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  1. Article ; Online: Correction to: Assessing Case Fatality on Cases of Thrombosis with Concurrent Thrombocytopenia Following COVID-19 Vaccine AstraZeneca (Vaxzevria) in the United Kingdom: A Review of Spontaneously Reported Data.

    Lane, Samantha / Shakir, Saad

    Drug safety

    2022  Volume 45, Issue 11, Page(s) 1439–1440

    Language English
    Publishing date 2022-09-03
    Publishing country New Zealand
    Document type Published Erratum
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-022-01233-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Assessing Case Fatality on Cases of Thrombosis with Concurrent Thrombocytopenia Following COVID-19 Vaccine AstraZeneca (Vaxzevria) in the United Kingdom: A Review of Spontaneously Reported Data.

    Lane, Samantha / Shakir, Saad

    Drug safety

    2022  Volume 45, Issue 9, Page(s) 1003–1008

    Abstract: Introduction: Thrombotic thrombocytopenia syndrome (TTS) events were reported very rarely following the coronavirus disease 2019 (COVID-19) vaccine AstraZeneca (Vaxzevria). Clinical and demographic characteristics of the affected people, including the ... ...

    Abstract Introduction: Thrombotic thrombocytopenia syndrome (TTS) events were reported very rarely following the coronavirus disease 2019 (COVID-19) vaccine AstraZeneca (Vaxzevria). Clinical and demographic characteristics of the affected people, including the outcomes of TTS events, need to be examined using available information to better understand aspects of this association.
    Objective: To analyse clinical and demographic information of TTS events, including calculating the case fatality of reported cases of TTS by age and sex, using spontaneously reported data from the UK's Yellow Card spontaneous reporting system of suspected adverse drug reactions.
    Methods: TTS events reported to the Yellow Card scheme were extracted at weekly time points between 12 May 2021 and 25 May 2022. Cumulative numbers of TTS cases and deaths were recorded for each weekly interval, overall and stratified by age, sex, and vaccine dose.
    Results: To 25 May 2022, 443 cases (81 fatal, 18.28%) had been reported in the UK. Events more frequently occurred following the first vaccine dose. No trends were observed for case fatality overall, or by age or sex.
    Conclusion: In the UK, case fatality of TTS events reported to the Medicines and Health products Regulatory Agency (MHRA) following Vaxzevria has been approximately 17-18% since May 2021. There were no statistical differences in fatality based on age or sex. Most reports followed the first vaccine dose; none have been reported following a third dose to date, although Vaxzervia was not recommended for a third dose of COVID-19 vaccine in the UK. TTS remains very rare, and benefits of vaccination outweigh the risks.
    MeSH term(s) Adverse Drug Reaction Reporting Systems ; Anemia ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; ChAdOx1 nCoV-19 ; Humans ; Thrombocytopenia/chemically induced ; Thrombocytopenia/epidemiology ; Thrombosis ; United Kingdom/epidemiology ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2022-08-04
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-022-01217-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: What Is the Difference Between Observed Association and Causal Association, Signals and Evidence? Examples Related to COVID-19.

    Osborne, Vicki / Shakir, Saad A W

    Frontiers in pharmacology

    2021  Volume 11, Page(s) 569189

    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.569189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Constitutive and Inducible Clindamycin Resistance Frequencies among

    Al-Amara, Saad Shakir Mahdi

    Reports of biochemistry & molecular biology

    2022  Volume 11, Issue 1, Page(s) 30–35

    Abstract: Background: Antibiotics called macrolide, lincosamide and streptogramin B (MLS: Methods: The 28 CoNS, traditional techniques and the Vitek®2 system were used to identify the isolates. The disk diffusion technique was used to detect methicillin ... ...

    Abstract Background: Antibiotics called macrolide, lincosamide and streptogramin B (MLS
    Methods: The 28 CoNS, traditional techniques and the Vitek®2 system were used to identify the isolates. The disk diffusion technique was used to detect methicillin resistance and antibiotic sensitivity patterns via cefoxitin, gentamicin, ciprofloxacin, amikacin, teicoplanin, linezolid, doxycycline and vancomycin disks. Erythromycin and clindamycin antibiotic disks was used to detect the inducible and constitutive clindamycin resistance as well as a D-test according to CLSI guidelines.
    Results: Among 28 CoNS isolated, the
    Conclusion: In order to achive the best result in choosing the suitable treatment and avoiding the loses the money and time, it is better to use the D-test for inducible clindamycin resistance in the daily routine work of antibiotic susceptibility testing in hospital and private clinical laboratories.
    Language English
    Publishing date 2022-06-28
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2743890-9
    ISSN 2322-3480
    ISSN 2322-3480
    DOI 10.52547/rbmb.11.1.30
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  5. Article ; Online: Modified BFGS Update (H-Version) Based on the Determinant Property of Inverse of Hessian Matrix for Unconstrained Optimization

    Saad Shakir Mahmood

    Baghdad Science Journal, Vol 17, Iss 3(Suppl.) (2020)

    2020  

    Abstract: The study presents the modification of the Broyden-Flecher-Goldfarb-Shanno (BFGS) update (H-Version) based on the determinant property of inverse of Hessian matrix (second derivative of the objective function), via updating of the vector s ( the ... ...

    Abstract The study presents the modification of the Broyden-Flecher-Goldfarb-Shanno (BFGS) update (H-Version) based on the determinant property of inverse of Hessian matrix (second derivative of the objective function), via updating of the vector s ( the difference between the next solution and the current solution), such that the determinant of the next inverse of Hessian matrix is equal to the determinant of the current inverse of Hessian matrix at every iteration. Moreover, the sequence of inverse of Hessian matrix generated by the method would never approach a near-singular matrix, such that the program would never break before the minimum value of the objective function is obtained. Moreover, the new modification of BFGS update (H-version) preserves the symmetric property and the positive definite property without any condition.
    Keywords BFGS update ; Hessian matrix ; Positive definite matrix ,Unconstrained Optimization ; Science ; Q
    Subject code 518
    Language Arabic
    Publishing date 2020-09-01T00:00:00Z
    Publisher College of Science for Women, University of Baghdad
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: A systematic review of flurbiprofen 8.75 mg dose and risk of adverse events (excluding haemorrhagic) resulting from drug-drug interactions.

    Evans, Alison / Roy, Debabrata / Dhanda, Sandeep / Lane, Samantha / Coutinho, Graça / Kulasekaran, Anuradha / Miller-Shakesby, David / Ramamoorthi, Nagalakshmi / Shakir, Saad

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1107185

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1107185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination

    Saad Shakir / Samantha Lane / Alison Yeomans

    BMJ Open, Vol 12, Iss

    2022  Volume 7

    Keywords Medicine ; R
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination

    Saad Shakir / Samantha Lane / Alison Yeomans

    BMJ Open, Vol 12, Iss

    a systematic review of spontaneously reported data from the UK, Europe and the USA and of the scientific literature

    2022  Volume 5

    Keywords Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination.

    Lane, Samantha / Yeomans, Alison / Shakir, Saad

    BMJ open

    2022  Volume 12, Issue 7, Page(s) e060425

    Abstract: Objectives: To determine whether spontaneous reporting rates of myocarditis and pericarditis differed in immunocompromised patients compared with the whole population overall, and in terms of demographics, vaccine dose and time-to-onset.: Design: ... ...

    Abstract Objectives: To determine whether spontaneous reporting rates of myocarditis and pericarditis differed in immunocompromised patients compared with the whole population overall, and in terms of demographics, vaccine dose and time-to-onset.
    Design: Systematic review of spontaneously reported data from the European Union/European Economic Area (EU/EEA), the USA and the UK.
    Data sources: EudraVigilance (EU/EEA), Vaccine Adverse Event Reporting System (VAERS; USA) and the Medicines and Healthcare products Regulatory Agency (UK) spontaneous reporting databases were searched from date of vaccine launch to 1 December 2021.
    Eligibility criteria: Publicly available spontaneous reporting data for 'myocarditis' and 'pericarditis' from EU/EEA and USA following COVID-19 messenger RNA vaccines. Reports with comorbidities or concurrent medication indicative of transplantation, HIV infection or cancer ('immunocompromised' population) were compared with each overall database population.
    Data extraction and synthesis: Two researchers extracted data. Spontaneously reported events of myocarditis and pericarditis were presented for immunocompromised populations for each data source, stratified by age, sex, dose and time-to-onset (where available). Seriousness of each event was determined according to the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline E2A definition. Proportional reporting ratio (PRR) was calculated.
    Results: There were 178 reports of myocarditis and pericarditis among immunocompromised individuals overall. Seriousness was comparable between the immunocompromised and overall populations in both databases. No trends in age or sex were observed among immunocompromised individuals. Most reports followed a second vaccine dose and occurred within 14 days. The frequency of reporting was similar to the wider population (PRR=1.36 (95% CI=0.89 to 1.82) for VAERS population).
    Conclusions: Myocarditis and pericarditis following COVID-19 vaccination are very rare, and benefits of COVID-19 vaccination continue to outweigh any perceived risks. Reporting rates of myocarditis and pericarditis were similar in immunocompromised individuals, however defining characteristics differed compared with the whole population; therefore, continued monitoring of adverse events following vaccination remains vital to understand differences between population subgroups.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Immunocompromised Host ; Myocarditis/epidemiology ; Pericarditis/epidemiology ; Transplant Recipients
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-060425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination: a systematic review of spontaneously reported data from the UK, Europe and the USA and of the scientific literature.

    Lane, Samantha / Yeomans, Alison / Shakir, Saad

    BMJ open

    2022  Volume 12, Issue 5, Page(s) e059223

    Abstract: Objectives: To combine spontaneously reported data from multiple countries to estimate reporting rate, and better understand risk factors for myocarditis and pericarditis following COVID-19 messenger RNA (mRNA) vaccines.: Design: Systematic review of ...

    Abstract Objectives: To combine spontaneously reported data from multiple countries to estimate reporting rate, and better understand risk factors for myocarditis and pericarditis following COVID-19 messenger RNA (mRNA) vaccines.
    Design: Systematic review of spontaneously reported data from UK, USA and European Union/European Economic Area (EU/EEA) and of the scientific literature.
    Data sources: UK Yellow Card scheme, Vaccine Adverse Event Reporting System (VAERS), EudraVigilance were searched from date of vaccine launch to 14 March 2022-16 March 2022. PubMed/MEDLINE and Embase were searched to 15 March 2022.
    Eligibility criteria: We included publicly available spontaneous reporting data for 'Myocarditis' and 'Pericarditis' from UK, USA and EU/EEA following COVID-19 mRNA vaccines. Pharmacoepidemiological observational studies investigating myocarditis/pericarditis following mRNA COVID-19 vaccines were included (no restrictions on language or date). Critical Appraisal Skills Programme tools assessed study quality.
    Data extraction and synthesis: Two researchers extracted data. Events of myocarditis and pericarditis were presented for each data source, stratified by vaccine, age, sex and dose (where available). Reporting rates were calculated for myocarditis and pericarditis for each population. For published pharmacoepidemiological studies, design, participant characteristics, and study results were tabulated.
    Results: Overall, 18 204 myocarditis and pericarditis events were submitted to the UK, USA and EU/EEA regulators during the study period. Males represented 62.24% (n=11 331) of myocarditis and pericarditis reports. In the UK and USA, most reports concerned vaccinees aged <40 years (59.7% and 47.3% of reported events, respectively); trends in age were less clear for EU/EEA. Reports were more frequent following a second dose (47.1% of reports, where data available). Reporting rates were consistent between the data sources. Thirty-two pharmacoepidemiological studies were included; results were consistent with our spontaneous report analyses.
    Conclusions: Younger vaccinees more frequently report myocarditis and pericarditis following mRNA COVID-19 vaccines than older vaccinees. Results from published literature supported the results of our analyses.
    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Europe/epidemiology ; Female ; Humans ; Male ; Myocarditis/chemically induced ; Pericarditis/chemically induced ; SARS-CoV-2 ; United Kingdom/epidemiology ; United States/epidemiology ; Vaccination/adverse effects ; mRNA Vaccines/adverse effects
    Chemical Substances COVID-19 Vaccines ; mRNA Vaccines
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-059223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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