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Article ; Online: Yin and yang of cannabinoid CB1 receptor

Kathryn Miranda / William Becker / Philip B. Busbee / Nicholas Dopkins / Osama A. Abdulla / Yin Zhong / Jiajia Zhang / Mitzi Nagarkatti / Prakash S. Nagarkatti

iScience, Vol 25, Iss 9, Pp 104994- (2022)

CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity

2022

Abstract: Summary: While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested. The current study investigated the role of CB1 in immune vs non-immune cells ... ...

Abstract	Summary: While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been tested. The current study investigated the role of CB1 in immune vs non-immune cells during DIO by generating radiation-induced bone marrow chimeric mice that expressed functional CB1 in all cells except the immune cells or expressed CB1 only in immune cells. CB1−/− recipient hosts were resistant to DIO, indicating that CB1 in non-immune cells is necessary for induction of DIO. Interestingly, chimeras with CB1−/− in immune cells showed exacerbation in DIO combined with infiltration of bone-marrow-derived macrophages to the brain and visceral adipose tissue, elevated food intake, and increased glucose intolerance. These results demonstrate the opposing role of CB1 in hematopoietic versus non-hematopoietic cells during DIO and suggests that targeting immune CB1 receptors provides a new pathway to ameliorate obesity and related metabolic disorders.
Keywords	Immunology ; Hematology ; Human metabolism ; Science ; Q
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Twelve-component pharmacokinetic study of rat plasma after oral administration of You-Gui-Wan in osteoporosis rats with kidney-yin deficiency and kidney-yang deficiency.

Wang, Yahong / Zhang, Jianhua / Wang, Ling / Yin, Hua

Biomedical chromatography : BMC

2023 Volume 37, Issue 6, Page(s) e5619

Abstract: ... and yin-nourishing and kidney essence-replenishing herbs. Considering that the pharmacokinetics ... behaviors of You-Gui-Wan in osteoporosis rats with kidney-yin and kidney-yang deficiency were compared ...

Abstract	You-Gui-Wan is a widely used traditional Chinese medicine preparation for the treatment of osteoporosis with kidney-yang deficiency, and is composed of both yang-invigorating and kidney-tonifying herbs, and yin-nourishing and kidney essence-replenishing herbs. Considering that the pharmacokinetics of drugs might differ in different pathological conditions, it is necessary to study the pharmacokinetic characteristics of You-Gui-Wan under different osteoporotic conditions. In this study, the pharmacokinetic behaviors of You-Gui-Wan in osteoporosis rats with kidney-yin and kidney-yang deficiency were compared. The results showed that the absorption, metabolism, and disposition of You-Gui-Wan varied widely in animals with different types of osteoporosis. The active components belonging to the yang-invigorating herbs, such as aconitine, hypaconitine, mesaconitine, benzoylaconine, benzoylhypacoitine, benzoylmesaconine, chlorogenic acid and pinoresinol diglucoside, had a higher uptake and slower elimination in osteoporosis rats with kidney-yang deficiency, which corresponds to the opinion that You-Gui-Wan is used to treat kidney-yang deficiency syndrome, and indicates the scientific nature of Bian-Zheng-Lun-Zhi.
MeSH term(s)	Rats ; Animals ; Yang Deficiency/drug therapy ; Yang Deficiency/metabolism ; Yang Deficiency/pathology ; Yin Deficiency/drug therapy ; Yin Deficiency/metabolism ; Yin Deficiency/pathology ; Drugs, Chinese Herbal/metabolism ; Medicine, Chinese Traditional ; Kidney/metabolism ; Administration, Oral ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Osteoporosis/pathology
Chemical Substances	you-gui-wan ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5619
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Article ; Online: Understanding Yin-Yang Philosophic Concept Behind Tai Chi Practice.

Liu, Hao Howe / Nichols, Charles / Zhang, Hong

Holistic nursing practice

2023 Volume 37, Issue 5, Page(s) E75–E82

Abstract: Yin-yang theorizes that everything in the world is interoppositionally unified with 2 dynamic ... opposites (yin and yang), interrooted, interchangeable, and interconvertible. Tai chi (TC) movements and ... postures are essentially yin-yang concept-based. However, there is still a lack of understanding ...

Abstract	Yin-yang theorizes that everything in the world is interoppositionally unified with 2 dynamic opposites (yin and yang), interrooted, interchangeable, and interconvertible. Tai chi (TC) movements and postures are essentially yin-yang concept-based. However, there is still a lack of understanding of yin-yang concepts and applications among people practicing TC. So, in this concept review, we aimed to provide basic understanding of the yin-yang concept and characteristics behind TC practice. Terms derived from the yin-yang concept in TC practice may include blood/qi (energy), stability/mobility, closing/opening moves, expiration/inspiration, solid/empty stance, and defensive/offensive hand movements and postures. These yin-yang attributes are interrestricted and dependent on maintaining a dynamic mind-body harmony. With the yin-yang application, TC can be considered a self-controlled balance perturbation exercise to challenge the stability-mobility (yin-yang) to a new level of harmony. As a health promotion holistic intervention, TC can facilitate the flow in blood/qi pathways or meridians to improve medical conditions. As an integrative mind-body exercise, TC can activate different body parts and brain regions to participate in and coordinate the combined physical and mental activities.
MeSH term(s)	Humans ; Yin-Yang ; Tai Ji ; Meridians ; Exercise Therapy ; Health Promotion
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	639032-8
ISSN	1550-5138 ; 0887-9311
ISSN (online)	1550-5138
ISSN	0887-9311
DOI	10.1097/HNP.0000000000000598
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Article: [Clinical efficacy of Jujing Decoction on teratospermia: An investigation based on the theory of "yin forming"].

Fan, Qian / Xue, Jian-Guo / Zhang, Xing / Wang, Qing / Sun, Zhi-Xing / Huang, Jian / Chen, Yun

Zhonghua nan ke xue = National journal of andrology

2023 Volume 28, Issue 9, Page(s) 817–821

Abstract: Objective: To study the clinical efficacy of Jujing Decoction (JJD) based on the theory of "yin ... the ultrastructure of sperm mitochondria, and analyzed the data obtained based on the "yin forming" theory ...

Abstract	Objective: To study the clinical efficacy of Jujing Decoction (JJD) based on the theory of "yin forming" in the treatment of teratospermia and its effects on semen parameters, sperm morphology, sperm DNA fragmentation index (DFI) and the ultrastructure of sperm mitochondria. Methods: We randomly divided 40 patients with teratospermia into a blank control group (n = 16) and a JJD group (n = 24), the former treated by reproductive health guidance and the latter with JJD, respectively. After 12 weeks of intervention, we observed the clinical effects and changes in the semen volume, sperm concentration, percentages of progressively motile sperm (PMS) and morphologically abnormal sperm (MAS), sperm DFI and the ultrastructure of sperm mitochondria, and analyzed the data obtained based on the "yin forming" theory. Results: The total effectiveness rate was significantly higher in the JJD than in the blank control group (87.50% vs 6.66%, P < 0.05). Compared with the baseline, the patients after treated with JJD showed significant improvement in semen volume (［3.27 ± 1.14］ vs ［4.16 ± 1.84］ ml, P < 0.05), sperm concentration (［38.85 ± 15.88］ vs ［39.35 ± 14.58］ × 10⁶/ml, P < 0.05), PMS (［37.47 ± 2.74］% vs ［42.55 ± 7.07］%, P < 0.05), MAS (［97.43 ± 1.01］% vs ［95.52 ± 0.85］%, P < 0.05), acrosomal integrity (［45.27 ± 5.14］% vs ［51.88 ± 4.48］%, P < 0.05), and DFI (［25.53 ± 6.89］% vs ［17.68 ± 2.38］%, P < 0.05), while the blank controls exhibited only slightly increased semen volume (［3.67 ± 1.77］ vs ［4.40 ± 1.78］ ml) and sperm concentration (［37.24 ± 9.31］ vs ［38.32 ± 10.54］ ×10⁶/ml), but no significant improvement in the other parameters (P> 0.05). Before treatment, folded and discontinuous sperm acrosomal membrane was observed under the transmission electron microscope in the sperm mitochondria of the two groups of patients, the mitochondria stacked and differently sized in the neck and disorderly arranged and some obviously swollen around the tail microtubule. After treated with JJD, the ultrastructure of sperm mitochondria was significantly improved, with relative continuity and integrity of the acrosomal membrane and well-arranged and relatively intact and uniform-sized mitochondria in the neck and tail. Conclusion: Jujing Decoction can increase the semen volume, sperm concentration and percentage of progressively motile sperm, reduce the percentage of morphologically abnormal sperm and sperm DFI, improve sperm acrosomal integrity, maintain the stability of sperm ultrastructure and protect the structure of sperm mitochondria.
MeSH term(s)	Humans ; Male ; DNA Fragmentation ; Infertility, Male/drug therapy ; Infertility, Male/genetics ; Semen/chemistry ; Semen Analysis ; Sperm Count ; Sperm Motility ; Spermatozoa ; Teratozoospermia/drug therapy ; Treatment Outcome
Language	Chinese
Publishing date	2023-10-14
Publishing country	China
Document type	English Abstract ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Zs.A 6577: Show issues

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Article: Yin-Cold

Zhu, Yan-Juan / Zhang, Hai-Bo / Liu, Li-Rong / Liu, Yi-Hong / Zhang, Fu-Li / Bai, Jian-Ping / Li, Yong / Qu, Yan-Chun / Qu, Xin / Chen, Xian / Li, Yan / Luo, Shu-Yi / Ou, Ai-Hua

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 7063859

Abstract: Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the ... ...

Abstract	Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM
Language	English
Publishing date	2017-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/7063859
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Article ; Online: Comment on: "Triceps skinfold-albumin index significantly predicts the prognosis of cancer cachexia: A multicentre cohort study" by Yin et al. - the authors reply.

Yin, Liangyu / Cui, Jiuwei / Lin, Xin / Li, Long / Li, Na / Fan, Yang / Zhang, Ling / Liu, Jie / Chong, Feifei / Lu, Zongliang / Wang, Chang / Liang, Tingting / Liu, Xiangliang / Deng, Li / Yang, Mei / Yu, Jiami / Wang, Xiaojie / Cong, Minghua / Li, Zengning /

Weng, Min / Yao, Qinghua / Jia, Pingping / Guo, Zengqing / Li, Wei / Song, Chunhua / Shi, Hanping / Xu, Hongxia

Journal of cachexia, sarcopenia and muscle

2023 Volume 14, Issue 6, Page(s) 2993–2994

MeSH term(s)	Humans ; Albumins ; Cachexia/diagnosis ; Cachexia/etiology ; Cohort Studies ; Neoplasms/complications ; Prognosis
Chemical Substances	Albumins
Language	English
Publishing date	2023-09-21
Publishing country	Germany
Document type	Multicenter Study ; Letter
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13338
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Article: The Protective Effect of Sheng Mai Yin on Diabetic Cardiomyopathy via NLRP3/Caspase-1 Pathway.

Li, Jing-Ya / Zhao, Chun-Chun / Peng, Jian-Fei / Zhang, Meng / Wang, Liang / Yin, Gang / Zhou, Peng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 1234434

Abstract: Sheng Mai Yin (SMY) has therapeutic effects on myocardial infarction (MI), heart failure (HF ...

Abstract	Sheng Mai Yin (SMY) has therapeutic effects on myocardial infarction (MI), heart failure (HF), diabetic cardiomyopathy (DCM), and myocarditis. To study whether SMY can relieve pyroptosis and play a protective role in diabetic cardiomyopathy, a molecular docking technique was used to predict the possible mechanism of SMY against DCM. Then, a DCM rat model was induced by intraperitoneal injection of streptozotocin (STZ), divided into 5 groups: the DM group (model), SMY-L group (2.7 mL/kg SMY), SMY-M group (5.4 mL/kg SMY), SMY-H group (10.8 mL/kg SMY), and Met group (120 mg/kg metformin). Rats in the CTL group (control) and DM group were given normal saline. After 8 weeks, the levels of blood glucose, lipids, and myocardial enzymes were detected according to the kit instructions. Cardiac function was detected by echocardiography. HE and Masson were used to observing the pathological changes, collagen deposition, and collagen volume fraction (CVF). The apoptosis rate of cardiomyocytes was determined by Tunel. The IL-1
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/1234434
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Article ; Online: Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis.

Zhang, Peiguang / Cao, Jieqiong / Liang, Xujing / Su, Zijian / Zhang, Bihui / Wang, Zhenyu / Xie, Junye / Chen, Gengrui / Chen, Xue / Zhang, Jinting / Feng, Yanxian / Xu, Qin / Song, Jianping / Hong, An / Chen, Xiaojia / Zhang, Yibo

Acta biochimica et biophysica Sinica

2024 Volume 56, Issue 4, Page(s) 621–633

Abstract: ... therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin resistance. Given that NAFLD is another disease involved in insulin resistance, we hypothesize that LMY might be a promising formula for NAFLD therapy. Herein, we verify that the LMY formula effectively reduces hepatic steatosis in diet-induced zebrafish and NAFLD model mice in a time- and dose-dependent manner. Mechanistically, LMY suppresses Yap1-mediated Foxm1 activation, which is crucial for the occurrence and development of NAFLD. Consequently, lipogenesis is ameliorated by LMY administration. In summary, the LMY formula alleviates diet-induced NAFLD in zebrafish and mice by inhibiting Yap1/Foxm1 signaling-mediated NAFLD pathology.
MeSH term(s)	Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Lipogenesis ; Zebrafish ; Insulin Resistance ; Diabetes Mellitus, Type 2/metabolism ; Liver/metabolism ; Diet, High-Fat ; Transcription Factors/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Lipids ; Mice, Inbred C57BL ; Forkhead Box Protein M1/metabolism
Chemical Substances	Transcription Factors ; Adaptor Proteins, Signal Transducing ; Lipids ; FOXM1 protein, human ; Forkhead Box Protein M1
Language	English
Publishing date	2024-03-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2024025
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Article: Nourishing Yin traditional Chinese medicine: potential role in the prevention and treatment of type 2 diabetes.

Dai, Yu-Ping / Duan, Yan / Lu, Yu-Ting / Ni, Xiao-Ting / Zhang, Yun-Kun / Li, Juan / Li, Shun-Xiang

American journal of translational research

2024 Volume 16, Issue 1, Page(s) 234–254

Abstract: ... Pharmacological studies have shown that nourishing yin traditional Chinese medicine (NYTCM) can play a positive ...

Abstract	Type 2 diabetes mellitus (T2DM), a common and frequently occurring disease in contemporary society, has become a global health threat. However, current mainstream methods of prevention and treatment, mainly including oral hypoglycemic drugs and insulin injections, do not fundamentally block the progression of T2DM. Therefore, it is imperative to find new ways to prevent and treat diabetes. Traditional Chinese medicine is characterized by multiple components, pathways, and targets with mild and long-lasting effects. Pharmacological studies have shown that nourishing yin traditional Chinese medicine (NYTCM) can play a positive role in the treatment of T2DM by regulating pathways such as the phosphatidylinositol 3-kinase/serine-threonine kinase, mitogen-activated protein kinase, nuclear factor-kappa B, and other pathways to stimulate insulin secretion, protect and repair pancreatic β cells, alleviate insulin resistance, ameliorate disordered glucose and lipid metabolism, mitigate oxidative stress, inhibit inflammatory responses, and regulate the intestinal flora. The pharmacologic activity, mechanisms, safety, and toxicity of NYTCM in the treatment of T2DM are also reviewed in this manuscript.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Effects of supplementary Da Dingfeng Zhu therapy on patients with Parkinson's disease of liver-kidney yin deficiency pattern.

Liu, Meili / Jia, Zhiwei / Yao, Tianyu / Zhang, Guoxian / Wang, Xuejing

Parkinsonism & related disorders

2024 Volume 123, Page(s) 106560

Abstract: Background: This study aimed to verify whether the combined use of Da Dingfengzhu and Western medicine in treating Parkinson's disease (PD) can lead to therapeutic efficacy and symptom alleviation, thereby achieving a complementary and synergistic ... ...

Abstract	Background: This study aimed to verify whether the combined use of Da Dingfengzhu and Western medicine in treating Parkinson's disease (PD) can lead to therapeutic efficacy and symptom alleviation, thereby achieving a complementary and synergistic effect. Methods: In this study, 158 patients were initially enrolled, with 116 eligible patients randomly divided into a control and an observation group. The control group received levodopa/benserazide and pramipexole, while the observation group received Da Dingfengzhu combined with levodopa/benserazide and pramipexole for 12 weeks. Baseline patient characteristics, adverse reactions, and blood samples were collected at baseline and 12 weeks post-treatment. The Unified Parkinson's Disease Rating Scale (UPDRS) was used to assess symptom severity at baseline, four weeks into treatment, and 12 weeks post-treatment. Results: Adverse reactions during treatment were similar in both groups, suggesting that the combined therapy in the observation group did not increase adverse effects. Both groups showed improvements in UPDRS scores, with the observation group displaying more significant symptom alleviation at 4 and 12 weeks. Moreover, the observation group exhibited more pronounced increases in serum neurotrophic factor-3 and dopamine levels and greater reductions in oxidative stress and inflammatory response markers. Conclusion: In conclusion, the combination of Da Dingfengzhu with levodopa/benserazide and pramipexole for treating PD shows significant clinical potential and is worthy of broader application.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2024.106560
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