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  1. Article ; Online: Fabrication of reprogrammable shape-memory polymer actuators for robotics.

    Lendlein, Andreas

    Science robotics

    2018  Volume 3, Issue 18

    Abstract: Shape-memory polymer actuators, whose actuation geometry and switching temperatures are reprogrammable by physical fabrication schemes, were recently suggested for robotics with the option for self-healing and degradability. ...

    Abstract Shape-memory polymer actuators, whose actuation geometry and switching temperatures are reprogrammable by physical fabrication schemes, were recently suggested for robotics with the option for self-healing and degradability.
    Language English
    Publishing date 2018-01-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2470-9476
    ISSN (online) 2470-9476
    DOI 10.1126/scirobotics.aat9090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Shape-Memory Polymers Designed in View of Thermomechanical Energy Storage and Conversion Systems.

    Lendlein, Andreas / Heuchel, Matthias

    ACS central science

    2021  Volume 7, Issue 10, Page(s) 1599–1601

    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type News
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.1c01032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Co-delivery of genes can be confounded by bicistronic vector design.

    Moradian, Hanieh / Gossen, Manfred / Lendlein, Andreas

    MRS communications

    2022  Volume 12, Issue 2, Page(s) 145–153

    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645443-9
    ISSN 2159-6867 ; 2159-6859
    ISSN (online) 2159-6867
    ISSN 2159-6859
    DOI 10.1557/s43579-021-00128-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multivariate Analysis of Cellular Uptake Characteristics for a (Co)polymer Particle Library.

    Baudis, Stefan / Roch, Toralf / Balk, Maria / Wischke, Christian / Lendlein, Andreas / Behl, Marc

    ACS biomaterials science & engineering

    2024  Volume 10, Issue 3, Page(s) 1481–1493

    Abstract: Controlling cellular responses to nanoparticles so far is predominantly empirical, typically requiring multiple rounds of optimization of particulate carriers. In this study, a systematic model-assisted approach should lead to the identification of key ... ...

    Abstract Controlling cellular responses to nanoparticles so far is predominantly empirical, typically requiring multiple rounds of optimization of particulate carriers. In this study, a systematic model-assisted approach should lead to the identification of key parameters that account for particle properties and their cellular recognition. A copolymer particle library was synthesized by a combinatorial approach in soap free emulsion copolymerization of styrene and methyl methacrylate, leading to a broad compositional as well as constitutional spectrum. The proposed structure-property relationships could be elucidated by multivariate analysis of the obtained experimental data, including physicochemical characteristics such as molar composition, molecular weight, particle diameter, and particle charge as well as the cellular uptake pattern of nanoparticles. It was found that the main contributors for particle size were the polymers' molecular weight and the zeta potential, while particle uptake is mainly directed by the particles' composition. This knowledge and the reported model-assisted procedure to identify relevant parameters affecting particle engulfment of particulate carriers by nonphagocytic and phagocytic cells can be of high relevance for the rational design of pharmaceutical nanocarriers and assessment of biodistribution and nanotoxicity, respectively.
    MeSH term(s) Polymers/chemistry ; Tissue Distribution ; Multivariate Analysis
    Chemical Substances Polymers
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Design of Reservoirs Enabling Stress-Induced Sequential Release Systems.

    Altabal, Osamah / Wischke, Christian / Lendlein, Andreas

    Pharmaceutics

    2022  Volume 14, Issue 12

    Abstract: Mechanical stress is recognized as a principle for opening enclosed compartments through compression, stretching, or shear, eventually resulting in the onset of a diffusion-controlled release. Here, we hypothesized that the geometrical design of cavities ...

    Abstract Mechanical stress is recognized as a principle for opening enclosed compartments through compression, stretching, or shear, eventually resulting in the onset of a diffusion-controlled release. Here, we hypothesized that the geometrical design of cavities (cut-outs) introduced as containers in elastic polymer substrates and sealed with a brittle coating layer would enable a pre-defined release of different compounds by stress concentration phenomena. Design criteria such as cut-out shapes, orientations, and depths were initially assessed for suitably different stress concentrations in computational models. In substrates fabricated from polydimethylsiloxane by photolithographic techniques, the local strains at horizontal rectangular, circular, and vertical rhombus-shaped cut-outs systematically increased under horizontal stretching as proposed. When filled with model compounds and coated with poly(
    Language English
    Publishing date 2022-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14122611
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  6. Article ; Online: Shape-Memory Polymers Designed in View of Thermomechanical Energy Storage and Conversion Systems

    Andreas Lendlein / Matthias Heuchel

    ACS Central Science, Vol 7, Iss 10, Pp 1599-

    2021  Volume 1601

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Actively moving polymers.

    Behl, Marc / Lendlein, Andreas

    Soft matter

    2020  Volume 3, Issue 1, Page(s) 58–67

    Abstract: The ability of polymers to move actively in response to an external stimulus such as heat or light is of high scientific and technological significance. In any instance stimuli-responsive effects on the molecular level are converted into macroscopic ... ...

    Abstract The ability of polymers to move actively in response to an external stimulus such as heat or light is of high scientific and technological significance. In any instance stimuli-responsive effects on the molecular level are converted into macroscopic movement, whereby generally two different moving behaviors have to be differentiated for polymer-based materials: the shape-memory effect and the shape-changing capability. Basic concepts for the molecular design of suitable polymer architectures for shape-memory polymers as well as tailored programming processes are presented. The thermally-induced shape-memory effect of polymers is described as well as the extension of this concept to other stimuli than heat. Indirect actuation of the thermally-induced effect by IR-irradiation, electric current, humidity or alternating magnetic fields are outlined as well as recent work on light-induced shape-memory polymers. For shape-changing polymers, two basic concepts are presented: shape changes occurring during phase orientation of liquid crystal elastomers (LCE) and the photomechanical effect based on photoisomerization of moieties, such as azo-groups incorporated in suitable polymer systems.
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/b610611k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Degradable shape-memory polymer networks from oligo[(l-lactide)-ran-glycolide]dimethacrylates.

    Choi, Nok-Young / Lendlein, Andreas

    Soft matter

    2020  Volume 3, Issue 7, Page(s) 901–909

    Abstract: In this paper degradable shape-memory polymer networks synthesized from oligo[(-lactide)--glycolide]dimethaycrylates are introduced. The macrodimethacrylates are prepared a two-step synthesis: hydroxy telechelic oligo[(-lactide)--glycolide]s with number ... ...

    Abstract In this paper degradable shape-memory polymer networks synthesized from oligo[(-lactide)--glycolide]dimethaycrylates are introduced. The macrodimethacrylates are prepared a two-step synthesis: hydroxy telechelic oligo[(-lactide)--glycolide]s with number average molecular weights ranging from 1000 to 5700 g mol were synthesized by ring-opening polymerization from ,-dilactide, diglycolide and ethylene glycol as initiator using dibutyltin oxide as the catalyst. These oligodiols are reacted with methacryloyl chloride resulting in terminal methacrylate groups. Crosslinking of macrodimethacrylates is performed under exposure to UV light without applying a photo initiator. The polymer networks obtained are transparent and hydrolytically degradable. While the mechanical properties at temperatures higher than depend on crosslinking density, is almost constant at about 55 °C. The shape-memory functionality of the amorphous polymer network was investigated by cyclic, thermomechanical tests under the systematic variation of different programming parameters. Good shape-memory properties with strain recovery rates close to 100% were obtained under stress-controlled programming. Under strain-controlled conditions, it needs to be considered that relatively high stresses can be generated during programming. Potential biomedical applications are intelligent implants or smart drug release systems.
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/b702515g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages.

    Moradian, Hanieh / Roch, Toralf / Anthofer, Larissa / Lendlein, Andreas / Gossen, Manfred

    Molecular therapy. Nucleic acids

    2022  Volume 27, Page(s) 854–869

    Abstract: ... In ... ...

    Abstract In vitro
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2022.01.004
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  10. Article ; Online: Thiol-Thioester Exchange Reactions in Precursors Enable pH-Triggered Hydrogel Formation.

    Folikumah, Makafui Y / Behl, Marc / Lendlein, Andreas

    Biomacromolecules

    2021  Volume 22, Issue 5, Page(s) 1875–1884

    Abstract: Bio-interactive hydrogel ... ...

    Abstract Bio-interactive hydrogel formation
    MeSH term(s) Hydrogels ; Hydrogen-Ion Concentration ; Polyethylene Glycols ; Polymers ; Sulfhydryl Compounds
    Chemical Substances Hydrogels ; Polymers ; Sulfhydryl Compounds ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.0c01690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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