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Book ; Online: Transgenic Insects

Benedict, Mark Quentin / Scott, Maxwell J

Techniques and Applications (2nd edition)

2022

Keywords	Insects (entomology) ; insects; transgenic modification
Language	English
Size	1 electronic resource (624 pages)
Publisher	CABI
Document type	Book ; Online
Note	English
HBZ-ID	HT030381907
ISBN	9781800621176 ; 1800621175
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease.

Cantu, Edward / Appel, James Z / Hartwig, Matthew G / Woreta, Hiwot / Green, Cindy / Messier, Robert / Palmer, Scott M / Davis, R Duane

The Annals of thoracic surgery

2004 Volume 78, Issue 4, Page(s) 1142–51; discussion 1142–51

Abstract: Background: Chronic allograft dysfunction limits the long-term success of lung transplantation. Increasing evidence suggests nonimmune mediated injury such as due to reflux contributes to the development of bronchiolitis obliterans syndrome. We have ... ...

Abstract	Background: Chronic allograft dysfunction limits the long-term success of lung transplantation. Increasing evidence suggests nonimmune mediated injury such as due to reflux contributes to the development of bronchiolitis obliterans syndrome. We have previously demonstrated that fundoplication can reverse bronchiolitis obliterans syndrome in some lung transplant recipients with reflux. We hypothesized that treatment of reflux with early fundoplication would prevent bronchiolitis obliterans syndrome and improve survival. Methods: A retrospective analysis of 457 patients who underwent lung transplantation from April 1992 through July 2003 was conducted. Patients were stratified into four groups: no history of reflux, history of reflux, history of reflux and early (< 90 days) fundoplication and history of reflux and late fundoplication. Results: Incidence of postoperative reflux was 76% (127 of 167 patients) in pH confirmed subgroups. In 14 patients with early fundoplication, actuarial survival was 100% at 1 and 3 years when compared with those with reflux and no intervention (92% +/- 3.3, 76% +/- 5.8; p < 0.02). Further, those who underwent early fundoplication had improved freedom from bronchiolitis obliterans syndrome at 1 and 3 years (100%, 100%) when compared with no fundoplication in patients with reflux (96% +/- 2.5, 60% +/- 7.5; p < 0.01). Conclusions: Reflux is a frequent medical complication after lung transplantation. Although the number of patients undergoing early fundoplication is small, our results suggest early aggressive surgical treatment of reflux results in improved rates of bronchiolitis obliterans syndrome and survival. Further research into the mechanisms and treatment of nonalloimmune mediated lung allograft injury is needed to reduce rates of chronic lung failure.
MeSH term(s)	Adult ; Bronchiolitis Obliterans/epidemiology ; Bronchiolitis Obliterans/etiology ; Bronchiolitis Obliterans/prevention & control ; Disease-Free Survival ; Female ; Fundoplication ; Gastric Acidity Determination ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/surgery ; Graft Rejection/prevention & control ; Humans ; Hydrogen-Ion Concentration ; Immunosuppressive Agents/therapeutic use ; Incidence ; Life Tables ; Lung Transplantation ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Retrospective Studies ; Time Factors ; Transplantation, Homologous
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2004-10
Publishing country	Netherlands
Document type	Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2004.04.044
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: J. Maxwell Chamberlain Memorial Paper for adult cardiac surgery. Less-invasive mitral valve operations: trends and outcomes from the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Gammie, James S / Zhao, Yue / Peterson, Eric D / O'Brien, Sean M / Rankin, J Scott / Griffith, Bartley P

The Annals of thoracic surgery

2010 Volume 90, Issue 5, Page(s) 1401–8, 1410.e1; discussion 1408–10

Abstract: Background: The purpose of this study was to examine utilization and outcomes of less-invasive mitral valve (LIMV) operations in North America.: Methods: Between 2004 and 2008, 28,143 patients undergoing isolated mitral valve (MV) operations were ... ...

Abstract	Background: The purpose of this study was to examine utilization and outcomes of less-invasive mitral valve (LIMV) operations in North America. Methods: Between 2004 and 2008, 28,143 patients undergoing isolated mitral valve (MV) operations were identified in The Society of Thoracic Surgeons Adult Cardiac Surgical Database (STS ACSD). The LIMV operations were defined as those performed with femoral arterial and venous cannulation. Results: The LIMV operations increased from 11.9% of MV operations in 2004 to 20.1% in 2008 (p < 0.0001). In 2008, 26% of STS ACSD centers performed at least one LIMV operation, with a median of 3 per year. Patients in the LIMV group were younger and had fewer comorbidities. Median perfusion (135 versus 108 minutes) and cross-clamp times (100 versus 80 minutes, p < 0.0001) were longer in the LIMV group. Mitral valve repair rates were higher in the LIMV group (85% versus 67%, p < 0.0001). Adjusted operative mortality was similar (odds ratio 1.13, 95% confidence interval: 0.84 to 1.51, p = 0.47). Blood transfusion was less common (odds ratio 0.86, 95% confidence interval: 0.76 to 0.97, p < 0.0001) while stroke was more common (OR 1.96, 95% confidence interval: 1.46 to 2.63, p < 0.0001) in the LIMV group. Conclusions: In selected patients, LIMV operations can be performed with equivalent operative mortality, shorter hospital stay, fewer blood transfusions, and higher rates of MV repair than conventional sternotomy. However, perfusion and cross-clamp times were longer, and the risk of stroke was significantly higher. Beating- or fibrillating-heart LIMV techniques are associated with particularly high risks for perioperative stroke.
MeSH term(s)	Aneurysm, Dissecting/etiology ; Aortic Aneurysm/etiology ; Cardiac Surgical Procedures ; Female ; Humans ; Male ; Middle Aged ; Mitral Valve/surgery ; Postoperative Complications/etiology ; Sternotomy/adverse effects ; Stroke/etiology
Language	English
Publishing date	2010-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2010.05.055
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Book ; Online ; E-Book: Transgenic Insects

Benedict, Mark Quentin / Scott, Maxwell J. / Ahmed, Hassan M. M. / Akbar, Omar S. / Aksoy, Serap / Alcalay, Yehonatan / Alphey, Luke / Arien, Yael / Avraham, Rotem Daniel / Beech, Camilla

Techniques and Applications

(CABI Biotechnology)

2022

Abstract: This book describes the huge opportunity to modify insect phenotypes through genetic engineering to benefit human health and agriculture. Precise DNA modifications and gene drive approaches are much more focused with improved safety. The development of ... ...

Series title	CABI Biotechnology
Abstract	This book describes the huge opportunity to modify insect phenotypes through genetic engineering to benefit human health and agriculture. Precise DNA modifications and gene drive approaches are much more focused with improved safety. The development of modelling, ethical considerations, public response and regulatory oversight is covered.
Keywords	Transgenic animals ; Insects/Genetic engineering ; Insect cell biotechnology
Subject code	636.0821
Language	English
Size	1 online resource (762 pages)
Edition	2nd ed.
Publisher	CAB International
Publishing place	Oxford
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-80062-116-7 ; 1-80062-117-5 ; 9781800621152 ; 978-1-80062-116-9 ; 978-1-80062-117-6 ; 1800621159
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Evaluation of Additional

Yamamoto, Akihiko / Yadav, Amarish K / Scott, Maxwell J

Frontiers in bioengineering and biotechnology

2022 Volume 10, Page(s) 829620

Abstract: Drosophila suzukii (D. suzukii) ...

Abstract	Drosophila suzukii (D. suzukii)
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.829620
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Aedes aegypti (Diptera: Culicidae) hsp83 Gene Promoter Drives Strong Ubiquitous DsRed and ZsGreen Marker Expression in Transgenic Mosquitoes.

Webster, Sophia H / Scott, Maxwell J

Journal of medical entomology

2021 Volume 58, Issue 6, Page(s) 2533–2537

Abstract: Transgenic strains of the mosquito disease vector Aedes aegypti (L.) are being developed for population suppression or modification. Transgenic mosquitoes are identified using fluorescent protein genes. Here we describe DsRed and ZsGreen marker genes ... ...

Abstract	Transgenic strains of the mosquito disease vector Aedes aegypti (L.) are being developed for population suppression or modification. Transgenic mosquitoes are identified using fluorescent protein genes. Here we describe DsRed and ZsGreen marker genes driven by the constitutive Ae. aegypti heat shock protein 83 (hsp83) promoter in transgenic mosquitoes. Transgenic larvae and pupae show strong full body expression of the red and green fluorescent proteins. This greatly assists in screening for transgenic individuals while making new or maintaining already established lines. Transient marker gene expression after embryo microinjection was readily visible in developing larvae allowing the separation of individuals that are more likely to produce transgenic offspring. The strongly expressed marker genes developed in this study should facilitate the detection of transgenic Ae. aegypti larvae or pupae in the field.
MeSH term(s)	Aedes/genetics ; Aedes/growth & development ; Aedes/metabolism ; Animals ; Animals, Genetically Modified ; Genetic Markers ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Larva/growth & development ; Larva/metabolism ; Luminescent Proteins/metabolism ; Promoter Regions, Genetic ; Pupa/growth & development ; Pupa/metabolism
Chemical Substances	Genetic Markers ; Heat-Shock Proteins ; Insect Proteins ; Luminescent Proteins
Language	English
Publishing date	2021-07-24
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjab128
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Author Correction: A transgenic embryonic sexing system for the Australian sheep blow fly Lucilia cuprina.

Yan, Ying / Scott, Maxwell J

Scientific reports

2020 Volume 10, Issue 1, Page(s) 6908

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Language	English
Publishing date	2020-04-20
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-63126-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CRISPR/Cas9 Genome Editing in the New World Screwworm and Australian Sheep Blowfly.

Paulo, Daniel F / Williamson, Megan E / Scott, Maxwell J

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2495, Page(s) 173–201

Abstract: Blowflies are of interest for medical applications (maggot therapy), forensic investigations, and for evolutionary developmental studies such as the evolution of parasitism. It is because of the latter that some blowflies such as the New World screwworm ... ...

Abstract	Blowflies are of interest for medical applications (maggot therapy), forensic investigations, and for evolutionary developmental studies such as the evolution of parasitism. It is because of the latter that some blowflies such as the New World screwworm and the Australian sheep blowfly are considered major economic pests of livestock. Due to their importance, annotated assembled genomes for several species are now available. Here, we present a detailed guide for using the Streptococcus pyogenes Cas9 RNA-guided nuclease to efficiently generate both knockout and knock-in mutations in screwworm and sheep blowfly. These methods should accelerate genetic investigations in these and other closely related species and lead to a better understanding of the roles of selected genes in blowfly development and behavior.
MeSH term(s)	Animals ; Australia ; CRISPR-Cas Systems/genetics ; Calliphoridae ; Diptera/genetics ; Gene Editing/methods ; RNA, Guide, CRISPR-Cas Systems/genetics
Chemical Substances	RNA, Guide, CRISPR-Cas Systems
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2301-5_10
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction

Ying Yan / Maxwell J. Scott

Scientific Reports, Vol 10, Iss 1, Pp 1-

A transgenic embryonic sexing system for the Australian sheep blow fly Lucilia cuprina

2020 Volume 2

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Presynaptic Rac1 in the hippocampus selectively regulates working memory.

Kim, Jaebin / Bustamante, Edwin / Sotonyi, Peter / Maxwell, Nicholas D / Parameswaran, Pooja / Kent, Julie K / Wetsel, William C / Soderblom, Erik J / Rácz, Bence / Soderling, Scott H

bioRxiv : the preprint server for biology

2024

Abstract: One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous studies have shown that Rac1-mediated signaling is ... ...

Abstract	One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous studies have shown that Rac1-mediated signaling is associated with hippocampal-dependent working memory and longer-term forms of learning and memory and that Rac1 can modulate forms of both pre- and postsynaptic plasticity. How these different cognitive functions and forms of plasticity mediated by Rac1 are linked, however, is unclear. Here, we show that spatial working memory is selectively impaired following the expression of a genetically encoded Rac1-inhibitor at presynaptic terminals, while longer-term cognitive processes are affected by Rac1 inhibition at postsynaptic sites. To investigate the regulatory mechanisms of this presynaptic process, we leveraged new advances in mass spectrometry to identify the proteomic and post-translational landscape of presynaptic Rac1 signaling. We identified serine/threonine kinases and phosphorylated cytoskeletal signaling and synaptic vesicle proteins enriched with active Rac1. The phosphorylated sites in these proteins are at positions likely to have regulatory effects on synaptic vesicles. Consistent with this, we also report changes in the distribution and morphology of synaptic vesicles and in postsynaptic ultrastructure following presynaptic Rac1 inhibition. Overall, this study reveals a previously unrecognized presynaptic role of Rac1 signaling in cognitive processes and provides insights into its potential regulatory mechanisms.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.18.585488
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