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  1. Article ; Online: Reply To Chang and Liaw.

    Ofman, Gaston / Lang, Mark L

    The Journal of infectious diseases

    2021  Volume 225, Issue 8, Page(s) 1494–1495

    Language English
    Publishing date 2021-12-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab618
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    Zs.MO 445: Show issues

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  2. Article ; Online: CD1d-dependent CLL progression?

    Lang, Mark L

    Blood

    2017  Volume 129, Issue 26, Page(s) 3398–3399

    MeSH term(s) Antigens, CD1 ; Antigens, CD1d ; Humans
    Chemical Substances Antigens, CD1 ; Antigens, CD1d
    Language English
    Publishing date 2017-06-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-05-783662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  3. Article: The Influence of Invariant Natural Killer T Cells on Humoral Immunity to T-Dependent and -Independent Antigens.

    Lang, Mark L

    Frontiers in immunology

    2018  Volume 9, Page(s) 305

    Abstract: Vaccination with CD1d-binding glycolipid adjuvants and co-administered protein, lipid, and carbohydrate antigens leads to invariant natural killer T (NKT) cell-dependent enhancement of protective B cell responses. NKT cell activation boosts the ... ...

    Abstract Vaccination with CD1d-binding glycolipid adjuvants and co-administered protein, lipid, and carbohydrate antigens leads to invariant natural killer T (NKT) cell-dependent enhancement of protective B cell responses. NKT cell activation boosts the establishment of protein antigen-specific B cell memory and long-lived plasma cell (LLPC) compartments. NKT cells may exert a similar effect on some carbohydrate-specific B cells, but not lipid-specific B cells. The mechanisms of action of NKT cells on B cell responsiveness and subsequent differentiation into memory B cells and LLPC is dependent on CD1d expression by dendritic cells and B cells that can co-present glycolipids on CD1d and antigen-derived peptide on MHCII. CD1d/glycolipid-activated NKT cells are able to provide help to B cells in a manner dependent on cognate and non-cognate interactions. More recently, a glycolipid-expanded subset of IL-21-secreting NKT cells known as NKT follicular helper cells has been suggested to be a driver of NKT-enhanced humoral immunity. This review summarizes established and recent findings on how NKT cells impact humoral immunity and suggests possible areas of investigation that may allow the incorporation of NKT-activating agents into vaccine adjuvant platforms.
    MeSH term(s) Animals ; Antigens/immunology ; Humans ; Immunity, Humoral ; Immunologic Memory ; Lymphocyte Activation ; Natural Killer T-Cells/immunology ; Plasma Cells/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances Antigens
    Language English
    Publishing date 2018-02-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.00305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The AANS/CNS Section on Tumors: a summary of 40 years of advocacy to advance the care of patients with brain and spine tumors.

    Parney, Ian F / Warnick, Ronald E / Lang, Frederick F / Rutka, James T / Kalkanis, Steven / Glick, Roberta / Rosenblum, Mark L / Germano, Isabelle M

    Journal of neurosurgery

    2024  , Page(s) 1–7

    Abstract: The AANS/CNS Section on Tumors was founded 40 years ago in 1984 to assist in the education of neurosurgeons interested in neuro-oncology, and serves as a resource for other national organizations regarding the clinical treatment of nervous system tumors. ...

    Abstract The AANS/CNS Section on Tumors was founded 40 years ago in 1984 to assist in the education of neurosurgeons interested in neuro-oncology, and serves as a resource for other national organizations regarding the clinical treatment of nervous system tumors. The Section on Tumors was the first national physicians' professional organization dedicated to the study and treatment of patients with brain and spine tumors. Over the past 40 years, the Section on Tumors has built solid foundations, including establishing the tumor section satellite meetings, founding the Journal of Neuro-Oncology (the first medical journal dedicated to brain and spine surgical oncology), advancing surgical neuro-oncology education and research, promoting neurosurgical involvement in neuro-oncology clinical trials, and advocating for patients with brain and spine tumors. This review provides a synopsis of the Section on Tumors' history, its challenges, and its opportunities, drawing on the section's archives and input from the 17 section chairs who led it during its first 40 years.
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2023.12.JNS232781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Peptide Aggregation Induced Immunogenic Rupture (PAIIR).

    Gunay, Gokhan / Hamsici, Seren / Lang, Gillian A / Lang, Mark L / Kovats, Susan / Acar, Handan

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Volume 9, Issue 21, Page(s) e2105868

    Abstract: Immunogenic cell death (ICD) arises when cells are under stress, and their membranes are damaged. They release damage-associated molecular patterns (DAMPs) that stimulate and drive the type and magnitude of the immune response. In the presence of an ... ...

    Abstract Immunogenic cell death (ICD) arises when cells are under stress, and their membranes are damaged. They release damage-associated molecular patterns (DAMPs) that stimulate and drive the type and magnitude of the immune response. In the presence of an antigen, DAMPs ride the longevity and efficacy of antigen-specific immunity. Yet, no tool can induce the controlled ICD with predictable results. A peptide-based tool, [II], is designed that aggregates in the cell and causes cell membrane damage, generates ICD and DAMPs release on various cell types, and hence can act as an adjuvant. An influenza vaccine is prepared by combining [II] with influenza hemagglutinin (HA) subunit antigens. The results show that [II] induced significantly higher HA-specific immunoglobulin G1 (IgG1) and IgG2a antibodies than HA-only immunized mice, while the peptide itself did not elicit antibodies. This paper demonstrates the first peptide-aggregation induced immunogenic rupture (PAIIR) approach as a vaccine adjuvant. PAIIR is a promising adjuvant with a high potential to promote universal protection upon influenza HA vaccination.
    MeSH term(s) Adjuvants, Immunologic ; Animals ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Humans ; Influenza Vaccines ; Influenza, Human ; Mice ; Mice, Inbred BALB C ; Peptides
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines ; Peptides
    Language English
    Publishing date 2022-05-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202105868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses.

    Amadou Amani, Souwelimatou / Lang, Mark L

    Frontiers in immunology

    2020  Volume 11, Page(s) 565648

    Abstract: Bacterial enteric pathogens individually and collectively represent a serious global health burden. Humoral immune responses following natural or experimentally-induced infections are broadly appreciated to contribute to pathogen clearance and prevention ...

    Abstract Bacterial enteric pathogens individually and collectively represent a serious global health burden. Humoral immune responses following natural or experimentally-induced infections are broadly appreciated to contribute to pathogen clearance and prevention of disease recurrence. Herein, we have compared observations on humoral immune mechanisms following infection with
    MeSH term(s) Animals ; Bacteria ; Bacterial Infections/immunology ; Humans ; Immunity, Humoral ; Intestinal Diseases/immunology
    Language English
    Publishing date 2020-09-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.565648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Use of a

    Lang, Gillian A / Norman, Kaylee / Amadou Amani, Souwelimatou / Shadid, Tyler M / Ballard, Jimmy D / Lang, Mark L

    Frontiers in immunology

    2022  Volume 12, Page(s) 818734

    Abstract: Adjuvant combinations may enhance or broaden the expression of immune responses to vaccine antigens. Information on whether established Alum type adjuvants can be combined with experimental CD1d ligand adjuvants is currently lacking. In this study, we ... ...

    Abstract Adjuvant combinations may enhance or broaden the expression of immune responses to vaccine antigens. Information on whether established Alum type adjuvants can be combined with experimental CD1d ligand adjuvants is currently lacking. In this study, we used a murine
    MeSH term(s) Adjuvants, Vaccine/administration & dosage ; Adjuvants, Vaccine/chemistry ; Alum Compounds ; Animals ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Biomarkers ; Clostridioides difficile/immunology ; Clostridium Infections/immunology ; Clostridium Infections/prevention & control ; Disease Models, Animal ; Dose-Response Relationship, Immunologic ; Female ; Immunization ; Immunophenotyping ; Ligands ; Lymphocyte Activation/immunology ; Mice ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism
    Chemical Substances Adjuvants, Vaccine ; Alum Compounds ; Bacterial Vaccines ; Biomarkers ; Ligands ; aluminum sulfate (34S289N54E)
    Language English
    Publishing date 2022-01-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.818734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The importance of B cell CD1d expression for humoral immunity.

    Lang, Mark L

    Expert review of vaccines

    2014  Volume 13, Issue 11, Page(s) 1275–1278

    Abstract: It was reported over a decade previously that CD1d-restricted Natural Killer T (NKT) cells could interact with CD1d-expressing B cells and facilitate antibody secretion. Since then, several studies have observed that NKT cells can provide B-cell help for ...

    Abstract It was reported over a decade previously that CD1d-restricted Natural Killer T (NKT) cells could interact with CD1d-expressing B cells and facilitate antibody secretion. Since then, several studies have observed that NKT cells can provide B-cell help for production of antibody against model and pathogen-derived glycolipids, carbohydrates and proteins. In regard to T cell-dependent protein antigens, it is still not entirely clear to what extent cognate interactions between CD1d-expressing B cells and NKT cells contribute to initial and long-lived B-cell responses that are characteristic of such antigens. In this editorial, we review evidence that NKT cells provide CD1d-dependent cognate and non-cognate forms of B-cell help following immunization with protein antigen. Elucidating these mechanisms will be important for harnessing NKT cells during vaccination.
    MeSH term(s) Animals ; Antigens/immunology ; Antigens, CD1d/biosynthesis ; B-Lymphocytes/immunology ; Gene Expression ; Humans ; Immunity, Humoral ; Killer Cells, Natural/immunology ; Proteins/immunology
    Chemical Substances Antigens ; Antigens, CD1d ; Proteins
    Language English
    Publishing date 2014-06-20
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1586/14760584.2014.932693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Murine Neonatal Fc Receptor Is Required for Transport of Immunization-Induced C. difficile-Specific IgG to the Gut and Protection against Disease but Does Not Affect Disease Susceptibility.

    Amadou Amani, Souwelimatou / Lang, Gillian A / Ballard, Jimmy D / Lang, Mark L

    Infection and immunity

    2021  Volume 89, Issue 10, Page(s) e0027421

    Abstract: The pathology associated with Clostridioides difficile disease is caused in large part by TcdB, an intracellular bacterial toxin that inactivates small GTPases. Despite C. difficile causing enteric disease, antitoxin IgG is a clear correlate of ... ...

    Abstract The pathology associated with Clostridioides difficile disease is caused in large part by TcdB, an intracellular bacterial toxin that inactivates small GTPases. Despite C. difficile causing enteric disease, antitoxin IgG is a clear correlate of protection against infection-associated pathology. Immunization with TcdB-based immunogens or passive transfer of monoclonal antibodies specific for the TcdB carboxy-terminal domain (CTD) confers protection following C. difficile infection. Whether the mechanism by which circulating IgG is delivered to the gut depends on specific receptor-mediated transport or is solely reflective of infection-induced damage to the gut remains unclear. Here, we tested the hypothesis that neonatal Fc receptor (FcRn) is required for the delivery of systemic TcdB-specific IgG to the gut and protection against C. difficile-associated pathology. FcRn-expressing mice and FcRn-deficient littermates were immunized subcutaneously with Alhydrogel adjuvant-adsorbed CTD before challenge with live C. difficile spores. FcRn was required for the delivery of systemic TcdB-specific IgG to the gut and for vaccine-induced protection against C. difficile-associated disease. The lack of FcRn expression had minimal effects on the composition of the gut microbiome and did not affect susceptibility to C. difficile infection in nonimmunized mice. In further experiments, intraperitoneal injection of immune sera in FcRn-deficient mice led to the transport of protective IgG to the gut independently of infection, confirming a reported method of bypassing the FcRn. Our results reveal an FcRn-dependent mechanism by which systemic immunization-induced IgG protects the gut during enteric C. difficile infection. These findings may be beneficial for the targeting of C. difficile-specific IgG to the gut.
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/immunology ; Antitoxins/immunology ; Bacterial Toxins/immunology ; Clostridioides difficile/immunology ; Clostridium Infections/immunology ; Clostridium Infections/microbiology ; Digestive System/immunology ; Digestive System/microbiology ; Disease Susceptibility/immunology ; Disease Susceptibility/microbiology ; Enterotoxins/immunology ; Female ; Histocompatibility Antigens Class I/immunology ; Immunity/immunology ; Immunization/methods ; Immunoglobulin G/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Fc/immunology ; Vaccination/methods
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antitoxins ; Bacterial Toxins ; Enterotoxins ; Histocompatibility Antigens Class I ; Immunoglobulin G ; Receptors, Fc ; Fc receptor, neonatal (TW3XAW0RCY)
    Language English
    Publishing date 2021-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00274-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Adaptive immune constraints on C. difficile vaccination.

    Lang, Mark L / Shrestha, Binu

    Expert review of vaccines

    2017  Volume 16, Issue 11, Page(s) 1053–1055

    MeSH term(s) Adaptive Immunity/immunology ; Animals ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Clostridium Infections/immunology ; Clostridium Infections/prevention & control ; Clostridium difficile/immunology ; Humans
    Chemical Substances Bacterial Vaccines
    Language English
    Publishing date 2017-09-19
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2017.1379397
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