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  1. Book ; Online: Chapter Il significato incarnato dell'architettura

    Johnson, Mark L.

    (Ricerche. Architettura, Pianificazione, Paesaggio, Design)

    2021  

    Series title Ricerche. Architettura, Pianificazione, Paesaggio, Design
    Keywords Meaning making ; ecological logic ; body schemas ; philosophy in the flesh ; enactive rela-tion ; image-schematic
    Language 0|i
    Size 1 electronic resource (18 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note Italian ; Open Access
    HBZ-ID HT021614748
    ISBN 9788855182867 ; 8855182862
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Robust Approaches to the Quantitative Analysis of Genome Formula Variation in Multipartite and Segmented Viruses.

    Johnson, Marcelle L / Zwart, Mark P

    Viruses

    2024  Volume 16, Issue 2

    Abstract: When viruses have segmented genomes, the set of frequencies describing the abundance of segments is called the genome formula. The genome formula is often unbalanced and highly variable for both segmented and multipartite viruses. A growing number of ... ...

    Abstract When viruses have segmented genomes, the set of frequencies describing the abundance of segments is called the genome formula. The genome formula is often unbalanced and highly variable for both segmented and multipartite viruses. A growing number of studies are quantifying the genome formula to measure its effects on infection and to consider its ecological and evolutionary implications. Different approaches have been reported for analyzing genome formula data, including qualitative description, applying standard statistical tests such as ANOVA, and customized analyses. However, these approaches have different shortcomings, and test assumptions are often unmet, potentially leading to erroneous conclusions. Here, we address these challenges, leading to a threefold contribution. First, we propose a simple metric for analyzing genome formula variation: the genome formula distance. We describe the properties of this metric and provide a framework for understanding metric values. Second, we explain how this metric can be applied for different purposes, including testing for genome-formula differences and comparing observations to a reference genome formula value. Third, we re-analyze published data to illustrate the applications and weigh the evidence for previous conclusions. Our re-analysis of published datasets confirms many previous results but also provides evidence that the genome formula can be carried over from the inoculum to the virus population in a host. The simple procedures we propose contribute to the robust and accessible analysis of genome-formula data.
    MeSH term(s) Viruses/genetics ; Genome, Viral ; Biological Evolution
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16020270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: A dialogue on opioid misuse and abuse: best practices for population health

    Fatodu, Hugh / Garofoli, Mark / Johnson, Gary L. / Lopes, Maria / Mccarberg, Bill / Prescott, Jeff / Ryan, Shawn / Weaver, Michael / Weiss, Roger D.

    multistakeholder roundtable

    (The American journal of managed care ; vol. 24, no. 12, sup. (July 2018))

    2018  

    Title variant Multistakeholder roundtable: a dialogue on opioid misuse and abuse: best practices for population health
    Author's details Hugh Fatodu, RPh, MBA; Mark Garofoli, PharmD, MBA, BCGP, CPE; Gary L. Johnson, MD, MS, MBA; Maria Lopes, MD, MS; Bill McCarberg, MD; Jeff Prescott, PharmD; Shawn Ryan, MD, MBA; Michael Weaver, MD; and Roger D. Weiss, MD
    Series title The American journal of managed care ; vol. 24, no. 12, sup. (July 2018)
    Collection
    Language English
    Size Seite S249-S264
    Publisher Managed Care & Healthcare Communications, LLC
    Publishing place Plainsboro, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT019840175
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 5353 -24,12,Suppl.- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Optical coherence tomography angular hyperreflectivity as an early sign in acute macular neuroretinopathy.

    Bommakanti, Nikhil / Young, Benjamin K / Johnson, Mark W / Miller, Jason M L

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2023  Volume 58, Issue 6, Page(s) e272–e274

    MeSH term(s) Humans ; Tomography, Optical Coherence/methods ; Retinal Diseases/diagnosis ; Scotoma/diagnosis ; White Dot Syndromes ; Acute Disease ; Macula Lutea ; Fluorescein Angiography
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2023.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: En face optical coherence tomography for diagnosis of unexplained snowflake scotoma.

    Jakpor, Otana A / Miller, Jason M L / Johnson, Mark W

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2022  Volume 58, Issue 2, Page(s) e88–e90

    MeSH term(s) Humans ; Scotoma/diagnosis ; Scotoma/etiology ; Tomography, Optical Coherence/methods ; Retinal Diseases/diagnosis ; Fundus Oculi ; Fluorescein Angiography/methods
    Language English
    Publishing date 2022-08-31
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2022.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Drug Approval for the Treatment of Geographic Atrophy: How We Got Here and Where We Need to Go.

    Csaky, Karl G / Miller, Jason M L / Martin, Daniel F / Johnson, Mark W

    American journal of ophthalmology

    2024  Volume 263, Page(s) 231–239

    Abstract: Purpose: To discuss the clinical trial results leading to the US Food and Drug Administration (FDA) approval of anti-complement therapies for geographic atrophy (GA), perspectives on functional data from the GA clinical trials, and how lessons from the ... ...

    Abstract Purpose: To discuss the clinical trial results leading to the US Food and Drug Administration (FDA) approval of anti-complement therapies for geographic atrophy (GA), perspectives on functional data from the GA clinical trials, and how lessons from the FDA approval may guide future directions for basic and clinical research in AMD.
    Design: Selected literature review with analysis and perspective METHODS: We performed a targeted review of publicly available data from the clinical trials of pegcetacoplan and avacincaptad for the treatment of GA, as well as scientific literature on the natural history of GA and the genetics and basic science of complement in AMD.
    Results: The approval of pegcetacoplan and avacincaptad was based on an anatomic endpoint of a reduction in the rate of GA expansion over time. However, functional data from 2 phase 3 clinical trials for each drug demonstrated no visual benefit to patients in the treatment groups. Review of the genetics of AMD and the basic science of the role for complement in AMD provides only modest support for targeting complement as treatment for GA expansion, and alternative molecular targets for GA treatment are therefore discussed. Reasons for the disconnect between anatomic and functional outcomes in the clinical trials of anti-complement therapies are discussed, providing insight to guide the configuration of future clinical studies for GA.
    Conclusion: Although avacincaptad and pegcetacoplan are our first FDA-approved treatments for GA, results from the clinical trials failed to show any functional improvement after 1 and 2 years, respectively, calling into question whether the drugs represent a "clinically relevant outcome." To improve the chances of more impactful therapies in the future, we provide basic-science rationale for pursuing non-complement targets; emphasize the importance of ongoing clinical research that more closely pins anatomic features of GA to functional outcomes; and provide suggestions for clinical endpoints for future clinical trials on GA.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2024.02.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sperm quality of artificially matured shortfinned eel is not affected by human chorionic gonadotropin dose and route of administration.

    Divers, Sean L / Johnson, Sheri L / Lokman, P Mark

    PeerJ

    2022  Volume 10, Page(s) e13742

    Abstract: Background: Acquisition of high quality sperm is key to the artificial propagation of eels in captivity, but fertility drugs are expensive and repeated handling is stressful to the fish. An interrupted treatment regime (an initial hormone injection to ... ...

    Abstract Background: Acquisition of high quality sperm is key to the artificial propagation of eels in captivity, but fertility drugs are expensive and repeated handling is stressful to the fish. An interrupted treatment regime (an initial hormone injection to stimulate spermatogenesis, followed several weeks later by weekly booster injections to induce sperm maturation) for acquisition of sperm in captive male eels has promise for high sperm quality on the one hand, and animal welfare benefits on the other. To further develop this approach for shortfinned eel,
    Methods: Male eels were artificially induced to mature with a single injection of 0, 250, 500 or 1,000 IU/fish of hCG, administered either intramuscularly (IM) or intraperitoneally (IP). Sperm maturation was induced with 150 IU hCG/fish from week 5 onwards and sperm collected for evaluation of quality by computer-assisted sperm analysis.
    Results: Control males did not mature and hence, sperm could not be retrieved and analysed, but all other treatments were effective in inducing testicular maturation. Milt volume tended to be higher for fish injected IM compared to those injected IP, whereas hCG dose had no effect. Conversely, the concentration of spermatozoa tended to be higher for several sperm collection time points in IP-injected than in IM-injected fish. Sperm quality, represented by percent motility, percent progressive motility and curvilinear velocity, was equal in fish given an initial dose of 250 IU hCG to those given higher initial doses of hCG.
    Conclusions: We recommend that an initial dose of 250 IU hCG/fish be administered to induce spermatogenesis in male
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.13742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Research Techniques Made Simple in 2020: Great Ideas Have Lasting Impact.

    Udey, Mark C / Johnson, Jodi L

    The Journal of investigative dermatology

    2020  Volume 140, Issue 10, Page(s) 1879

    MeSH term(s) Dermatology ; Journal Impact Factor ; Periodicals as Topic ; Research Design
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2020.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Radiology-pathology correlation: Giant tumefactive perivascular spaces.

    Benson, John C / Trejo-Lopez, Jorge A / Cormier, Jason L / Parney, Ian F / Mark, Ian T / Madhavan, Ajay A / Kotsenas, Amy L / Rydberg, Charlotte H / Luetmer, Patrick H / Eckel, Laurence J / Johnson, Derek R

    The neuroradiology journal

    2024  , Page(s) 19714009241247459

    Abstract: Dilated perivascular spaces (PVSs) are common and easily recognized on imaging. However, rarer giant tumefactive PVSs (GTPVSs) can have unusual multilocular cystic configurations, and are often confused for other pathologic entities, including neoplasms, ...

    Abstract Dilated perivascular spaces (PVSs) are common and easily recognized on imaging. However, rarer giant tumefactive PVSs (GTPVSs) can have unusual multilocular cystic configurations, and are often confused for other pathologic entities, including neoplasms, cystic infarctions, and neuroepithelial cysts. Because GTPVSs are scarcely encountered and even more infrequently operated upon, many radiologists are unaware of the imaging and pathologic features of these lesions. Here, a case of a resected GTPVS is presented, highlighting both its radiologic and histologic characteristics, and discussing how such lesions can be differentiated from their closest mimickers on imaging.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/19714009241247459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A 2-week medical student curriculum in an outpatient allergy clinic.

    Rosenberg, Daniel L / Moss, Mark H / Johnson, Sarah K / Osman, Fauzia

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Volume 129, Issue 4, Page(s) 525–527

    MeSH term(s) Curriculum ; Education, Medical, Undergraduate ; Humans ; Hypersensitivity/therapy ; Outpatients ; Students, Medical
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.03.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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