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  1. Article ; Online: Different but Equal: Outcomes of Prolonged Postanesthesia Care Unit Stay After Trauma Laparotomy.

    Schachter, Aubrey E / Byerly, Saskya / Dong, Caroline / Malach, Lillian / Lenart, Emily K / Soule, Sara / Fischer, Peter E / Filiberto, Dina M

    The Journal of surgical research

    2024  Volume 298, Page(s) 341–346

    Abstract: ... trauma center over a 5 y period. Demographics, injuries, and resuscitation markers at 12 and 24 h were collected ... of patients were resuscitated at 24 h; 76% underwent eventual primary fascial closure. Under-resuscitation ... at 24 h (adjusted odds ratio [AOR] 0.55; 95% confidence interval [CI] 0.31-0.95, P = 0.03), increased ...

    Abstract Introduction: Hospital overcrowding is common and can lead to delays in intensive care unit (ICU) admission, resulting in increased morbidity and mortality in medical and surgical patients. Data on delayed ICU admission are limited in the postsurgical trauma cohort. Damage control laparotomy with temporary abdominal closure (DCL-TAC) for severely injured patients is often followed by an aggressive early resuscitation phase, usually occurring in the ICU. We hypothesized that patients who underwent DCL-TAC with initial postanesthesia care unit (PACU) stay would have worse outcomes than those directly admitted to ICU.
    Methods: A retrospective chart review identified all trauma patients who underwent DCL-TAC at a level 1 trauma center over a 5 y period. Demographics, injuries, and resuscitation markers at 12 and 24 h were collected. Patients were stratified by location after index laparotomy (PACU versus ICU) and compared. Outcomes included composite morbidity and mortality. Multivariable logistic regression was performed.
    Results: Of the 561 patients undergoing DCL-TAC, 134 (24%) patients required PACU stay due to ICU bed shortage, and 427 (76%) patients were admitted directly to ICU. There was no difference in demographics, injury severity score, time to resuscitation, complications, or mortality between PACU and ICU groups. Only 46% of patients were resuscitated at 24 h; 76% underwent eventual primary fascial closure. Under-resuscitation at 24 h (adjusted odds ratio [AOR] 0.55; 95% confidence interval [CI] 0.31-0.95, P = 0.03), increased age (AOR 1.04; 95% CI 1.02-10.55, P < 0.0001), and increased injury severity score (AOR 1.04; 95% CI 1.02-1.07, P < 0.0001) were associated with mortality on multivariable logistic regression. The median time in PACU was 3 h.
    Conclusions: PACU hold is not associated with worse outcomes in patients undergoing DCL-TAC. While ICU was designed for the resuscitation of critically ill patients, PACU is an appropriate alternative when an ICU bed is unavailable.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2024.03.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of presbyopia treatment pilocarpine hydrochloride 1.25% on night-driving performance.

    Waring, George O / Brujic, Mile / McGee, Selina / Micheletti, J Morgan / Zhao, Cathy / Schachter, Scott / Liu, Haixia / Safyan, Eleonora

    Clinical & experimental optometry

    2023  , Page(s) 1–8

    Abstract: Clinical relevance: Patients prescribed pilocarpine ophthalmic solution are advised to be cautious when driving at night, but studies evaluating the effects of pilocarpine hydrochloride ophthalmic solution 1.25% (pilo), approved to treat presbyopia, on ... ...

    Abstract Clinical relevance: Patients prescribed pilocarpine ophthalmic solution are advised to be cautious when driving at night, but studies evaluating the effects of pilocarpine hydrochloride ophthalmic solution 1.25% (pilo), approved to treat presbyopia, on driving at night are lacking.
    Background: This double-masked, crossover, phase 3b study evaluated night-driving performance with pilo or the placebo once daily.
    Methods: Forty-three adults (40-55 years) with presbyopia impacting daily activities and mesopic, high-contrast, binocular distance-corrected near vision 6/12-6/30 were randomised to bilateral treatment with pilo followed by placebo or placebo followed by pilo (with a ≥7-day washout between interventions). Night-driving performance was evaluated at twilight at a closed-circuit course. Primary efficacy endpoint: overall composite night-driving performance Z score at the end of the 7-14-day intervention period, 1 hour post-instillation. Pilo was considered non-inferior if the lower limit of the 95% confidence interval (CI) for the least squares mean difference (LSMD, pilo minus placebo) was >-0.25. Other efficacy endpoints: individual components of the night-driving performance test (hazard avoidance rate; road sign recognition rate and distance; pedestrians recognition distance; overall driving and lane-keeping times) and night-driving experience questionnaire. Safety included treatment-emergent adverse events (TEAEs).
    Results: The mean overall composite Z scores were -0.121 (pilo) and 0.118 (placebo). The LSMD (pilo minus placebo) was -0.224 (95% CI, -0.346, -0.103), with 3 of the 7 individual tasks being significantly better with the placebo. The questionnaire did not reveal significant differences between pilo and the placebo. There were no serious or severe TEAEs and no TEAE-related discontinuations. The most common ocular TEAEs were headache and visual impairment with pilo (both 27.9%), and dry eye (7.0%) with the placebo.
    Conclusion: The overall performance of night driving was inferior with pilo, compared with placebo. The study findings are consistent with the current class labelling and provide evidence to inform regulators and assist clinicians considering prescribing pilo to adults who seek treatment of presbyopia symptoms and drive at night.
    Language English
    Publishing date 2023-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1080/08164622.2023.2279189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Trust in provider and stigma during second-trimester abortion.

    Chesnokova, Arina E / Nagendra, Divyah / Dixit, Eshani / McAllister, Arden / Schachter, Allison / Schreiber, Courtney A / Roe, Andrea H / Sonalkar, Sarita

    Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

    2023  Volume 39, Page(s) 100932

    Abstract: ... significantly associated with the ILAS score. Higher trust in provider scores were (m 4.0, SD 0.49) and ...

    Abstract Objective: To determine whether trust in the provider and sociodemographics are associated with individual-level abortion stigma.
    Methods: We performed a cross sectional and exploratory study design using secondary analysis of a randomized trial that enrolled participants undergoing second trimester abortion. We collected baseline survey data from 70 trial participants to assess stigma (Individual Level of Abortion Stigma scale, ILAS; range 0-4), trust in provider (Trust in Physician scale; range 1-5), anxiety, depression, and sociodemographics. We performed multiple linear regression, for which ILAS score was the outcome of interest. Univariate associations were used to inform the regression model.
    Results: The mean abortion stigma score was at the low end of the ILAS at 1.21 (range 0.2-2.8, SD 0.66). Age, race, income, BMI, parity, gestational age at time of abortion, and reasons for ending the pregnancy were not significantly associated with the ILAS score. Higher trust in provider scores were (m 4.0, SD 0.49) and inversely related to the ILAS score, even after adjustment for confounders (β -0.02, CI -0.03 to -0.004, p = 0.013). Screening positive for anxiety or depression was associated with a higher ILAS score ((β 0.48, CI 0.10, 0.90, p = 0.015); (β = 0.27 CI -0.097, 0.643)), while cohabitation was associated with lower ILAS score (β -0.44, CI -0.82 to -0.57, p = 0.025).
    Conclusions: Trust in an abortion provider, anxiety, depression, and cohabitation are associated with abortion stigma among people seeking second trimester abortion care. Interventions that improve trust in a provider may be an area of focus for addressing abortion stigma. Future research should confirm these findings in larger populations and across diverse locations and demographics and to conduct qualitative research to understand what patients perceive as trust-promoting behaviors and words during abortion encounters.
    MeSH term(s) Female ; Humans ; Pregnancy ; Abortion, Induced ; Cross-Sectional Studies ; Income ; Pregnancy Trimester, Second ; Social Stigma ; Trust ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-11-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541869-5
    ISSN 1877-5764 ; 1877-5756
    ISSN (online) 1877-5764
    ISSN 1877-5756
    DOI 10.1016/j.srhc.2023.100932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vitiligo induced by dupilumab treatment: A case series.

    Ren, Hongyi / Akabane, Andressa L / Kelleher, Kiera / Halverstam, Caroline / Hicks, Maria / Schachter, Jordana R / Silverman, Robert / Chachkin, Samuel / Sherman-Bergman, Shany / Harris, John E / Kuohung, Victoria

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 37, Issue 11, Page(s) 2259–2261

    MeSH term(s) Humans ; Vitiligo/chemically induced ; Antibodies, Monoclonal, Humanized/adverse effects ; Hypopigmentation
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: ShlA toxin of Serratia induces P2Y2- and α5β1-dependent autophagy and bacterial clearance from host cells.

    Tuttobene, Marisel R / Schachter, Julieta / Álvarez, Cora L / Saffioti, Nicolás A / Leal Denis, M Florencia / Kessler, Horst / García Véscovi, Eleonora / Schwarzbaum, Pablo J

    The Journal of biological chemistry

    2023  Volume 299, Issue 9, Page(s) 105119

    Abstract: Serratia marcescens is an opportunistic human pathogen involved in antibiotic-resistant hospital acquired infections. Upon contact with the host epithelial cell and prior to internalization, Serratia induces an early autophagic response that is entirely ... ...

    Abstract Serratia marcescens is an opportunistic human pathogen involved in antibiotic-resistant hospital acquired infections. Upon contact with the host epithelial cell and prior to internalization, Serratia induces an early autophagic response that is entirely dependent on the ShlA toxin. Once Serratia invades the eukaryotic cell and multiples inside an intracellular vacuole, ShlA expression also promotes an exocytic event that allows bacterial egress from the host cell without compromising its integrity. Several toxins, including ShlA, were shown to induce ATP efflux from eukaryotic cells. Here, we demonstrate that ShlA triggered a nonlytic release of ATP from Chinese hamster ovary (CHO) cells. Enzymatic removal of accumulated extracellular ATP (eATP) or pharmacological blockage of the eATP-P2Y2 purinergic receptor inhibited the ShlA-promoted autophagic response in CHO cells. Despite the intrinsic ecto-ATPase activity of CHO cells, the effective concentration and kinetic profile of eATP was consistent with the established affinity of the P2Y2 receptor and the known kinetics of autophagy induction. Moreover, eATP removal or P2Y2 receptor inhibition also suppressed the ShlA-induced exocytic expulsion of the bacteria from the host cell. Blocking α5β1 integrin highly inhibited ShlA-dependent autophagy, a result consistent with α5β1 transactivation by the P2Y2 receptor. In sum, eATP operates as the key signaling molecule that allows the eukaryotic cell to detect the challenge imposed by the contact with the ShlA toxin. Stimulation of P2Y2-dependent pathways evokes the activation of a defensive response to counteract cell damage and promotes the nonlytic clearance of the pathogen from the infected cell.
    MeSH term(s) Animals ; Cricetinae ; Adenosine Triphosphate/metabolism ; Autophagy/drug effects ; CHO Cells ; Cricetulus ; Exocytosis/drug effects ; Host-Pathogen Interactions/drug effects ; Integrin alpha5beta1/antagonists & inhibitors ; Integrin alpha5beta1/metabolism ; Receptors, Purinergic P2Y2/metabolism ; Serratia/chemistry ; Serratia/drug effects ; Serratia/physiology ; Toxins, Biological/pharmacology ; Humans
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; CD39 antigen (EC 3.6.1.5) ; Integrin alpha5beta1 ; Receptors, Purinergic P2Y2 ; Toxins, Biological
    Language English
    Publishing date 2023-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genetic Modification of Tumor-Infiltrating Lymphocytes

    Weinstein-Marom, Hadas / Gross, Gideon / Levi, Michal / Brayer, Hadar / Schachter, Jacob / Itzhaki, Orit / Besser, Michal J

    Frontiers in immunology

    2021  Volume 11, Page(s) 584148

    Abstract: Adoptive T cell therapy (ACT) holds great promise for cancer treatment. One approach, which has regained wide interest in recent years, employs antitumor T cells isolated from tumor lesions ("tumor-infiltrating lymphocytes" or TIL). It is now appreciated ...

    Abstract Adoptive T cell therapy (ACT) holds great promise for cancer treatment. One approach, which has regained wide interest in recent years, employs antitumor T cells isolated from tumor lesions ("tumor-infiltrating lymphocytes" or TIL). It is now appreciated that a considerable proportion of anti-melanoma TIL recognize new HLA-binding peptides resulting from somatic mutations, which occurred during tumor progression. The clinical efficacy of TIL can potentially be improved
    MeSH term(s) Antigens, CD19/immunology ; Cell Line, Tumor ; Humans ; Immunotherapy, Adoptive/methods ; Interferon-gamma/immunology ; K562 Cells ; Lymphocyte Activation/immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Melanoma/immunology ; Receptors, Chimeric Antigen/immunology ; Retroviridae/immunology
    Chemical Substances Antigens, CD19 ; Receptors, Chimeric Antigen ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-01-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.584148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Blood pressure during myopathies; biometric and statistical data.

    ROGER, H / SCHACHTER, M

    Le Progres medical

    2010  Volume 73, Issue 5-6, Page(s) 87

    Title translation La tension artérielle au cours des myopathies; données biométrico-statistiques.
    MeSH term(s) Blood Pressure ; Blood Pressure Determination ; Disease ; Genetic Variation ; Humans ; Muscles ; Muscular Diseases
    Language French
    Publishing date 2010-08-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 209297-9
    ISSN 0033-0450
    ISSN 0033-0450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Statistical study on the role of age, sex and localization in facial neuralgia.

    ROGER, H / SCHACHTER, M

    Bulletins et memoires de la Societe medicale des hopitaux de Paris

    2010  Volume 63, Issue 5-6, Page(s) 83

    Title translation Etude statistique sur le rôle de l'âge, du sexe et de la localisation dans la névralgie faciale.
    MeSH term(s) Facial Neuralgia ; Humans ; Neuralgia
    Language French
    Publishing date 2010-02-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 215081-5
    ISSN 0366-1334 ; 0150-9853
    ISSN 0366-1334 ; 0150-9853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy for Richter Transformation: An International, Multicenter, Retrospective Study.

    Kittai, Adam S / Bond, David / Huang, Ying / Bhat, Seema A / Blyth, Emily / Byrd, John C / Chavez, Julio C / Davids, Matthew S / Dela Cruz, Jamie P / Dowling, Mark R / Duffy, Caitlyn / Ho, Carrie / Jacobson, Caron / Jaglowski, Samantha / Jain, Nitin / Lin, Kevin H / Miller, Cecelia / McCarthy, Christine / Omer, Zulfa /
    Parry, Erin / Rai, Manoj / Rogers, Kerry A / Saha, Aditi / Schachter, Levanto / Scott, Hamish / Senapati, Jayastu / Shadman, Mazyar / Siddiqi, Tanya / Stephens, Deborah M / Vanguru, Vinay / Wierda, William / Woyach, Jennifer A / Thompson, Philip A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  , Page(s) JCO2400033

    Abstract: Purpose: Outcomes for Richter transformation (RT) are poor with current therapies. The efficacy and safety of anti-CD19 chimeric antigen receptor T-cell therapy (CAR-T) for RT are not established.: Methods: We performed an international multicenter ... ...

    Abstract Purpose: Outcomes for Richter transformation (RT) are poor with current therapies. The efficacy and safety of anti-CD19 chimeric antigen receptor T-cell therapy (CAR-T) for RT are not established.
    Methods: We performed an international multicenter retrospective study of patients with RT who received CAR-T. Patient, disease, and treatment characteristics were summarized using descriptive statistics, and modeling analyses were used to determine association with progression-free survival (PFS) and overall survival (OS). PFS and OS were estimated from the date of CAR-T infusion.
    Results: Sixty-nine patients were identified. The median age at CAR-T infusion was 64 years (range, 27-80). Patients had a median of four (range, 1-15) previous lines of therapy for CLL and/or RT, including previous Bruton tyrosine kinase inhibitor and/or BCL2 inhibitor therapy in 58 (84%) patients. The CAR-T product administered was axicabtagene ciloleucel in 44 patients (64%), tisagenlecleucel in 17 patients (25%), lisocabtagene maraleucel in seven patients (10%), and brexucabtagene autoleucel in one patient (1%). Eleven patients (16%) and 25 patients (37%) experienced grade ≥3 cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, respectively. The overall response rate was 63%, with 46% attaining a complete response (CR). After a median follow-up of 24 months, the median PFS was 4.7 months (95% CI, 2.0 to 6.9); the 2-year PFS was 29% (95% CI, 18 to 41). The median OS was 8.5 months (95% CI, 5.1 to 25.4); the 2-year OS was 38% (95% CI, 26 to 50). The median duration of response was 27.6 months (95% CI, 14.5 to not reached) for patients achieving CR.
    Conclusion: CAR-T demonstrates clinical efficacy for patients with RT.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.24.00033
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  10. Article ; Online: Effects of bariatric surgery on male lower urinary tract symptoms and sexual function.

    Groutz, Asnat / Gordon, David / Schachter, Pinhas / Amir, Hadar / Shimonov, Mordechai

    Neurourology and urodynamics

    2017  Volume 36, Issue 3, Page(s) 636–639

    Abstract: ... 8 ± 5.3 and 31.3 ± 5.4 kg/m: Results: Preoperatively, 41 (77%) men (mean age 40 ± 12.9, mean BMI ... 42.2 ± 5 kg/m: Conclusion: Male storage phase LUTS and erectile function were significantly and ...

    Abstract Aim: To investigate the effect of bariatric surgery on male lower urinary tract symptoms (LUTS) and sexual function.
    Methods: Fifty-five consecutive obese men who underwent a laparoscopic sleeve gastrectomy were prospectively enrolled. Two validated questionnaires, the International Prostate Symptoms Score (IPSS) and the International Index of Erectile Function (IIEF) were used to assess LUTS and sexual function, before and 3 months after surgery. Fifty-three men (mean age 39 ± 12.5 years) completed all pre and postoperative questionnaires. Mean body mass index (BMI) before and 3 months after surgery was 42.8 ± 5.3 and 31.3 ± 5.4 kg/m
    Results: Preoperatively, 41 (77%) men (mean age 40 ± 12.9, mean BMI 42.2 ± 5 kg/m
    Conclusion: Male storage phase LUTS and erectile function were significantly and rapidly improved following bariatric surgery. Larger and long-term studies are required to investigate these apparently beneficial effects. Neurourol. Urodynam. 36:636-639, 2017. © 2016 Wiley Periodicals, Inc.
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.22980
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