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Article: Anmerkungen zu dem Diskussionsbeitrag von C. H. Hanf, H. Jochimsen, C. Langbehn und K. Riebe

Köhne, M / Hanf, C. H / Jochimsen, H / Langbehn, C / Riebe, K

Forschung und Ausbildung im Bereich der Wirtschafts- und Sozialwissenschaften des Landbaues. Mit Beitr von H. J. Blcok [u.a.]. Im Auftr. der Gesellschaft für Wirtschafts- und Sozialwissenschaften des Landbaues e.V. , p. 101-102

1975 , Page(s) 101–102

Author's details	M. Köhne
Keywords	Agrarbetrieb
Publisher	BLV- Verl.-Ges.
Publishing place	München; Bern; Wien
Document type	Article
Database	ECONomics Information System

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Conference proceedings ; Online: Anmerkungen zu dem Diskussionsbeitrag von C.H. Hanf, H. Jochimsen, C. Langben und K. Riebe

Köhne, M.

1975

Keywords	Farm Management ; Research Methods/ Statistical Methods
Language	German
Publishing country	us
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Frequency of potentially pathogenic bacterial and fungal isolates among 28,887 endometrial samples from mares, with an emphasis on multi-drug resistant bacteria in Germany (2018-2022).

Köhne, Martin / Hegger, Anna / Tönissen, Anna / Heusinger, Anton / Hader, Corinna / Görgens, Alexandra / Sieme, Harald

Journal of equine veterinary science

2024 Volume 133, Page(s) 105008

Abstract: Antimicrobial-resistant bacteria pose a serious threat to the wellbeing of animals and humans. In equine reproduction, endometritis caused by facultative microbial pathogens is a condition, which is usually treated with antibiotics. Data from Germany on ... ...

Abstract	Antimicrobial-resistant bacteria pose a serious threat to the wellbeing of animals and humans. In equine reproduction, endometritis caused by facultative microbial pathogens is a condition, which is usually treated with antibiotics. Data from Germany on prevalence of facultative pathogenic microorganisms cultured in samples from the equine uterus and the frequency of multi-drug resistant (MDR) bacteria is lacking. The aim of the study was to provide representative numbers for both. Microbiological culture results (n = 28,887) of endometrial samples submitted to a large veterinary diagnostic laboratory from 2018-2022 were analyzed. An average of 25.9 % of the culture results showed growth of facultative pathogenic bacteria. The dominant isolated bacteria were β-hemolytic streptococci (79.7 %) followed by Escherichia (E.) coli variatio haemolytica (5.2 %). E. coli were cultured in 4.3 % of the samples and occurred more often than Klebsiella pneumoniae (3.9 %), Candida species (2.9 %), Pseudomonas aeruginosa (2.0 %), and Staphylococcus aureus (1.5 %). Antibiotic susceptibility testing revealed sensitivity of β-hemolytic streptococci towards penicillins in almost 100 % of the cultured samples (99.5 %). E. coli-isolates were sensitive to gentamicin in 96.2 % of the cases. The frequency of multidrug-resistant extended spectrum beta-lactamase (ESBL)-positive bacteria and methicillin-resistant Staphylococcus aureus (MRSA) was 3.1 % of all positive culture results. The number of ESBL-positive isolates (n = 159) and MRSA was stable from 2018-2022. In conclusion, the situation regarding occurrence of MDR bacteria in Germany is favorable, but should further be monitored.
MeSH term(s)	Humans ; Horses ; Animals ; Female ; Methicillin-Resistant Staphylococcus aureus ; Escherichia coli ; Microbial Sensitivity Tests/veterinary ; Bacteria ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2024.105008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current stages of adjuvant treatment of colon cancer.

Köhne, C H

Annals of oncology : official journal of the European Society for Medical Oncology

2012 Volume 23 Suppl 10, Page(s) x71–6

MeSH term(s)	Aged ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bevacizumab ; Camptothecin/analogs & derivatives ; Camptothecin/therapeutic use ; Cetuximab ; Chemotherapy, Adjuvant/methods ; Chemotherapy, Adjuvant/trends ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Fluorouracil/therapeutic use ; Humans ; Irinotecan ; Leucovorin/therapeutic use ; Neoplasm Staging ; Organoplatinum Compounds/therapeutic use ; Survival Analysis
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Organoplatinum Compounds ; Bevacizumab (2S9ZZM9Q9V) ; Irinotecan (7673326042) ; Cetuximab (PQX0D8J21J) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2012-09-14
Publishing country	England
Document type	Congress ; Overall
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1093/annonc/mds354
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Article ; Online: How to integrate molecular targeted agents in the continuum of care.

Köhne, C-H

Annals of oncology : official journal of the European Society for Medical Oncology

2010 Volume 21 Suppl 7, Page(s) vii134–9

Abstract: ... activity but are only active in k-ras wt tumors. In combination with FOLFIRI or FOLFOX they can improve RR ... of the CRYSTAL study FOLFIRI plus cetuxcimab is also an options in k-ras wt tumors as this is the only regimen ... with an EGFR antibody in k-ras mut tumors and combinations of EGFR and VEGF antibodies in combinations ...

Abstract	Molecular targeted agents have enriched the therapeutic options. The VEGF inhibitor Bevacizumab has no single agent activity. It was studied in several phase III chemotherapy trials. The best results were achieved when bevacizumab was combined with fluoropyrimidies (infusional 5-FU and capecitabine) alone or with IFL (bolus 5-FU), while randomized data for the infusional schedule FOLFIRI is missing and data on FOLFOX is negative. The EGF receptor antibodies cetuximab or panitumumab have single agent activity but are only active in k-ras wt tumors. In combination with FOLFIRI or FOLFOX they can improve RR, PFS and OS according to randomized trials. For the use of targeted agents clinicians have to determine the treatment strategy. If cure is the aim or a rapid relieve of tumor related symptoms in aggressive tumors is necessary regimens inducing a high RR such as FOLFOXIRI or FOLFOX / FOLFIRI plus an EGFR antibody are optimal. The treatment of patients with a slow tumor progression or a low tumor burden may start with 5-FU or capecitabine alone of in combination with bevacizumab. According to recently published data of the CRYSTAL study FOLFIRI plus cetuxcimab is also an options in k-ras wt tumors as this is the only regimen that prolongs survival statistically significant and clinically relevant. FOLFOX should not be combined with an EGFR antibody in k-ras mut tumors and combinations of EGFR and VEGF antibodies in combinations with chemotherapy should be avoided outside a clinical trial, as inferior outcomes have been observed.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma/drug therapy ; Carcinoma/pathology ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Continuity of Patient Care ; Disease Progression ; Humans ; Molecular Targeted Therapy/methods ; Remission Induction ; Systems Integration
Chemical Substances	Adjuvants, Immunologic
Language	English
Publishing date	2010-10-11
Publishing country	England
Document type	Evaluation Study ; Journal Article ; Review
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1093/annonc/mdq374
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Book ; Online ; Thesis: „Treibermutationen und Checkpoint Proteinexpression des Adenokarzinoms der Lunge hinsichtlich der Verteilung von Subpopulationen immunkompetenter Zellen in der direkten Tumorumgebung und des Langzeitüberlebens“

Zink, Peter Clemens [Verfasser] / Griesinger, Frank [Akademischer Betreuer] / Loser, Karin [Akademischer Betreuer] / Köhne, C.H. [Akademischer Betreuer]

2022

Author's details	Peter Clemens Zink ; Frank Griesinger, Karin Loser, C.H. Köhne
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	BIS der Universität Oldenburg
Publishing place	Oldenburg
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Analysis of gene and protein expression in the endometrium for validation of an ex vivo model of the equine uterus using PCR, digital and visual histopathology.

Köhne, Martin / Diel, Emilia / Packeiser, Eva-Maria / Böttcher, Denny / Tönissen, Anna / Unruh, Christin / Goericke-Pesch, Sandra / Ulrich, Reiner / Sieme, Harald

Theriogenology

2024 Volume 221, Page(s) 38–46

Abstract: ... perfused with autologous blood for 6 h. Cycle stage was determined by examination of the ovaries ...

Abstract	In the past, most research in equine reproduction has been performed in vivo but the use of in vitro and ex vivo models has recently increased. This study aimed to evaluate the functional stability of an ex vivo hemoperfused model for equine uteri with molecular characterization of marker genes and their proteins. In addition, the study validated the respective protein expression and the aptness of the software QuPath for identifying and scoring immunohistochemically stained equine endometrium. After collection, uteri (n = 12) were flushed with preservation solution, transported to the laboratory on ice, and perfused with autologous blood for 6 h. Cycle stage was determined by examination of the ovaries for presence of Graafian follicles or corpora lutea and analysis of plasma progesterone concentration (estrus: n = 4; diestrus: n = 4; anestrus: n = 4). Samples were obtained directly after slaughter, after transportation, and during perfusion (240, 300, 360 min). mRNA expression levels of progesterone (PGR), estrogen (ESR1) and oxytocin (OXTR) receptor as well as of MKI67 (marker of cell growth) and CASP3 (marker of apoptosis) were analyzed by RT-qPCR, and correlation to protein abundance was validated by immunohistochemical staining. Endometrial samples were analyzed by visual and computer-assisted evaluation of stained antigens via QuPath. For PGR, effects of the perfusion and cycle stage on expression were found (P < 0.05), while ESR1 was affected only by cycle stage (P < 0.05) and OXTR was unaffected by perfusion and cycle stage. MKI67 was lower after 360 min of perfusion as compared to samples collected before perfusion (P < 0.05). For CASP3, differences in gene expression were found after transport and samples taken after 240 min (P < 0.05). Immunohistochemical staining revealed effects of perfusion on stromal and glandular cells for steroid hormone receptors, but not for Ki-67 and active Caspase 3. OXTR was visualized in all layers of the endometrium and was unaffected by perfusion. Comparison of QuPath and visual analysis resulted in similar results. For most cell types and stained antigens, the correlation coefficient was r > 0.5. In conclusion, the isolated hemoperfused model of the equine uterus was successfully validated at the molecular level, demonstrating stability of key marker gene expression. The utility of computer-assisted immunohistochemical analysis of equine endometrial samples was also confirmed.
MeSH term(s)	Female ; Horses/genetics ; Animals ; Progesterone ; Caspase 3/metabolism ; Uterus/metabolism ; Endometrium/metabolism ; Estrogens/metabolism ; Oxytocin/genetics ; Receptors, Oxytocin/genetics ; Polymerase Chain Reaction/veterinary
Chemical Substances	Progesterone (4G7DS2Q64Y) ; Caspase 3 (EC 3.4.22.-) ; Estrogens ; Oxytocin (50-56-6) ; Receptors, Oxytocin
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2024.03.015
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Article ; Online: Evaluation of an ex vivo model of the blood-perfused equine uterus.

Köhne, Martin / Unruh, Christin / Böttcher, Denny / Tönissen, Anna / Ulrich, Reiner / Sieme, Harald

Theriogenology

2022 Volume 184, Page(s) 82–91

Abstract: ... isolated perfused with autologous blood for 6 h (n = 12). For negative control, one uterus was handled ... as described but left without perfusion for 6 h. The cycle stage was determined by examination of the ovaries ... to record spontaneous contractions and the response to 0.5 IU oxytocin after 6 h of perfusion. Analyses ...

Abstract	Uterine pathologies are the most common causes of infertility in mares. This study aimed to establish an ex vivo blood-perfused model for equine uteri and investigate the possible effects of different cycle stages (estrus, diestrus and anestrus) on the applicability of the model. Uteri (n = 13) were collected at an abattoir, flushed with preservation solution, transported to the laboratory on ice, and isolated perfused with autologous blood for 6 h (n = 12). For negative control, one uterus was handled as described but left without perfusion for 6 h. The cycle stage was determined by examination of the ovaries for the presence of Graafian follicles or corpora lutea and analysis of plasma progesterone concentration (estrus: n = 4; diestrus: n = 4; anestrus: n = 4). Sonomicrometry crystals were implanted into the myometrium to record spontaneous contractions and the response to 0.5 IU oxytocin after 6 h of perfusion. Analyses of the arterial and venous perfusate were performed every hour to determine glucose consumption, lactate production, pH, lactate dehydrogenase activity (LDH), and potassium concentration (K
MeSH term(s)	Animals ; Female ; Glucose/pharmacology ; Horses ; Lactic Acid ; Myometrium ; Oxytocin/pharmacology ; Uterus/physiology
Chemical Substances	Lactic Acid (33X04XA5AT) ; Oxytocin (50-56-6) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2022.02.026
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Article: Palliative Therapie des kolorektalen Karzinoms.

Köhne, C-H

Onkologie

2003 Volume 26 Suppl 7, Page(s) 41–47

Abstract: Systemic chemotherapy has a key role in the palliative treatment of patients with metastatic colorectal cancer. Compared to best supportive care, 5-fluorouracil (5-FU)-based therapy prolongs survival and improves quality of life. 5-FU continuous infusion ...

Title translation	Palliative therapy of colorectal cancer.
Abstract	Systemic chemotherapy has a key role in the palliative treatment of patients with metastatic colorectal cancer. Compared to best supportive care, 5-fluorouracil (5-FU)-based therapy prolongs survival and improves quality of life. 5-FU continuous infusion modulated by Leukovorin (LV) is the optimal basis for a combination therapy with irinotecan or oxaliplatin. Randomized trials investigating the role of irinotecan in combination with 5-FU/LV relative to 5-FU/LV alone demonstrated a significant improvement in the response rate, progression free survival and overall survival. Randomized studies using oxaliplatin/ 5-FU/LV vs. FU/LV alone resulted in a higher response rate and longer progression-free survival while the overall survival was not significantly different. Today, all patients should receive combination treatment in first line and should be offered all active compounds during the course of their disease. Hereby, median survival times of more than 20 months are achievable. The use of oral fluoropyrimidines as a substitute of infusional 5-FU in combination with irinotecan or oxaliplatin is promising and subject of clinical trials. Monoclonal antibodies directed against the EGF-receptor or against VEGF have demonstrated interesting results and may be a treatment option in the future.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Clinical Trials as Topic ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Disease Progression ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Humans ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/pathology ; Neoplasm Staging ; Palliative Care ; Survival Rate
Chemical Substances	Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
Language	German
Publishing date	2003-12
Publishing country	Switzerland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	549601-9
ISSN	1423-0240 ; 0378-584X
ISSN (online)	1423-0240
ISSN	0378-584X
DOI	10.1159/000076174
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Article ; Online: Herpes zoster prophylaxis with low-dose acyclovir in patients with malignant lymphoma and multiple myeloma treated with autologous stem cell transplantation.

Abbasov, Emin / Metzner, Bernd / Müller, Thomas H / Casper, Jochen / Kimmich, Christoph / Petershofen, Eduard K / Renzelmann, Andrea / Rosien, Bernd / Thole, Ruth / Voß, Andreas / Köhne, Claus Henning

European journal of haematology

2022 Volume 109, Issue 3, Page(s) 298–304

Abstract: Background: Herpes zoster (HZ) is a frequent complication after autologous stem cell transplantation (ASCT). The option of zoster prophylaxis with an antiviral drug is described in the literature, but there is no consensus on the drug and the dosage.: ...

Abstract	Background: Herpes zoster (HZ) is a frequent complication after autologous stem cell transplantation (ASCT). The option of zoster prophylaxis with an antiviral drug is described in the literature, but there is no consensus on the drug and the dosage. Patients and methods: We analyzed the records of 310 patients treated with ASCT who were controlled regularly regarding HZ inter alia for at least 24 months following ASCT. Since 01/2015 patients received prophylactic low-dose acyclovir (400 mg per day) during the first 12 months following discharge after ASCT (n = 107). Results: Twenty percent of patients without this kind of prophylaxis and 2.8% of patients with prophylaxis developed HZ (p < .001). No patient with this prophylaxis developed HZ in the first year after ASCT, 2.8% of patients in the second year after ASCT. A prognostic factor was the kind of diagnosis: 30% of lymphoma patients and 14% of myeloma patients developed HZ in the first 24 months after ASCT without prophylaxis, but only 6.3% and 0% of patients with prophylaxis, respectively. Neither an increase of HZ cases following prophylaxis nor acyclovir refractory HZ cases were observed. Conclusions: Zoster prophylaxis with low-dose acyclovir over 12 months after ASCT is effective and well tolerated.
MeSH term(s)	Acyclovir/adverse effects ; Hematopoietic Stem Cell Transplantation/adverse effects ; Herpes Zoster/diagnosis ; Herpes Zoster/etiology ; Herpes Zoster/prevention & control ; Herpesvirus 3, Human ; Humans ; Lymphoma/complications ; Lymphoma/diagnosis ; Lymphoma/therapy ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis ; Multiple Myeloma/therapy ; Retrospective Studies ; Stem Cell Transplantation/adverse effects ; Transplantation, Autologous/adverse effects
Chemical Substances	Acyclovir (X4HES1O11F)
Language	English
Publishing date	2022-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13810
Database	MEDical Literature Analysis and Retrieval System OnLINE

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