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Book ; Online: Crystal growth and optical properties of Ce-doped (La,Y)$_2$Si$_2$O$_7$ single crystal

Horiai, Takahiko / Paterek, Juraj / Pejchal, Jan / Jarosova, Marketa / Rohlicek, Jan / Kurosawa, Shunsuke / Hanada, Takashi / Yoshino, Masao / Yamaji, Akihiro / Toyoda, Satoshi / Sato, Hiroki / Ohashi, Yuji / Kamada, Kei / Yokota, Yuui / Yoshikawa, Akira / Nikl, Martin

2021

Abstract: We have grown Ce-doped (La,Y)$_2$Si$_2$O$_7$ single crystal by micro-pulling-down method and ... with (Ce$_{0.015}$La$_{0.600}$Y$_{0.385}$)$_2$Si$_2$O$_7$ composition. The observed thermal quenching ... respectively. These results indicate that (Ce$_{0.015}$La$_{0.600}$Y$_{0.385}$)$_2$Si$_2$O$_7$ has a great ...

Abstract	We have grown Ce-doped (La,Y)$_2$Si$_2$O$_7$ single crystal by micro-pulling-down method and investigated its optical and scintillation properties. We have successfully prepared the single crystal with (Ce$_{0.015}$La$_{0.600}$Y$_{0.385}$)$_2$Si$_2$O$_7$ composition. The observed thermal quenching process could be characterized by the quenching temperature (T50%) of 526 K and its activation energy was determined to be 0.62 eV. Further considering the thermal quenching factors, it was found that the thermal quenching was caused by at least the thermal ionization and maybe also by classical thermal quenching. The light output and scintillation decay time were evaluated to be ~12,000 photons/MeV and ~42 ns, respectively. These results indicate that (Ce$_{0.015}$La$_{0.600}$Y$_{0.385}$)$_2$Si$_2$O$_7$ has a great potential for application in scintillation materials.
Keywords	Physics - Optics ; Condensed Matter - Materials Science
Publishing date	2021-04-15
Publishing country	us
Document type	Book ; Online
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Article ; Online: Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS.

Yamanaka, Tomoyuki / Tosaki, Asako / Miyazaki, Haruko / Kurosawa, Masaru / Koike, Masato / Uchiyama, Yasuo / Maity, Sankar N / Misawa, Hidemi / Takahashi, Ryosuke / Shimogori, Tomomi / Hattori, Nobutaka / Nukina, Nobuyuki

Scientific reports

2016 Volume 6, Page(s) 34575

Abstract: ... Y in different sets of neurons resulted in cell type-specific neuropathologies and gene ... downregulation in mouse CNS. In striatal and cerebellar neurons, NF-Y inactivation led to ubiquitin/p62 ... by NF-Y deletion in cortical neurons. In contrast, NF-Y inactivation in motor neurons induced neuronal ...

Abstract	The mammalian central nervous system (CNS) contains various types of neurons with different neuronal functions. In contrast to established roles of cell type-specific transcription factors on neuronal specification and maintenance, whether ubiquitous transcription factors have conserved or differential neuronal function remains uncertain. Here, we revealed that inactivation of a ubiquitous factor NF-Y in different sets of neurons resulted in cell type-specific neuropathologies and gene downregulation in mouse CNS. In striatal and cerebellar neurons, NF-Y inactivation led to ubiquitin/p62 pathologies with downregulation of an endoplasmic reticulum (ER) chaperone Grp94, as we previously observed by NF-Y deletion in cortical neurons. In contrast, NF-Y inactivation in motor neurons induced neuronal loss without obvious protein deposition. Detailed analysis clarified downregulation of another ER chaperone Grp78 in addition to Grp94 in motor neurons, and knockdown of both ER chaperones in motor neurons recapitulated the pathology observed after NF-Y inactivation. Finally, additional downregulation of Grp78 in striatal neurons suppressed ubiquitin accumulation induced by NF-Y inactivation, implying that selective ER chaperone downregulation mediates different neuropathologies. Our data suggest distinct roles of NF-Y in protein homeostasis and neuronal maintenance in the CNS by differential regulation of ER chaperone expression.
Language	English
Publishing date	2016-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep34575
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Article ; Online: NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization.

Yamanaka, Tomoyuki / Tosaki, Asako / Kurosawa, Masaru / Matsumoto, Gen / Koike, Masato / Uchiyama, Yasuo / Maity, Sankar N / Shimogori, Tomomi / Hattori, Nobutaka / Nukina, Nobuyuki

Nature communications

2014 Volume 5, Page(s) 3354

Abstract: Nuclear transcription factor-Y (NF-Y), a key regulator of cell-cycle progression, often loses ... its activity during differentiation into nonproliferative cells. In contrast, NF-Y is still active in mature ... identify several NF-Y physiological targets including Grp94 potentially involved in ER disorganization ...

Abstract	Nuclear transcription factor-Y (NF-Y), a key regulator of cell-cycle progression, often loses its activity during differentiation into nonproliferative cells. In contrast, NF-Y is still active in mature, differentiated neurons, although its neuronal significance remains obscure. Here we show that conditional deletion of the subunit NF-YA in postmitotic mouse neurons induces progressive neurodegeneration with distinctive ubiquitin/p62 pathology; these proteins are not incorporated into filamentous inclusion but co-accumulated with insoluble membrane proteins broadly on endoplasmic reticulum (ER). The degeneration also accompanies drastic ER disorganization, that is, an aberrant increase in ribosome-free ER in the perinuclear region, without inducing ER stress response. We further perform chromatin immunoprecipitation and identify several NF-Y physiological targets including Grp94 potentially involved in ER disorganization. We propose that NF-Y is involved in a unique regulation mechanism of ER organization in mature neurons and its disruption causes previously undescribed novel neuropathology accompanying abnormal ubiquitin/p62 accumulation.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; CCAAT-Binding Factor/genetics ; CCAAT-Binding Factor/metabolism ; Cell Line, Tumor ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress/genetics ; Endoplasmic Reticulum Stress/physiology ; Female ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Sequestosome-1 Protein ; Ubiquitin/genetics ; Ubiquitin/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; CCAAT-Binding Factor ; HSP70 Heat-Shock Proteins ; Heat-Shock Proteins ; Membrane Proteins ; Sequestosome-1 Protein ; Sqstm1 protein, mouse ; Ubiquitin ; glucose-regulated proteins ; nuclear factor Y
Language	English
Publishing date	2014-02-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/ncomms4354
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Article: (90)Y bremsstrahlung emission computed tomography using gamma cameras.

Ito, Shigeki / Kurosawa, Hiroyuki / Kasahara, Hiroyuki / Teraoka, Satomi / Ariga, Eiji / Deji, Shizuhiko / Hirota, Masahiro / Saze, Takuya / Minamizawa, Takao / Nishizawa, Kunihide

Annals of nuclear medicine

2009 Volume 23, Issue 3, Page(s) 257–267

Abstract: Objective: This study demonstrates images obtained by (90)Y bremsstrahlung ... emission computed tomography (BECT), and characterizes the system performance of gamma cameras.: Methods: (90)Y BECT images ... and 50% (139-232 keV) at 185 keV were set on a (90)Y bremsstrahlung spectrum. The images obtained ...

Abstract	Objective: This study demonstrates images obtained by (90)Y bremsstrahlung emission computed tomography (BECT), and characterizes the system performance of gamma cameras. Methods: (90)Y BECT images of phantoms were acquired using a gamma camera equipped with a medium energy general purpose parallel-hole collimator. Three energy window widths of 50% (57-94 keV) centered at 75 keV, 30% (102-138 keV) at 120 keV, and 50% (139-232 keV) at 185 keV were set on a (90)Y bremsstrahlung spectrum. The images obtained with three energy windows were reconstructed using filtered back projection (FBP) and ordered subsets expectation maximization (OSEM) methods. The images of the sum window were obtained by fusing the images of the 75, 120, and 185 keV windows. Results: The OSEM method improved the full width at half maximum by 20% and the standard deviation by 9% compared with the FBP method. BECT displayed (90)Y biodistribution and quantified (90)Y activity. BECT images obtained with OSEM method using the 120 keV window showed the highest resolution and lowest uncertainty. The sum window showed the highest sensitivity, while its resolution was 10% inferior to that of the 120 keV window. One whole-body image can be taken over 100 min using the sum window. An absorber to cover the body surface reduced background by 30%. Conclusions: (90)Y BECT imaging can be used for patient assessment without modifying current treatment procedures.
MeSH term(s)	Absorption ; Gamma Cameras ; Heart Neoplasms/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Phantoms, Imaging ; Radiography ; Sensitivity and Specificity ; Tomography, Emission-Computed/instrumentation ; Yttrium Radioisotopes
Chemical Substances	Yttrium Radioisotopes
Language	English
Publishing date	2009-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1146984-5
ISSN	1864-6433 ; 0914-7187
ISSN (online)	1864-6433
ISSN	0914-7187
DOI	10.1007/s12149-009-0233-9
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Article ; Online: Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.

Yamanaka, Tomoyuki / Miyazaki, Haruko / Oyama, Fumitaka / Kurosawa, Masaru / Washizu, Chika / Doi, Hiroshi / Nukina, Nobuyuki

The EMBO journal

2008 Volume 27, Issue 6, Page(s) 827–839

Abstract: ... we show that mutant Huntingtin aggregates interact with the components of the NF-Y transcriptional factor ... lysates showed reduction in NF-Y binding to the promoter region of HSP70, one of the NF-Y targets. RT-PCR ... analysis revealed reduced HSP70 expression in these brains. We further clarified the importance of NF-Y ...

Abstract	In Huntington's disease (HD), mutant Huntingtin, which contains expanded polyglutamine stretches, forms nuclear aggregates in neurons. The interactions of several transcriptional factors with mutant Huntingtin, as well as altered expression of many genes in HD models, imply the involvement of transcriptional dysregulation in the HD pathological process. The precise mechanism remains obscure, however. Here, we show that mutant Huntingtin aggregates interact with the components of the NF-Y transcriptional factor in vitro and in HD model mouse brain. An electrophoretic mobility shift assay using HD model mouse brain lysates showed reduction in NF-Y binding to the promoter region of HSP70, one of the NF-Y targets. RT-PCR analysis revealed reduced HSP70 expression in these brains. We further clarified the importance of NF-Y for HSP70 transcription in cultured neurons. These data indicate that mutant Huntingtin sequesters NF-Y, leading to the reduction of HSP70 gene expression in HD model mice brain. Because suppressive roles of HSP70 on the HD pathological process have been shown in several HD models, NF-Y could be an important target of mutant Huntingtin.
MeSH term(s)	Animals ; CCAAT-Binding Factor/antagonists & inhibitors ; CCAAT-Binding Factor/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; HSP70 Heat-Shock Proteins/antagonists & inhibitors ; HSP70 Heat-Shock Proteins/biosynthesis ; HSP70 Heat-Shock Proteins/genetics ; Huntingtin Protein ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Male ; Mice ; Mice, Transgenic ; Mutation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/physiology ; Nuclear Proteins/genetics ; Nuclear Proteins/physiology ; Protein Binding/genetics
Chemical Substances	CCAAT-Binding Factor ; HSP70 Heat-Shock Proteins ; Htt protein, mouse ; Huntingtin Protein ; Nerve Tissue Proteins ; Nuclear Proteins
Language	English
Publishing date	2008-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/emboj.2008.23
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cardiac dysfunction and biphasic neurological symptoms due to head trauma.

Ito, Yusaku / Aoki, Kazunori / Kawamoto, Shohei / Kurosawa, Hiroshi

Pediatrics international : official journal of the Japan Pediatric Society

2024 Volume 66, Issue 1, Page(s) e15737

MeSH term(s)	Humans ; Infant ; Child ; Craniocerebral Trauma/complications ; Craniocerebral Trauma/diagnosis ; Seizures ; Heart Diseases ; Child Abuse/diagnosis
Language	English
Publishing date	2024-02-26
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15737
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Article ; Online: Early-onset West syndrome with developmental delay associated with a novel KLHL20 variant.

Kuroda, Yukiko / Ikeda, Azusa / Naruto, Takuya / Kurosawa, Kenji

American journal of medical genetics. Part A

2024 , Page(s) e63600

Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108614-X
ISSN	1552-4833 ; 0148-7299 ; 1552-4825
ISSN (online)	1552-4833
ISSN	0148-7299 ; 1552-4825
DOI	10.1002/ajmg.a.63600
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Article ; Online: A novel ACTB variant in an atypical case of Baraitser-Winter syndrome with cerebellar hypoplasia and diaphragmatic hernia.

Kuroda, Yukiko / Saito, Yoko / Enomoto, Yumi / Naruto, Takuya / Kurosawa, Kenji

Clinical dysmorphology

2024 Volume 33, Issue 2, Page(s) 75–78

MeSH term(s)	Humans ; Hernias, Diaphragmatic, Congenital/diagnosis ; Hernias, Diaphragmatic, Congenital/genetics ; Nervous System Malformations ; Cerebellum/abnormalities ; Developmental Disabilities ; Growth Disorders ; Hydrocephalus ; Facies ; Obesity ; Mental Retardation, X-Linked
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1121482-x
ISSN	1473-5717 ; 0962-8827
ISSN (online)	1473-5717
ISSN	0962-8827
DOI	10.1097/MCD.0000000000000484
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Article: Analysis of Gene-Environment Interactions Related to Developmental Disorders.

Nishimura, Yuhei / Kurosawa, Kenji

Frontiers in pharmacology

2022 Volume 13, Page(s) 863664

Abstract: Various genetic and environmental factors are associated with developmental disorders (DDs). It has been suggested that interaction between genetic and environmental factors ( ... ...

Abstract	Various genetic and environmental factors are associated with developmental disorders (DDs). It has been suggested that interaction between genetic and environmental factors (G
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.863664
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Article: Preparation of mouse-human chimeric antibody to an embryonic carbohydrate antigen, Lewis Y.

Kaneko, T / Iba, Y / Zenita, K / Shigeta, K / Nakano, K / Itoh, W / Kurosawa, Y / Kannagi, R / Yasukawa, K

Journal of biochemistry

1993 Volume 113, Issue 1, Page(s) 114–117

Abstract: ... with a previously established hybridoma producing a monoclonal antibody (named H18A) to Lewis Y antigen, which is ... Lewis Y antigen with the same dose-response curve as the original H18A. The chimeric H18A looks more ...

Abstract	Stage-specific embryonic antigen-1 (SSEA-1) is a well-known carbohydrate antigen that is specifically expressed on the surface of cancer cells as well as embryonic cells. In this study, starting with a previously established hybridoma producing a monoclonal antibody (named H18A) to Lewis Y antigen, which is closely related to SSEA-1, we cloned genomic DNA encoding active variable regions both of heavy and light chains of the antibody. Sequence analysis showed that VH and V kappa genes of H18A were in the VH 7183 family and V kappa C1 family, respectively. A transfected cell line named HC-H18A-7 expressing a recombinant chimeric H18A composed of mouse-derived antigen-binding variable regions and human-derived constant regions was established. The chimeric H18A was purified to homogeneity and shown to bind purified Lewis Y antigen with the same dose-response curve as the original H18A. The chimeric H18A looks more promising for clinical application than the original mouse-derived H18A because its antigenicity is expected to be reduced.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antibodies/genetics ; Antibodies/immunology ; Base Sequence ; Carbohydrate Sequence ; DNA/chemistry ; Genes, Immunoglobulin ; Genetic Vectors ; Humans ; Immunoglobulin Heavy Chains/chemistry ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Light Chains/chemistry ; Immunoglobulin Light Chains/genetics ; Lewis Blood-Group System/chemistry ; Lewis Blood-Group System/immunology ; Lewis X Antigen/chemistry ; Lewis X Antigen/immunology ; Mice ; Molecular Sequence Data ; Plasmids ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Transfection
Chemical Substances	Antibodies ; Immunoglobulin Heavy Chains ; Immunoglobulin Light Chains ; Lewis Blood-Group System ; Lewis X Antigen ; Recombinant Fusion Proteins ; DNA (9007-49-2)
Language	English
Publishing date	1993-01
Publishing country	England
Document type	Journal Article
ZDB-ID	218073-x
ISSN	1756-2651 ; 0021-924X
ISSN (online)	1756-2651
ISSN	0021-924X
DOI	10.1093/oxfordjournals.jbchem.a123993
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