cellular function of FAM111B was studied in HT1080 using various cell-based functional assays, and the Y621D mutation was genotyped by PCR-RFLP.
    Results: Expression studies showed upregulated FAM111B mRNA and protein in the cancer cells. High FAM111B expression with robust nuclear localization occurred in HT1080. Additionally, expression data and cell-based assays indicated that FAM111B led to the upregulation of cell migration, decreased cell apoptosis, and modulatory effects on cell proliferation. Y621D mutation showed similar effects on cell migration but minimal impact on cell apoptosis. FAM111B mRNA and protein expression were markedly downregulated (p ≤ 0.05) in the POIKTMP-patient's fibroblasts. The PCR-RFLP method successfully genotyped Y621D gene mutation.
    Discussion: FAM111B is a cancer-associated nuclear protein: Its modulation by mutations or overexpression may contribute to the malignancy of cancers and POIKTMP/fibrosis and poor clinical outcomes and represents a viable prognostic marker or therapeutic target. Furthermore, the PCR-RFLP method could prove a valuable tool for FAM111B mutation validation or screening in resource-constrained laboratories.
    MeSH term(s) Humans ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Mutation ; Fibrosarcoma/genetics ; Genotype ; Polymorphism, Restriction Fragment Length
    Chemical Substances Cell Cycle Proteins ; FAM111B protein, human
    Language English
    Publishing date 2023-01-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2022.100679
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Beyond "ethnicity" in dermatology.

    Khumalo, Nonhlanhla P

    Dermatologic clinics

    2014  Volume 32, Issue 2, Page(s) ix–xii

    MeSH term(s) Cosmetic Techniques ; Dermatology/standards ; Ethnic Groups/statistics & numerical data ; Humans ; Skin Diseases/ethnology ; Skin Diseases/therapy
    Language English
    Publishing date 2014-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 82798-8
    ISSN 1558-0520 ; 0733-8635
    ISSN (online) 1558-0520
    ISSN 0733-8635
    DOI 10.1016/j.det.2014.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Comment on "Prevention of flares in children with atopic dermatitis with regular use of an emollient containing glycerol and paraffin: A randomised controlled study".

    Hlela, Carol / Khumalo, Nonhlanhla P

    Pediatric dermatology

    2017  Volume 34, Issue 6, Page(s) 743

    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Letter
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.13264
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars.

    Kidzeru, Elvis Banboye / Lebeko, Maribanyana / Sharma, Jyoti Rajan / Nkengazong, Lucia / Adeola, Henry Ademola / Ndlovu, Hlumani / P Khumalo, Nonhlanhla / Bayat, Ardeshir

    Experimental dermatology

    2023  Volume 32, Issue 5, Page(s) 570–587

    Abstract: Raised dermal scars including hypertrophic, and keloid scars as well as scalp-associated fibrosing Folliculitis Keloidalis Nuchae (FKN) are a group of fibrotic raised dermal lesions that mostly occur following cutaneous injury. They are characterized by ... ...

    Abstract Raised dermal scars including hypertrophic, and keloid scars as well as scalp-associated fibrosing Folliculitis Keloidalis Nuchae (FKN) are a group of fibrotic raised dermal lesions that mostly occur following cutaneous injury. They are characterized by increased extracellular matrix (ECM) deposition, primarily excessive collagen type 1 production by hyperproliferative fibroblasts. The extent of ECM deposition is thought to be proportional to the severity of local skin inflammation leading to excessive fibrosis of the dermis. Due to a lack of suitable study models, therapy for raised dermal scars remains ill-defined. Immune cells and their associated markers have been strongly associated with dermal fibrosis. Therefore, modulation of the immune system and use of anti-inflammatory cytokines are of potential interest in the management of dermal fibrosis. In this review, we will discuss the importance of immune factors in the pathogenesis of raised dermal scarring. The aim here is to provide an up-to-date comprehensive review of the literature, from PubMed, Scopus, and other relevant search engines in order to describe the known immunological factors associated with raised dermal scarring. The importance of immune cells including mast cells, macrophages, lymphocytes, and relevant molecules such as cytokines, chemokines, and growth factors, antibodies, transcription factors, and other immune-associated molecules as well as tissue lymphoid aggregates identified within raised dermal scars will be presented. A growing body of evidence points to a shift from proinflammatory Th1 response to regulatory/anti-inflammatory Th2 response being associated with the development of fibrogenesis in raised dermal scarring. In summary, a better understanding of immune cells and associated molecular markers in dermal fibrosis will likely enable future development of potential immune-modulated therapeutic, diagnostic, and theranostic targets in raised dermal scarring.
    MeSH term(s) Humans ; Cicatrix, Hypertrophic/metabolism ; Keloid/metabolism ; Extracellular Matrix/metabolism ; Fibroblasts/metabolism ; Fibrosis ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-02-20
    Publishing country Denmark
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14734
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top