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  1. Article: Exophthalmos and thiouracil therapy.

    BEIERWALTES, W H

    Archives of internal medicine (Chicago, Ill. : 1908)

    2008  Volume 81, Issue 3, Page(s) 364–368

    MeSH term(s) Animals ; Exophthalmos ; Thiouracil ; Thiourea/analogs & derivatives ; Thiourea/therapy ; Weevils
    Chemical Substances Thiouracil (59X161SCYL) ; Thiourea (GYV9AM2QAG)
    Language English
    Publishing date 2008-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211575-x
    ISSN 1538-3679 ; 0730-188X ; 0003-9926 ; 0888-2479
    ISSN (online) 1538-3679
    ISSN 0730-188X ; 0003-9926 ; 0888-2479
    DOI 10.1001/archinte.1948.00220210118011
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  2. Article: Complications following the administration of thiouracil.

    BEIERWALTES, W H / STURGIS, C C

    The American journal of the medical sciences

    2010  Volume 212, Issue 5, Page(s) 513–522

    MeSH term(s) Thiouracil/toxicity
    Chemical Substances Thiouracil (59X161SCYL)
    Language English
    Publishing date 2010-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1097/00000441-194611000-00001
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  3. Article: Remissions in thyrotoxicosis after discontinuing thiouracil.

    BEIERWALTES, W H / STURGIS, C C

    Journal of the American Medical Association

    2010  Volume 131, Page(s) 735–738

    MeSH term(s) Goiter ; Hypertrophy ; Neoplasms ; Thiouracil ; Thyroid Gland ; Thyrotoxicosis
    Chemical Substances Thiouracil (59X161SCYL)
    Language English
    Publishing date 2010-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0002-9955 ; 0254-9077 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0002-9955 ; 0254-9077 ; 0098-7484
    DOI 10.1001/jama.1946.02870260019004
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  4. Article: Pulmonary arteriovenous aneurysm with secondary polycythemia; report of the first case treated by lobectomy.

    BEIERWALTES, W H / BYRON, F X

    Journal of the American Medical Association

    2009  Volume 134, Issue 13, Page(s) 1069–1072

    MeSH term(s) Aneurysm ; Arteriovenous Fistula ; Arteriovenous Malformations ; Humans ; Polycythemia
    Language English
    Publishing date 2009-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0002-9955 ; 0254-9077 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0002-9955 ; 0254-9077 ; 0098-7484
    DOI 10.1001/jama.1947.02880300011004
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  5. Article: Macula densa stimulation of renin is reversed by selective inhibition of neuronal nitric oxide synthase.

    Beierwaltes, W H

    The American journal of physiology

    1997  Volume 272, Issue 5 Pt 2, Page(s) R1359–64

    Abstract: ... angiotensin (ANG) I.ml-1.h-1; P < 0.001; RSR = 3.0 +/- 0.9 vs. 13.1 +/- 4.1 ng ANG I.h-1.min-1; P < 0.025 ... restricted group (to 9.9 +/- 1.6 ng ANG I-ml-1.h-1; P < 0.001) and reduced RSR to normal (diet) levels (to 3 ... 9 +/- 1.4 ng ANG I.h-1.min-1; P < 0.05). Although selective NOS inhibition by 7-NI did not affect BP ...

    Abstract The neuronal isoform of nitric oxide synthase (nNOS) exists in the renal cortex predominantly in the macula densa, suggesting that nitric oxide (NO) derived from the macula densa plays a role in feedback regulation of renin in response to altered sodium metabolism. To determine if nNOS is a critical component in renin stimulation induced by dietary sodium restriction, rats received either normal sodium or a sodium-restricted diet (0.03%) for 7 days and subsequently were or were not treated with the selective inhibitor of nNOS 7-nitroindazole (7-NI) either acutely (50 mg/kg body wt ip) on the final day or chronically (20 mg/kg body wt ip 2 x/day) over the final 5 days. On the last day, rats were anesthetized with Inactin and fitted with arterial and renal venous catheters to collect blood and monitor blood pressure (BP) and a flow probe to measure renal blood flow (RBF). BP (105 vs. 108 mmHg) was similar in normal and low-sodium dietary groups, respectively, whereas RBF tended to be higher in the sodium-restricted group (6.5 +/- 0.3 vs. 7.6 +/- 0.4 ml.min-1.g kidney wt-1). Both renal venous renin (RR) and renin secretion rate (RSR) were elevated approximately fourfold by sodium restriction [RR = 5.8 +/- 0.8 vs. 20.5 +/- 2.7 ng angiotensin (ANG) I.ml-1.h-1; P < 0.001; RSR = 3.0 +/- 0.9 vs. 13.1 +/- 4.1 ng ANG I.h-1.min-1; P < 0.025]. Acute 7-NI did not change BP, RR, or RSR, but reduced RBF in sodium-restricted rats by 8% (P < 0.05). Chronic 7-NI had no effect on renin in rats on a normal diet, but reduced RR by one-half in the sodium-restricted group (to 9.9 +/- 1.6 ng ANG I-ml-1.h-1; P < 0.001) and reduced RSR to normal (diet) levels (to 3.9 +/- 1.4 ng ANG I.h-1.min-1; P < 0.05). Although selective NOS inhibition by 7-NI did not affect BP, RBF, or renin in control rats on a normal diet, chronic 7-NI reversed the stimulation of renin induced by dietary sodium restriction. These data suggest that nNOS-derived NO plays an important role in the macula densa during feedback stimulation of renin induced by dietary sodium restriction.
    MeSH term(s) Animals ; Diet, Sodium-Restricted ; Enzyme Inhibitors/pharmacology ; Indazoles/pharmacology ; Isoenzymes/antagonists & inhibitors ; Kidney/enzymology ; Kidney/physiology ; Kidney Cortex/metabolism ; Male ; Neurons/enzymology ; Nitric Oxide Synthase/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Renin/metabolism
    Chemical Substances Enzyme Inhibitors ; Indazoles ; Isoenzymes ; Nitric Oxide Synthase (EC 1.14.13.39) ; Renin (EC 3.4.23.15) ; 7-nitroindazole (UX0N37CMVH)
    Language English
    Publishing date 1997-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2948-8
    ISSN 0002-9513
    ISSN 0002-9513
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  6. Article: Selective neuronal nitric oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo.

    Beierwaltes, W H

    The American journal of physiology

    1995  Volume 269, Issue 1 Pt 2, Page(s) F134–9

    Abstract: ... Decreasing renal perfusion pressure doubled RSR from 11.8 +/- 3.3 to 22.9 +/- 5.7 ng ANG I.h-1.min-1 (P < 0 ... 1.8 to 20.5 +/- 6.2 ng ANG I.h-1.min-1 (P < 0.01). Renal hemodynamics and RSR were measured ...

    Abstract The macula densa is a regulatory site for renin. It contains exclusively the neuronal isoform of nitric oxide synthase (NOS), suggesting NO could stimulate renin secretion through the macula densa pathway. To test whether neuronal NOS mediates renin secretion, renin was stimulated by either the renal baroreceptor or the diuretic furosemide (acting through the macula densa pathway). Renin secretion rate (RSR) was measured in 12 Inactin-anesthetized rats at normal (104 +/- 3 mmHg) and reduced renal perfusion pressure (65 +/- 1 mmHg), before and after selective blockade of the neuronal NOS with 7-nitroindazole (7-NI, 50 mg/kg ip). 7-NI had no effect on basal blood pressure (102 +/- 2 mmHg) or renal blood flow (RBF). Decreasing renal perfusion pressure doubled RSR from 11.8 +/- 3.3 to 22.9 +/- 5.7 ng ANG I.h-1.min-1 (P < 0.01) (ANG I is angiotensin I). Similarly, in 7-NI-treated rats, reduced perfusion doubled RSR from 8.5 +/- 1.8 to 20.5 +/- 6.2 ng ANG I.h-1.min-1 (P < 0.01). Renal hemodynamics and RSR were measured in response to 5 mg/kg iv furosemide in 12 control rats and 11 rats treated with 7-NI. Blocking neuronal NOS did not alter blood pressure (102 +/- 2 mmHg), RBF (5.8 +/- 0.4 ml.min-1.g kidney wt-1), or renal vascular resistance (18.7 +/- 1.4 mmHg.ml-1.min.g kidney wt).(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Amino Acid Oxidoreductases/antagonists & inhibitors ; Animals ; Enzyme Inhibitors/pharmacology ; Furosemide/pharmacology ; Indazoles/pharmacology ; Kidney/innervation ; Male ; Neurons/enzymology ; Nitric Oxide Synthase ; Pressoreceptors/physiology ; Rats ; Rats, Sprague-Dawley ; Renin/antagonists & inhibitors ; Renin/secretion
    Chemical Substances Enzyme Inhibitors ; Indazoles ; Furosemide (7LXU5N7ZO5) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Amino Acid Oxidoreductases (EC 1.4.-) ; Renin (EC 3.4.23.15) ; 7-nitroindazole (UX0N37CMVH)
    Language English
    Publishing date 1995-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2948-8
    ISSN 0002-9513
    ISSN 0002-9513
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  7. Article: Nitric oxide participates in calcium-mediated regulation of renin release.

    Beierwaltes, W H

    Hypertension (Dallas, Tex. : 1979)

    1994  Volume 23, Issue 1 Suppl, Page(s) I40–4

    Abstract: ... 6 +/- 8.9 versus 66.7 +/- 5.8 [ng Ang I/h]/mg per 30 minutes incubation, P < .05). When calcium was ... eliminated from the incubation medium, basal renin release doubled (to 133.1 +/- 15.2 [ng Ang I/h]/mg per 30 ... on renin release (126.8 +/- 17.7 [ng Ang I/h]/mg per 30 minutes incubation). High-calcium medium (7.8 mmol ...

    Abstract The regulation of renin release is unusual in that intracellular calcium reportedly acts as an inhibitory second messenger. Increased calcium not only inhibits renin release but is a cofactor in nitric oxide synthesis. Also, nitric oxide can inhibit renin release. This study was done in vitro using rat renal cortical slices to determine whether calcium-mediated renin inhibition could be in part due to the concurrent production of nitric oxide. Renin concentration in the incubation medium was determined by radioimmunoassay for angiotensin I (Ang I) generation (in nanograms Ang I per hour per milligram per 30 minutes of incubation). In all studies, n = 6 to 17. In normal-calcium incubation medium (2.6 mmol/L), 10(-4) mol/L NG-monomethyl L-arginine, which blocks nitric oxide synthesis, caused an 18% increase in basal renin release (78.6 +/- 8.9 versus 66.7 +/- 5.8 [ng Ang I/h]/mg per 30 minutes incubation, P < .05). When calcium was eliminated from the incubation medium, basal renin release doubled (to 133.1 +/- 15.2 [ng Ang I/h]/mg per 30 minutes incubation, P < .001). Without calcium, inhibiting nitric oxide synthesis had no further effect on renin release (126.8 +/- 17.7 [ng Ang I/h]/mg per 30 minutes incubation). High-calcium medium (7.8 mmol/L) reduced basal renin release by half (30.8 +/- 4.8 [ng Ang I/h]/mg per 30 minutes incubation, P < .001), but inhibiting nitric oxide synthesis in high-calcium medium stimulated renin release by 50% (46.9 +/- 6.2 [ng Ang I/h]/mg per 30 minutes incubation, P < .005). Addition of the calmodulin inhibitor W-7 completely reversed the inhibition of renin by high-calcium medium.(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Angiotensin II/pharmacology ; Animals ; Arginine/analogs & derivatives ; Arginine/pharmacology ; Calcium/pharmacology ; Calmodulin/antagonists & inhibitors ; Egtazic Acid/pharmacology ; In Vitro Techniques ; Isoproterenol/pharmacology ; Kidney Cortex/drug effects ; Kidney Cortex/enzymology ; Kinetics ; Male ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/metabolism ; Rats ; Rats, Sprague-Dawley ; Renin/metabolism ; Sulfonamides/pharmacology ; omega-N-Methylarginine
    Chemical Substances Calmodulin ; Sulfonamides ; Angiotensin II (11128-99-7) ; omega-N-Methylarginine (27JT06E6GR) ; Nitric Oxide (31C4KY9ESH) ; Egtazic Acid (526U7A2651) ; W 7 (65595-90-6) ; Arginine (94ZLA3W45F) ; Renin (EC 3.4.23.15) ; Isoproterenol (L628TT009W) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1994-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/01.hyp.23.1_suppl.i40
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  8. Article: Hyperthyroidism treated with radioiodine; a seven-year experience.

    BEIERWALTES, W H / JOHNSON, P C

    A.M.A. archives of internal medicine

    2003  Volume 97, Issue 4, Page(s) 393–402

    MeSH term(s) Humans ; Hyperthyroidism/therapy ; Iodine ; Iodine Radioisotopes ; Radioisotopes
    Chemical Substances Iodine Radioisotopes ; Radioisotopes ; Iodine (9679TC07X4)
    Language English
    Publishing date 2003-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211575-x
    ISSN 1538-3679 ; 0888-2479 ; 0003-9926 ; 0730-188X
    ISSN (online) 1538-3679
    ISSN 0888-2479 ; 0003-9926 ; 0730-188X
    DOI 10.1001/archinte.1956.00250220013001
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  9. Article: Thyroxin and triiodothyronine in excessive dosage to euthyroid humans.

    BEIERWALTES, W H / RUFF, G E

    A.M.A. archives of internal medicine

    2003  Volume 101, Issue 3, Page(s) 569–576

    MeSH term(s) Basal Metabolism/drug effects ; Cholesterol/blood ; Iodides ; Iodine/blood ; Thyroxine/pharmacology ; Triiodothyronine/pharmacology
    Chemical Substances Iodides ; Triiodothyronine (06LU7C9H1V) ; Iodine (9679TC07X4) ; Cholesterol (97C5T2UQ7J) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2003-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 211575-x
    ISSN 1538-3679 ; 0888-2479 ; 0003-9926 ; 0730-188X
    ISSN (online) 1538-3679
    ISSN 0888-2479 ; 0003-9926 ; 0730-188X
    DOI 10.1001/archinte.1958.00260150057007
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  10. Article: Endocrine imaging in the management of goiter and thyroid nodules: Part I.

    Beierwaltes, W H

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    1991  Volume 32, Issue 7, Page(s) 1455–1461

    MeSH term(s) Goiter, Endemic/diagnostic imaging ; Humans ; Iodine Radioisotopes ; Radionuclide Imaging ; Thyroid Neoplasms/diagnostic imaging ; Thyroiditis, Autoimmune/diagnostic imaging
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 1991-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
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