LIVIVO - Search results -

Search results

Result 1 - 10 of total 43

Search options

Article ; Online: PnPP-15, a Synthetic Peptide Derived from a Toxin from

Mariano, Xavier Maia / de Assis Ferreira, Luana Caroline / Almeida-Leite, Camila Megale / de Castro Junior, Célio José / de Lima, Maria Elena

Toxins

2023 Volume 15, Issue 9

Abstract: Diabetic neuropathic pain is one of the complications that affect a wide variety of the diabetic population and is often difficult to treat. Only a small number of patients experience pain relief, which usually comes with onerous side effects and low ... ...

Abstract	Diabetic neuropathic pain is one of the complications that affect a wide variety of the diabetic population and is often difficult to treat. Only a small number of patients experience pain relief, which usually comes with onerous side effects and low levels of satisfaction. The search for new analgesic drugs is necessary, given the limitations that current drugs present. Combining drugs to treat neuropathic pain has been attracting interest to improve their efficacy compared to single-drug monotherapies while also reducing dose sizes to minimize side effects. The aim of our study was to verify the antinociceptive effect of a synthetic peptide, PnPP-15, alone and combined with pregabalin, in male Swiss diabetic mice using the von Frey method. PnPP-15 is a synthetic peptide derived from PnPP19, a peptide representing a discontinuous epitope of the primary structure of the toxin PnTx2-6 from the venom of the spider
MeSH term(s)	Humans ; Rats ; Mice ; Male ; Animals ; Pregabalin/pharmacology ; Pregabalin/therapeutic use ; Rats, Wistar ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Spider Venoms/therapeutic use ; Spider Venoms/toxicity ; Spider Venoms/chemistry ; Peptides/pharmacology ; Peptides/therapeutic use ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Neuralgia/drug therapy
Chemical Substances	Pregabalin (55JG375S6M) ; Spider Venoms ; Peptides ; Analgesics
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins15090560
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: How psychosocial and economic impacts of COVID-19 pandemic can interfere on bruxism and temporomandibular disorders?

Almeida-Leite, Camila Megale / Stuginski-Barbosa, Juliana / Conti, Paulo César Rodrigues

Journal of applied oral science : revista FOB

2020 Volume 28, Page(s) e20200263

MeSH term(s)	Anxiety/physiopathology ; Betacoronavirus ; Bruxism/physiopathology ; Bruxism/psychology ; COVID-19 ; Coronavirus Infections/physiopathology ; Coronavirus Infections/psychology ; Humans ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/psychology ; Risk Factors ; SARS-CoV-2 ; Socioeconomic Factors ; Temporomandibular Joint Disorders/physiopathology ; Temporomandibular Joint Disorders/psychology
Keywords	covid19
Language	English
Publishing date	2020-05-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2152066-5
ISSN	1678-7765 ; 1678-7765
ISSN (online)	1678-7765
ISSN	1678-7765
DOI	10.1590/1678-7757-2020-0263
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: How psychosocial and economic impacts of COVID-19 pandemic can interfere on bruxism and temporomandibular disorders?

Almeida-Leite, Camila Megale / Stuginski-Barbosa, Juliana / Conti, Paulo César Rodrigues

J Appl Oral Sci

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #251535
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: King's Parkinson's Disease Pain Scale (KPPS): Cross-cultural adaptation to Brazilian Portuguese and content validity.

Coimbra, Márcia Regina / Almeida-Leite, Camila Megale / de Faria-Fortini, Iza / Christo, Paulo Pereira / Scalzo, Paula Luciana

Clinical neurology and neurosurgery

2021 Volume 208, Page(s) 106815

Abstract: Pain is one of the most common and troublesome non-motor symptoms of Parkinson's disease (PD). The King's Parkinson's Disease Pain Scale (KPPS) is the first scale of its kind to evaluate the burden and characterization of various phenotypes of pain in ... ...

Abstract	Pain is one of the most common and troublesome non-motor symptoms of Parkinson's disease (PD). The King's Parkinson's Disease Pain Scale (KPPS) is the first scale of its kind to evaluate the burden and characterization of various phenotypes of pain in individuals with PD. The purpose of this study was to adapt the KPPS to Brazilian culture and to assess its content validity using the Delphi method. The process of adapting the original instrument to the Brazilian context occurred in six stages according to international standards. Following the pilot tests with individuals with PD, the pre-final version of the KPPS-Brazil was developed and submitted to judges to assess content validity. Three evaluation rounds were conducted, in which several corrections and changes suggested by the judges were accepted. The Content Validity Index (CVI) was calculated to determine the judges' degree of agreement. The results demonstrated that the KPPS-Brazil showed a quite satisfactory level of semantic, idiomatic, cultural, and conceptual equivalence. The judges' opinion showed adequate content validity for all of the KPPS-Brazil items and the scale. The use of the KPPS-Brazil will enable an adequate assessment of pain in individuals with PD, contributing to clinical practice and research.
MeSH term(s)	Aged ; Brazil ; Cross-Cultural Comparison ; Female ; Humans ; Male ; Middle Aged ; Pain/diagnosis ; Pain/physiopathology ; Pain Measurement ; Reproducibility of Results
Language	English
Publishing date	2021-07-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2021.106815
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui I Zs.53: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia.

Romero, Jgaj / Costa, Grazielle Mara Ferreira / Rocha, Luiz Paulo Carvalho / Siqueira, Srdt / Moreira, Paula Rocha / Almeida-Leite, Camila Megale

Clinical neurology and neurosurgery

2021 Volume 208, Page(s) 106880

Abstract: Subjects: Trigeminal neuralgia is a neuropathic pain characterized by episodes of severe shock-like pain within the distribution of one or more divisions of the trigeminal nerve. Pain can be influenced by ethnicity, environment, gender, psychological ... ...

Abstract	Subjects: Trigeminal neuralgia is a neuropathic pain characterized by episodes of severe shock-like pain within the distribution of one or more divisions of the trigeminal nerve. Pain can be influenced by ethnicity, environment, gender, psychological traits, and genetics. Molecules Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 have been involved in mechanisms that underlie pain and neurological conditions. Objective: The aim of this case-control study was to investigate the occurrence of genetic polymorphisms in Nav1.6 sodium channel (SCN8A/rs303810), Brain-derived Neurotrophic Factor (BDNF/rs6265/Val66Met), Catechol-O-methyltransferase (COMT/rs4680/Val158Met), and Guanosine Triphosphate Cyclohydrolase 1 (GCH1/rs8007267) genes in trigeminal neuralgia patients. Methods: Ninety-six subjects were divided into two groups: 48 with trigeminal neuralgia diagnosis and 48 controls. Pain was evaluated by visual analog scale and genomic DNA was obtained from oral swabs and analyzed by real-time polymerase chain reaction. Results: No association was observed among SCN8A, BDNF, COMT or GCH1 polymorphisms and the presence of trigeminal neuralgia. Genotype distribution and allele frequencies did not correlate to pain severity. Conclusions: Although no association of evaluated polymorphisms and trigeminal neuralgia or pain was observed, our data contributes to the knowledge of genetic susceptibility to trigeminal neuralgia, which is very scarce. Further studies may focus on other polymorphisms and mutations, as well as on epigenetics and transcriptional regulation of these genes, in order to clarify or definitively exclude the role of Nav1.6, BDNF, COMT or GCH1 in trigeminal neuralgia susceptibility and pathophysiology.
MeSH term(s)	Aged ; Brain-Derived Neurotrophic Factor/genetics ; Case-Control Studies ; Catechol O-Methyltransferase/genetics ; Female ; GTP Cyclohydrolase/genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; NAV1.6 Voltage-Gated Sodium Channel/genetics ; Polymorphism, Single Nucleotide ; Trigeminal Neuralgia/genetics
Chemical Substances	Brain-Derived Neurotrophic Factor ; NAV1.6 Voltage-Gated Sodium Channel ; SCN8A protein, human ; Catechol O-Methyltransferase (EC 2.1.1.6) ; GTP Cyclohydrolase (EC 3.5.4.16)
Language	English
Publishing date	2021-08-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2021.106880
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui I Zs.53: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mice chronically fed a high-fat diet are resistant to malaria induced by Plasmodium berghei ANKA.

Oliveira-Lima, Onésia Cristina / Almeida, Natália Lourenço / Almeida-Leite, Camila Megale / Carvalho-Tavares, Juliana

Parasitology research

2019 Volume 118, Issue 10, Page(s) 2969–2977

Abstract: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) develop neurological symptoms and die 6--7-day post-inoculation in the absence of high parasitemia. The effects of chronic intake of a high-fat diet on this process are largely unknown. In this ... ...

Abstract	C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) develop neurological symptoms and die 6--7-day post-inoculation in the absence of high parasitemia. The effects of chronic intake of a high-fat diet on this process are largely unknown. In this study, we assessed the effect of a high-fat diet on the host-parasite response to malarial infection. Mice were fed ad libitum with either standard or a high-fat diet for 8 weeks and afterwards were infected with PbA. PbA-infected mice feeding a standard diet presented blood parasitemia, hepatic and cerebral histopathological alterations, and hepatic injury with increased hemozoin deposition in the liver. By contrast, these changes were not observed in the malaria high-fat diet group. In addition, mice fed a high-fat diet did not develop the expected neurological symptoms of cerebral malaria and were resistant to death. Taken together, our results indicate that chronic ingestion of high-fat diet prevents the development of experimental malaria induced by PbA injection, suggesting a relationship between a high-fat diet and malaria, which is an interesting subject for further study in humans.
MeSH term(s)	Animals ; Brain/pathology ; Diet, High-Fat ; Disease Models, Animal ; Hemeproteins/metabolism ; Liver/metabolism ; Liver/pathology ; Malaria/parasitology ; Malaria/pathology ; Malaria/prevention & control ; Mice, Inbred C57BL ; Parasitemia/parasitology ; Parasitemia/prevention & control ; Plasmodium berghei/growth & development ; Plasmodium berghei/physiology
Chemical Substances	Hemeproteins ; hemozoin (39404-00-7)
Language	English
Publishing date	2019-09-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-019-06427-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh II Zs.124: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: How psychosocial and economic impacts of COVID-19 pandemic can interfere on bruxism and temporomandibular disorders?

ALMEIDA-LEITE, Camila Megale / STUGINSKI-BARBOSA, Juliana / CONTI, Paulo César Rodrigues

Journal of Applied Oral Science v.28 2020

2020

Keywords	covid19
Language	English
Publishing date	2020-01-01
Publisher	Faculdade De Odontologia De Bauru - USP
Publishing country	br
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Association of sleep quality and psychological aspects with reports of bruxism and TMD in Brazilian dentists during the COVID-19 pandemic.

Peixoto, Karen Oliveira / Resende, Camila Maria Bastos Machado de / Almeida, Erika Oliveira de / Almeida-Leite, Camila Megale / Conti, Paulo César Rodrigues / Barbosa, Gustavo Augusto Seabra / Barbosa, Juliana Stuginski

Journal of applied oral science : revista FOB

2021 Volume 29, Page(s) e20201089

Abstract: Background: Dentists are exposed to contamination by SARS-CoV-2 due to dental interventions, leading to a state of alert and potential risk of negative impact in mental health and sleep quality, associated with Temporomandibular Disorder (TMD) and ... ...

Abstract	Background: Dentists are exposed to contamination by SARS-CoV-2 due to dental interventions, leading to a state of alert and potential risk of negative impact in mental health and sleep quality, associated with Temporomandibular Disorder (TMD) and bruxism. Objective: to evaluate the psychosocial status, sleep quality, symptoms of TMD, and bruxism in Brazilian dentists (DSs) during the COVID-19 pandemic. Methodology: The sample (n=641 DSs) was divided into three groups (quarantined DSs; DSs in outpatient care; and frontline professionals), which answered an electronic form containing the TMD Pain Screening Questionnaire (Diagnostic Criteria for Temporomandibular Disorders - DC/TMD), the Pittsburgh Sleep Quality Index (PSQI), the Depression, Anxiety and Stress Scale (DASS-21), and the sleep and awake bruxism questionnaire. ANOVA test and Mann Whitney post-test were used, with Bonferroni adjustment (p<0.016) and a 95% confidence level. Results: Probable TMD was found in 24.3% (n=156) of the participants, while possible sleep and awake bruxism were diagnosed in 58% (n=372) and 53.8% (n=345) of them, respectively. Among all variables evaluated, only symptoms of depression were significantly greater in the quarantined DSs group when compared to those who were working at the clinical care (p=0.002). Working DSs were significantly less likely (OR=0.630, p=0.001) to have depressive symptoms. Those who were not worried or less worried about the pandemic were less likely to experience stress (OR=0.360), anxiety (OR=0.255), and poor sleep quality (OR=0.256). Sleep had a strong positive and moderate correlation with psychological factors on frontline workers and DSs in outpatient care, respectively. Conclusion: The results suggest confinement may have a more negative impact on the life of DSs than the act of being actively working. The concern about Covid-19 and poor sleep quality was significantly prevalent and may negatively affect the quality of life of DSs. Thus, further research on the topic is needed.
MeSH term(s)	Brazil/epidemiology ; Bruxism ; COVID-19 ; Dentists ; Humans ; Pandemics ; Quality of Life ; SARS-CoV-2 ; Sleep ; Sleep Bruxism/epidemiology ; Temporomandibular Joint Disorders/epidemiology
Language	English
Publishing date	2021-07-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2152066-5
ISSN	1678-7765 ; 1678-7765
ISSN (online)	1678-7765
ISSN	1678-7765
DOI	10.1590/1678-7757-2020-1089
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Acupuncture for pain, mandibular function and oral health-related quality of life in patients with masticatory myofascial pain: A randomised controlled trial.

de Salles-Neto, Franklin Teixeira / de Paula, Janice Simpson / Romero, João Gabriel de Azevedo José / Almeida-Leite, Camila Megale

Journal of oral rehabilitation

2020 Volume 47, Issue 10, Page(s) 1193–1201

Abstract: Background: Masticatory myofascial pain is the most prevalent muscular temporomandibular disorders (TMD). It primarily affects masseter and temporal muscles. Several treatments, including acupuncture, have been recommended. However, systematic reviews ... ...

Abstract	Background: Masticatory myofascial pain is the most prevalent muscular temporomandibular disorders (TMD). It primarily affects masseter and temporal muscles. Several treatments, including acupuncture, have been recommended. However, systematic reviews have highlighted gaps in studies and absence of conclusive results. Objectives: We performed a randomised controlled clinical trial to evaluate the effectiveness of acupuncture in improving pain, mandibular function and oral health-related quality of life in women with masticatory myofascial pain. Methods: Thirty-six patients diagnosed with masticatory myofascial pain according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) were divided into the following two groups: acupuncture and control (non-penetrating acupuncture).Treatment was performed weekly for 5 weeks, and pain, mandibular function and oral health-related quality of life were evaluated one week before treatment, one week after treatment and one month after treatment. Non-parametric and parametric tests were used for comparisons between times and treatment groups (significance level of P ≤ .05). Results: The acupuncture group showed a significant reduction in pain (P ≤ .01), which was not observed in the control group. Pain intensity was reduced by 61% and 84% at 1 week and 1 month after treatment, respectively. Both groups showed significant improvements in mandibular function and oral health-related quality of life over time (P ≤ .01). Statistical analysis did not show a significant difference between the groups for any other evaluated outcome (P > .05). Conclusion: Although acupuncture was effective in pain reduction, non-specific factors may have influenced mandibular function and oral health-related quality of life improvements in both groups, and this needs to be further addressed.
MeSH term(s)	Acupuncture Therapy ; Female ; Humans ; Masticatory Muscles ; Pain ; Patients ; Quality of Life ; Treatment Outcome
Language	English
Publishing date	2020-07-31
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	187079-8
ISSN	1365-2842 ; 0305-182X
ISSN (online)	1365-2842
ISSN	0305-182X
DOI	10.1111/joor.13055
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 991: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Mice chronically fed a high-fat diet are resistant to malaria induced by Plasmodium berghei ANKA

Oliveira-Lima, Onésia Cristina / Almeida, Natália Lourenço / Almeida-Leite, Camila Megale / Carvalho-Tavares, Juliana

Parasitology research. 2019 Oct., v. 118, no. 10

2019

Abstract: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) develop neurological symptoms and die 6-–7-day post-inoculation in the absence of high parasitemia. The effects of chronic intake of a high-fat diet on this process are largely unknown. In this ... ...

Abstract	C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) develop neurological symptoms and die 6-–7-day post-inoculation in the absence of high parasitemia. The effects of chronic intake of a high-fat diet on this process are largely unknown. In this study, we assessed the effect of a high-fat diet on the host-parasite response to malarial infection. Mice were fed ad libitum with either standard or a high-fat diet for 8 weeks and afterwards were infected with PbA. PbA-infected mice feeding a standard diet presented blood parasitemia, hepatic and cerebral histopathological alterations, and hepatic injury with increased hemozoin deposition in the liver. By contrast, these changes were not observed in the malaria high-fat diet group. In addition, mice fed a high-fat diet did not develop the expected neurological symptoms of cerebral malaria and were resistant to death. Taken together, our results indicate that chronic ingestion of high-fat diet prevents the development of experimental malaria induced by PbA injection, suggesting a relationship between a high-fat diet and malaria, which is an interesting subject for further study in humans.
Keywords	Plasmodium berghei ; ad libitum feeding ; blood ; cerebral malaria ; death ; disease resistance ; high fat diet ; histopathology ; ingestion ; liver ; mice ; parasitemia
Language	English
Dates of publication	2019-10
Size	p. 2969-2977.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-019-06427-2
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 75/710: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED