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  1. Article ; Online: Is Africa part of the partnership?

    Yap Boum II

    Medicine Anthropology Theory, Vol 5, Iss

    2018  Volume 2

    Abstract: This essay presents an African perspective on medical research partnerships done in Africa. While African institutions have a long history of establishing research partnerships with Western institutions it is important to assess how they have been ... ...

    Abstract This essay presents an African perspective on medical research partnerships done in Africa. While African institutions have a long history of establishing research partnerships with Western institutions it is important to assess how they have been contributing to this relationship. After describing how partnerships are established and how they currently function for many institutions, I discuss how mutual and antagonistic interests can affect those global health relationships that finish in ‘divorce’. I end with defining the place of Africa in its partnerships with Western institutions in medical research, and argue for a new mind-set that would bolster African ownership and funding of research done in Africa.
    Keywords africa ; global health ; partnership ; research ; Anthropology ; GN1-890 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher University of Edinburgh Library
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Mpox: The alarm went off. Have we gone back to sleep?

    Olliaro, Piero / Bourner, Josephine / Boum Ii, Yap / Nakouné, Emmanuel / Pesonel, Elise / Rojek, Amanda / Yazdanpanah, Yazdan / Lescure, François-Xavier / Calmy, Alexandra / Grinsztejn, Beatriz / Horby, Peter / Merson, Laura / Dunning, Jake

    PLoS neglected tropical diseases

    2024  Volume 18, Issue 1, Page(s) e0011871

    MeSH term(s) Humans ; Mpox (monkeypox)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: How to ensure a needs-driven and community-centred vaccination strategy for COVID-19 in Africa.

    Boum Ii, Yap / Ouattara, Ali / Torreele, Els / Okonta, Chibuzo

    BMJ global health

    2021  Volume 6, Issue 2

    MeSH term(s) Africa ; COVID-19/prevention & control ; Health Services Needs and Demand ; Humans ; SARS-CoV-2 ; Vaccination Coverage/organization & administration
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2021-005306
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  4. Article ; Online: How to ensure a needs-driven and community-centred vaccination strategy for COVID-19 in Africa

    Els Torreele / Yap Boum II / Ali Ouattara / Chibuzo Okonta

    BMJ Global Health, Vol 6, Iss

    2021  Volume 2

    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
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  5. Article ; Online: Ten tips for overcoming language barriers in science.

    Amano, Tatsuya / Rios Rojas, Clarissa / Boum Ii, Yap / Calvo, Margarita / Misra, Biswapriya B

    Nature human behaviour

    2021  Volume 5, Issue 9, Page(s) 1119–1122

    MeSH term(s) Communication ; Communication Barriers ; Humans ; Information Storage and Retrieval ; Interprofessional Relations ; Multilingualism ; Research Personnel
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-021-01137-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mpox

    Piero Olliaro / Josephine Bourner / Yap Boum II / Emmanuel Nakouné / Elise Pesonel / Amanda Rojek / Yazdan Yazdanpanah / François-Xavier Lescure / Alexandra Calmy / Beatriz Grinsztejn / Peter Horby / Laura Merson / Jake Dunning

    PLoS Neglected Tropical Diseases, Vol 18, Iss

    The alarm went off. Have we gone back to sleep?

    2024  Volume 1

    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Advancing equitable global health research partnerships in Africa.

    Boum Ii, Yap / Burns, Bridget F / Siedner, Mark / Mburu, Yvonne / Bukusi, Elizabeth / Haberer, Jessica E

    BMJ global health

    2018  Volume 3, Issue 4, Page(s) e000868

    Language English
    Publishing date 2018-08-23
    Publishing country England
    Document type Journal Article
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2018-000868
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  8. Article: Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda): Observational Cohort Study Protocol of the "PI-POC" Trial.

    Gaudenzi, Giulia / Kumbakumba, Elias / Rasti, Reza / Nanjebe, Deborah / Réu, Pedro / Nyehangane, Dan / Mårtensson, Andreas / Nassejje, Milly / Karlsson, Jens / Mzee, John / Nilsson, Peter / Businge, Stephen / Loh, Edmund / Boum Ii, Yap / Andersson-Svahn, Helene / Gantelius, Jesper / Mwanga-Amumpaire, Juliet / Alfvén, Tobias

    JMIR research protocols

    2020  Volume 9, Issue 11, Page(s) e21430

    Abstract: Background: A timely differential diagnostic is essential to identify the etiology of central nervous system (CNS) infections in children, in order to facilitate targeted treatment, manage patients, and improve clinical outcome.: Objective: The ... ...

    Abstract Background: A timely differential diagnostic is essential to identify the etiology of central nervous system (CNS) infections in children, in order to facilitate targeted treatment, manage patients, and improve clinical outcome.
    Objective: The Pediatric Infection-Point-of-Care (PI-POC) trial is investigating novel methods to improve and strengthen the differential diagnostics of suspected childhood CNS infections in low-income health systems such as those in Southwestern Uganda. This will be achieved by evaluating (1) a novel DNA-based diagnostic assay for CNS infections, (2) a commercially available multiplex PCR-based meningitis/encephalitis (ME) panel for clinical use in a facility-limited laboratory setting, (3) proteomics profiling of blood from children with severe CNS infection as compared to outpatient controls with fever yet not severely ill, and (4) Myxovirus resistance protein A (MxA) as a biomarker in blood for viral CNS infection. Further changes in the etiology of childhood CNS infections after the introduction of the pneumococcal conjugate vaccine against Streptococcus pneumoniae will be investigated. In addition, the carriage and invasive rate of Neisseria meningitidis will be recorded and serotyped, and the expression of its major virulence factor (polysaccharide capsule) will be investigated.
    Methods: The PI-POC trial is a prospective observational study of children including newborns up to 12 years of age with clinical features of CNS infection, and age-/sex-matched outpatient controls with fever yet not severely ill. Participants are recruited at 2 Pediatric clinics in Mbarara, Uganda. Cerebrospinal fluid (for cases only), blood, and nasopharyngeal (NP) swabs (for both cases and controls) sampled at both clinics are analyzed at the Epicentre Research Laboratory through gold-standard methods for CNS infection diagnosis (microscopy, biochemistry, and culture) and a commercially available ME panel for multiplex PCR analyses of the cerebrospinal fluid. An additional blood sample from cases is collected on day 3 after admission. After initial clinical analyses in Mbarara, samples will be transported to Stockholm, Sweden for (1) validation analyses of a novel nucleic acid-based POC test, (2) biomarker research, and (3) serotyping and molecular characterization of S. pneumoniae and N. meningitidis.
    Results: A pilot study was performed from January to April 2019. The PI-POC trial enrollment of patients begun in April 2019 and will continue until September 2020, to include up to 300 cases and controls. Preliminary results from the PI-POC study are expected by the end of 2020.
    Conclusions: The findings from the PI-POC study can potentially facilitate rapid etiological diagnosis of CNS infections in low-resource settings and allow for novel methods for determination of the severity of CNS infection in such environment.
    Trial registration: ClinicalTrials.gov NCT03900091; https://clinicaltrials.gov/ct2/show/NCT03900091.
    International registered report identifier (irrid): DERR1-10.2196/21430.
    Keywords covid19
    Language English
    Publishing date 2020-11-04
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/21430
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  9. Article ; Online: Timing of malaria in pregnancy and impact on infant growth and morbidity: a cohort study in Uganda.

    De Beaudrap, Pierre / Turyakira, Eleanor / Nabasumba, Carolyn / Tumwebaze, Benon / Piola, Patrice / Boum Ii, Yap / McGready, Rose

    Malaria journal

    2016  Volume 15, Page(s) 92

    Abstract: Background: Malaria in pregnancy (MiP) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-Saharan Africa. Understanding of the impact of MiP on infant growth and infant risk of malaria or morbidity is poorly ... ...

    Abstract Background: Malaria in pregnancy (MiP) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-Saharan Africa. Understanding of the impact of MiP on infant growth and infant risk of malaria or morbidity is poorly characterized. The objective of this study was to describe the impact of MIP on subsequent infant growth, malaria and morbidity.
    Methods: Between 2006 and 2009, 82 % (832/1018) of pregnant women with live-born singletons and ultrasound determined gestational age were enrolled in a prospective cohort with active weekly screening and treatment for malaria. Infants were followed monthly for growth and morbidity and received active monthly screening and treatment for malaria during their first year of life. Multivariate analyses were performed to analyse the association between malaria exposure during pregnancy and infants' growth, malaria infections, diarrhoea episodes and acute respiratory infections.
    Results: Median time of infant follow-up was 12 months and infants born to a mother who had MiP were at increased risk of impaired height and weight gain (-2.71 cm, 95 % CI -4.17 to -1.25 and -0.42 kg, 95 % CI -0.76 to -0.08 at 12 months for >1 MiP compared to no MiP) and of malaria infection (relative risk 10.42, 95 % CI 2.64-41.10 for infants born to mothers with placental malaria). The risks of infant growth restriction and infant malaria infection were maximal when maternal malaria occurred in the 12 weeks prior to delivery. Recurrent MiP was also associated with acute respiratory infection (RR 1.96, 95 % CI 1.25-3.06) and diarrhoea during infancy (RR 1.93, 95 % CI 1.02-3.66).
    Conclusion: This study shows that despite frequent active screening and prompt treatment of MiP, impaired growth and an increased risk of malaria and non-malaria infections can be observed in the infants. Effective preventive measures in pregnancy remain a research priority. This study was registered with ClinicalTrials.gov, number NCT00495508.
    MeSH term(s) Adult ; Female ; Humans ; Infant, Low Birth Weight/physiology ; Malaria/complications ; Pregnancy ; Pregnancy Complications, Parasitic/physiopathology ; Prospective Studies ; Time Factors ; Uganda ; Young Adult
    Language English
    Publishing date 2016-02-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1475-2875
    ISSN (online) 1475-2875
    DOI 10.1186/s12936-016-1135-7
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  10. Article ; Online: Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy

    Lisa M. Bebell / Annet Kembabazi / Nicholas Musinguzi / Jeffrey N. Martin / Peter W. Hunt / Yap Boum, II / Kelli N. O'Laughlin / Conrad Muzoora / Jessica E. Haberer / Mwebesa Bosco Bwana / David R. Bangsberg / Mark J. Siedner / Alexander C. Tsai

    SSM - Mental Health, Vol 1, Iss , Pp 100034- (2021)

    A cohort study in rural Uganda

    2021  

    Abstract: Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies of PHIV have examined the relationship between HIV-related stigma ... ...

    Abstract Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies of PHIV have examined the relationship between HIV-related stigma and depression. Data were analyzed from the 2007-15 Uganda AIDS Rural Treatment Outcomes (UARTO) Study, a cohort of 454 antiretroviral therapy (ART)-naïve PHIV (68% women) starting ART. Our primary outcome was depression symptom severity over the first two years of ART, measured using a locally adapted version of the Hopkins Symptom Checklist; our primary exposure was the 6-item Internalized AIDS-Related Stigma Scale. Both scores were measured at enrollment and at quarterly follow-up visits. We fit linear generalized estimating equations (GEE) regression models to estimate the association between stigma and depression symptom severity, adjusting for potential confounders. We included a stigma × time product term to assess the modifying effect of ART on the association between internalized stigma and depression symptom severity. UARTO participants had a median age of 32 years and median enrollment CD4 count of 217 cells/mm3. Both depression symptom severity and internalized stigma declined on ART, particularly during the first treatment year. In multivariable regression models, depression symptom severity was positively associated with internalized stigma (b = 0.03; 95% confidence interval [CI], 0.02 to 0.04) and negatively associated with ART duration >6 months (b = −0.16; 95% CI, −0.19 to −0.13). The estimated product term coefficient was negative and statistically significant (P = 0.004), suggesting that the association between internalized stigma and depression symptom severity weakened over time on ART. Thus, in this large cohort of PHIV initiating ART in rural Uganda, depression symptom severity was associated with internalized stigma but the association declined with time on ART. These findings underscore the potential value of ART as a stigma reduction ...
    Keywords Antiretroviral therapy ; Depression ; Discrimination ; HIV ; Mental health ; Prejudice ; Mental healing ; RZ400-408 ; Public aspects of medicine ; RA1-1270
    Subject code 700
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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