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  1. Article: Drivers, passengers, agents - new directions in breast cancer research. Interview with Dr. Giuseppe Curigliano

    Maibach, R. / Curigliano, Giuseppe

    Schweizer Krebs-Bulletin

    2011  Volume 31, Issue 3, Page(s) 199

    Language English ; French ; German
    Document type Article
    ZDB-ID 1340924-4
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4528: Show issues Location:
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  2. Book ; Online ; E-Book: Artificial Intelligence for Medicine

    David, Shai Ben / Curigliano, Giuseppe / Koff, David / Jereczek-Fossa, Barbara Alicja / Torre, Davide La / Pravettoni, Gabriella

    An Applied Reference for Methods and Applications

    (Advanced Studies in Complex Systems Series)

    2024  

    Series title Advanced Studies in Complex Systems Series
    Subject code 610.28563
    Language English
    Size 1 online resource (296 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-13672-6 ; 0-443-13671-8 ; 978-0-443-13672-6 ; 978-0-443-13671-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Unveiling the Untapped Potential of Antibody Drug Conjugates in Precision Oncology.

    Trapani, Dario / Katrini, Jalissa / Curigliano, Giuseppe

    JAMA oncology

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2024.0008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CDK4/6 inhibitors for HR

    Curigliano, Giuseppe

    Nature reviews. Clinical oncology

    2020  Volume 18, Issue 2, Page(s) 67–68

    MeSH term(s) Aminopyridines/therapeutic use ; Benzimidazoles ; Breast Neoplasms/drug therapy ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; Humans
    Chemical Substances Aminopyridines ; Benzimidazoles ; abemaciclib (60UAB198HK) ; CDK4 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22)
    Language English
    Publishing date 2020-11-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-020-00453-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6029: Show issues Location:
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    Zs.MG 103: Show issues

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  5. Article ; Online: Cancer Patients and Risk of Mortality for COVID-19.

    Curigliano, Giuseppe

    Cancer cell

    2020  Volume 38, Issue 2, Page(s) 161–163

    Abstract: Two recent Lancet and Lancet Oncology papers report that cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have higher mortality rates. Common independent factors associated with increased risk of death were ... ...

    Abstract Two recent Lancet and Lancet Oncology papers report that cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have higher mortality rates. Common independent factors associated with increased risk of death were older age, history of smoking status, number of comorbidities, more advanced performance status, and active cancer.
    MeSH term(s) Age Factors ; Aged ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Infection Control/standards ; Infectious Disease Transmission, Professional-to-Patient/prevention & control ; Neoplasms/immunology ; Neoplasms/mortality ; Neoplasms/therapy ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Risk Assessment ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2020.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5650: Show issues Location:
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    Zs.MG 104: Show issues

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  6. Article ; Online: How to Guarantee the Best of Care to Patients with Cancer During the COVID-19 Epidemic: The Italian Experience.

    Curigliano, Giuseppe

    The oncologist

    2020  Volume 25, Issue 6, Page(s) 463–467

    Abstract: Italy and the rest of the world are experiencing an outbreak of a novel beta-coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this context, in Italy, we reorganized the National Health System and prioritized the ... ...

    Abstract Italy and the rest of the world are experiencing an outbreak of a novel beta-coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this context, in Italy, we reorganized the National Health System and prioritized the clinical cancer care scenario, balancing risk of SARS-CoV-2 transmission versus the magnitude of clinical benefit deriving from a specific therapeutic approach. As initial actions, we recommended that routine screening be suspended and that patients with early and advanced cancer be treated as outpatients as much as possible and at the nearest medical center. Patients who need to be hospitalized for cancer treatment were protected from potential SARS-CoV-2 infection by creating a dedicated diagnostic and therapeutic internal pathway for cancer treatment. We implemented reorganization of the hospital networks, based on a hub-and-spoke design. Stronger personal protection was made available for patients with cancer. Because of the extreme burden created by COVID-19, antitumor treatment was initiated only after considering patient performance status, comorbidities, biology of disease, and the likely impact of treatment on outcome. Treatment strategies were discussed in the context of a multidisciplinary tumor board. Treatment decision making balanced risk and benefits of treatment in the context of the specific pandemic level, on a case-by-case basis.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Clinical Decision-Making ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Hospitalization ; Humans ; Infection Control/organization & administration ; Infection Control/standards ; Infection Control/trends ; Italy/epidemiology ; Mass Screening/organization & administration ; Mass Screening/standards ; Mass Screening/trends ; Medical Oncology/organization & administration ; Medical Oncology/standards ; Medical Oncology/trends ; Neoplasms/therapy ; Pandemics ; Patient Care ; Patient Care Team/organization & administration ; Patient Care Team/standards ; Patient Care Team/trends ; Patient Selection ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2020-0267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4845: Show issues Location:
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    Zs.MO 494: Show issues

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  7. Article: Mechanisms of Endocrine Resistance in Hormone Receptor-Positive Breast Cancer.

    Marra, Antonio / Trapani, Dario / Ferraro, Emanuela / Curigliano, Giuseppe

    Cancer treatment and research

    2024  Volume 188, Page(s) 219–235

    Abstract: Hormone receptor-positive (HR+) breast cancer (BC) accounts for approximately 70% of all breast invasive tumors. Endocrine therapy (ET) represents the standard treatment for HR + BC. Most patients, however, eventually develop resistance to ET, which ... ...

    Abstract Hormone receptor-positive (HR+) breast cancer (BC) accounts for approximately 70% of all breast invasive tumors. Endocrine therapy (ET) represents the standard treatment for HR + BC. Most patients, however, eventually develop resistance to ET, which limits their effectiveness and poses a major challenge for the management of HR + BC. Several mechanisms that contribute to ET resistance have been described. One of the most common mechanisms is the upregulation of alternative signaling pathways that can bypass estrogen dependency, such as activation of the PI3K/Akt/mTOR as well as mitogen-activated protein kinase (MAPK) and the insulin-like growth factor 1 receptor (IGF-1R) pathways. Another common mechanism of endocrine resistance is the acquisition of activating mutations of ESR1, which encodes for the estrogen receptor, that lead to structural changes of the receptor, prevent the binding to anti-estrogen drugs and result in constitutive activation of the receptor, even in the absence of estrogens. Epigenetic changes, such as DNA methylation and histone modifications, can also contribute to ET resistance by altering the expression of genes that are involved in estrogen signaling. Understanding the mechanisms of resistance to ET is crucial for the development of new therapies that can overcome resistance and improve outcomes for patients with HR + BC.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Phosphatidylinositol 3-Kinases ; Estrogens ; Receptors, Estrogen ; Signal Transduction
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Estrogens ; Receptors, Estrogen
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-031-33602-7_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Next-Generation Sequencing for Advanced Breast Cancer: What the Way to Go?

    Trapani, Dario / Crimini, Edoardo / Sandoval, José / Curigliano, Giuseppe

    Cancer treatment and research

    2024  Volume 188, Page(s) 343–351

    Abstract: The rapid implementation of precision medicine tools in diagnosing and treating breast cancer (BC) has widened the potential therapeutic options for patients. The applications of gene sequencing, including next-generation gene sequencing (NGS), have led ... ...

    Abstract The rapid implementation of precision medicine tools in diagnosing and treating breast cancer (BC) has widened the potential therapeutic options for patients. The applications of gene sequencing, including next-generation gene sequencing (NGS), have led to numerous questions on how to validate, implement, interpret, prioritize and operationalize precision medicine tools to deliver meaningful and impactful interventions. Limited benefit has been portended with earlier experiences of NGS-driven treatment, in BC. However, the development and use of frameworks of clinical actionability of genomic alterations, for example, detected with NGS, has resulted in better patient selection, and potentially higher therapeutic value. The European Society for Medical Oncology Scale for Clinical Actionability of molecular Targets (ESCAT) is a framework that includes five tiers of clinical actionability, with tier 1 reserved for approved drugs with demonstrated benefits for targetable genomic alterations. The re-analysis of clinical studies by grouping the genomic alterations and matched drugs with ESCAT, in high vs lower tiers has demonstrated a significant benefit portended by high tiers alterations, with the availability of efficacious treatments. As a result, frameworks for actionability, like ESCAT, should be fundamental in developing and implementing NGS-driven, and broadly, precision medicine research and treatments.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; High-Throughput Nucleotide Sequencing ; Precision Medicine ; Genomics ; Medical Oncology
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-031-33602-7_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comment on "Reply: Comment on BIA-ALCL: Comparing the Risk Profiles of Smooth and Textured Breast Implants".

    Longo, Benedetto / Curigliano, Giuseppe / Cervelli, Valerio

    Aesthetic plastic surgery

    2023  

    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Letter
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-023-03556-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: De-escalation in low-risk, HER2-positive breast cancer.

    Geuna, Elena / Curigliano, Giuseppe / Montemurro, Filippo

    The Lancet. Oncology

    2023  Volume 24, Issue 3, Page(s) 200–201

    MeSH term(s) Humans ; Female ; Breast Neoplasms ; Risk
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00064-5
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