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  1. Article: Recent radiation accidents. Chernobyl and Goiania: their impact and global implications. A presentation by Robert Peter Gale, MD, PhD.

    Gale, R P / Thompson, M A / Crawford, M A

    The Alabama journal of medical sciences

    1988  Volume 25, Issue 4, Page(s) 439–444

    MeSH term(s) Accidents ; Brazil ; Cesium Radioisotopes/adverse effects ; Disaster Planning ; Emergency Medical Services/organization & administration ; Global Health ; Humans ; Nuclear Reactors ; Nuclear Warfare ; Radiation Injuries/prevention & control ; Ukraine
    Chemical Substances Cesium Radioisotopes
    Language English
    Publishing date 1988-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 137493-x
    ISSN 0002-4252
    ISSN 0002-4252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 234: Show issues Location:
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  2. Article ; Online: Can Immune Therapy Cure Acute Myeloid Leukemia?

    Gale, Robert Peter

    Current treatment options in oncology

    2023  Volume 24, Issue 5, Page(s) 381–386

    Abstract: Opinion statement: Although safe and effective immune therapies have been developed in several cancers, this has not been so in acute myeloid leukaemia (AML). Studies of antibodies to CD33, CD123 and CLL-1 report with unconvincing efficacy and ... ...

    Abstract Opinion statement: Although safe and effective immune therapies have been developed in several cancers, this has not been so in acute myeloid leukaemia (AML). Studies of antibodies to CD33, CD123 and CLL-1 report with unconvincing efficacy and substantial adverse events. Lacking AML-specific target antigens, these approaches using non-specific antigen targets often cause unacceptable bone marrow toxicity and off-target adverse events. Studies of AML incidence in persons with immune deficiency indicate little if any immune surveillance against AML. In contrast, data studies of recipients of haematopoietic cell transplants support an effective allogeneic anti-AML effect associated with graft-versus-host disease (GvHD) and possibly a specific graft-versus-leukaemia (GvL) effect. A special problem in the immune therapy of AML is few neo-antigens compared with solid cancers because of a relatively low mutation frequency. Studies of CAR-T-, CAR-NK-adaptor CAR-T- and allogeneic NK-cells are progressing as are approaches using synthetic biology. Presently, there are no convincing data of efficacy of immune therapy in AML.
    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; Leukemia, Myeloid, Acute/etiology ; Leukemia, Myeloid, Acute/therapy ; Immunotherapy ; Immunotherapy, Adoptive
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-023-01066-3
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    Zs.A 5523: Show issues Location:
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  3. Article ; Online: Measurable residual disease in childhood B-cell acute lymphoblastic leukemia.

    Gale, Robert Peter

    Blood science (Baltimore, Md.)

    2022  Volume 4, Issue 4, Page(s) 209–210

    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article
    ISSN 2543-6368
    ISSN (online) 2543-6368
    DOI 10.1097/BS9.0000000000000112
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  4. Article ; Online: Chimeric antigen receptor-T-cell therapy: China leading the way.

    Gale, Robert Peter

    Blood science (Baltimore, Md.)

    2022  Volume 4, Issue 3, Page(s) 176

    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 2543-6368
    ISSN (online) 2543-6368
    DOI 10.1097/BS9.0000000000000118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Russian invasion of Ukraine: Implications for haematologists.

    Gale, Robert Peter

    British journal of haematology

    2022  Volume 197, Issue 6, Page(s) 791–792

    MeSH term(s) Armed Conflicts ; Hematology ; Humans ; Russia ; Ukraine
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18142
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  6. Article ; Online: Chronic lymphocytic leukemia in China.

    Gale, Robert Peter

    Chinese medical journal

    2022  Volume 135, Issue 8, Page(s) 883–886

    MeSH term(s) China/epidemiology ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology
    Language English
    Publishing date 2022-04-20
    Publishing country China
    Document type Editorial
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001811
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  7. Article ; Online: Reply to Amir Alexander Bahadori.

    Gale, Robert Peter / Hoffman, F Owen

    Health physics

    2023  Volume 124, Issue 6, Page(s) 491

    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2406-5
    ISSN 1538-5159 ; 0017-9078
    ISSN (online) 1538-5159
    ISSN 0017-9078
    DOI 10.1097/HP.0000000000001690
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    Zs.A 128: Show issues Location:
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    Zs.MO 253: Show issues

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  8. Article ; Online: Progress in Transplants for Acute Lymphoblastic Leukemia.

    Gale, Robert Peter

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 5, Page(s) 813–815

    Abstract: Hematopoietic cell transplants are used to treat some adults with acute lymphoblastic leukemia, especially those with high-risk features, such as those with BCR::ABL1. This strategy may be changing given the safety and efficacy of modern tyrosine kinase ... ...

    Abstract Hematopoietic cell transplants are used to treat some adults with acute lymphoblastic leukemia, especially those with high-risk features, such as those with BCR::ABL1. This strategy may be changing given the safety and efficacy of modern tyrosine kinase inhibitors. Although these transplants are often successful, leukemia relapse remains the dominant cause of transplant failure. There are several approaches to this problem discussed by the authors of a recent article in the journal. The good news is therapy of recurrent leukemia posttransplant seems increasingly successful and for diverse reasons, survival is increasing substantially. See related article by Bazarbachi et al., p. 1004.
    MeSH term(s) Adult ; Fusion Proteins, bcr-abl ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Recurrence
    Chemical Substances Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-21-3959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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  9. Article ; Online: Radiation and leukaemia: Which leukaemias and what doses?

    Gale, Robert Peter

    Blood reviews

    2022  Volume 58, Page(s) 101017

    Abstract: The cause(s) of most cases of leukaemia is unknown. Save for several rare inherited disorders the most convincingly-identified causes of leukaemia are exposures to ionizing radiations, to some chemicals and to some anti-cancer drugs. Data implicating ... ...

    Abstract The cause(s) of most cases of leukaemia is unknown. Save for several rare inherited disorders the most convincingly-identified causes of leukaemia are exposures to ionizing radiations, to some chemicals and to some anti-cancer drugs. Data implicating ionizing radiations as a cause of leukaemias come from several sources including persons exposed to the atomic bomb explosions in Japan, persons receiving radiation therapy for cancer and other disorders, persons occupationally exposed to radiation such as radiologists and nuclear facility workers, cigarette smokers, and others. Although ionizing radiations can be a cause of almost all types of leukaemias, some are especially sensitive to induction such as acute and chronic myeloid leukaemias (AML and CML) and acute lymphoblastic leukaemia (ALL). Whether chronic lymphocytic leukaemia can be caused by radiation exposure is controversial. The mechanism(s) by which ionizing radiations cause leukaemia differs for different leukaemia types. I discuss these issues and close with a hypothesis which might explain why haematopoietic stem cells are localized to the bone marrow.
    MeSH term(s) Humans ; Bone Marrow ; Leukemia, Myeloid, Acute ; Leukemia, Lymphocytic, Chronic, B-Cell ; Radiation, Ionizing ; Hematopoietic Stem Cells
    Language English
    Publishing date 2022-09-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2022.101017
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  10. Article ; Online: Emil J Freireich and Baruch Spinoza: birds of a feather?

    Gale, Robert Peter

    Bone marrow transplantation

    2021  Volume 56, Issue 7, Page(s) 1768–1769

    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01273-2
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