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  1. Article ; Online: How does SARS-CoV-2 cause COVID-19?

    Matheson, Nicholas J / Lehner, Paul J

    Science (New York, N.Y.)

    2020  Volume 369, Issue 6503, Page(s) 510–511

    MeSH term(s) Adaptive Immunity ; Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Epithelial Cells/virology ; Gastrointestinal Tract/cytology ; Gastrointestinal Tract/virology ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Receptors, Virus/metabolism ; Respiratory System/cytology ; Respiratory System/virology ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abc6156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection.

    Gerber, Pehuén Pereyra / Donde, Maria J / Matheson, Nicholas J / Taylor, Alexander I

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6716

    Abstract: The unprecedented emergence and spread of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, underscores the need for diagnostic and therapeutic technologies that can be rapidly tailored to novel threats. Here, we show that site-specific ... ...

    Abstract The unprecedented emergence and spread of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, underscores the need for diagnostic and therapeutic technologies that can be rapidly tailored to novel threats. Here, we show that site-specific RNA endonuclease XNAzymes - artificial catalysts composed of single-stranded synthetic xeno-nucleic acid oligonucleotides (in this case 2'-deoxy-2'-fluoro-β-D-arabino nucleic acid) - may be designed, synthesised and screened within days, enabling the discovery of a range of enzymes targeting SARS-CoV-2 ORF1ab, ORF7b, spike- and nucleocapsid-encoding RNA. Three of these are further engineered to self-assemble into a catalytic nanostructure with enhanced biostability. This XNA nanostructure is capable of cleaving genomic SARS-CoV-2 RNA under physiological conditions, and when transfected into cells inhibits infection with authentic SARS-CoV-2 virus by RNA knockdown. These results demonstrate the potential of XNAzymes to provide a platform for the rapid generation of antiviral reagents.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; RNA, Viral/genetics ; Pandemics ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use
    Chemical Substances RNA, Viral ; Antiviral Agents
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34339-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How does SARS-CoV-2 cause COVID-19?

    Matheson, Nicholas J. / Lehner, Paul J.

    Science

    2020  Volume 369, Issue 6503, Page(s) 510–511

    Keywords Multidisciplinary ; covid19
    Language English
    Publisher American Association for the Advancement of Science (AAAS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abc6156
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Covid-19: should the public wear face masks?

    Javid, Babak / Weekes, Michael P / Matheson, Nicholas J

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m1442

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Masks ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1442
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  6. Article ; Online: Mass testing of university students for covid-19.

    Matheson, Nicholas J / Warne, Ben / Weekes, Michael P / Maxwell, Patrick H

    BMJ (Clinical research ed.)

    2021  Volume 375, Page(s) n2388

    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing/methods ; Humans ; Mass Screening/methods ; Pandemics ; SARS-CoV-2 ; United Kingdom/epidemiology ; United States/epidemiology ; Universities
    Language English
    Publishing date 2021-10-01
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n2388
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  8. Book ; Online: Covid-19

    Javid, Babak / Weekes, Michael P / Matheson, Nicholas J

    should the public wear face masks?

    2020  

    Keywords EDITORIALS ; covid19
    Language English
    Publishing date 2020-04-09 07:05:53.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Covid-19

    Javid, Babak / Weekes, Michael P / Matheson, Nicholas J

    BMJ

    should the public wear face masks?

    2020  , Page(s) m1442

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1442
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Neuraminidase inhibitors beneficial for treatment and prevention of influenza in children.

    Matheson, Nicholas J

    The Journal of pediatrics

    2010  Volume 156, Issue 3, Page(s) 510–511

    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2009.11.070
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